{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:56:39Z","timestamp":1793706999233,"version":"4.6.1"},"reference-count":184,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["21706221"],"award-info":[{"award-number":["21706221"]}]},{"name":"National Natural Science Foundation of China","award":["2018J05143"],"award-info":[{"award-number":["2018J05143"]}]},{"name":"National Natural Science Foundation of China","award":["2023J011614"],"award-info":[{"award-number":["2023J011614"]}]},{"name":"Natural Science Foundation of Fujian Province","award":["21706221"],"award-info":[{"award-number":["21706221"]}]},{"name":"Natural Science Foundation of Fujian Province","award":["2018J05143"],"award-info":[{"award-number":["2018J05143"]}]},{"name":"Natural Science Foundation of Fujian Province","award":["2023J011614"],"award-info":[{"award-number":["2023J011614"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Effective drug delivery is essential for cancer treatment. Drug delivery systems, which can be tailored to targeted transport and integrated tumor therapy, are vital in improving the efficiency of cancer treatment. Peptides play a significant role in various biological and physiological functions and offer high design flexibility, excellent biocompatibility, adjustable morphology, and biodegradability, making them promising candidates for drug delivery. This paper reviews peptide-mediated drug delivery systems, focusing on self-assembled peptides and peptide\u2013drug conjugates. It discusses the mechanisms and structural control of self-assembled peptides, the varieties and roles of peptide\u2013drug conjugates, and strategies to augment peptide stability. The review concludes by addressing challenges and future directions.<\/jats:p>","DOI":"10.3390\/pharmaceutics16020240","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T07:50:12Z","timestamp":1707205812000},"page":"240","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Peptide-Mediated Nanocarriers for Targeted Drug Delivery: Developments and Strategies"],"prefix":"10.3390","volume":"16","author":[{"given":"Yubo","family":"Wang","sequence":"first","affiliation":[{"name":"Medical College, Guangxi University, Da-Xue-Dong Road No. 100, Nanning 530004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Xiamen University, Xiamen 361005, China"},{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, 55 Zhenhai Road, Xiamen 361003, China"},{"name":"The School of Clinical Medicine, Fujian Medical University, Fuzhou 351002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sanadgol, N., and Wackerlig, J. 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