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Self-unfolding foils support unidirectional drug release in close proximity to the intestinal epithelium, the main drug absorption site following oral administration. The foils are loaded with a solid-state formulation containing the active pharmaceutical ingredient and then coated and rolled into enteric capsules. The coated lid must remain intact to ensure drug protection in the rolled state until targeted release in the small intestine after capsule disintegration. Despite promising results in previous studies, the deposition of an enteric top coating that remains intact after rolling is still challenging. In this study, we compare different mixtures of enteric polymers and a plasticizer, PEG 6000, as potential coating materials. We evaluate mechanical properties as well as drug protection and targeted release in gastric and intestinal media, respectively. Commercially available Eudragit\u00ae FL30D-55 appears to be the most suitable material due to its high strain at failure and integrity after capsule fitting. In vitro studies of coated foils in gastric and intestinal media confirm successful pH-triggered drug release. This indicates the potential advantage of the selected material in the development of self-unfolding foils for oral drug delivery.<\/jats:p>","DOI":"10.3390\/pharmaceutics16010081","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T07:59:20Z","timestamp":1704700760000},"page":"81","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foils: Applications for Oral Drug Delivery"],"prefix":"10.3390","volume":"16","author":[{"given":"Carmen","family":"Mili\u00e1n-Guimer\u00e1","sequence":"first","affiliation":[{"name":"The Danish National Research Foundation and Villum Foundation\u2019s Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8858-9503","authenticated-orcid":false,"given":"Laura","family":"De Vittorio","sequence":"additional","affiliation":[{"name":"The Danish National Research Foundation and Villum Foundation\u2019s Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-8251","authenticated-orcid":false,"given":"Reece","family":"McCabe","sequence":"additional","affiliation":[{"name":"The Danish National Research Foundation and Villum Foundation\u2019s Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuray","family":"G\u00f6nc\u00fc","sequence":"additional","affiliation":[{"name":"The Danish National Research Foundation and Villum Foundation\u2019s Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samvrta","family":"Krishnan","sequence":"additional","affiliation":[{"name":"The Danish National Research Foundation and Villum Foundation\u2019s Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9498-1529","authenticated-orcid":false,"given":"Lasse H\u00f8jlund Eklund","family":"Thamdrup","sequence":"additional","affiliation":[{"name":"The Danish National Research Foundation and Villum Foundation\u2019s Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Boisen","sequence":"additional","affiliation":[{"name":"The Danish National Research Foundation and Villum Foundation\u2019s Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Ghavami","sequence":"additional","affiliation":[{"name":"The Danish National Research Foundation and Villum Foundation\u2019s Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"113814","DOI":"10.1016\/j.addr.2021.05.024","article-title":"Physical Methods for Enhancing Drug Absorption from the Gastrointestinal Tract","volume":"175","author":"Luo","year":"2021","journal-title":"Adv. Drug Deliv. 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