{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:20:35Z","timestamp":1789996835541,"version":"4.0.1"},"reference-count":73,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Federal Ministry of Education and Research of Germany (BMBF)","award":["03ZZ0928L"],"award-info":[{"award-number":["03ZZ0928L"]}]},{"name":"Federal Ministry of Education and Research of Germany (BMBF)","award":["03ZZ0928D"],"award-info":[{"award-number":["03ZZ0928D"]}]},{"name":"China Scholarship Council (CSC)","award":["03ZZ0928L"],"award-info":[{"award-number":["03ZZ0928L"]}]},{"name":"China Scholarship Council (CSC)","award":["03ZZ0928D"],"award-info":[{"award-number":["03ZZ0928D"]}]},{"name":"NiedersachsenOPEN","award":["03ZZ0928L"],"award-info":[{"award-number":["03ZZ0928L"]}]},{"name":"NiedersachsenOPEN","award":["03ZZ0928D"],"award-info":[{"award-number":["03ZZ0928D"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Preserving residual hearing after cochlear implant (CI) surgery remains a crucial challenge. The application of dexamethasone (DEX) has been proven to positively affect residual hearing. To deliver DEX in a localized and controlled way, a round window niche implant (RNI), allowing drug diffusion via the round window membrane into the cochlea, may be used. To prove this concept, an RNI for guinea pigs as a CI-trauma model was manufactured by molding and tested for its drug release in vitro and biological effects in vivo. Methods: The RNIs were molded using silicone containing 10% DEX. Release was analyzed over time using high-performance liquid chromatography (HPLC). Fourteen adult guinea pigs were randomly assigned to two groups (CI or CI + RNI group). All animals received a unilateral CI electrode insertion trauma followed by CI insertion. The CI + RNI group was additionally implanted with an RNI containing 10% DEX. Animals were followed up for 4 weeks. Acoustically evoked auditory brainstem response and impedance measurement, micro-computed tomography (\u00b5CT) imaging, and histology were performed for evaluation. Results: DEX was released for more than 250 days in vitro, with an initial burst followed by a slower release over time. Comparing the hearing threshold shift (from day 0 to day 28) of the CI and CI + RNI groups, significant differences were observed at 32 and 40 kHz. The impedance shift at basal contacts was lower in the CI + RNI group than in the CI group. Moreover, the fibrosis in the lower basal turn was reduced in the CI + RNI group in contrast to the CI group. Conclusions: The RNI containing 10% DEX has anti-inflammatory potential concerning fibrosis inhibition and has beneficial effects on hearing preservation at high frequencies.<\/jats:p>","DOI":"10.3390\/pharmaceutics16091236","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T09:15:07Z","timestamp":1727082907000},"page":"1236","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Molded Round Window Niche Implant as a Dexamethasone Delivery System in a Cochlear Implant-Trauma Animal Model"],"prefix":"10.3390","volume":"16","author":[{"given":"Chunjiang","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"},{"name":"Cluster of Excellence \u201cHearing4all\u201d, German Research Foundation (DFG; \u201cDeutsche Forschungsgemeinschaft\u201d), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"},{"name":"Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), Stadtfelddamm 34, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-8838","authenticated-orcid":false,"given":"Ziwen","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"},{"name":"Cluster of Excellence \u201cHearing4all\u201d, German Research Foundation (DFG; \u201cDeutsche Forschungsgemeinschaft\u201d), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"},{"name":"ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3748-4275","authenticated-orcid":false,"given":"Robert","family":"Mau","sequence":"additional","affiliation":[{"name":"Microfluidics, Faculty of Mechanical Engineering and Marine Technology, University of Rostock, Justus-von-Liebig Weg 6, 18059 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eickner","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Engineering, University Medical Center Rostock, University of Rostock, Friedrich-Barnewitz Stra\u00dfe 4, 18119 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"J\u00fcttner","sequence":"additional","affiliation":[{"name":"Kunststoff-Zentrum in Leipzig gGmbH, Erich-Zeigner-Allee 44, 04229 Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4436-7010","authenticated-orcid":false,"given":"Nicklas","family":"Fiedler","sequence":"additional","affiliation":[{"name":"Institute for Biomedical Engineering, University Medical Center Rostock, University of Rostock, Friedrich-Barnewitz Stra\u00dfe 4, 18119 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-0090","authenticated-orcid":false,"given":"Hermann","family":"Seitz","sequence":"additional","affiliation":[{"name":"Microfluidics, Faculty of Mechanical Engineering and Marine Technology, University of Rostock, Justus-von-Liebig Weg 6, 18059 Rostock, Germany"},{"name":"Department Life, Light & Matter, Interdisciplinary Faculty, University of Rostock, Albert-Einstein-Str. 25, 18059 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-5989","authenticated-orcid":false,"given":"Thomas","family":"Lenarz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"},{"name":"Cluster of Excellence \u201cHearing4all\u201d, German Research Foundation (DFG; \u201cDeutsche Forschungsgemeinschaft\u201d), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"},{"name":"Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), Stadtfelddamm 34, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8618-8793","authenticated-orcid":false,"given":"Verena","family":"Scheper","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"},{"name":"Cluster of Excellence \u201cHearing4all\u201d, German Research Foundation (DFG; \u201cDeutsche Forschungsgemeinschaft\u201d), Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany"},{"name":"Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), Stadtfelddamm 34, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Miller, J., Le Prell, C.G., and Rybak, L. 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