{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:48:59Z","timestamp":1769269739176,"version":"3.49.0"},"reference-count":137,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81760642"],"award-info":[{"award-number":["81760642"]}]},{"name":"National Natural Science Foundation of China","award":["82060645"],"award-info":[{"award-number":["82060645"]}]},{"name":"National Natural Science Foundation of China","award":["82260698"],"award-info":[{"award-number":["82260698"]}]},{"name":"National Natural Science Foundation of China","award":["202101AT070099"],"award-info":[{"award-number":["202101AT070099"]}]},{"name":"National Natural Science Foundation of China","award":["202003AC100013"],"award-info":[{"award-number":["202003AC100013"]}]},{"name":"Key Natural Science Foundation of Yunnan Province","award":["81760642"],"award-info":[{"award-number":["81760642"]}]},{"name":"Key Natural Science Foundation of Yunnan Province","award":["82060645"],"award-info":[{"award-number":["82060645"]}]},{"name":"Key Natural Science Foundation of Yunnan Province","award":["82260698"],"award-info":[{"award-number":["82260698"]}]},{"name":"Key Natural Science Foundation of Yunnan Province","award":["202101AT070099"],"award-info":[{"award-number":["202101AT070099"]}]},{"name":"Key Natural Science Foundation of Yunnan Province","award":["202003AC100013"],"award-info":[{"award-number":["202003AC100013"]}]},{"name":"Key R&amp;D Project of Yunnan Provincial Science and Technology Department","award":["81760642"],"award-info":[{"award-number":["81760642"]}]},{"name":"Key R&amp;D Project of Yunnan Provincial Science and Technology Department","award":["82060645"],"award-info":[{"award-number":["82060645"]}]},{"name":"Key R&amp;D Project of Yunnan Provincial Science and Technology Department","award":["82260698"],"award-info":[{"award-number":["82260698"]}]},{"name":"Key R&amp;D Project of Yunnan Provincial Science and Technology Department","award":["202101AT070099"],"award-info":[{"award-number":["202101AT070099"]}]},{"name":"Key R&amp;D Project of Yunnan Provincial Science and Technology Department","award":["202003AC100013"],"award-info":[{"award-number":["202003AC100013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Ischemic stroke (IS) is a prevalent form of stroke and a leading cause of mortality and disability. Recently, cell membrane-derived nanovehicles (CMNVs) derived from erythrocytes, thrombocytes, neutrophils, macrophages, neural stem cells, and cancer cells have shown great promise as drug delivery systems for IS treatment. By precisely controlling drug release rates and targeting specific sites in the brain, CMNVs enable the reduction in drug dosage and minimization of side effects, thus significantly enhancing therapeutic strategies and approaches for IS. While there are some reviews regarding the applications of CMNVs in the treatment of IS, there has been limited attention given to important aspects such as carrier construction, structural design, and functional modification. Therefore, this review aims to address these key issues in CMNVs preparation, structural composition, modification, and other relevant aspects, with a specific focus on targeted therapy for IS. Finally, the challenges and prospects in this field are discussed.<\/jats:p>","DOI":"10.3390\/pharmaceutics16010006","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T06:03:11Z","timestamp":1702965791000},"page":"6","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cell Membrane-Derived Nanovehicles for Targeted Therapy of Ischemic Stroke: From Construction to Application"],"prefix":"10.3390","volume":"16","author":[{"given":"Cui","family":"Hao","sequence":"first","affiliation":[{"name":"School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma","family":"Sha","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China"},{"name":"Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengxiao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China"},{"name":"Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Kunming 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0140-6736(16)30962-X","article-title":"Stroke","volume":"389","author":"Hankey","year":"2017","journal-title":"Lancet"},{"key":"ref_2","unstructured":"(2021). 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