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Photodynamic therapy (PDT), largely employed as a clinical treatment for several malignant pathologies, has also gained importance as a promising antimicrobial approach. Antimicrobial PDT (aPDT) relies on the application of a photosensitizer able to produce singlet oxygen (1O2) or other cytotoxic reactive oxygen species (ROS) upon exposure to appropriate light, which leads to cell death after the induced photodamage. Among different types of 2D nanomaterials with antimicrobial properties, phosphorene, the exfoliated form of black phosphorus (bP), has the unique property intrinsic photoactivity exploitable for photothermal therapy (PTT) as well as for PDT against pathogenic bacteria.<\/jats:p>","DOI":"10.3390\/pharmaceutics15122748","type":"journal-article","created":{"date-parts":[[2023,12,11]],"date-time":"2023-12-11T06:56:00Z","timestamp":1702277760000},"page":"2748","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Innovative Phosphorene Nanoplatform for Light Antimicrobial Therapy"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5006-2531","authenticated-orcid":false,"given":"Elisa","family":"Passaglia","sequence":"first","affiliation":[{"name":"National Research Council-Institute of Chemistry of OrganoMetallic Compounds (CNR-ICCOM), SS Pisa, Via Moruzzi 1, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0858-3293","authenticated-orcid":false,"given":"Antonella","family":"Sgarbossa","sequence":"additional","affiliation":[{"name":"National Research Council-Nanoscience Institute (CNR-NANO) and NEST-Scuola Normale Superiore, Piazza S. Silvestro 12, 56127 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,9]]},"reference":[{"key":"ref_1","unstructured":"Global AMR R&D Hub, and WHO (2023). Incentivising the Development of New Antibacterial Treatments, WHO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/s12668-019-00658-4","article-title":"World Health Organization Report: Current Crisis of Antibiotic Resistance","volume":"9","author":"Rizvanov","year":"2019","journal-title":"BioNanoScience"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrmicro3380","article-title":"Molecular Mechanisms of Antibiotic Resistance","volume":"13","author":"Blair","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mancuso, G., Midiri, A., Gerace, E., and Biondo, C. (2021). Bacterial Antibiotic Resistance: The Most Critical Pathogens. 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