{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T11:11:59Z","timestamp":1782817919930,"version":"3.54.5"},"reference-count":40,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Landiolol, a highly cardioselective agent with a short half-life (2.4\u20134 min), is commonly used as a perfusor or bolus application to treat tachycardic arrhythmia. Some small studies suggest that prior oral \u03b2-blocker use results in a less effective response to intravenous \u03b2-blockers. Methods: This study investigated whether prior chronic oral \u03b2-blocker (L\u03b2) or no prior chronic oral \u03b2-blocker (L\u2013) intake influences the response to intravenous push-dose Landiolol in intensive care patients with acute tachycardic arrhythmia. Results: The effects in 30 patients (67 [55\u201372] years) were analyzed, 10 (33.3%) with and 20 (66.7%) without prior oral \u03b2-blocker therapy. Arrhythmias were diagnosed as tachycardic atrial fibrillation in 14 patients and regular, non-fluid-dependent, supraventricular tachycardia in 16 cases. Successful heart rate control (L\u03b2 4 vs. L\u2013 7, p = 1.00) and rhythm control (L\u03b2 3 vs. L\u2013 6, p = 1.00) did not significantly differ between the two groups. Both groups showed a significant decrease in heart rate when comparing before and after the bolus administration, without significant differences between the two groups (L\u03b2 \u221226\/min vs. L\u2013 \u221233\/min, p = 0.528). Oral \u03b2-blocker therapy also did not influence the change in mean arterial blood pressure after Landiolol bolus administration (L\u03b2 \u22125 mmHg vs. L\u2013 \u22124 mmHg, p = 0.761). Conclusions: A prior chronic intake of \u03b2-blockers neither affected the effectiveness of push-dose Landiolol in heart rate or rhythm control nor impacted the difference in heart rate or mean arterial blood pressure before and after the Landiolol boli.<\/jats:p>","DOI":"10.3390\/pharmaceutics16060839","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T05:33:28Z","timestamp":1718948008000},"page":"839","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Chronic Oral Beta-Blocker Intake on Intravenous Bolus Landiolol Response in Hospitalized Intensive Care Patients with Sudden-Onset Supraventricular Tachycardia\u2014A Post Hoc Analysis of a Cross-Sectional Trial"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-415X","authenticated-orcid":false,"given":"Felix","family":"Eibensteiner","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmilie","family":"Mosor","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Tihanyi","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Clinic Ottakring, Vienna Healthcare Group, 1160 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Anders","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Clinic Penzing, Vienna Healthcare Group, 1140 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kornfehl","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Neymayer","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-9886","authenticated-orcid":false,"given":"Julia","family":"Oppenauer","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5556-2970","authenticated-orcid":false,"given":"Christoph","family":"Veigl","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9196-1936","authenticated-orcid":false,"given":"Valentin","family":"Al Jalali","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-6946","authenticated-orcid":false,"given":"Hans","family":"Domanovits","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Sulzgruber","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0057-8200","authenticated-orcid":false,"given":"Sebastian","family":"Schnaubelt","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ghallab, M., Ahmed, M.S., Ostrow, T.H., Rasool, M.H., Alagha, Z., Miller, D., Frishman, W.H., Aronow, W.S., and Frenkel, D. (Cardiol. Rev., 2024). Landiolol for Treating Arrhythmias: A State-of-The-Art Review, Cardiol. Rev., ahead of print.","DOI":"10.1097\/CRD.0000000000000687"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1067\/mcp.2000.108733","article-title":"Pharmacokinetics of landiolol hydrochloride, a new ultra-short-acting beta-blocker, in patients with cardiac arrhythmias","volume":"68","author":"Atarashi","year":"2000","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejps.2016.06.022","article-title":"Pharmacokinetics and pharmacodynamics of two different landiolol formulations in a healthy Caucasian group","volume":"92","author":"Krumpl","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1248\/cpb.40.1462","article-title":"Development of a highly cardioselective ultra short-acting beta-blocker, ONO-1101","volume":"40","author":"Iguchi","year":"1992","journal-title":"Chem. Pharm. Bull."},{"key":"ref_5","first-page":"407","article-title":"The role of the ultra short-acting \u03b21-adrenoreceptor antagonist Landiolol in the treatment of atrial fibrillation: Pharmacology, clinical application and current evidence in anaesthesiology, intensive care and emergency medicine","volume":"59","author":"Gibb","year":"2018","journal-title":"An\u00e4sthesiologie Intensivmed."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s00228-023-03584-3","article-title":"Mechanisms of landiolol-mediated positive inotropy in critical care settings","volume":"79","author":"Chalkias","year":"2023","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"A15","DOI":"10.1093\/eurheartj\/sux039","article-title":"Landiolol for managing atrial fibrillation in intensive care","volume":"20","author":"Rehberg","year":"2018","journal-title":"Eur. Heart J. Suppl."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s00540-007-0573-3","article-title":"Clinical role and efficacy of landiolol in the intensive care unit","volume":"22","author":"Yoshida","year":"2008","journal-title":"J. Anesth."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/cc8026","article-title":"Bench-to-bedside review: Beta-adrenergic modulation in sepsis","volume":"13","author":"Aboab","year":"2009","journal-title":"Crit. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/TA.0b013e31821e0f93","article-title":"High circulating adrenaline levels at admission predict increased mortality after trauma","volume":"72","author":"Johansson","year":"2012","journal-title":"J. Trauma. Acute Care Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1053\/j.jvca.2019.10.017","article-title":"Adrenergic Downregulation in Critical Care: Molecular Mechanisms and Therapeutic Evidence","volume":"34","author":"Belletti","year":"2020","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"735841","DOI":"10.3389\/fphar.2021.735841","article-title":"Beta-Adrenergic Blockade in Critical Illness","volume":"12","author":"Bruning","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1161\/CIRCRESAHA.113.300308","article-title":"Adrenergic Nervous System in Heart Failure","volume":"113","author":"Lymperopoulos","year":"2013","journal-title":"Circ. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1080\/07853890.2022.2098376","article-title":"Beta-blocker treatment in the critically ill: A systematic review and meta-analysis","volume":"54","author":"Heliste","year":"2022","journal-title":"Ann. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1253\/circj.CJ-12-0663","article-title":"Safety and efficacy of a bolus injection of landiolol hydrochloride as a premedication for multidetector-row computed tomography coronary angiography","volume":"77","author":"Osawa","year":"2013","journal-title":"Circ. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1253\/circj.CJ-19-0661","article-title":"Open-Label Two-Dose Pilot Study of Landiolol for the Treatment of Atrial Fibrillation\/Atrial Flutter in Caucasian Patients","volume":"84","author":"Stix","year":"2019","journal-title":"Circ. J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Schnaubelt, S., Eibensteiner, F., Oppenauer, J., Tihanyi, D., Neymayer, M., Brock, R., Kornfehl, A., Veigl, C., Al Jalali, V., and Anders, S. (2023). Hemodynamic and Rhythmologic Effects of Push-Dose Landiolol in Critical Care&mdash;A Retrospective Cross-Sectional Study. Pharmaceuticals, 16.","DOI":"10.3390\/ph16020134"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"Hindricks","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Joglar","year":"2024","journal-title":"Circulation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.36628\/ijhf.2019.0009","article-title":"Optimization of Heart Failure Treatment by Heart Rate Reduction","volume":"2","author":"Bewarder","year":"2020","journal-title":"Int. J. Heart Fail."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.bja.2021.11.016","article-title":"Management of new onset atrial fibrillation in critically unwell adult patients: A systematic review and narrative synthesis","volume":"128","author":"Johnston","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1253\/circj.CJ-12-1618","article-title":"Urgent management of rapid heart rate in patients with atrial fibrillation\/flutter and left ventricular dysfunction: Comparison of the ultra-short-acting \u03b21-selective blocker landiolol with digoxin (J-Land Study)","volume":"77","author":"Nagai","year":"2013","journal-title":"Circ. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s00595-013-0615-4","article-title":"Landiolol hydrochloride for early postoperative tachycardia after transthoracic esophagectomy","volume":"44","author":"Mori","year":"2014","journal-title":"Surg. Today"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S2213-2600(20)30037-0","article-title":"Efficacy and safety of landiolol, an ultra-short-acting \u03b21-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): A multicentre, open-label, randomised controlled trial","volume":"8","author":"Kakihana","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jclinane.2014.07.003","article-title":"Landiolol in the treatment of the intraoperative supraventricular tachycardia: A multicenter, randomized, double-blind, placebo-controlled study","volume":"27","author":"Xiao","year":"2015","journal-title":"J. Clin. Anesth."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1253\/circrep.CR-19-0076","article-title":"Urgent Control of Rapid Atrial Fibrillation by Landiolol in Patients With Acute Decompensated Heart Failure With Severely Reduced Ejection Fraction","volume":"1","author":"Iwahashi","year":"2019","journal-title":"Circ. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5492\/wjccm.v4.i3.251","article-title":"Landiolol, an ultra-short-acting \u03b21-blocker, is useful for managing supraventricular tachyarrhythmias in sepsis","volume":"4","author":"Okajima","year":"2015","journal-title":"World J. Crit. Care Med."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Levy, B., Slama, M., Lakbar, I., Maizel, J., Kato, H., Leone, M., and Okada, M. (2024). Landiolol for Treatment of New-Onset Atrial Fibrillation in Critical Care: A Systematic Review. J. Clin. Med., 13.","DOI":"10.3390\/jcm13102951"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Nasoufidou, A., Papazoglou, A.S., Stachteas, P., Karagiannidis, E., Samaras, A., Alexiou, S., Mourtzos, M.A., Kassimis, G., and Fragakis, N. (2024). Intravenous Landiolol for Rate Control in Supraventricular Tachyarrhythmias in Patients with Left Ventricular Dysfunction: A Systematic Review and Meta-Analysis. J. Clin. Med., 13.","DOI":"10.3390\/jcm13061683"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1053\/j.jvca.2015.09.007","article-title":"Efficacy and Safety of Landiolol Compared to Amiodarone for the Management of Postoperative Atrial Fibrillation in Intensive Care Patients","volume":"30","author":"Shibata","year":"2016","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00228-016-2176-0","article-title":"Bolus application of landiolol and esmolol: Comparison of the pharmacokinetic and pharmacodynamic profiles in a healthy Caucasian group","volume":"73","author":"Krumpl","year":"2017","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/BF00316470","article-title":"Effect of pretreatment with the selective beta 1-adrenoceptor antagonist bisoprolol on the subsequent cardiovascular actions and beta-adrenoceptor subtype specific occupancy of celiprolol in healthy man","volume":"44","author":"Beithaupt","year":"1993","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s13318-014-0244-3","article-title":"Evaluation of clinical bradycardiac effect and respiratory adverse effect of \u03b2-blocking agents in coronary computed tomography angiography based on theoretical analysis","volume":"41","author":"Fujito","year":"2016","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1248\/bpb.b16-00992","article-title":"Analysis of Clinical Efficacy and Adverse Effects of \u03b2-Blocking Agents Used Clinically for Chronic Heart Failure","volume":"40","author":"Takayanagi","year":"2017","journal-title":"Biol. Pharm. Bull."},{"key":"ref_35","first-page":"328","article-title":"Beta adrenoceptor subtype binding activity in plasma and beta blockade by propranolol and beta-1 selective bisoprolol in humans. Evaluation with Schild-plots","volume":"246","author":"Wellstein","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1161\/01.CIR.0000070983.15903.A2","article-title":"Beta-Adrenergic Blockers","volume":"107","author":"Frishman","year":"2003","journal-title":"Circulation"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/00005344-199006165-00002","article-title":"Pharmacology of beta-blockers: Classical aspects and recent developments","volume":"16","author":"Haeusler","year":"1990","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Miranda-Ackerman, R.C., Lira-Trujillo, M., Gollaz-Cervantez, A.C., Cort\u00e9s-Flores, A.O., Zuloaga-Fern\u00e1ndez Del Valle, C.J., Garc\u00eda-Gonz\u00e1lez, L.A., Morgan-Villela, G., Barbosa-Camacho, F.J., Pintor-Belmontes, K.J., and Guzm\u00e1n-Ram\u00edrez, B.G. (2020). Associations between stressors and difficulty sleeping in critically ill patients admitted to the intensive care unit: A cohort study. BMC Health Serv. Res., 20.","DOI":"10.1186\/s12913-020-05497-8"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Dammassa, V., Voltini, M., Colombo, C.N.J., Siano, G.M., Lo Coco, C., Rizzo, V., Corradi, F., Mojoli, F., and Tavazzi, G. (2023). Endogenous Catecholamine Release in COVID-19 Related Acute Respiratory Distress Syndrome: Link between Enhanced Sympathetic Stimulation, Cardiac Dysfunction and Outcome. J. Clin. Med., 12.","DOI":"10.3390\/jcm12041557"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jcrc.2014.10.006","article-title":"Sympathoadrenal activation and endothelial damage in patients with varying degrees of acute infectious disease: An observational study","volume":"30","author":"Ostrowski","year":"2015","journal-title":"J. Crit. Care"}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/16\/6\/839\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:01:52Z","timestamp":1760108512000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/16\/6\/839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["pharmaceutics16060839"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics16060839","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,20]]}}}