{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:12:13Z","timestamp":1792026733068,"version":"4.4.0"},"reference-count":212,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science, Technology &amp; Innovation Commission of Shenzhen Municipality","award":["JCYJ20210324113411032"],"award-info":[{"award-number":["JCYJ20210324113411032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Glucose, a primary energy source derived from animals\u2019 feed ration, is crucial for their growth, production performance, and health. However, challenges such as metabolic stress, oxidative stress, inflammation, and gut microbiota disruption during animal production practices can potentially impair animal glucose metabolism pathways. Phytochemicals, probiotics, prebiotics, and trace minerals are known to change the molecular pathway of insulin-dependent glucose metabolism and improve glucose uptake in rodent and cell models. These compounds, commonly used as animal feed additives, have been well studied for their ability to promote various aspects of growth and health. However, their specific effects on glucose uptake modulation have not been thoroughly explored. This article focuses on glucose metabolism is on discovering alternative non-pharmacological treatments for diabetes in humans, which could have significant implications for developing feed additives that enhance animal performance by promoting insulin-dependent glucose metabolism. This article also aims to provide information about natural materials that impact glucose uptake and to explore their potential use as non-antibiotic feed additives to promote animal health and production. Further exploration of this topic and the materials involved could provide a basis for new product development and innovation in animal nutrition.<\/jats:p>","DOI":"10.3390\/pharmaceutics16091208","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T11:29:59Z","timestamp":1726226999000},"page":"1208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Glucose Metabolism-Modifying Natural Materials for Potential Feed Additive Development"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7476-5394","authenticated-orcid":false,"given":"Wei-Chih","family":"Lin","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China"},{"name":"Kemin (China) Technologies Co., Ltd., Zhuhai 519040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2017-9111","authenticated-orcid":false,"given":"Boon-Chin","family":"Hoe","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China"},{"name":"Kemin (China) Technologies Co., Ltd., Zhuhai 519040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianming","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daizheng","family":"Lian","sequence":"additional","affiliation":[{"name":"Shenzhen People\u2019s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-2689","authenticated-orcid":false,"given":"Xiaowei","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen 518107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7083","DOI":"10.3168\/jds.2014-8941","article-title":"Short communication: Characterizing metabolic and oxidant status of pastured dairy cows postpartum in an automatic milking system","volume":"98","author":"Elischer","year":"2015","journal-title":"J. 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