{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T01:18:47Z","timestamp":1790299127132,"version":"4.1.0"},"reference-count":150,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>This perspective begins with an overview of the major impact that the dendron, dendrimer, and dendritic state (DDDS) discovery has made on traditional polymer science. The entire DDDS technology is underpinned by an unprecedented new polymerization strategy referred to as step-growth, amplification-controlled polymerization (SGACP). This new SGACP paradigm allows for routine polymerization of common monomers and organic materials into precise monodispersed, dendritic macromolecules (i.e., dendrons\/dendrimers) with nanoscale sizes and structure-controlled features that match and rival discrete in vivo biopolymers such as proteins and nucleic acids (i.e., DNA, siRNA, mRNA, etc.). These dendritic architectures exhibit unprecedented new intrinsic properties widely recognized to define a new fourth major polymer architecture class, namely: Category (IV): dendrons, dendrimers, and random hyperbranched polymers after traditional categories: (I) linear, (II) cross-linked, and (III) simple-branched types. Historical confusion over the first examples of the structure confirmed and verified cascade, dendron, dendrimer, and arborol syntheses, while associated misuse of accepted dendritic terminology is also reviewed and clarified. The importance of classifying all dendrons and dendrimers based on branch cell symmetry and the significant role of critical nanoscale-design parameters (CNDPs) for optimizing dendritic products for pharma\/nanomedicine applications with a focus on enhancing stealth, non-complement activation properties is presented. This is followed by an overview of the extraordinary growth observed for amphiphilic dendron\/dendrimer syntheses and their self-assembly into dendritic supramolecular assemblies, as well as many unique applications demonstrated in pharma and nanomedicine, especially involving siRNA delivery and mRNA vaccine development. This perspective is concluded with optimistic expectations predicted for new dendron and dendrimer application roles in pharma, nanomedicine, and life sciences.<\/jats:p>","DOI":"10.3390\/pharmaceutics16121530","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T10:19:42Z","timestamp":1732789182000},"page":"1530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Dendrimers, Dendrons, and the Dendritic State: Reflection on the Last Decade with Expected New Roles in Pharma, Medicine, and the Life Sciences"],"prefix":"10.3390","volume":"16","author":[{"given":"Donald A.","family":"Tomalia","sequence":"first","affiliation":[{"name":"The National Dendrimer & Nanotechnology Center, NanoSynthons LLC, Mt. Pleasant, MI 48858, USA"},{"name":"Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA"},{"name":"Department of Physics, Virginia Commonwealth University, Richmond, VA 23284, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1021\/acs.bioconjchem.8b00544","article-title":"Bioinspired amphiphilic peptide dendrimers as specific and effective compounds against drug resistant clinical isolates of E. coli","volume":"29","author":"Sowinska","year":"2018","journal-title":"Biconjugate Chem."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lu, J., Atochina-Vasserman, E.N., Maurya, D.S., Irhash Shalihin, M., Zhang, D., Chenna, S.S., Adamson, J., Liu, M., Ur Rehman Shah, H., and Shah, H. (2023). Screening Libraries to Discover Molecular Design Principles for the Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers Derived from Plant Phenolic Acids. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15061572"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ornelas, C., and Astruc, D. (2023). Ferrocene-Based Drugs, Delivery Nanomaterials and Fenton Mechanism: State of the Art, Recent Developments and Prospects. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15082044"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Caminade, A.-M., Milewski, M., and Hey-Hawkins, E. (2023). Dendritic Structures Functionalized with Boron Clusters, in Particular Carboranes, and Their Biological Properties. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15082117"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Fernanda Romero, J., Herziger, S., Cherri, M., Dimde, M., Achazi, K., Mohammadifar, E., and Haag, R. (2023). Dendritic Glycerol-Cholesterol Amphiphiles as Drug Delivery Systems: A Comparison between Monomeric and Polymeric Structures. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15102452"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Wu, T., Liu, C., and Kannan, R.M. (2023). Systemic Dendrimer-Peptide Therapies for Wet Age-Related Macular Degeneration. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15102428"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Dockery, L.T., and Daniel, M.-C. (2023). Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15082103"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sztandera, K., Rodr\u00edguez-Garc\u00eda, J.L., and Ce\u00f1a, V. (2024). In Vivo Applications of Dendrimers: A Step toward the Future of Nanoparticle-Mediated Therapeutics. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16040439"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Shiba, H., Hirose, T., Sakai, A., Nakase, I., Matsumoto, A., and Kojima, C. (2024). Structural Optimization of Carboxy-Terminal Phenylalanine-Modified Dendrimers for T-Cell Association and Model Drug Loading. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16060715"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-S\u00e1nchez, S., Barrios-Gumiel, A., Javier de la Mata, F., and Garc\u00eda-Gallego, S. (2024). Fine-Tuning the Amphiphilic Properties of Carbosilane Dendritic Networks towards High-Swelling Thermogels. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16040495"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mencia, G., Algar, S., Lozano-Cruz, T., Mu\u00f1oz-Fern\u00e1ndez, M.A., Gillies, E.R., Cano, J., Valiente, M., and G\u00f3mez, R. (2024). Carbosilane Dendritic Amphiphiles from Cholesterol or Vitamin E for Micelle Formation. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16040451"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Cavalieri, G., Marson, D., Giurgevich, N., Valeri, R., Felluga, F., Laurini, E., and Pricl, S. (2024). Molecular Ballet: Investigating the Complex Interaction between Self-Assembling Dendrimers and Human Serum Albumin via Computational and Experimental Methods. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16040533"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Calvo-Serrano, S., Matamoros, E., C\u00e9spedes, J.A., Fern\u00e1ndez-Santamar\u00eda, R., Gil-Oca\u00f1a, V., Perez-Inestrosa, E., Frecha, C., Monta\u00f1ez, M.I., and Torres, M.J. (2024). New Approaches for Basophil Activation Tests Employing Dendrimeric Antigen\u2013Silica Nanoparticle Composites. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16081039"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"5958","DOI":"10.1021\/ma980725b","article-title":"Controlled\/\u201cLiving\u201d Radical Polymerization. Atom Transfer Radical Polymerization of Acrylates at Ambient Temperature","volume":"31","author":"Xia","year":"1998","journal-title":"Macromolecules"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1002\/pola.10301","article-title":"Discovery of dendrimers and dendritic polymers: A brief historical perspective","volume":"40","author":"Tomalia","year":"2002","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.progpolymsci.2005.01.007","article-title":"Birth of a new macromolecular architecture: Dendrimers as quantized building blocks for nanoscale synthetic polymer chemistry","volume":"30","author":"Tomalia","year":"2005","journal-title":"Prog. Polym. Sci."},{"key":"ref_17","first-page":"321","article-title":"Twenty-First Century Polymer Science After Staudinger: The Emergence of Dendrimers\/Dendritic Polymers as a Fourth Major Architecture and Window to a New Nano-periodic System","volume":"Volume XVI","author":"Percec","year":"2013","journal-title":"Hierarchical Macomolecular Structures: 60 Years After the Staudinger Nobel Prize I"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1515\/pac-2016-1217","article-title":"Nomenclature and terminology for dendrimers with regular dendrons for hyperbranched polymers (IUPAC Recommendations 2017)","volume":"91","author":"Fradet","year":"2019","journal-title":"Pure Appl. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Jeevanandam, J., Tan, K.X., and Rodrigues, J. (2023). Target-specific delivery and bioavailability of pharmaceuticals via Janus and dendrimer particles. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15061614"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Wang, J., Li, B., Qiu, L., Qiao, X., and Yang, H. (2022). Dendrimer-based drug delivery systems: History, challenges, and latest developments. J. Biol. Eng., 16.","DOI":"10.1186\/s13036-022-00298-5"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"S861","DOI":"10.1080\/21691401.2018.1438451","article-title":"Dendritic platforms for biomimicry and biotechnological applications","volume":"46","author":"Nagpal","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1055\/s-1978-24702","article-title":"Cascade\u2014And nonskid-chain-like syntheses of molecular cavity topologies","volume":"405","author":"Buhleier","year":"1978","journal-title":"Synthesis"},{"key":"ref_23","unstructured":"Denkewalter, R.G., Kolc, J.F., and Lukasavage, W.J. (1981). Macromolecular Highly Branched Homogenous Compound Based on Lysine Units. (4,289,872), U.S. Patent."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/cber.19931260516","article-title":"Repetitive synthesis of bulky dendrimers\u2014A reversibly photoactive dendrimer with six azobenzene side chains","volume":"126","author":"Mekelburger","year":"1993","journal-title":"Chem. Ber."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/anie.199313081","article-title":"Poly(propylene imine) dendrimers: Large-scale synthesis by hetereogeneously catalyzed hydrogenations","volume":"32","author":"Meijer","year":"1993","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/anie.199313061","article-title":"Polynitrile and polyamine functional poly(trimethylene imine) dendrimers","volume":"32","author":"Worner","year":"1993","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1351\/pac200072122343","article-title":"Dendrimers as reactive modules for the synthesis of new structure controlled, higher complexity\u2014Megamers","volume":"72","author":"Tomalia","year":"2000","journal-title":"Pure Appl. Chem."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Tomalia, D.A., Christensen, J.B., and Boas, U. (2012). Dendrimers, Dendrons, and Dendritic Polymers: Discovery, Applications and the Future, Cambridge University Press.","DOI":"10.1017\/CBO9781139048859"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1016\/j.addr.2005.09.011","article-title":"Characterization of dendrimers","volume":"57","author":"Caminade","year":"2005","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Tomalia, D.A., Christensen, J.B., and Boas, U. (2012). Characterization methodologies. Dendrimers, Dendrons, and Dendritic Polymers: Discovery, Applications and the Future, Cambridge University Press.","DOI":"10.1017\/CBO9781139048859"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1295\/polymj.17.117","article-title":"A new class of polymers: Starburst dendritic macromolecules","volume":"17","author":"Tomalia","year":"1985","journal-title":"Polym. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0021-9673(98)00419-1","article-title":"Slab-gel and capillary electrophoretic characterization of polyamidoamine dendrimers","volume":"814","author":"Piehler","year":"1998","journal-title":"J. Chromatogr. A"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1021\/ma00163a029","article-title":"Dendritic macromolecules: Synthesis of Starburst dendrimers","volume":"19","author":"Tomalia","year":"1986","journal-title":"Macromolecules"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7347","DOI":"10.1021\/la990517s","article-title":"Characterization of core-shell tecto(dendrimers) molecules by tapping mode atomic force microscopy","volume":"15","author":"Li","year":"1999","journal-title":"Langmuir"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1021\/la000035c","article-title":"Visualization and characterization of poly(amidoamine) dendrimers by atomic force microscopy","volume":"16","author":"Li","year":"2000","journal-title":"Langmuir"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1002\/(SICI)1099-0488(199712)35:17<2913::AID-POLB14>3.0.CO;2-A","article-title":"A SAXS study of the internal structure of dendritic polymer systems","volume":"35","author":"Prosa","year":"1997","journal-title":"J. Polym. Sci Part B Polym. Physics"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/anie.199001381","article-title":"Starburst dendrimers: Molecular level control of size, shape, surface chemistry, topology and flexibility from atoms to macroscopic matter","volume":"29","author":"Tomalia","year":"1990","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1021\/ma00205a039","article-title":"Photoinduced electron transfer reaction to probe the structure of Starburst dendrimers","volume":"23","author":"Orellana","year":"1990","journal-title":"Macromolecules"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1021\/ja963270j","article-title":"Electrically conducting dendrimers","volume":"119","author":"Miller","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/rcm.1290050902","article-title":"Molecular weight determination of a polyamidoamine Starburst polymer by electrospray ionization mass spectrometry","volume":"5","author":"Kallos","year":"1991","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/rcm.1290091516","article-title":"Detection of high molecular weight Starburst dendrimers by electrospray ionization mass spectrometry","volume":"9","author":"Schwartz","year":"1995","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0168-1176(97)00161-4","article-title":"Electrospray ionization fourier transform ion cyclotron resonance mass spectrometric characterization of high molecular mass starburst dendrimers","volume":"165\/166","author":"Tolic","year":"1997","journal-title":"Int. J. Mass Spectrom. Ion Process."},{"key":"ref_43","unstructured":"Tomalia, D.A., and Dewald, J.R. (1985). Dense Star Polymers Having Core, Core Branches, Terminal Groups. (4,507,466), U.S. Patent."},{"key":"ref_44","unstructured":"Tomalia, D.A. (1983, January 10\u201314). Starburst Macromolecules. Proceedings of the Flory-Pauling Macromolecular Conference (Gordon Conference)\u2014Frontiers in Synthetic Polymer Chemistry, Santa Barbara, CA, USA."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/(SICI)1521-4095(200006)12:11<796::AID-ADMA796>3.0.CO;2-1","article-title":"Core-shell tecto(dendrimers): I. Synthesis and characterization of saturated shell models","volume":"12","author":"Uppuluri","year":"2000","journal-title":"Adv. Mater."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1073\/pnas.062684999","article-title":"Partial shell-filled core-shell tecto(dendrimers): A strategy to surface differentiated nano-clefts and cusps","volume":"99","author":"Tomalia","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1021\/jo00211a052","article-title":"Cascade molecules: A new approach to micelles. A [27]-arborol","volume":"50","author":"Newkome","year":"1985","journal-title":"J. Org. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0040-4039(97)00054-3","article-title":"Synthesis of totally chiral, multiple armed, poly glu and poly asp scaffoldings on bifunctional adamantane core","volume":"38","author":"Ranganathan","year":"1997","journal-title":"Tetrahedron Lett."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Tomalia, D.A., Nixon, L.S., and Hedstrand, D.M. (2020). The Role of Branch Cell Symmetry and Other Critical Nanoscale Design Parameters in the Determination of Dendrimer Encapsulation Properties. Biomolecules, 10.","DOI":"10.3390\/biom10040642"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1021\/ma00232a026","article-title":"Size and Solution Properties of Globular tert-Butyloxycarbonyl-Poly(\u03b1,i\u03b5-L-Lysine)","volume":"15","author":"Aharoni","year":"1982","journal-title":"Macromolecules"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1126\/science.2675315","article-title":"Electrospray ionization for mass spectrometry of large biomolecules","volume":"246","author":"Fenn","year":"1989","journal-title":"Science"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1039\/C39900001010","article-title":"A new convergent approach to monodisperse dendritic macromolecules","volume":"15","author":"Hawker","year":"1990","journal-title":"J. Chem. Soc. Chem. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1021\/ma00223a036","article-title":"Control of surface functionality in the synthesis of dendritic macromolecules using the convergent-growth approach","volume":"23","author":"Hawker","year":"1990","journal-title":"Macromolecules"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7638","DOI":"10.1021\/ja00177a027","article-title":"Preparation of polymers with controlled molecular architecture. A new convergent approach to dendritic macromolecules","volume":"112","author":"Hawker","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1021\/cr990116h","article-title":"Convergent dendrons and dendrimers: From synthesis to applications","volume":"101","author":"Grayson","year":"2001","journal-title":"Chem. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/cm00017a005","article-title":"Convergent synthesis of monodisperse aryl ester dendrimers","volume":"3","author":"Kwock","year":"1991","journal-title":"Chem. Mater."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1021\/cm00010a006","article-title":"Convergent synthesis of monodisperse dendrimers based upon 1,3,5-trisubstituted benzenes","volume":"2","author":"Miller","year":"1990","journal-title":"Chem. Mat."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1021\/cr970414j","article-title":"Dendrimers containing heteroatoms (Si, P, B, Ge, or Bi)","volume":"99","author":"Majoral","year":"1999","journal-title":"Chem. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Caminade, A.-M., Turrin, C.-O., and Majoral, J.-P. (2018). Phosphorus Dendrimers in Biology and Nanomedicine, Pan Stanford Publishing Pte. Ltd.","DOI":"10.1201\/9781315110851"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1021\/ma00171a051","article-title":"Starburst dendrimers IV. Covalently fixed unimolecular assemblages reminiscent of spheroidal micelles","volume":"20","author":"Tomalia","year":"1987","journal-title":"Macromolecules"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1021\/ja00239a068","article-title":"Starburst dendrimers III. The importance of branch junction symmetry in the development of topological shell molecules","volume":"109","author":"Tomalia","year":"1987","journal-title":"J. Am. Chem. Soc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1021\/ja00188a079","article-title":"Starburst dendrimers 5. Molecular shape control","volume":"111","author":"Naylor","year":"1989","journal-title":"J. Am. Chem. Soc."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1039\/C1NJ20501C","article-title":"Dendritic effects: Dependency of dendritic nano-periodic property patterns on critical nanoscale design parameters (CNDPs)","volume":"36","author":"Tomalia","year":"2012","journal-title":"New J. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"11391","DOI":"10.1021\/acs.chemrev.9b00153","article-title":"Designer peptide and protein dendrimers: A cross-sectional analysis","volume":"119","author":"Sapra","year":"2019","journal-title":"Chem. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1002\/anie.201508428","article-title":"Peptide-decorated dendrimers and their bioapplications","volume":"55","author":"Wan","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.1021\/acs.biomac.7b00649","article-title":"Bioreducible peptide-dendrimeric nanogels and abundant expanded voids for efficient drug entrapment and delivery","volume":"18","author":"Zhong","year":"2017","journal-title":"Biomacromolecules"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Falanga, A., Del Genio, V., and Galdiero, S. (2021). Peptides and Dendrimers: How to Combat Viral and Bacterial Infections. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13010101"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Biswaro, L.S., da Costa Sousa, M.G., Rezende, T.M.B., Dias, S.C., and Franco, O.L. (2018). Antimicrobial Peptides and Nanotechnology, Recent Advances and Challenges. Front. Microbiol., 9.","DOI":"10.3389\/fmicb.2018.00855"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Mahlapuu, M., Hakansson, J., Ringstad, L., and Bjorn, C. (2016). Antrimicrobial peptides: An emerging category of therapeutic agents. Front. Cell. Infect. Microbiol., 6.","DOI":"10.3389\/fcimb.2016.00194"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Garcia-Gallego, S., Franci, G., Falanga, A., Gomez, R., Folliero, V., Galdiero, S., de la Mata, F.J., and Galdiero, M. (2017). Function oriented molecular design: Dendrimers as novel antimicrobial. Molecules, 22.","DOI":"10.3390\/molecules22101581"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1039\/B917370F","article-title":"Dendrons\/Dendrimer: Quantized, nano-element like building blocks for soft-soft and soft-hard nano-compound synthesis","volume":"6","author":"Tomalia","year":"2010","journal-title":"Soft Matter"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/joim.12280","article-title":"Emerging concepts in dendrimer-based nanomedicine: From design principles to clinical applications","volume":"276","author":"Kannan","year":"2014","journal-title":"J. Intern. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s11051-018-4318-z","article-title":"Engineering of \u201ccritical nanoscale design parameters\u201d (CNDPs) in PAMAM dendrimer nanoparticles for drug delivery applications","volume":"20","author":"Chauhan","year":"2018","journal-title":"J. Nanopart. Res."},{"key":"ref_74","unstructured":"Chauhan, H.K.A. (2020). Engineering critical nanoscale design parameters (CNDPs): A strategy for developing effective nanomedicine therapies and assessing quatitative nanoscale structure-activity relationships (QNSARs). Pharmaceutical Applications of Dendrimers, Elsevier Inc."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.nano.2013.02.011","article-title":"Nanomedicine and the complement paradigm","volume":"9","author":"Moghimi","year":"2013","journal-title":"Nanomedicine"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.addr.2012.05.010","article-title":"Genomic perspectives in inter-individual adverse responses following nanomedicine administration: The way forward","volume":"64","author":"Moghimi","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"8454","DOI":"10.1021\/nn2038252","article-title":"Reshaping the future of nanopharmaceuticals: Ad Iudicium","volume":"5","author":"Moghimi","year":"2011","journal-title":"ACS Nano"},{"key":"ref_78","unstructured":"Tomalia, D.A., Hedstrand, D.M., and Nixon, L.S. (2021). Pyrrolidone Derivatives, Oligomers and Polymers. (10,968,176 B2), U.S. Patent."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/acs.molpharmaceut.7b00515","article-title":"Pyrrolidone modification prevents PAMAM dendrimers from activation pro-inflammatory signaling pathways in human monocytes","volume":"15","author":"Janaszewska","year":"2018","journal-title":"Mol. Pharm."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4858","DOI":"10.1038\/s41467-021-24960-6","article-title":"Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchiking","volume":"12","author":"Wu","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"114079","DOI":"10.1016\/j.addr.2021.114079","article-title":"To PEGylate or not to PEGylate: Immunological properties of nanomedicine\u2019s most popular component, poly(ethyle) glycol and its alternatives","volume":"180","author":"Shi","year":"2022","journal-title":"Adv Drug Deliv. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Kong, Y.W., and Dreaden, E.C. (2022). PEG: Will it come back to you? Polyethelyne glycol immunogencity, COVID Vaccines, and the Case for New PEG Derivatives and Alternatives. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.879988"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"11769","DOI":"10.1021\/acsnano.2c04543","article-title":"Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine","volume":"16","author":"Ju","year":"2022","journal-title":"ACS Nano"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"102043","DOI":"10.1016\/j.nano.2019.102043","article-title":"An innovative in situ method of creating hybrid dendrimer nano-assembly: An efficient next generation dendritic platorm for drug delivery","volume":"21","author":"Singh","year":"2019","journal-title":"Nanomedicine"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejps.2016.09.005","article-title":"Poly(amidoamine) dendrimer-mediated hybrid formulation for combination therapy of ramipril and hydrochlorothiazide","volume":"96","author":"Singh","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_86","first-page":"10","article-title":"New hybridized mult-dendrimer platforms based on the supramolecular assembly guided by systematic CNDP engineering","volume":"17","author":"Singh","year":"2023","journal-title":"Mater. Matters"},{"key":"ref_87","first-page":"157","article-title":"Non-aqueous lyotropic liquid crystal with a STARBURST\u00ae dendrimer as a solvent","volume":"164","author":"Friberg","year":"1988","journal-title":"Mol. Cryst. Liq. Cryst."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1039\/a700860k","article-title":"Hydrophobically modified poly(amidoamine) (PAMAM) dendrimers: Their properties at the air-water interface and use as nanoscopic container molecules","volume":"7","author":"Hedstrand","year":"1997","journal-title":"J. Mater. Chem."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1126\/science.268.5217.1592","article-title":"Polystyrene-dendrimer amphiphilic block copolymers with a generation-dependent aggregation","volume":"268","author":"Delnoye","year":"1995","journal-title":"Science"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"11441","DOI":"10.1021\/ja00151a008","article-title":"Rational design of the first nonspherical dendrimer which displays calamitic nematic and smectic thermotropic liquid crystalline phases","volume":"117","author":"Percec","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"ref_91","unstructured":"Israelachvili, J.N. (1992). Intermolecular and Surface Forces, Academic Press. [2nd ed.]."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1126\/science.271.5252.1095","article-title":"Self-Assembling Dendrimers","volume":"271","author":"Zimmerman","year":"1996","journal-title":"Science"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1021\/cm970441q","article-title":"Self-assembled lanthanide-cored dendrimer complexes: Enhancement of the luminescence properties of lanthanide ions through site-isolation and antenna effects","volume":"10","author":"Kawa","year":"1998","journal-title":"Chem. Mater."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/bm901055a","article-title":"Multivalent supramolecular dendrimer-based drugs","volume":"11","author":"Galeazzi","year":"2010","journal-title":"Biomacromolecules"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1002\/pola.21050","article-title":"Self-assembly of a new class of amphiphilic poly(amidoamine) dendrimers and their electrochemical properties","volume":"43","author":"Wang","year":"2005","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1081\/MC-120023912","article-title":"Dendrimeric supramolecular and supramacromolecular assemblies","volume":"C43","author":"Tomalia","year":"2003","journal-title":"J. Macromol. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1073\/pnas.082013899","article-title":"Dendrimers and supramolecular chemistry","volume":"99","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_98","unstructured":"Tomalia, D.A., Pulgam, V.R., Swanson, D.R., and Huang, B. (2011). Janus Dendrimers and Dendrons. (7,977,452 B2), U.S. Patent."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1021\/ar800086w","article-title":"Induced helical backbone conformations of self-oganizable dendronized polymers","volume":"41","author":"Rudick","year":"2008","journal-title":"Accts. Chem. Res"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"6275","DOI":"10.1021\/cr900157q","article-title":"Dendron-mediated self-assembly, disassembly, and self-organization of complex systems","volume":"109","author":"Rosen","year":"2009","journal-title":"Chem. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"17500","DOI":"10.1021\/ja907882n","article-title":"Predicting the structure of supramolecular dendrimers via the analysis of libraries of AB3 and constitutional isomeric AB2 biphenylpropyl ether self-assembling dendrons","volume":"131","author":"Rosen","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"10273","DOI":"10.1021\/ja0024643","article-title":"Increasing the diameter of cylindrical and spherical supramolecular dendrimers by decreasing the solid angle of their monodendrons via periphery functionalization","volume":"122","author":"Percec","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"11061","DOI":"10.1021\/ja9819007","article-title":"Structural analysis of cylindrical and spherical supramolecular dendrimers quantifies the concept of monodendron shape control by generation number","volume":"120","author":"Percec","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1430002","DOI":"10.1142\/S0217984914300026","article-title":"In quest of a systematic framework for unifying and defining nanoscience","volume":"28","author":"Tomalia","year":"2014","journal-title":"Mod. Phys. Lett. B"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1021\/acs.chemrev.5b00367","article-title":"A systematic framework and nanoparticle concept for unifying nanoscience: Hard\/soft nanoelements, superatoms, meta-atoms, new emerging properties, periodic patterns, and predictive Mendeleev-like nanoperiodic tables","volume":"116","author":"Tomalia","year":"2016","journal-title":"Chem. Rev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1021\/cen-09115-scitech2","article-title":"Developing superatom science","volume":"91","author":"Kemsley","year":"2013","journal-title":"Chem. Eng. News"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1016\/S0040-4020(03)00430-7","article-title":"Structure control within poly(amidoamine) dendrimers: Size, shape and regio-chemical mimicry of globular proteins","volume":"59","author":"Tomalia","year":"2003","journal-title":"Tetrahedron"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1021\/nl034957m","article-title":"Designed dendrimers syntheses by self-assembly of single-site, ssDNA functionalized dendrons","volume":"4","author":"DeMattei","year":"2004","journal-title":"Nano Lett."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1126\/science.1185547","article-title":"Self-assembly of Janus dendrimers into uniform dendrimersomes and other complex architectures","volume":"328","author":"Percec","year":"2010","journal-title":"Science"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"10899","DOI":"10.1002\/anie.201403186","article-title":"Mimicking biological membranes with programmable glycan ligands self-assembled from amphiphilic Janus glycodendrimers","volume":"53","author":"Zhang","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Percec, V., Sahoo, D., and Adamson, J. (2023). Stimuli-responsive principles of supramolecular organizations emerging from self-assembling and self-organizable dendrons, dendrimers, and dendronized polymers. Polymers, 15.","DOI":"10.3390\/polym15081832"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"8478","DOI":"10.1002\/anie.201203920","article-title":"An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo","volume":"51","author":"Yu","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3667","DOI":"10.1002\/smll.201503866","article-title":"Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing","volume":"12","author":"Chen","year":"2016","journal-title":"Small"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1039\/b616050f","article-title":"Supramolecular nanocarriers integrated with dendrimers encapsulating photosensitizers for effective photodynamic therapy and photochemical gene delivery","volume":"31","author":"Nishiyama","year":"2007","journal-title":"New J. Chem."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"7337","DOI":"10.1039\/C4SM01143K","article-title":"Controlling the number of dendrimer in dendrimicelle nanoconjugates from 1 to more than 100","volume":"10","author":"Wang","year":"2014","journal-title":"Soft Matter"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1021\/acs.biomac.0c01645","article-title":"Dendritic macromolecular architectures: Dendrimer-based polyion complex micelles","volume":"22","author":"Mignani","year":"2021","journal-title":"Biomacromolecules"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"18619","DOI":"10.1039\/C7NR06773A","article-title":"Dendrimer-encapsulated nanoparticle-core micelles as a modular strategy for particle-in-a-box-in-a-box nanostructures","volume":"9","author":"Wang","year":"2017","journal-title":"Nanoscale"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"7893","DOI":"10.1039\/D0SM00458H","article-title":"Dendrimicelles with pH-controlled aggregation number of core-dendrimers and stability","volume":"16","author":"Wang","year":"2020","journal-title":"Soft Matter"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"14634","DOI":"10.1021\/ja9065442","article-title":"Nanoparticle Size Determination by 1H NMR Spectroscopy","volume":"131","author":"Gomez","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1021\/ja807488d","article-title":"NMR Characterization of Fourth-Generation PAMAM Dendrimers in the Presence and Absence of Palladium Dendrimer-Encapsulated Nanoparticles","volume":"131","author":"Gomez","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"4877","DOI":"10.1021\/ja980438n","article-title":"Preparation of Cu nanoclusters within dendrimer templates","volume":"120","author":"Zhao","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"5207","DOI":"10.1038\/s41467-018-07568-1","article-title":"Manipulating and monitoring nanoparticles in micellar thin film superstructures","volume":"9","author":"Velders","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Ten Hove, J.B., van Oosterom, M.N., van Leeuwen, F.W.B., and Velders, A.H. (2018). Nanoparticles reveal extreme size-sorting and morphologies in complex coacervate superstructures. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-32240-5"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1021\/acsnano.7b05541","article-title":"Size-sorting and pattern formation of nanoparticle-loaded micellar superstructures in biconcave thin films","volume":"11","author":"Wang","year":"2017","journal-title":"ACS Nano"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"15422","DOI":"10.1039\/D1NR04556C","article-title":"Multicompartment dendrimicelles with binary, ternary and quaternary core composition","volume":"13","author":"Kaup","year":"2021","journal-title":"Nanoscale"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"14611","DOI":"10.1021\/acsnano.2c05144","article-title":"Controlling trapping, release, and exchange dynamics of micellar core components","volume":"16","author":"Kaup","year":"2022","journal-title":"ACS Nano"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1021\/acsnano.0c09322","article-title":"Dendroids, discrete covalenty cross-linked dendrimer superstructures","volume":"15","author":"Kaup","year":"2021","journal-title":"ACS Nano"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1039\/C2NJ41002H","article-title":"Regio-specific size, shape and surface chemistry designed dendrimers based on differentiated dendroid templates","volume":"37","author":"Tang","year":"2013","journal-title":"New J. Chem."},{"key":"ref_129","unstructured":"Denkewalter, R.G., Kolc, J.F., and Lukasavage, W.J. (1983). Macromolecular Having Highly Branched Homogenous Compounds. (4,410,688), U.S. Patent."},{"key":"ref_130","unstructured":"Tomalia, D.A., Dewald, J.R., Hall, M.J., Martin, S.J., and Smith, P.B. (1984, January 20\u201324). In Proceedings of the Preprints of the 1st SPSJ International Polymer Conference, Society of Polymer Science, Kyoto, Japan."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1021\/bc00023a012","article-title":"Polyamidoamine cascade polymers mediate efficient transfection of cells inculture","volume":"4","author":"Haensler","year":"1993","journal-title":"Bioconjugate Chem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1093\/nar\/24.11.2176","article-title":"Regulation of in vitro gene expression using antisense oligonucleotides or antisense expression plasmids transfected using Starburst PAMAM dendrimers","volume":"24","author":"Bielinska","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1073\/pnas.93.10.4897","article-title":"Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers","volume":"93","author":"Bielinska","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1023\/A:1016458104359","article-title":"The Lower-Generation Polypropylenimine Dendrimers Are Effective Gene-Transfer Agents","volume":"19","author":"Zinselmeyer","year":"2002","journal-title":"Pharm. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jconrel.2008.07.035","article-title":"Characterization of carbosilane dendrimers as effective carriers of siRNA and HIV-infected lymphocytes","volume":"132","author":"Weber","year":"2008","journal-title":"J. Control. Release"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1039\/b601381c","article-title":"PAMAM dendrimers for efficient siRNA delivery and potent gene silencing","volume":"22","author":"Zhou","year":"2006","journal-title":"Chem. Commun."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1126\/science.278.5337.449","article-title":"Direct Visualization of Individual Cylindrical and Spherical Supramolecular Dendrimers","volume":"278","author":"Hudson","year":"1997","journal-title":"Science"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41573-019-0017-4","article-title":"The current state and future directiions of RNAi-based therapeutics","volume":"18","author":"Setten","year":"2019","journal-title":"Nat. Drug Rev. Drug Disc."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Dzmitruk, V., Apartsin, E., Ihnatsyeu-Kachan, A., Abashkin, V., Shcharbin, D., and Bryszewska, M. (2018). Dendrimers show promise for siRNA and microRNA Therapeutics. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10030126"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nrd4278","article-title":"mRNA-based therapeutics\u2014Developing a new class of drugs","volume":"13","author":"Sahin","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Weng, Y., Li, C., Yang, T., Hu, B., Zhang, M., Guo, S., Xiao, H., Liang, X.-J., and Huang, Y. (2021). The challenge and prospect of mRNA therapeutics landscape. Biotechnol. Adv., 40.","DOI":"10.1016\/j.biotechadv.2020.107534"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"9255","DOI":"10.1021\/nn503118f","article-title":"Bio-Inspired Supramolecular Hybrid Dendrimers Self-Assembled from Low-Generation Peptide Dendrons for Highly Efficient Gene Delivery and Biological Tracking","volume":"8","author":"Xu","year":"2014","journal-title":"ACS Nano"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Kisakova, L.A., Apartsin, E.K., Nizolenko, L.F., and Karpenko, L.I. (2023). Dendrimer-mediated delivery of DNA and RNA Vaccines. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15041106"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"E4133","DOI":"10.1073\/pnas.1600299113","article-title":"Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza and Toxoplasma gondii challenges with a single dose","volume":"113","author":"Chahal","year":"2016","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"17975","DOI":"10.1021\/jacs.1c09585","article-title":"Targeted delivery of mRNA with one-component ionizable amphiphilic Janus dendrimers","volume":"143","author":"Zhang","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"12315","DOI":"10.1021\/jacs.1c05813","article-title":"The unexpected importance of the primary structure of the hydrophobic part of one-component ionizable amphiphilic Janus dendrimers in targeted mRNA delivery activity","volume":"143","author":"Zhang","year":"2021","journal-title":"J. Am. Chem. Soc."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1021\/jacs.3c13569","article-title":"The constitutional isomerism of one-component ionizable amphiphilic Janus dendrimers orchestrates the total and targeted activities of mRNA delivery","volume":"146","author":"Sahoo","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"18760","DOI":"10.1021\/jacs.3c07337","article-title":"Targeted and equally distributed deliery of mRNA to organs with pentaerythritol-based one-component ionizable amphiphilic Janus dendrimers","volume":"145","author":"Lu","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Tomalia, D.A., Christensen, J.B., and Boas, U. (2012). The past, present, and future for dendrons and dendrimers. Dendrimers, Dendrons, and Dendritic Polymers: Discovery, Applications and the Future, Cambridge University Press.","DOI":"10.1017\/CBO9781139048859"},{"key":"ref_150","unstructured":"Singh, M.K. (2024, July 21). Dendrimer Technology: Concept to Cutting-Edge Applications, 57th SPSR International Webinar on Dendrimer Technology. Available online: https:\/\/www.youtube.com\/live\/sAUfDi8XI64?app=desktop&feature=share."}],"updated-by":[{"DOI":"10.3390\/pharmaceutics17040403","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000}}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/16\/12\/1530\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T14:41:23Z","timestamp":1754232083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/16\/12\/1530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,28]]},"references-count":150,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["pharmaceutics16121530"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics16121530","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,28]]}}}