{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:54:30Z","timestamp":1793163270790,"version":"4.5.0"},"reference-count":100,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>This comprehensive review consolidates insights from two sources to emphasize the transformative impact of scaffold-based drug delivery systems in revolutionizing oral cancer therapy. By focusing on their core abilities to facilitate targeted and localized drug administration, these systems enhance therapeutic outcomes significantly. Scaffolds, notably those coated with anti-cancer agents such as cisplatin and paclitaxel, have proven effective in inhibiting oral cancer cell proliferation, establishing a promising avenue for site-specific drug delivery. The application of synthetic scaffolds, including Poly Ethylene Glycol (PEG) and poly(lactic-co-glycolic acid) (PLGA), and natural materials, like collagen or silk, in 3D systems has been pivotal for controlled release of therapeutic agents, executing diverse anti-cancer strategies. A key advancement in this field is the advent of smart scaffolds designed for sequential cancer therapy, which strive to refine drug delivery systems, minimizing surgical interventions, accentuating the significance of 3D scaffolds in oral cancer management. These systems, encompassing local drug-coated scaffolds and other scaffold-based platforms, hold the potential to transform oral cancer treatment through precise interventions, yielding improved patient outcomes. Local drug delivery via scaffolds can mitigate systemic side effects typically associated with chemotherapy, such as nausea, alopecia, infections, and gastrointestinal issues. Post-drug release, scaffolds foster a conducive environment for non-cancerous cell growth, adhering and proliferation, demonstrating restorative potential. Strategies for controlled and targeted drug delivery in oral cancer therapy span injectable self-assembling peptide hydrogels, nanocarriers, and dual drug-loaded nanofibrous scaffolds. These systems ensure prolonged release, synergistic effects, and tunable targeting, enhancing drug delivery efficiency while reducing systemic exposure. Smart scaffolds, capable of sequential drug release, transitioning to cell-friendly surfaces, and enabling combinatorial therapy, hold the promise to revolutionize treatment by delivering precise interventions and optimized outcomes. In essence, scaffold-based drug delivery systems, through their varied forms and functionalities, are reshaping oral cancer therapy. They target drug delivery efficiency, diminish side effects, and present avenues for personalization. Challenges like fabrication intricacy, biocompatibility, and scalability call for additional research. Nonetheless, the perspective on scaffold-based systems in oral cancer treatment is optimistic, as ongoing advancements aim to surmount current limitations and fully leverage their potential in cancer therapy.<\/jats:p>","DOI":"10.3390\/pharmaceutics16060802","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T08:52:10Z","timestamp":1718355130000},"page":"802","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Application of Scaffold-Based Drug Delivery in Oral Cancer Treatment: A Novel Approach"],"prefix":"10.3390","volume":"16","author":[{"given":"Elham","family":"Saberian","sequence":"first","affiliation":[{"name":"Klinika and Akad\u00e9mia Ko\u0161ice, Pavol Jozef \u0160af\u00e1rik University, n.o. 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J. Cancer Biol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Roudsari, M.H., Saeidi, N., Kabiri, N., Ahmadi, A., Tabrizi, M.M., Shahmabadi, H.E., Khiyavi, A.A., and Reghbati, B. (2016). Investigation of Characteristics and Behavior of Loaded Carboplatin on the, Liposomes Nanoparticles, on the Lung and Ovarian Cancer: An In-Vitro Evaluation. Asian Pac. J. Cancer Biol., 1.","DOI":"10.31557\/apjcb.2016.1.1.9-13"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.31557\/apjcb.2019.4.4.71-74","article-title":"Cytotoxic Activity of Epigallocatechin and Trans-Cinnamaldehyde in Gastric Cancer Cell Line","volume":"4","author":"Milani","year":"2019","journal-title":"Asian Pac. J. Cancer Biol."},{"key":"ref_4","first-page":"17","article-title":"Anticancer, antimicrobial, anti-inflammatory, and neuroprotective effects of bisdemethoxycurcumin: Micro and nano facets","volume":"2","author":"Aliakba","year":"2023","journal-title":"Micro Nano Bio. Asp."},{"key":"ref_5","first-page":"65","article-title":"Enhancing Effects of Curcumin on Cytotoxicity of Paclitaxel, Methotrexate and Vincristine in Gastric Cancer Cells","volume":"18","author":"Ebrahimifar","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/cbdd.12786","article-title":"Preparation, characterization, and cytotoxic effects of liposomal nanoparticles containing cisplatin: An in vitro study","volume":"88","author":"Poy","year":"2016","journal-title":"Chem. Biol. Drug Des."},{"key":"ref_7","first-page":"629","article-title":"Toxicity of cisplatin-loaded poly butyl cyanoacrylate nanoparticles in a brain cancer cell line: Anionic polymerization results","volume":"18","author":"Mohamadi","year":"2017","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_8","first-page":"62","article-title":"Cancer of the oral cavity and oropharynx","volume":"10","author":"Vogel","year":"2010","journal-title":"Cancer Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.31557\/apjcb.2023.8.4.379-386","article-title":"Oral Cancer at a Glance","volume":"8","author":"Saberian","year":"2023","journal-title":"Asian Pac. J. Cancer Biol."},{"key":"ref_10","first-page":"e2133","article-title":"Knowledge and Attitude of Cancer Patient\u2019s Companions towards Chemotherapy and Radiotherapy-induced Oral Complications and Dental Considerations","volume":"25","author":"Ghahremanfard","year":"2023","journal-title":"Iran. Red. Crescent Med. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ajoms.2023.03.012","article-title":"Clinical efficacy of LLLT in treatment of trigeminal neuralgia\u2013Case report","volume":"35","author":"Sadrabad","year":"2023","journal-title":"J. Oral Maxillofac. Surg. Med. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21442","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.oraloncology.2008.06.002","article-title":"Global epidemiology of oral and oropharyngeal cancer","volume":"45","author":"Warnakulasuriya","year":"2009","journal-title":"Oral. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/ije\/dyp350","article-title":"Sexual behaviours and the risk of head and neck cancers: A pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium","volume":"39","author":"Heck","year":"2009","journal-title":"Int. J. Epidemiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/raon-2013-0057","article-title":"Oral cavity and oropharyngeal squamous cell carcinoma in young adults: A review of the literature","volume":"48","author":"Majchrzak","year":"2014","journal-title":"Radiol. Oncol."},{"key":"ref_18","first-page":"219","article-title":"Circadian clock and oral cancer","volume":"8","author":"Nirvani","year":"2018","journal-title":"Mol. Clin. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3389\/fphys.2019.00399","article-title":"System biology approaches and precision oral health: A circadian clock perspective","volume":"10","author":"Adeola","year":"2019","journal-title":"Front. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10147-014-0689-z","article-title":"Current status of oral cancer treatment strategies: Surgical treatments for oral squamous cell carcinoma","volume":"19","author":"Omura","year":"2014","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/jofs.jofs_115_17","article-title":"Importance of depth of invasion in patients with oral squamous cell carcinoma: A review article","volume":"10","author":"Ghazi","year":"2018","journal-title":"J. Orofac. Sci."},{"key":"ref_22","first-page":"1218","article-title":"The Most Common Side Effects Experienced by Patients Were Receiving First Cycle of Chemotherapy","volume":"47","author":"Altun","year":"2018","journal-title":"Iran. J. Public Health"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Lu, Y., Zheng, Z., Yuan, Y., Pathak, J.L., Yang, X., Wang, L., Ye, Z., Cho, W.C., Zeng, M., and Wu, L. (2021). The emerging role of exosomes in oral squamous cell carcinoma. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.628103"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13039-016-0293-1","article-title":"Early detection and personalized treatment in oral cancer: The impact of omics approaches","volume":"9","author":"Ribeiro","year":"2016","journal-title":"Mol. Cytogenet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.12688\/f1000research.22941.1","article-title":"Oral squamous cell carcinoma: Metastasis, potentially associated malignant disorders, etiology and recent advancements in diagnosis. Version 1","volume":"9","author":"Bugshan","year":"2020","journal-title":"F1000Research"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"603160","DOI":"10.3389\/froh.2020.603160","article-title":"Major Molecular Signaling Pathways in Oral Cancer Associated With Therapeutic Resistance","volume":"1","author":"Usman","year":"2020","journal-title":"Front. Oral. Health"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ijrobp.2016.06.2448","article-title":"Timing of radiotherapy and chemotherapy after breast-conserving surgery for node-positive breast cancer: Long term results from IBCSG Trials VI and VIIInt","volume":"96","author":"Karlsson","year":"2016","journal-title":"J. Radiat. Oncol. Biol. Phys."},{"key":"ref_28","first-page":"615","article-title":"PI3Kpathway- directed therapeutic strategies in cancer","volume":"11","author":"Agarwal","year":"2010","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"ref_29","first-page":"57","article-title":"Targeted therapy for cancer","volume":"2","author":"Wu","year":"2006","journal-title":"J. Cancer Mol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/21691401.2023.2189913","article-title":"Evaluation of a docetaxel-cisplatin-fluorouracil-Au complex in human oralcarcinoma cell line","volume":"51","author":"Khamaikawina","year":"2023","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1634\/theoncologist.7-6-516","article-title":"Improvement of oral drug treatment by temporary inhibition of drug transporters and\/or cytochrome P450 in the gastrointestinal tract and liver: An overview","volume":"7","author":"Kruijtzer","year":"2002","journal-title":"Oncologist"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"961","DOI":"10.3332\/ecancer.2019.961","article-title":"Innovative approaches for cancer treatment: Current perspectives and new challenges","volume":"13","author":"Pucci","year":"2019","journal-title":"Ecancermedicalscience"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2174\/1574888X14666181205121658","article-title":"Biomaterials and gene therapy: A smart combination for MSC musculoskeletal engineering","volume":"14","author":"Mesure","year":"2019","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1080\/09205063.2017.1354674","article-title":"Design and fabrication of porous biodegradable scaffolds: A strategy for tissue engineering., J","volume":"28","author":"Hokmabad","year":"2017","journal-title":"Biomater. Sci. Polym. Ed."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.msec.2017.05.017","article-title":"Scaffolds for bone tissue engineering: State of the art and new perspectives","volume":"78","author":"Roseti","year":"2017","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Xu, K., Ganapathy, K., Andl, T., Wang, Z., Copland, J.A., Chakrabarti, R., and Florczyk, S.J. (2019). 3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines. Biomaterials, 217.","DOI":"10.1016\/j.biomaterials.2019.119311"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s10439-016-1640-4","article-title":"3D printing of tissue engineered constructs for in vitro modeling of disease progression and drug screening","volume":"45","author":"Vanderburgh","year":"2017","journal-title":"Ann. Biomed. Eng."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.8493529","article-title":"Tissue engineering","volume":"260","author":"Langer","year":"1993","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.31557\/APJCP.2023.24.9.3291","article-title":"Characteristics and Cytotoxic Effects of Nano-Liposomal Paclitaxel on Gastric Cancer Cells","volume":"24","author":"Ghanbarikondori","year":"2023","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"345","DOI":"10.31557\/apjcb.2023.8.4.345-350","article-title":"Investigating the Properties and Cytotoxicity of Cisplatin-Loaded Nano-Polybutylcyanoacrylate on Breast Cancer Cells","volume":"4","author":"Gorgzadeh","year":"2023","journal-title":"Asian Pac. J. Cancer Biol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Tangsiri, M., Hheidari, A., Liaghat, M., Razlansari, M., Ebrahimi, N., Akbari, A., Varnosfaderani, S.M.N., Maleki-Sheikhabadi, F., Norouzi, A., and Bakhtiyari, M. (2024). Promising applications of nanotechnology in inhibiting chemo-resistance in solid tumors by targeting epithelial-mesenchymal transition (EMT). Biomed. Pharmacother. J., 170.","DOI":"10.1016\/j.biopha.2023.115973"},{"key":"ref_42","first-page":"3985","article-title":"Toxicity of Carboplatin-Niosomal Nanoparticles in a Brain Cancer Cell Line","volume":"24","author":"Abbasi","year":"2023","journal-title":"Asian Pac. J."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Shineh, G., Mobaraki, M., Afzali, E., Alakija, F., Velisdeh, Z.J., and Mills, D.K. (2024). Antimicrobial Metal and Metal Oxide Nanoparticles in Bone Tissue Repair. Biomed. Mater. Devices.","DOI":"10.1007\/s44174-024-00159-3"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"113736","DOI":"10.1016\/j.mcat.2023.113736","article-title":"Copper nanoparticles embedded into nitrogen-doped carbon fiber felt as recyclable catalyst for benzene oxidation under mild conditions","volume":"553","author":"Tavasolikejani","year":"2024","journal-title":"Mol. Catal."},{"key":"ref_45","first-page":"412","article-title":"Fabrication and modeling of nanocomposites with bioceramic nanoparticles for rapid wound healing: An experimental and molecular dynamics investigation","volume":"8","author":"Tavasolikejani","year":"2023","journal-title":"Nanomed. Res. J."},{"key":"ref_46","first-page":"285","article-title":"Comparison of the Shear Bond Strength of Orthodontic Composites Containing Silver and Amorphous Tricalcium Phosphate Nanoparticles: An ex vivo Study","volume":"24","author":"Tavakolinejad","year":"2023","journal-title":"J. Dent."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4274\/tjps.galenos.2020.44452","article-title":"Development and characterization of conducting-polymer-based hydrogel dressing for wound healing","volume":"18","author":"Avinash","year":"2021","journal-title":"Turkish J. Pharm. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.carbpol.2016.09.095","article-title":"A composite chitosan-gelatin Bi-layered, biomimetic macroporous scaffold for blood vessel tissue engineering","volume":"3","author":"Badhe","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.msec.2018.04.059","article-title":"Synthesis, and biocompatibility of dual-responsive thermosonic injectable organogels based on crosslinked N-(isopropyl acrylamide) for tumour microenvironment targeting","volume":"90","author":"Zardad","year":"2018","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"8907","DOI":"10.1038\/s41598-018-27097-7","article-title":"3D biodegradable scaffolds of polycaprolactone with silicate-containing hydroxyapatite microparticles for bone tissue engineering: High-resolution tomography and in vitro study","volume":"8","author":"Shkarina","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Shahriar, S.M.S., Andrabi, S.M., Islam, F., An, J.M., Schindler, S.J., Matis, M.P., Lee, D.Y., and Lee, Y.-K. (2022). Next-Generation 3D Scaffolds for Nano-Based Chemotherapeutics Delivery and Cancer Treatment. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14122712"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ketabat, F., Pundir, M., Mohabatpour, F., Lobanova, L., Koutsopoulos, S., Hadjiiski, L., Chen, X., Papagerakis, P., and Papagerakis, S. (2019). Controlled Drug Delivery Systems for Oral Cancer Treatment\u2014Current Status and Future Perspectives. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11070302"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zhang, M., and Liang, J. (2020). Current Trends of Targeted Drug Delivery for Oral Cancer Therapy. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.618931"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.2147\/JMDH.S313968","article-title":"Targeted drug delivery\u2014From magic bullet to nanomedicine: Principles, challenges, and future perspectives","volume":"14","author":"Tewabe","year":"2021","journal-title":"J. Multidiscip. Healthc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1158\/1535-7163.MCT-17-0682","article-title":"Nano-engineered mesenchymal stem cells increase therapeutic efficacy of anticancer drug through true active tumor targeting","volume":"17","author":"Layek","year":"2018","journal-title":"Mol. Cancer Ther."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.2147\/IJN.S179226","article-title":"Enhanced photo\/chemo combination efficiency against bladder tumor by encapsulation of DOX and ZnPC into in situ-formed thermosensitive polymer hydrogel","volume":"13","author":"Huang","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1600766","DOI":"10.1002\/adhm.201600766","article-title":"Biomaterial-based implantable devices for cancer therapy","volume":"6","author":"Chew","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Alsuraifi, A., Curtis, A., Lamprou, D.A., and Hoskins, C. (2018). Stimuli responsive polymeric systems for cancer therapy. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10030136"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"13065","DOI":"10.1038\/s41598-021-92391-w","article-title":"Targeted SPION siderophore conjugate loaded with doxorubicin as a theranostic agent for imaging and treatment of colon carcinoma","volume":"11","author":"Nosrati","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1038\/s41467-019-13115-3","article-title":"Extravascular gelation shrinkage-derived internal stress enables tumor starvation therapy with suppressed metastasis and recurrence","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"189","DOI":"10.7150\/thno\/v01p0189","article-title":"Integrin targeted delivery of chemotherapeutics","volume":"1","author":"Chen","year":"2011","journal-title":"Theranostics"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12645-021-00086-8","article-title":"Breast cancer drug delivery by novel drug-loaded chitosan-coated magnetic nanoparticles","volume":"12","author":"Taherian","year":"2021","journal-title":"Cancer Nanotechnol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1039\/c2nr30731f","article-title":"Therapeutic application of injectable thermosensitive hydrogel in preventing local breast cancer recurrence and improving incision wound healing in a mouse model","volume":"4","author":"Lei","year":"2012","journal-title":"Nanoscale"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"23400","DOI":"10.1021\/acsami.7b05463","article-title":"Increasing cancer therapy efficiency through targeting and localized light activation","volume":"9","author":"Yang","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/10611860701794353","article-title":"Polymeric nanoparticles for cancer therapy","volume":"16","author":"Parveen","year":"2008","journal-title":"J. Drug Target."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Kumar, R., Sarkar, C., Panja, S., Khatua, C., Gugulothu, K., and Sil, D. (2022). Biomimetic Nanocomposites for Biomedical Applications. Biorenewable Nanocomposite Materials, Vol. 1: Electrocatalysts and Energy Storage, ACS Publications.","DOI":"10.1021\/bk-2022-1410.ch007"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Nunes, D., Andrade, S., Ramalho, M.J., Loureiro, J.A., and Pereira, M.C. (2022). Polymeric Nanoparticles-Loaded Hydrogels for Biomedical Applications: A Systematic Review on in Vivo Findings. Polymers, 14.","DOI":"10.3390\/polym14051010"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jconrel.2014.03.057","article-title":"EPR: Evidence and fallacy","volume":"190","author":"Nichols","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.1039\/D1BM01398J","article-title":"Passive targeting of high-grade gliomas via the EPR effect: A closed path for metallic nanoparticles?","volume":"9","author":"Caro","year":"2021","journal-title":"Biomater. Sci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.addr.2018.07.007","article-title":"Tumor targeting via EPR: Strategies to enhance patient responses","volume":"130","author":"Golombek","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2217\/nnm.15.86","article-title":"Cancer nanomedicine: Addressing the dark side of the enhanced permeability and retention effect","volume":"10","author":"Huynh","year":"2015","journal-title":"Nanomedicine"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2000055","DOI":"10.1002\/adma.202000055","article-title":"Designing stimuli-responsive upconversion nanoparticles that exploit the tumor microenvironment","volume":"32","author":"Ovais","year":"2020","journal-title":"Adv. Mater."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.addr.2014.05.009","article-title":"In vivo delivery of miRNAs for cancer therapy: Challenges and strategies","volume":"81","author":"Chen","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"34773","DOI":"10.1039\/C8RA06327C","article-title":"Lecithin\u2013chitosan\u2013TPGS nanoparticles as nanocarriers of (\u2212)-epicatechin enhanced its anticancer activity in breast cancer cells","volume":"8","author":"Ganem","year":"2018","journal-title":"RSC Adv."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/s41401-020-0423-5","article-title":"Reversal of the immunosuppressive tumor microenvironment by nanoparticle-based activation of immune-associated cells","volume":"41","author":"Qi","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Yao, Y., Zhou, Y., Liu, L., Xu, Y., Chen, Q., Wang, Y., Wu, S., Deng, Y., Zhang, J., and Shao, A. (2020). Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance. Front. Mol. Biosci., 7.","DOI":"10.3389\/fmolb.2020.00193"},{"key":"ref_77","first-page":"1","article-title":"Recent Progress in Antitumoral Nanotechnology","volume":"1","author":"Mendez","year":"2015","journal-title":"Int. J. Nanopart. Nanotech"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Basak, D., Arrighi, S., Darwiche, Y., and Deb, S. (2021). Comparison of Anticancer Drug Toxicities: Paradigm Shift in Adverse Effect Profile. Life, 12.","DOI":"10.3390\/life12010048"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3389\/fchem.2019.00675","article-title":"Injectable hydrogels for localized cancer therapy","volume":"7","author":"Fan","year":"2019","journal-title":"Front. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"20724","DOI":"10.1021\/acsomega.9b03694","article-title":"Development of a Smart Scaffold for Sequential Cancer Chemotherapy and Tissue Engineering","volume":"5","author":"Sengupta","year":"2020","journal-title":"ACS Omega"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Shin, G.R., Kim, H.E., Kim, J.H., Choi, S., and Kim, M.S. (2021). Advances in injectable in situ-forming hydrogels for intratumoral treatment. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111953"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"100032","DOI":"10.1016\/j.oor.2023.100032","article-title":"Potential use of anti-cancer drugs coated scaffolds for local drug delivery in cancer cell lines","volume":"6","author":"Gupta","year":"2023","journal-title":"Oral. Oncol. Rep."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Wu, Y., Du, H., Li, Z., Bai, X., Wu, Y., Li, H., Zhou, M., Cao, Y., and Chen, X. (2024). Nano-Drug Delivery Systems in Oral Cancer Therapy: Recent Developments and Prospective. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16010007"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Li, J., Luo, Y., Li, B., Xia, Y., Wang, H., and Fu, C. (2020). Implantable and Injectable Biomaterial Scaffolds for Cancer Immunotherapy. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.612950"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Girard, Y.K., Wang, C., Ravi, S., Howell, M.C., Mallela, J., Alibrahim, M., Green, R., Hellermann, G., Mohapatra, S.S., and Mohapatra, S. (2013). A 3D Fibrous Scaffold Inducing Tumoroids: A Platform for Anticancer Drug Development. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0075345"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Abdolahinia, E.D., and Han, X. (2023). The Three-Dimensional In Vitro Cell Culture Models in the Study of Oral Cancer Immune Microenvironment. Cancers, 15.","DOI":"10.3390\/cancers15174266"},{"key":"ref_87","first-page":"300","article-title":"Three-dimensional (3D) scaffolds as powerful weapons for tumor immunotherapy","volume":"17","author":"Han","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Almela, T., Tayebi, L., and Moharamzadeh, K. (2021). 3D Bioprinting for In Vitro Models of Oral Cancer: Toward Development and Validation. Bioprinting, 22.","DOI":"10.1016\/j.bprint.2021.e00132"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jconrel.2023.05.042","article-title":"Scaffolds for drug delivery and tissue engineering: The role of genetics","volume":"359","author":"Karczewski","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"616101","DOI":"10.3389\/fphar.2020.616101","article-title":"Research Progress and Prospect of Nanoplatforms for Treatment of Oral Cancer","volume":"11","author":"Zhao","year":"2020","journal-title":"Front. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Mei, Y., He, C., Gao, C., Zhu, P., Lu, G., and Li, H. (2021). 3D-Printed Degradable Anti-Tumor Scaffolds for Controllable Drug Delivery. Int. J. Bioprint, 7.","DOI":"10.18063\/ijb.v7i4.418"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Hernandez, A., Hartgerink, J.D., and Young, S. (2023). Self-assembling peptides as immunomodulatory biomaterials. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1139782"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Lee, J.H. (2018). Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering. Biomater. Res., 22.","DOI":"10.1186\/s40824-018-0138-6"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1080\/10717544.2022.2058647","article-title":"Self-assembling peptides-based nano-cargos for targeted chemotherapy and immunotherapy of tumors: Recent developments, challenges, and future perspectives","volume":"29","author":"Wang","year":"2022","journal-title":"Drug Deliv."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"132597","DOI":"10.1016\/j.matlet.2022.132597","article-title":"Dual drug loaded polyhydroxy butyric acid\/gelatin nanofibrous scaffold for possible post-surgery cancer treatment","volume":"323","author":"Ramanathan","year":"2022","journal-title":"Mater. Lett."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"31","DOI":"10.61186\/rabms.10.1.31","article-title":"Gingival bullae\u2014A rare visible case report","volume":"10","author":"Saberian","year":"2024","journal-title":"J. Res. Appl. Basic Med. Sci."},{"key":"ref_97","first-page":"140","article-title":"Dental Pulp Stem Cells in Pulp Regeneration","volume":"2","author":"Sabarian","year":"2021","journal-title":"SunText Rev. Med. Clin. Res."},{"key":"ref_98","first-page":"1","article-title":"Plasma Therapy for Medication-Related Osteonecrosis of the Jaws\u2013a Case Report","volume":"8","author":"Sadrabad","year":"2023","journal-title":"Case Rep. Clin. Pract."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.joen.2023.12.005","article-title":"Success in Tooth Bud Regeneration: A Short Communication","volume":"50","author":"Sadrabad","year":"2024","journal-title":"J. Endod."},{"key":"ref_100","first-page":"214","article-title":"The effect of dentin matrix proteins on differentiation of autologous guinea pig dental pulp stem cells","volume":"50","author":"Sadrabad","year":"2023","journal-title":"J. Sci. Soc."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/16\/6\/802\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:58:27Z","timestamp":1760108307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/16\/6\/802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,14]]},"references-count":100,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["pharmaceutics16060802"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics16060802","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,14]]}}}