{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:25:34Z","timestamp":1789788334502,"version":"4.0.1"},"reference-count":45,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T00:00:00Z","timestamp":1709510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Center (Poland)","doi-asserted-by":"publisher","award":["2020\/39\/D\/NZ7\/01824"],"award-info":[{"award-number":["2020\/39\/D\/NZ7\/01824"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"National Science Center (Poland)","doi-asserted-by":"publisher","award":["DS. 544"],"award-info":[{"award-number":["DS. 544"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical University of Lublin","award":["2020\/39\/D\/NZ7\/01824"],"award-info":[{"award-number":["2020\/39\/D\/NZ7\/01824"]}]},{"name":"Medical University of Lublin","award":["DS. 544"],"award-info":[{"award-number":["DS. 544"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The plant material Scutellariae baicalensis radix, which is rich in flavones (baicalin), possesses antibacterial, antifungal, antioxidant, and anti-inflammatory properties. This work aimed to develop a 3D-printed chitosan-based hydrogel rich in Scutellariae baicalensis extract as an innovative approach for the personalized treatment of periodontal diseases. Chitosan-based hydrogels were prepared, and the printability of the prepared hydrogels was determined. The hydrogel with 2.5% w\/v of high molecular-weight chitosan (CS), 2% w\/v gelatin (Gel), and 10% w\/w of extract (Ex) presented the best printability, producing smooth and uniform scaffolds. It was proved that the CS\/Gel\/Ex hydrogel was stabilized by hydrogen bonds and remained in amorphous dispersion in the 3D-printed structures (confirmed by ATR-FTIR and XRPD). Due to the amorphization of the active substance, a significant increase in the release of baicalin in vitro was observed. It was demonstrated that there was an initial burst release and a continuous release profile (n = 3). Higuchi kinetic was the most likely baicalin release kinetic. The second fit, the Korsmeyer\u2013Peppas kinetics model, showed coupled diffusion of the active ingredient in the hydrated matrix and polymer relaxation regulated release, with n values ranging from 0.45 to 0.89. The anti-inflammatory properties of 3D-printed scaffolds were assessed as the ability to inhibit the activity of the hyaluronidase enzyme. Activity was assessed as IC50 = 63.57 \u00b1 4.98 mg hydrogel\/mL (n = 6). Cytotoxicity tests demonstrated the biocompatibility of the material. After 24 h of exposure to the 2.5CS\/2Gel\/10Ex scaffold, fibroblasts migrated toward the scratch, closed the \u201cwound\u201d by 97.1%, and significantly accelerated the wound healing process. The results render the 3D-printed CS\/Gel\/extract scaffolds as potential candidates for treating periodontal diseases.<\/jats:p>","DOI":"10.3390\/pharmaceutics16030359","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T05:31:12Z","timestamp":1709530272000},"page":"359","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["3D-Printed Chitosan-Based Scaffolds with Scutellariae baicalensis Extract for Dental Applications"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0418-9336","authenticated-orcid":false,"given":"Magdalena","family":"Paczkowska-Walendowska","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Koumentakou","sequence":"additional","affiliation":[{"name":"Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3220-1494","authenticated-orcid":false,"given":"Maria","family":"Lazaridou","sequence":"additional","affiliation":[{"name":"Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-4952","authenticated-orcid":false,"given":"Dimitrios","family":"Bikiaris","sequence":"additional","affiliation":[{"name":"Laboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6792-4281","authenticated-orcid":false,"given":"Andrzej","family":"Miklaszewski","sequence":"additional","affiliation":[{"name":"Faculty of Mechanical Engineering and Management, Institute of Materials Science and Engineering, Poznan University of Technology, 61-138 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-8435","authenticated-orcid":false,"given":"Tomasz","family":"Plech","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Medical University of Lublin, 20-080 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-5419","authenticated-orcid":false,"given":"Judyta","family":"Cielecka-Piontek","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, 60-806 Poznan, Poland"},{"name":"Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants, 60-630 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2146160","DOI":"10.1155\/2020\/2146160","article-title":"Global Prevalence of Periodontal Disease and Lack of Its Surveillance","volume":"2020","author":"Nazir","year":"2020","journal-title":"Sci. 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