{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:08:51Z","timestamp":1790986131891,"version":"4.1.0"},"reference-count":89,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,24]],"date-time":"2024-11-24T00:00:00Z","timestamp":1732406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The National Key Research and Development Program of China","award":["2019YFC1521301"],"award-info":[{"award-number":["2019YFC1521301"]}]},{"name":"The National Key Research and Development Program of China","award":["2021016"],"award-info":[{"award-number":["2021016"]}]},{"name":"Zhejiang Science and Technology Projects of Cultural Relics Protection","award":["2019YFC1521301"],"award-info":[{"award-number":["2019YFC1521301"]}]},{"name":"Zhejiang Science and Technology Projects of Cultural Relics Protection","award":["2021016"],"award-info":[{"award-number":["2021016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: The use of natural colourants is gaining attention due to their biocompatibility and functional benefits. This study introduces a different approach using turmeric (Curcuma longa L.) dye extract combined with chitosan to significantly enhance the antibacterial and UV-shielding properties of silk. Methods: The turmeric dye\u2019s chemical composition was analyzed using liquid chromatography mass spectrometry (LC-MS), UV\u2013visible spectroscopy, and Fourier-transform infrared spectroscopy (FTIR). The dyed silk\u2019s colourfastness was tested through rubbing, washing, and light exposure. Results: The chitosan-mordanted silk showed strong antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), as well as antifungal activity against Aspergillus niger (A. niger). It also demonstrated a high ultraviolet protection factor (UPF). For comparison, alum-mordant was used, and chitosan proved more effective. Beyond its use as a dye, turmeric is renowned for its medicinal properties. Its antioxidant, anticancer, and anti-inflammatory properties have been extensively researched, which are primarily linked to its curcuminoid compounds. Turmeric is used in traditional medication to treat digestive issues, arthritis, and skin diseases. Conclusions: This work underscores the innovative use of plant-based dye extracts and natural mordants like chitosan as a sustainable alternative to conventional metallic mordants, paving the way for the evolution of bioactive silk with improved functional properties.<\/jats:p>","DOI":"10.3390\/pharmaceutics16121510","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T05:21:32Z","timestamp":1732512092000},"page":"1510","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bioactive Silk Revolution: Harnessing Curcuminoid Dye and Chitosan for Superior Antimicrobial Defence and UV Shielding"],"prefix":"10.3390","volume":"16","author":[{"given":"Khai Ly","family":"Do","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"},{"name":"Shengzhou Innovation Research Institute, Zhejiang Sci-Tech University, Shaoxing 312451, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8777-257X","authenticated-orcid":false,"given":"Taswar","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Institute of Plant Protection, Liaoning Academy of Agriculture Sciences, Shenyang 110161, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Wahab","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2256-3691","authenticated-orcid":false,"given":"Muhammad","family":"Tayyab","sequence":"additional","affiliation":[{"name":"Institute of Materials Research, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinqi","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Textile Science and Engineering (International Silk Institute), Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nengjie","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Textile Science and Engineering (International Silk Institute), Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Textile Science and Engineering (International Silk Institute), Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9747-6686","authenticated-orcid":false,"given":"Asim","family":"Mushtaq","sequence":"additional","affiliation":[{"name":"Institute for Intelligent Bio\/Chem Manufacturing (<i>i<\/i>BCM), Zhejiang University-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou 311200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-6047","authenticated-orcid":false,"given":"Miao","family":"Su","sequence":"additional","affiliation":[{"name":"College of Textile Science and Engineering (International Silk Institute), Zhejiang Sci-Tech University, Hangzhou 310018, China"},{"name":"Shengzhou Innovation Research Institute, Zhejiang Sci-Tech University, Shaoxing 312451, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,24]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"The Significance of the Introduction of Synthetic Dyes in the Mid 19th Century on the Democratisation of Western Fashion","volume":"11","author":"Forster","year":"2013","journal-title":"J. Intern. Colour. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9207","DOI":"10.1007\/s11356-022-24398-3","article-title":"Impact of Textile Dyes on Health and Ecosystem: A Review of Structure, Causes, and Potential Solutions","volume":"30","author":"Islam","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100829","DOI":"10.1016\/j.jics.2022.100829","article-title":"A Critical Review of Hazardous Waste Generation from Textile Industries and Associated Ecological Impacts","volume":"100","author":"Khan","year":"2023","journal-title":"J. Indian Chem. Soc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"113160","DOI":"10.1016\/j.ecoenv.2021.113160","article-title":"A Critical Review on the Treatment of Dye-Containing Wastewater: Ecotoxicological and Health Concerns of Textile Dyes and Possible Remediation Approaches for Environmental Safety","volume":"231","author":"Ali","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Li, N., Wang, Q., Zhou, J., Li, S., Liu, J., and Chen, H. (2022). Insight into the Progress on Natural Dyes: Sources, Structural Features, Health Effects, Challenges, and Potential. Molecules, 27.","DOI":"10.3390\/molecules27103291"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1007\/s12649-021-01443-9","article-title":"Natural Quinone Dyes: A Review on Structure, Extraction Techniques, Analysis and Application Potential","volume":"12","author":"Dulo","year":"2021","journal-title":"Waste Biomass Valoriz."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"C\u00e2mara, J.S., Locatelli, M., Pereira, J.A.M., Oliveira, H., Arlorio, M., Fernandes, I., Perestrelo, R., Freitas, V., and Bordiga, M. (2022). Behind the Scenes of Anthocyanins\u2014From the Health Benefits to Potential Applications in Food, Pharmaceutical and Cosmetic Fields. Nutrients, 14.","DOI":"10.3390\/nu14235133"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Nabi, B.G., Mukhtar, K., Ahmed, W., Manzoor, M.F., Ranjha, M.M.A.N., Kieliszek, M., Bhat, Z.F., and Aadil, R.M. (2023). Natural Pigments: Anthocyanins, Carotenoids, Chlorophylls, and Betalains as Colorants in Food Products. Food Biosci., 52.","DOI":"10.1016\/j.fbio.2023.102403"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"110675","DOI":"10.1016\/j.dyepig.2022.110675","article-title":"Indigo Dyeing from Isatis tinctoria L.: From Medieval to Modern Use","volume":"207","author":"Mocquard","year":"2022","journal-title":"Dyes. Pigm."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"110821","DOI":"10.1016\/j.foodres.2021.110821","article-title":"Betalain Plant Sources, Biosynthesis, Extraction, Stability Enhancement Methods, Bioactivity, and Applications","volume":"151","year":"2022","journal-title":"Food Res. Intern."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1080\/15440478.2021.1875378","article-title":"Antimicrobial Activity of Natural Dyes\u2014A Comprehensive Review","volume":"19","author":"Kamboj","year":"2022","journal-title":"J. Nat. Fibers"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1007\/s00289-021-03826-3","article-title":"Antimicrobial Textile: Recent Developments and Functional Perspective","volume":"79","author":"Gulati","year":"2022","journal-title":"Polym. Bull."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"25974","DOI":"10.1021\/acsomega.2c03291","article-title":"Natural Antioxidant Compounds as Potential Pharmaceutical Tools against Neurodegenerative Diseases","volume":"7","author":"Marino","year":"2022","journal-title":"Acs Omega"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/fsn3.3217","article-title":"Natural Antioxidants from Some Fruits, Seeds, Foods, Natural Products, and Associated Health Benefits: An Update","volume":"11","author":"Rahaman","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"154824","DOI":"10.1016\/j.phymed.2023.154824","article-title":"A Systematic Review of Natural Products for Skin Applications: Targeting Inflammation, Wound Healing, and Photo-Aging","volume":"115","author":"Fernandes","year":"2023","journal-title":"Phytomedicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"131489","DOI":"10.1016\/j.jclepro.2022.131489","article-title":"Textile Colouration with Natural Colourants: A Review","volume":"349","author":"Uddin","year":"2022","journal-title":"J. Clean. Prod."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Najmi, A., Javed, S.A., Al Bratty, M., and Alhazmi, H.A. (2022). Modern Approaches in the Discovery and Development of Plant-Based Natural Products and Their Analogues as Potential Therapeutic Agents. Molecules, 27.","DOI":"10.3390\/molecules27020349"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lama-Mu\u00f1oz, A., and Contreras, M.d.M. (2022). Extraction Systems and Analytical Techniques for Food Phenolic Compounds: A Review. Foods, 11.","DOI":"10.3390\/foods11223671"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/05704928.2014.1000461","article-title":"Application of Fourier Transform Infrared (FTIR) Spectroscopy in the Characterization of Tannins","volume":"50","author":"Ricci","year":"2015","journal-title":"Appl. Spectrosc. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"116501","DOI":"10.1016\/j.trac.2021.116501","article-title":"Analysis of Brown, Violet and Blue Pigments of Microorganisms by Raman Spectroscopy","volume":"146","author":"Edwards","year":"2022","journal-title":"Trends Analyt. Chem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"110482","DOI":"10.1016\/j.dyepig.2022.110482","article-title":"From Historical Dye to Bio-Colourant: Processing, Identification in Historical Textiles and Potential Applications of Anthraquinone-Based Morindone","volume":"205","author":"Do","year":"2022","journal-title":"Dyes Pigm."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cote.12711","article-title":"Alizarin Old and New: Extraction Techniques for Colouration, Advances in Detection Methods for Historical Textiles, and Novel Applications as a Functional Dye","volume":"140","author":"Do","year":"2024","journal-title":"Color. Technol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1007\/s12221-024-00575-8","article-title":"Unveiling the Use of Natural and Early Synthetic Dyes in Indonesian Historical Silk Textiles","volume":"25","author":"Do","year":"2024","journal-title":"Fibers Polym."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"43732","DOI":"10.1007\/s11356-022-20137-w","article-title":"Multiple Health Benefits of Curcumin and Its Therapeutic Potential","volume":"29","author":"Shah","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"134453","DOI":"10.1016\/j.foodchem.2022.134453","article-title":"Recent Advancements in Natural Colorants and Their Application as Coloring in Food and in Intelligent Food Packaging","volume":"404","author":"Echegaray","year":"2023","journal-title":"Food. Chem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1007\/s10311-024-01716-4","article-title":"Textile Dyeing Using Natural Mordants and Dyes: A Review","volume":"22","author":"Repon","year":"2024","journal-title":"Environ. Chem. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Quispe, C., Herrera-Bravo, J., Javed, Z., Khan, K., Raza, S., Gulsunoglu-Konuskan, Z., Da\u015ftan, S.D., Sytar, O., Martorell, M., and Sharifi-Rad, J. (2022). Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective. Biomed. Res. Int., 2022.","DOI":"10.1155\/2022\/1375892"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.semcancer.2020.02.011","article-title":"Curcumin and Colorectal Cancer: An Update and Current Perspective on This Natural Medicine","volume":"80","author":"Weng","year":"2022","journal-title":"Semin. Cancer. Biol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yoon, H.J., Zhang, X., Kang, M.G., Kim, G.J., Shin, S.Y., Baek, S.H., Lee, B.N., Hong, S.J., Kim, J.T., and Hong, K. (2018). Cytotoxicity Evaluation of Turmeric Extract Incorporated Oil-in-Water Nanoemulsion. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19010280"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Cerveira, M.M., Vianna, H.S., Ferrer, E.M.K., da Rosa, B.N., de Pereira, C.M.P., Baldissera, M.D., Lopes, L.Q.S., Rech, V.C., Giongo, J.L., and de Almeida Vaucher, R. (2021). Bioprospection of Novel Synthetic Monocurcuminoids: Antioxidant, Antimicrobial, and in Vitro Cytotoxic Activities. Biomed. Pharmacother., 133.","DOI":"10.1016\/j.biopha.2020.111052"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"103484","DOI":"10.1016\/j.jddst.2022.103484","article-title":"Exploring Z-Tyr-Phe-OH-Based Hydrogels Loaded with Curcumin for the Development of Dressings for Wound Healing","volume":"73","author":"Alves","year":"2022","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Uro\u0161evi\u0107, M., Nikoli\u0107, L., Gaji\u0107, I., Nikoli\u0107, V., Dini\u0107, A., and Miljkovi\u0107, V. (2022). Curcumin: Biological Activities and Modern Pharmaceutical Forms. Antibiotics, 11.","DOI":"10.3390\/antibiotics11020135"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1007\/s13197-013-1195-4","article-title":"Antimicrobial Activity of Turmeric Extract and Its Potential Use in Food Industry","volume":"52","author":"Gul","year":"2015","journal-title":"J. Food. Sci. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2853045","DOI":"10.1155\/2016\/2853045","article-title":"Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review","volume":"2016","author":"Teow","year":"2016","journal-title":"J. Trop. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Nasaj, M., Chehelgerdi, M., Asghari, B., Ahmadieh-Yazdi, A., Asgari, M., Kabiri-Samani, S., Sharifi, E., and Arabestani, M. (2024). Factors Influencing the Antimicrobial Mechanism of Chitosan Action and Its Derivatives: A Review. Int. J. Biol. Macromol., 277.","DOI":"10.1016\/j.ijbiomac.2024.134321"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/j.ijbiomac.2020.08.153","article-title":"Antimicrobial and Antioxidant Properties of Chitosan and Its Derivatives and Their Applications: A Review","volume":"164","author":"Shafi","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1007\/s12221-023-00158-z","article-title":"Eco-Dyeing and Functional Finishing of Cotton Fabric by Natural Dye Derived from Lotus Seedpod Waste with Chitosan-Assistance","volume":"24","author":"Fang","year":"2023","journal-title":"Fibers Polym."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2290856","DOI":"10.1080\/15440478.2023.2290856","article-title":"Sustainable Chitosan Biomordant Dyeing and Functionalization of Cotton Fabrics Using Pomegranate Rind and Onion Peel Extracts","volume":"21","author":"Rahman","year":"2023","journal-title":"J. Nat. Fibers"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1007\/s12221-023-00254-0","article-title":"Dyeing of Silk with Natural Lac Dye from Laccifer Lacca Kerr. and Evaluation of Antibacterial and UV-Protective Properties","volume":"24","author":"Do","year":"2023","journal-title":"Fibers Polym."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/cote.12750","article-title":"Flavonoid-Based Yellow Dye Extract from Safflower (Carthamus tinctorius L.) Combined with Chitosan for Anti-Bacterial and Ultraviolet-Protective Functionalisation of Silk","volume":"140","author":"Do","year":"2024","journal-title":"Color. Technol."},{"key":"ref_41","unstructured":"(2023). Standard test method for air permeability of textile fabrics (Standard No. ASTM D737-18)."},{"key":"ref_42","unstructured":"(2010). Textiles\u2014Tests for colour fastness\u2014Part C06: Colour fastness to domestic and commercial laundering (Standard No. ISO 105-C06)."},{"key":"ref_43","unstructured":"(2016). Textiles\u2014Tests for colour fastness\u2014Part X12: Colour fastness to rubbing (Standard No. ISO 105-X12:2016)."},{"key":"ref_44","unstructured":"(2013). Textiles\u2014Tests for colour fastness\u2014Part B02: Colour fastness to artificial light: Xenon arc fading lamp test (Standard No. ISO 105-B02:2013)."},{"key":"ref_45","unstructured":"(1993). Textiles\u2014Tests for colour fastness\u2014Part A02: Grey scale for assessing change in colour (Standard No. ISO 105-A02:1993)."},{"key":"ref_46","unstructured":"Schuessler, Z. (2024, October 31). Delta E 101. Available online: http:\/\/zschuessler.github.io\/DeltaE\/learn\/."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"128474","DOI":"10.1016\/j.cej.2021.128474","article-title":"Multifunctional Fabrics Finished Using Electrosprayed Hybrid Janus Particles Containing Nanocatalysts","volume":"411","author":"Hou","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.colsurfb.2012.11.037","article-title":"The Application of Bioactive Compounds from the Food Industry to Control Mold Growth in Indoor Waterborne Coatings","volume":"104","author":"Bellotti","year":"2013","journal-title":"Colloids. Surf. B"},{"key":"ref_49","unstructured":"(2020). Transmittance or blocking of erthemally weighted ultraviolet radiation through fabrics (Standard No. AATCC 183:2020)."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/rcm.2401","article-title":"Analysis of Curcuminoids by Positive and Negative Electrospray Ionization and Tandem Mass Spectrometry","volume":"20","author":"Jiang","year":"2006","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jchromb.2014.04.032","article-title":"Functionalized Magnetic Nanoparticles Coupled with Mass Spectrometry for Screening and Identification of Cyclooxygenase-1 Inhibitors from Natural Products","volume":"960","author":"Zhang","year":"2014","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.saa.2014.08.139","article-title":"Fourier Transform Infrared Spectroscopy Combined with Chemometrics for Discrimination of Curcuma longa, Curcuma xanthorrhiza and Zingiber cassumunar","volume":"137","author":"Rohaeti","year":"2015","journal-title":"Spectrochim. Acta. A Mol. Biomol. Spectrosc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.7324\/JAPS.2018.8916","article-title":"Liquid Chromatography and Fourier Transform Infrared Spectroscopy for Quantitative Analysis of Individual and Total Curcuminoid in Curcuma longa Extract","volume":"8","author":"Wulandari","year":"2018","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1007\/s11356-022-22450-w","article-title":"Assessment of Wild Turmeric\u2013Based Eco-Friendly Yellow Natural Bio-Colorant for Dyeing of Wool Fabric","volume":"30","author":"Habib","year":"2023","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"135303","DOI":"10.1016\/j.jclepro.2022.135303","article-title":"Sustainable One-Bath Natural Dyeing of Cotton Fabric Using Turmeric Root Extract and Chitosan Biomordant","volume":"382","author":"Rahman","year":"2023","journal-title":"J. Clean. Prod."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.indcrop.2016.11.037","article-title":"Enzyme-Assisted Ionic Liquid Extraction of Bioactive Compound from Turmeric (Curcuma longa L.): Isolation, Purification and Analysis of Curcumin","volume":"95","author":"Sahne","year":"2017","journal-title":"Ind. Crops Prod."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1080\/15440478.2019.1616650","article-title":"Examination of Dyeing Properties on Silk of Some Flavonoids by Spectroscopic Techniques","volume":"18","author":"Deveoglu","year":"2021","journal-title":"J. Nat. Fibers"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"101554","DOI":"10.1016\/j.scp.2024.101554","article-title":"Modern Ecofriendly Approach for Extraction of Luteolin Natural Dye from Weld for Silk Fabric and Wool Yarn Dyeing","volume":"39","author":"Adeel","year":"2024","journal-title":"Sustain. Chem. Pharm."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1007\/s12221-018-7553-0","article-title":"Mechanism and Analysis of Laccase-Mediated Coloration of Silk Fabrics","volume":"19","author":"Jia","year":"2018","journal-title":"Fibers Polym."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.ijbiomac.2020.07.061","article-title":"Wheat Starch, Gum Arabic and Chitosan Biopolymer Treatment of Wool Fabric for Improved Shrink Resistance Finishing","volume":"163","author":"Rani","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"40273","DOI":"10.1039\/C4RA04712E","article-title":"Effect of Al(III) and Curcumin on Silk Fibroin Conformation and Aggregation Morphology","volume":"4","author":"Yao","year":"2014","journal-title":"Rsc. Adv."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Chen, W., Ye, K., Zhu, X., Zhang, H., Si, R., Chen, J., Chen, Z., Song, K., Yu, Z., and Han, B. (2022). Actinomycin X2, an Antimicrobial Depsipeptide from Marine-Derived Streptomyces Cyaneofuscatus Applied as a Good Natural Dye for Silk Fabric. Mar. Drugs, 20.","DOI":"10.3390\/md20010016"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"119547","DOI":"10.1016\/j.molliq.2022.119547","article-title":"Aqueous and Chemical Extraction of Saponin of Acacia Concinna (Willd.) Dc.: An Effective Bio-Surfactant Solution to Extract Silk Fibroin from Muga Silk Cocoons","volume":"360","author":"Biswal","year":"2022","journal-title":"J. Mol. Liq."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12221-018-7315-4","article-title":"Application of Sterculia Foetida Fruit Shell Waste Biomolecules on Silk for Aesthetic and Wellness Properties","volume":"19","author":"Teli","year":"2018","journal-title":"Fibers Polym."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1177\/00405175211008617","article-title":"Dyeing Silk and Cotton Fabrics Using Fuji Apple Peel and the Properties of the Dyed Fabrics","volume":"91","author":"Yasukawa","year":"2021","journal-title":"Text. Res. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"117517","DOI":"10.1016\/j.indcrop.2023.117517","article-title":"Sustainable Dyeing of Mulberry Silk Fabric Using Extracts of Green Tea (Camellia sinensis): Extraction, Mordanting, Dyed Silk Fabric Properties and Silk-Dye Interaction Mechanism","volume":"205","author":"Borah","year":"2023","journal-title":"Ind. Crops Prod."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"101289","DOI":"10.1016\/j.mtchem.2022.101289","article-title":"Biodegradable Silk-Curcumin Composite for Sustained Drug Release and Visual Wound Monitoring","volume":"27","author":"Shanmugarajan","year":"2023","journal-title":"Mater. Today Chem."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.indcrop.2014.09.041","article-title":"Simultaneous Dyeing and Functionalization of Silk with Three Natural Yellow Dyes","volume":"64","author":"Zhou","year":"2015","journal-title":"Ind. Crops Prod."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s12221-012-1079-7","article-title":"Micro-Fading Spectrometry: A Tool for Real-Time Assessment of the Light-Fastness of Dye\/Textile Systems","volume":"13","author":"Mecklenburg","year":"2012","journal-title":"Fibers Polym."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s12221-018-8120-4","article-title":"Curcuma Dye with Modified Treatment Using Chitosan for Superior Fastness","volume":"19","author":"Shukla","year":"2018","journal-title":"Fibers Polym."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"107934","DOI":"10.1016\/j.jmgm.2021.107934","article-title":"Adsorption Study of Lac Dyes with Chitosan Coated on Silk Fibroin Using Molecular Dynamics Simulations","volume":"106","author":"Chimprasit","year":"2021","journal-title":"J. Mol. Graph. Model."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/cote.12199","article-title":"Metal Mordanting in Dyeing with Natural Colourants","volume":"132","author":"Manian","year":"2016","journal-title":"Color. Technol."},{"key":"ref_73","first-page":"304","article-title":"Biological Properties of Metal Complexes of Curcumin","volume":"45","author":"Shakeri","year":"2019","journal-title":"Bio. Fact."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12221-013-0201-9","article-title":"Antibacterial Properties and Color Fastness of Silk Fabric Dyed with Turmeric Extract","volume":"14","author":"Ghoreishian","year":"2013","journal-title":"Fibers Polym."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Bide, M. (2016). Dyeing. Kirk-Othmer Encyclopedia of Chemical Technology, Wiley.","DOI":"10.1002\/0471238961.0425051919130920.a01.pub3"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Zheng, D., Huang, C., Huang, H., Zhao, Y., Khan, M.R.U., Zhao, H., and Huang, L. (2020). Antibacterial Mechanism of Curcumin: A Review. Chem. Biodivers., 17.","DOI":"10.1002\/cbdv.202000171"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Dai, C., Lin, J., Li, H., Shen, J., Shen, Z., Wang, Y., and Velkov, T. (2022). The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems. Antioxidants, 11.","DOI":"10.3390\/antiox11030459"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"19320","DOI":"10.1002\/jcp.28626","article-title":"Demethoxycurcumin: A Naturally Occurring Curcumin Analogue for Treating Non-Cancerous Diseases","volume":"234","author":"Hatamipour","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.vacuum.2017.10.003","article-title":"Antibacterial and Antifungal Activity of Silver Nanospheres Synthesized by Tri-Sodium Citrate Assisted Chemical Approach","volume":"146","author":"Khatoon","year":"2017","journal-title":"Vacuum"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"164091","DOI":"10.1016\/j.jallcom.2022.164091","article-title":"Noble Metal-Based Nanomaterials as Antibacterial Agents","volume":"904","author":"Ye","year":"2022","journal-title":"J. Alloys. Compd."},{"key":"ref_81","first-page":"225","article-title":"Emerging Trends and Future Challenges of Advanced 2D Nanomaterials for Combating Bacterial Resistance","volume":"38","author":"Hameed","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Ardean, C., Davidescu, C.M., Neme\u015f, N.S., Negrea, A., Ciopec, M., Duteanu, N., Negrea, P., Duda-seiman, D., and Musta, V. (2021). Factors Influencing the Antibacterial Activity of Chitosan and Chitosan Modified by Functionalization. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147449"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Ke, C.L., Deng, F.S., Chuang, C.Y., and Lin, C.H. (2021). Antimicrobial Actions and Applications of Chitosan. Polymers, 13.","DOI":"10.3390\/polym13060904"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1021\/cb900151k","article-title":"Discovery of a Small Molecule That Blocks Wall Teichoic Acid Biosynthesis in Staphylococcus aureus","volume":"4","author":"Swoboda","year":"2009","journal-title":"Acs. Chem. Biol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jclepro.2014.02.050","article-title":"Assessment of Antibacterial Activity of Wool Fabrics Dyed with Natural Dyes","volume":"72","author":"Mortazavi","year":"2014","journal-title":"J. Clean. Prod."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s40034-015-0069-x","article-title":"Natural Dye Extracted from Vitex Negundo as a Potential Alternative to Synthetic Dyes for Dyeing of Silk","volume":"97","author":"Gowda","year":"2016","journal-title":"J. Ins. Eng. India E"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.ijbiomac.2017.11.068","article-title":"Imparting Functionality Viz Color, Antioxidant and Antibacterial Properties to Develop Multifunctional Wool with Tectona Grandis Leaves Extract Using Reflectance Spectroscopy","volume":"109","author":"Wani","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2016.09.179","article-title":"Mechanisms of Antifungal and Anti-Aflatoxigenic Properties of Essential Oil Derived from Turmeric (Curcuma longa L.) on Aspergillus flavus","volume":"220","author":"Hu","year":"2017","journal-title":"Food. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Poznanski, P., Hameed, A., and Orczyk, W. (2023). Chitosan and Chitosan Nanoparticles: Parameters Enhancing Antifungal Activity. Molecules, 28.","DOI":"10.3390\/molecules28072996"}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/16\/12\/1510\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:38:30Z","timestamp":1760114310000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/16\/12\/1510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,24]]},"references-count":89,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["pharmaceutics16121510"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics16121510","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,24]]}}}