{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:08:20Z","timestamp":1760144900605,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T00:00:00Z","timestamp":1716681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil","award":["001","465,536\/2014\u20130","PIE0009\/2022"],"award-info":[{"award-number":["001","465,536\/2014\u20130","PIE0009\/2022"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnologico","award":["001","465,536\/2014\u20130","PIE0009\/2022"],"award-info":[{"award-number":["001","465,536\/2014\u20130","PIE0009\/2022"]}]},{"name":"Bahia State Research Support Foundation","award":["001","465,536\/2014\u20130","PIE0009\/2022"],"award-info":[{"award-number":["001","465,536\/2014\u20130","PIE0009\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The compound 6-methoxyseselin, derived from Zanthoxylum tingoassuiba, demonstrates various therapeutic properties, including vasorelaxation, antinociceptive, anti-inflammatory, and immunomodulatory effects, along with recently discovered antiasthmatic properties. This study aimed to evaluate its preclinical pharmacokinetics and pulmonary delivery in Balb\/c mice. The method involved administering the compound via inhalation and intravenous routes, followed by blood sample collection for analysis using high-performance liquid chromatography with diode array detection (HPLC-DAD). The results indicated good linearity, precision, accuracy, and stability of the compound in the biological samples. Pharmacokinetic parameters such as the rate of elimination, half-life, clearance, volume of distribution, area under the curve, and mean residence time were determined for both administration routes, showing similar profiles. The lung concentrations were notably higher than the plasma concentrations, indicating significant lung penetration. These findings suggest 6-methoxyseselin as a promising candidate for new anti-asthmatic drugs, supported by its favorable pharmacokinetic profiles and high lung penetration factors. This study represents the first exploration of the pharmacokinetics and pulmonary delivery of 6-methoxyseselin in mice, highlighting its potential for further drug development.<\/jats:p>","DOI":"10.3390\/pharmaceutics16060714","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T10:14:07Z","timestamp":1716804847000},"page":"714","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preclinical Pharmacokinetic Study and Lung Penetration of a Coumarin Extracted from Zanthoxylum tingoassuiba"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-5254","authenticated-orcid":false,"given":"Valdeene Vieira","family":"Santos","sequence":"first","affiliation":[{"name":"Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Ant\u00f4nio","family":"da Hora Borges","sequence":"additional","affiliation":[{"name":"Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoline Cristina","family":"Jatob\u00e1 da Silva","sequence":"additional","affiliation":[{"name":"Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"dos Santos Costa","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9075-9421","authenticated-orcid":false,"given":"Renan Fernandes do Esp\u00edrito","family":"Santo","sequence":"additional","affiliation":[{"name":"Center for Research on Aging, Department of Neural and Pain Sciences, University of Maryland, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eudes da Silva","family":"Velozo","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0113-7864","authenticated-orcid":false,"given":"Cristiane Flora","family":"Villarreal","sequence":"additional","affiliation":[{"name":"Pharmacy Graduate Program, College of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3625-0186","authenticated-orcid":false,"given":"Francine Johansson","family":"Azeredo","sequence":"additional","affiliation":[{"name":"Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural Products in Drug Discovery: Advances and Opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. 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