{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:42:56Z","timestamp":1791610976596,"version":"4.3.4"},"reference-count":157,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Diabetes is a widespread metabolic illness. Mismanagement of diabetes can lead to severe complications that tremendously impact patients\u2019 quality of life. The assimilation of nanotechnology in diabetes care holds the potential to revolutionize treatment paradigms, improve patient outcomes, and reduce the economic burden associated with this pervasive disease. This manuscript explores the multifaceted utilization of nanomaterials in diabetes care, emphasizing the unique features of nano-based medication delivery methods and smart drug delivery mechanisms. Additionally, this paper talks about research on nanocarrier-integrated oral, transdermal, and inhalable insulin delivery; dendrimer- and nanocarrier-coupled antisense oligonucleotide-driven gene therapy; the implementation of gold nanoparticles and quantum dots for glucose surveillance; and nucleic acid therapies. There are certain restrictions when using medication delivery methods that are commonly available to handle diabetes. In order to increase efficacy and safety, the rapidly developing science of nanotechnology is also being explored and employed in medical biology. Nanomaterials like liposomes, dendrimers, niosomes, polymeric and metallic nanocarriers, and solid lipid nanoparticles are among the nanocarriers that have been developed for better delivery of various oral hypoglycemic agents in comparison to conventional therapies. These nanocarriers provide great control over elevated blood glucose levels, making them one of the most intriguing and promising technologies available today. Furthermore, adding additional ligands to nanocarriers allows for more focused distribution while protecting the encapsulated hypoglycemic drugs.<\/jats:p>","DOI":"10.3390\/pharmaceutics16121572","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T06:16:14Z","timestamp":1733724974000},"page":"1572","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Nanotechnology-Based Approaches for the Management of Diabetes Mellitus: An Innovative Solution to Long-Lasting Challenges in Antidiabetic Drug Delivery"],"prefix":"10.3390","volume":"16","author":[{"given":"Shounak","family":"Sarkhel","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, WB, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikat Mollick","family":"Shuvo","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, JIS University, Agarpara, Kolkata 700109, WB, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Ahesan","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, WB, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourav","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, WB, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritam","family":"Kapat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, WB, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arindam","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, WB, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanima","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, WB, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranu","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, WB, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3657-1492","authenticated-orcid":false,"given":"Leonard Ionut","family":"Atanase","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cApollonia\u201d University of Iasi, 700511 Iasi, Romania"},{"name":"Academy of Romanian Scientists, 050045 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9112-7039","authenticated-orcid":false,"given":"Alexandru","family":"Carauleanu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Park, Y., and Dembele, T.A. (2022). Application of Nanoparticles: Diagnosis, Therapeutics, and Delivery of Insulin\/Anti-Diabetic Drugs to Enhance the Therapeutic Efficacy of Diabetes Mellitus. Life, 12.","DOI":"10.3390\/life12122078"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Aloke, C., Egwu, C.O., Aja, P.M., Obasi, N.A., Chukwu, A., Akumadu, B.O., Ogbu, P.N., and Achilonu, I. (2022). Current Advances in the Management of Diabetes Mellitus. Biomedicines, 10.","DOI":"10.3390\/biomedicines10102436"},{"key":"ref_3","unstructured":"World Health Organization (2024, June 24). Global Report on Diabetes. 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