{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:27:13Z","timestamp":1790620033889,"version":"4.1.0"},"reference-count":52,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Global Environment Facility (GEF) by the United Nations Development Programme","award":["00123168\/01-03"],"award-info":[{"award-number":["00123168\/01-03"]}]},{"name":"United Nations Development Programme of the Republic of Serbia","award":["00123168\/01-03"],"award-info":[{"award-number":["00123168\/01-03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The fruit processing industry generates large quantities of by-products well known to be rich in bioactive compounds with numerous nutritional properties and beneficial effects for human health. We developed a strategy to valorise raspberry seeds and obtain valuable ingredients with potential application in cosmetic skincare formulas. Cold press extraction technology was applied to extract oil, and the remaining defatted raspberry seed cake was treated with three proline based deep eutectic solvents (DES) to extract polyphenols. The most potent was proline\/citric acid extract, with free and total ellagic acid content (52.4 mg\/L and 86.4 mg\/L), total phenolic content (TPC, 550.1 mg GAE\/L) and radical scavenging activity (RSA, 4742.7 mmol TE\/L). After the direct mixing of the extract and after encapsulation with starch as a carrier, the skincare emulsion and microemulsion were characterised by irritation potential (Zein test), transepidermal water loss (TEWL), red blood cell (RBC), and DPPH antioxidant test. The resulting preparations were of improved quality in comparison to the control hand cream, with a low skin irritation effect, lower TEWL, and higher antioxidant potential. This work complies with circular economy principles and green technology standards, and represents the efficient model on how to reuse natural resources through waste minimization.<\/jats:p>","DOI":"10.3390\/pharmaceutics16050606","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T03:57:56Z","timestamp":1714622276000},"page":"606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Valorisation of Raspberry Seeds in Cosmetic Industry-Green Solutions"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3130-1266","authenticated-orcid":false,"given":"Ivanka","family":"\u0106iri\u0107","sequence":"first","affiliation":[{"name":"Innovative Centre Faculty of Chemistry Belgrade, University of Belgrade, Studentski Trg 12-16, 11158 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5454-5696","authenticated-orcid":false,"given":"Dragana","family":"Dabi\u0107 Zagorac","sequence":"additional","affiliation":[{"name":"Innovative Centre Faculty of Chemistry Belgrade, University of Belgrade, Studentski Trg 12-16, 11158 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9039-3201","authenticated-orcid":false,"given":"Milica","family":"Sredojevi\u0107","sequence":"additional","affiliation":[{"name":"Innovative Centre Faculty of Chemistry Belgrade, University of Belgrade, Studentski Trg 12-16, 11158 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-9145","authenticated-orcid":false,"given":"Milica","family":"Fotiri\u0107 Ak\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Rabrenovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, University of Belgrade, Nemanjina 6, 11080 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stevan","family":"Blagojevi\u0107","sequence":"additional","affiliation":[{"name":"Institute of General and Physical Chemistry, Studentski Trg 12-16, 11158 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-297X","authenticated-orcid":false,"given":"Maja","family":"Nati\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Belgrade, Studentski Trg 12-16, 11158 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6787","DOI":"10.1021\/acs.jafc.1c07104","article-title":"Novel Approaches in the Valorization of Agricultural Wastes and Their Applications","volume":"70","author":"Capanoglu","year":"2022","journal-title":"J. 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