{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:06:57Z","timestamp":1787774817114,"version":"build-2784847793"},"reference-count":70,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["CIAICO\/2022\/198"],"award-info":[{"award-number":["CIAICO\/2022\/198"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003359","name":"Generalitat Valenciana","doi-asserted-by":"publisher","award":["FUSP-PPC-19-8166C64B"],"award-info":[{"award-number":["FUSP-PPC-19-8166C64B"]}],"id":[{"id":"10.13039\/501100003359","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3n Universitaria San Pablo CEU","award":["CIAICO\/2022\/198"],"award-info":[{"award-number":["CIAICO\/2022\/198"]}]},{"name":"Fundaci\u00f3n Universitaria San Pablo CEU","award":["FUSP-PPC-19-8166C64B"],"award-info":[{"award-number":["FUSP-PPC-19-8166C64B"]}]},{"name":"CEU Cardenal Herrera FPI CEU-UCH","award":["CIAICO\/2022\/198"],"award-info":[{"award-number":["CIAICO\/2022\/198"]}]},{"name":"CEU Cardenal Herrera FPI CEU-UCH","award":["FUSP-PPC-19-8166C64B"],"award-info":[{"award-number":["FUSP-PPC-19-8166C64B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Infections are one of the main complications in arthroplasties. These infections are difficult to treat because the bacteria responsible for them settle in the prosthesis and form a biofilm that does not allow antimicrobials to reach the infected area. This study is part of a research project aimed at developing 3D-printed spacers (temporary prostheses) capable of incorporating antibacterials for the personalized treatment of arthroplasty infections. The main objective of this research was to analyze the impact of the layer thickness of 3D-printed constructs based on polylactic acid (PLA) for improved treatment of infections in arthroplasty. The focus is on the following parameters: resistance, morphology, drug release, and the effect of antibacterials incorporated in the printed temporary prostheses. The resistance studies revealed that the design and layer thickness of a printed spacer have an influence on its resistance properties. The thickness of the layer used in printing affects the amount of methylene blue (used as a model drug) that is released. Increasing layer thickness leads to a greater release of the drug from the spacer, probably as a result of higher porosity. To evaluate antibacterial release, cloxacillin and vancomycin were incorporated into the constructs. When incorporated into the 3D construct, both antibacterials were released, as evidenced by the growth inhibition of Staphylococcus aureus. In conclusion, preliminary results indicate that the layer thickness during the three-dimensional (3D) printing process of the spacer plays a significant role in drug release.<\/jats:p>","DOI":"10.3390\/pharmaceutics16091151","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T10:54:11Z","timestamp":1725015251000},"page":"1151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["An Antibacterial-Loaded PLA 3D-Printed Model for Temporary Prosthesis in Arthroplasty Infections: Evaluation of the Impact of Layer Thickness on the Mechanical Strength of a Construct and Drug Release"],"prefix":"10.3390","volume":"16","author":[{"given":"Carlos","family":"Tamarit-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Instituto de Ciencias Biom\u00e9dicas, Departamento de Farmacia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, C\/Santiago Ram\u00f3n y Cajal s\/n, 46115 Alfara del Patriarca, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Bernat-Just","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Biom\u00e9dicas, Departamento de Farmacia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, C\/Santiago Ram\u00f3n y Cajal s\/n, 46115 Alfara del Patriarca, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Bueno-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Biom\u00e9dicas, Departamento de Farmacia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, C\/Santiago Ram\u00f3n y Cajal s\/n, 46115 Alfara del Patriarca, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9642-1998","authenticated-orcid":false,"given":"Adri\u00e1n M.","family":"Alambiaga-Caravaca","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias Biom\u00e9dicas, Departamento de Farmacia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, C\/Santiago Ram\u00f3n y Cajal s\/n, 46115 Alfara del Patriarca, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-4664","authenticated-orcid":false,"given":"Virginia","family":"Merino","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia y Tecnolog\u00eda Farmac\u00e9utica y Parasitolog\u00eda, Facultad de Farmacia, Universitat de Val\u00e8ncia, Av. 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(2016). Patient-Related Risk Factors for Periprosthetic Joint Infection after Total Joint Arthroplasty: A Systematic Review and Meta-Analysis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0150866"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/21505594.2017.1313372","article-title":"Strategies for Combating Bacterial Biofilms: A Focus on Anti-Biofilm Agents and Their Mechanisms of Action","volume":"9","author":"Roy","year":"2018","journal-title":"Virulence"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrmicro2415","article-title":"The Biofilm Matrix","volume":"8","author":"Flemming","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2309499019847768","DOI":"10.1177\/2309499019847768","article-title":"Different Microbiological Profiles between Hip and Knee Prosthetic Joint Infections","volume":"27","author":"Tsai","year":"2019","journal-title":"J. Orthop. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Papadimitriou-Olivgeris, M., Senn, L., Bertelli, C., Grandbastien, B., Steinmetz, S., and Boillat-Blanco, N. (2022). Prevalence and Factors Associated with Prosthetic Joint Infections in Patients with Staphylococcus aureus Bacteraemia: A 7-Year Retrospective Study. Antibiotics, 11.","DOI":"10.3390\/antibiotics11101323"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.jiph.2020.09.006","article-title":"Prosthetic Joint Infection. A Relevant Public Health Issue","volume":"13","author":"Zardi","year":"2020","journal-title":"J. Infect. 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Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s42836-022-00142-7","article-title":"Patients at a High Risk of PJI: Can We Reduce the Incidence of Infection Using Dual Antibiotic-Loaded Bone Cement?","volume":"4","author":"Berberich","year":"2022","journal-title":"Arthroplasty"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Wang, J., Zhu, C., Cheng, T., Peng, X., Zhang, W., Qin, H., and Zhang, X. (2013). A Systematic Review and Meta-Analysis of Antibiotic-Impregnated Bone Cement Use in Primary Total Hip or Knee Arthroplasty. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0082745"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Xie, H., Liu, Y., An, H., Yi, J., Li, C., Wang, X., and Chai, W. (2022). Recent Advances in Prevention, Detection and Treatment in Prosthetic Joint Infections of Bioactive Materials. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.1053399"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s12178-015-9293-8","article-title":"The Use of Spacers (Static and Mobile) in Infection Knee Arthroplasty","volume":"8","author":"Mazzucchelli","year":"2015","journal-title":"Curr. Rev. Musculoskelet. Med."},{"key":"ref_15","first-page":"e20968","article-title":"Current Concepts on the Application, Pharmacokinetics and Complications of Antibiotic-Loaded Cement Spacers in the Treatment of Prosthetic Joint Infections","volume":"14","author":"Samelis","year":"2022","journal-title":"Cureus"},{"key":"ref_16","first-page":"328","article-title":"Research into Biocompatibility and Cytotoxicity of Daptomycin, Gentamicin, Vancomycin and Teicoplanin Antibiotics at Common Doses Added to Bone Cement","volume":"31","author":"Pazarci","year":"2020","journal-title":"Jt. Dis. Relat. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Cara, A., Ballet, M., Hemery, C., Ferry, T., Laurent, F., and Josse, J. (2021). Antibiotics in Bone Cements Used for Prosthesis Fixation: An Efficient Way to Prevent Staphylococcus aureus and Staphylococcus epidermidis Prosthetic Joint Infection. Front. Med., 7.","DOI":"10.3389\/fmed.2020.576231"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4055\/cios19058","article-title":"The Impact of Antibiotic-Loaded Bone Cement on Antibiotic Resistance in Periprosthetic Knee Infections","volume":"12","author":"Schmitt","year":"2020","journal-title":"CiOS Clin. Orthop. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00402-019-03155-1","article-title":"Staphylococcal Resistance Profiles in Deep Infection Following Primary Hip and Knee Arthroplasty: A Study Using the NJR Dataset","volume":"139","author":"Holleyman","year":"2019","journal-title":"Arch. Orthop. Trauma. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"111999","DOI":"10.1016\/j.msec.2021.111999","article-title":"A Meta-Analysis of Bone Cement Mediated Antibiotic Release: Overkill, but a Viable Approach to Eradicate Osteomyelitis and Other Infections Tied to Open Procedures","volume":"123","author":"Mensah","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Tan, D.K., Maniruzzaman, M., and Nokhodchi, A. (2020). Development and Optimisation of Novel Polymeric Compositions for Sustained Release Theophylline. Polymers, 12.","DOI":"10.3390\/polym12010027"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s11095-018-2454-x","article-title":"3D Printing in Pharmaceutical and Medical Applications","volume":"35","author":"Szafraniec","year":"2018","journal-title":"Pharm. Res."},{"key":"ref_23","first-page":"66","article-title":"Fabrication and Characterization of Novel 3D Porous Titanium-6Al-4V Scaffold for Orthopedic Application Using Selective Laser Melting Technique","volume":"43","author":"Attaeyan","year":"2024","journal-title":"Iran. J. Chem. Chem. Eng."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Zhu, X., Li, H., Huang, L., Zhang, M., Fan, W., and Cui, L. (2020). 3D Printing Promotes the Development of Drugs. Biomed. Pharmacother., 131.","DOI":"10.1016\/j.biopha.2020.110644"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6597","DOI":"10.3390\/ijms12106597","article-title":"Crystallization Study and Comparative in Vitro\u2013in Vivo Hydrolysis of PLA Reinforcement Ligament","volume":"12","author":"Beslikas","year":"2011","journal-title":"Int. J. Mol. Sci."},{"key":"ref_26","first-page":"357","article-title":"Antibiotic and Chemotherapeutic Enhanced Three-Dimensional Printer Filaments and Constructs for Biomedical Applications","volume":"10","author":"Weisman","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Benmassaoud, M.M., Kohama, C., Kim, T.W.B., Kadlowec, J.A., Foltiny, B., Mercurio, T., and Ranganathan, S.I. (2019). Efficacy of Eluted Antibiotics through 3D Printed Femoral Implants. Biomed. Microdevices, 21.","DOI":"10.1007\/s10544-019-0395-8"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Amekyeh, H., Tarlochan, F., and Billa, N. (2021). Practicality of 3D Printed Personalized Medicines in Therapeutics. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.646836"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"119732","DOI":"10.1016\/j.ijpharm.2020.119732","article-title":"3D Printing: An Appealing Route for Customized Drug Delivery Systems","volume":"588","author":"Elkasabgy","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1208\/s12249-020-01905-8","article-title":"3D Printing as a Promising Tool in Personalized Medicine","volume":"22","author":"Vaz","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.21070\/r.e.m.v7i2.1649","article-title":"Layer Height, Temperature Nozzle, Infill Geometry and Printing Speed Effect on Accuracy 3D Printing PETG","volume":"7","author":"Muhammad","year":"2022","journal-title":"REM J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.acme.2018.01.015","article-title":"The Role of Powder Layer Thickness on the Quality of SLM Printed Parts","volume":"18","author":"Nguyen","year":"2018","journal-title":"Arch. Civ. Mech. Eng."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Farzadi, A., Solati-Hashjin, M., Asadi-Eydivand, M., and Osman, N.A.A. (2014). Effect of Layer Thickness and Printing Orientation on Mechanical Properties and Dimensional Accuracy of 3D Printed Porous Samples for Bone Tissue Engineering. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0108252"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s00056-019-00180-y","article-title":"Influence of the Three-Dimensional Printing Technique and Printing Layer Thickness on Model Accuracy","volume":"80","author":"Zhang","year":"2019","journal-title":"J. Orofac. Orthop."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Elkaseer, A., Schneider, S., and Scholz, S.G. (2020). Experiment-Based Process Modeling and Optimization for High-Quality and Resource-Efficient FFF 3D Printing. Appl. Sci., 10.","DOI":"10.3390\/app10082899"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Bueno-L\u00f3pez, C., Tamarit-Mart\u00ednez, C., Alambiaga-Caravaca, A.M., Balaguer-Fern\u00e1ndez, C., Merino, V., L\u00f3pez-Castellano, A., and Rodilla, V. (2021). 3D Printing of Temporary Prostheses for Controlled-Release of Drugs: Design, Physical Characterization and Preliminary Studies. Pharmaceuticals, 14.","DOI":"10.3390\/ph14121240"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Bembenek, M., Kowalski, \u0141., and Koso\u0144-Schab, A. (2022). Research on the Influence of Processing Parameters on the Specific Tensile Strength of FDM Additive Manufactured PET-G and PLA Materials. Polymers, 14.","DOI":"10.3390\/polym14122446"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Hsueh, M.H., Lai, C.J., Wang, S.H., Zeng, Y.S., Hsieh, C.H., Pan, C.Y., and Huang, W.C. (2021). Effect of Printing Parameters on the Thermal and Mechanical Properties of 3d-Printed Pla and Petg, Using Fused Deposition Modeling. Polymers, 13.","DOI":"10.3390\/polym13111758"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/dta.253","article-title":"Catalytic Spectrophotometric Determination of Iodide in Pharmaceutical Preparations and Edible Salt","volume":"4","author":"Khaled","year":"2012","journal-title":"Drug Test. Anal."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Li, D., Wang, M., Song, W.L., Yu, D.G., and Bligh, S.W.A. (2021). Electrospun Janus Beads-on-a-String Structures for Different Types of Controlled Release Profiles of Double Drugs. Biomolecules, 11.","DOI":"10.3390\/biom11050635"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nano.2007.03.002","article-title":"Controlled Loading and Release of a Model Drug from Polypeptide Multilayer Nanofilms","volume":"3","author":"Zhong","year":"2007","journal-title":"Nanomedicine"},{"key":"ref_42","first-page":"37","article-title":"Tunable Drug Loading and Release from Polypeptide Multilayer Nanofi Lms","volume":"4","author":"Jiang","year":"2009","journal-title":"Int. J. Nanomed."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ijpharm.2008.09.004","article-title":"Mathematical Modeling of Drug Delivery","volume":"364","author":"Siepmann","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1517\/17425241003602259","article-title":"Drug Release Kinetics and Transport Mechanisms of Non-Degradable and Degradable Polymeric Delivery Systems","volume":"7","author":"Fu","year":"2010","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_45","unstructured":"Cockerill, F.R., Wikler, M.A., Alder, J., Dudley, M.N., Eliopoulos, G.M., Ferraro, M.J., Hardy, D.J., Hecht, D.W., Hindler, J.A., and Patel, J.B. (2012). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, Clinical and Laboratory Standards Institute. Approved Standard\u2014Ninth Edition."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3126","DOI":"10.1016\/j.arth.2017.04.057","article-title":"Bioactivity of Ceftazidime and Fluconazole Included in Polymethyl Methacrylate Bone Cement for Use in Arthroplasty","volume":"32","author":"Merino","year":"2017","journal-title":"J. Arthroplast."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.2147\/IJN.S315839","article-title":"Enhanced Antibacterial and Anti-Biofilm Activities of Antimicrobial Peptides Modified Silver Nanoparticles","volume":"16","author":"Xu","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Meiabadi, M.S., Moradi, M., Karamimoghadam, M., Ardabili, S., Bodaghi, M., Shokri, M., and Mosavi, A.H. (2021). Modeling the Producibility of 3d Printing in Polylactic Acid Using Artificial Neural Networks and Fused Filament Fabrication. Polymers, 13.","DOI":"10.3390\/polym13193219"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5834","DOI":"10.3390\/ma8095271","article-title":"Influence of Layer Thickness and Raster Angle on the Mechanical Properties of 3D-Printed PEEK and a Comparative Mechanical Study between PEEK and ABS","volume":"8","author":"Wu","year":"2015","journal-title":"Materials"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Syrlybayev, D., Zharylkassyn, B., Seisekulova, A., Akhmetov, M., Perveen, A., and Talamona, D. (2021). Optimisation of Strength Properties of FDM Printed Parts\u2014A Critical Review. Polymers, 13.","DOI":"10.3390\/polym13101587"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"772","DOI":"10.4012\/dmj.2020-232","article-title":"Can Polylactic Acid Be a CAD\/CAM Material for Provisional Crown Restorations in Terms of Fit and Fracture Strength?","volume":"40","author":"Benli","year":"2021","journal-title":"Dent. Mater. J."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Vakharia, V.S., Kuentz, L., Salem, A., Halbig, M.C., Salem, J.A., and Singh, M. (2021). Additive Manufacturing and Characterization of Metal Particulate Reinforced Polylactic Acid (Pla) Polymer Composites. Polymers, 13.","DOI":"10.3390\/polym13203545"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Xu, Q., Jiang, L., Ma, C., Niu, Q., and Wang, X. (2021). Effect of Layer Thickness on the Physical and Mechanical Properties of Sand Powder 3D Printing Specimens. Front. Earth Sci., 9.","DOI":"10.3389\/feart.2021.763202"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kuznetsov, V.E., Solonin, A.N., Urzhumtsev, O.D., Schilling, R., and Tavitov, A.G. (2018). Strength of PLA Components Fabricated with Fused Deposition Technology Using a Desktop 3D Printer as a Function of Geometrical Parameters of the Process. Polymers, 10.","DOI":"10.20944\/preprints201803.0036.v1"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Tzounis, L., Bangeas, P.I., Exadaktylos, A., and Petousis, M. (2020). Three-Dimensional Printed Polylactic Acid (PLA) Surgical Retractors with Sonochemically Immobilized Silver Nanoparticles: The Next Generation of Low-Cost Antimicrobial Surgery Equipment. Nanomaterials, 10.","DOI":"10.3390\/nano10050985"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijpharm.2018.07.002","article-title":"Development of Customised 3D Printed Biodegradable Projectile for Administrating Extended-Release Contraceptive to Wildlife","volume":"548","author":"Long","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Ilhan, E., Ulag, S., Sahin, A., Karademir, B., Ekren, N., Kilic, O., Sengor, M., Kalaskar, D.M., Nuzhet, F., and Gunduz, O. (2021). Journal of the Mechanical Behavior of Biomedical Materials Fabrication of Tissue-Engineered Tympanic Membrane Patches Using 3D-Printing Technology. J. Mech. Behav. Biomed. Mater., 114.","DOI":"10.1016\/j.jmbbm.2020.104219"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Altun, E., Yuca, E., Ekren, N., Kalaskar, D.M., Ficai, D., Dolete, G., Ficai, A., and Gunduz, O. (2021). Kinetic Release Studies of Antibiotic Patches for Local Transdermal Delivery. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13050613"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"120330","DOI":"10.1016\/j.ijpharm.2021.120330","article-title":"3D Printed Polymeric Drug-Eluting Implants","volume":"597","author":"Liaskoni","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Chunate, H.-T., Khamwannah, J., Azeez, A., Aliyu, A., Tantavisut, S., Puncreobutr, C., Khamkongkaeo, A., Tongyam, C., Tumkhanon, K., and Phetrattanarangsi, T. (2021). Titania Nanotube Architectures Synthesized on 3D-Printed Ti-6Al-4V Implant and Assessing Vancomycin Release Protocols. Materials, 14.","DOI":"10.3390\/ma14216576"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.addr.2021.04.020","article-title":"Controlling Drug Release with Additive Manufacturing-Based Solutions","volume":"174","author":"Patel","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3109\/03639045.2015.1120743","article-title":"3D Printing Technologies for Drug Delivery: A Review","volume":"42","author":"Prasad","year":"2016","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2174\/1381612822666161026162707","article-title":"Application of Fused Deposition Modelling (FDM) Method of 3D Printing in Drug Delivery","volume":"23","author":"Long","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijpharm.2018.09.042","article-title":"3D Printing and Coating to Fabricate a Hollow Bullet-Shaped Implant with Porous Surface for Controlled Cytoxan Release","volume":"552","author":"Yang","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jddst.2019.05.037","article-title":"Design and 3D Printing of Multi-Compartmental PVA Capsules for Drug Delivery","volume":"52","author":"Poropat","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1177\/0954411921993582","article-title":"Investigations of Process Parameters during Dissolution Studies of Drug Loaded 3D Printed Tablets","volume":"235","author":"Sharma","year":"2021","journal-title":"Proc. Inst. Mech. Eng. Part H J. Eng. Med."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Gueche, Y.A., Sanchez-Ballester, N.M., Bataille, B., Aubert, A., Rossi, J.C., and Soulairol, I. (2021). A Qbd Approach for Evaluating the Effect of Selective Laser Sintering Parameters on Printability and Properties of Solid Oral Forms. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13101701"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Maver, T., Mastnak, T., Miheli\u010d, M., Maver, U., and Fin\u0161gar, M. (2021). Clindamycin-Based 3D-Printed and Electrospun Coatings for Treatment of Implant-Related Infections. Materials, 14.","DOI":"10.3390\/ma14061464"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"12298","DOI":"10.1021\/acsami.9b00264","article-title":"3D Bioprinted Scaffolds Containing Viable Macrophages and Antibiotics Promote Clearance of Staphylococcus aureus Craniotomy-Associated Biofilm Infection HHS Public Access","volume":"11","author":"Aldrich","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Mai, H.N., Hyun, D.C., Park, J.H., Kim, D.Y., Lee, S.M., and Lee, D.H. (2020). Antibacterial Drug-Release Polydimethylsiloxane Coating for 3d-Printing Dental Polymer: Surface Alterations and Antimicrobial Effects. 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