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In order to contribute to changing this view, this work consisted of the development of complexes derived from MI metal ions with thioureas, aiming to obtain potential leishmanicidal agents. The thiourea ligands (HLR) were obtained by reactions of p-toluenesulfohydrazide with R-isothiocyanates and were used in complexation reactions with AgI and AuI, leading to the formation of complexes of composition [M(HLR)2]X (M = Ag or Au; X = NO3\u2212 or Cl\u2212). All compounds were characterized by FTIR, 1H NMR, UV-vis, emission spectroscopy and elemental analysis. Some representatives were additionally studied by ESI-MS and single-crystal XRD. Their properties were further analyzed by DFT calculations. Their cytotoxicity on Vero cells and the extracellular leishmanicidal activity on Leishmania infantum and Leishmania\u00a0braziliensis cells were evaluated. Additionally, the interaction of the complexes with the Old Yellow enzyme of the L. braziliensis (LbOYE) was examined. The biological tests showed that some compounds present remarkable leishmanicidal activity, even higher than that of the standard drug Glucantime, with different selectivity for the two species of Leishmania. Finally, the interaction studies with LbOYE revealed that this enzyme could be one of their biological targets.<\/jats:p>","DOI":"10.3390\/pharmaceutics16040452","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T12:50:49Z","timestamp":1711371049000},"page":"452","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gold(I) and Silver(I) Complexes Containing Hybrid Sulfonamide\/Thiourea Ligands as Potential Leishmanicidal Agents"],"prefix":"10.3390","volume":"16","author":[{"given":"Alice P.","family":"Borges","sequence":"first","affiliation":[{"name":"Bioactive Compounds Development Research Group, Federal University of Tri\u00e2ngulo Mineiro, Av. Dr. Randolfo Borges 1400, Uberaba 38025-440, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6849-1702","authenticated-orcid":false,"given":"Malu M. S.","family":"Obata","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Federal University of Tri\u00e2ngulo Mineiro, Av. Get\u00falio Guarita, Uberaba 38025-440, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia H.","family":"Libardi","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Chemistry, University of S\u00e3o Paulo, Av. Trabalhador S\u00e3o Carlense, 400, S\u00e3o Carlos 13566-590, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael O.","family":"Trevisan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Federal University of Tri\u00e2ngulo Mineiro, Av. Get\u00falio Guarita, Uberaba 38025-440, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor M.","family":"Deflon","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Chemistry, University of S\u00e3o Paulo, Av. Trabalhador S\u00e3o Carlense, 400, S\u00e3o Carlos 13566-590, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1747-7927","authenticated-orcid":false,"given":"Ulrich","family":"Abram","sequence":"additional","affiliation":[{"name":"Institute of Chemistry and Biochemistry, Freie Universit\u00e4t Berlin, Fabeckstr. 34\/36, 14195 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis B.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Associated Faculties of Uberaba, Av. do Tutuna 720, Uberaba 38061-500, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8544-2910","authenticated-orcid":false,"given":"Luiz Ant\u00f4nio S.","family":"Costa","sequence":"additional","affiliation":[{"name":"Computational Chemistry Research Group, Institute of Exact Sciences, Federal University of Juiz de Fora, Campus Universit\u00e1rio s\/n Martelos, Juiz de Fora 36036-900, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3141-3214","authenticated-orcid":false,"given":"Antonio O. T.","family":"Patroc\u00ednio","sequence":"additional","affiliation":[{"name":"Laboratory of Photochemistry and Material Science, Institute of Chemistry, Federal University of Uberl\u00e2ndia, Av. Jo\u00e3o Naves de \u00c1vila 2121, Uberl\u00e2ndia 38400-902, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-7621","authenticated-orcid":false,"given":"Marcos V.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Federal University of Tri\u00e2ngulo Mineiro, Av. Get\u00falio Guarita, Uberaba 38025-440, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4856-748X","authenticated-orcid":false,"given":"J\u00falio C.","family":"Borges","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Chemistry, University of S\u00e3o Paulo, Av. 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