{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:32:26Z","timestamp":1787592746429,"version":"build-2736575974"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"publisher","award":["lzujbkj2019ct07"],"award-info":[{"award-number":["lzujbkj2019ct07"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"publisher","award":["20JR10RA653ZDKF20210403"],"award-info":[{"award-number":["20JR10RA653ZDKF20210403"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"publisher","award":["20JR10FA670"],"award-info":[{"award-number":["20JR10FA670"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School of Stomatology, Lanzhou University","award":["lzujbkj2019ct07"],"award-info":[{"award-number":["lzujbkj2019ct07"]}]},{"name":"Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School of Stomatology, Lanzhou University","award":["20JR10RA653ZDKF20210403"],"award-info":[{"award-number":["20JR10RA653ZDKF20210403"]}]},{"name":"Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, School of Stomatology, Lanzhou University","award":["20JR10FA670"],"award-info":[{"award-number":["20JR10FA670"]}]},{"name":"Scientific and Technological Foundation of Gansu Province","award":["lzujbkj2019ct07"],"award-info":[{"award-number":["lzujbkj2019ct07"]}]},{"name":"Scientific and Technological Foundation of Gansu Province","award":["20JR10RA653ZDKF20210403"],"award-info":[{"award-number":["20JR10RA653ZDKF20210403"]}]},{"name":"Scientific and Technological Foundation of Gansu Province","award":["20JR10FA670"],"award-info":[{"award-number":["20JR10FA670"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Objective: To evaluate the drug release, cytocompatibility with periodontal ligament cells (PDLCs), and therapeutic efficacy of GelMA hydrogel loaded with resolvin D1 (RvD1) in treating rat periodontal inflammation and alveolar bone damage. Methods: An RvD1 complexed with GelMA was prepared, and its release kinetics and compatibility with PDLCs were assessed. Rats with induced periodontitis were treated weekly with topical applications of vehicle, GelMA, RvD1, or RvD1 complexed with GelMA for four weeks. Periodontal inflammation and tissue regeneration were evaluated using quantitative PCR (qPCR) and histochemical staining, while alveolar bone repair and regeneration were analyzed through micro-CT. Results: The RvD1 complexed with GelMA effectively released RvD1 and enhanced the proliferation and viability of PDLCs. Compared to RvD1 alone, treatment with RvD1 complexed with GelMA significantly reduced inflammatory cell infiltration, TNF-\u03b1 and RANKL expression, and osteoclast formation in periodontal tissues. Additionally, it promoted the expression of specific anti-inflammatory and regenerative markers. Micro-CT analysis confirmed significant new bone formation in the RvD1 complexed with GelMA-treated group. Conclusions: RvD1 complexed with GelMA provides sustained drug release and biocompatibility, effectively resolves periodontal inflammation, and promotes tissue regeneration in periodontitis.<\/jats:p>","DOI":"10.3390\/pharmaceutics17010016","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T19:19:32Z","timestamp":1735154372000},"page":"16","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Application of Resolvin D1-Loaded Gelatin Methacrylate in a Rat Periodontitis Model"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7419-2012","authenticated-orcid":false,"given":"Zhe","family":"Xing","sequence":"first","affiliation":[{"name":"School of Stomatology, Lanzhou University, Lanzhou 730000, China"},{"name":"Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, Lanzhou University, Lanzhou 730000, China"},{"name":"Clinical Research Center for Oral Diseases, Lanzhou University, Lanzhou 730000, China"},{"name":"Department of Medical Biology, Faculty of Health Sciences, UiT the Artic University of Norway, 9037 Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Stomatology, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazheng","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Stomatology, Lanzhou University, Lanzhou 730000, China"},{"name":"Department of Medical Biology, Faculty of Health Sciences, UiT the Artic University of Norway, 9037 Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Stomatology, Lanzhou University, Lanzhou 730000, China"},{"name":"Department of Stomatology Center, Suining Central Hospital, Suining 629099, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Stomatology, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Fujio","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Hadler-Olsen","sequence":"additional","affiliation":[{"name":"Department of Medical Biology, Faculty of Health Sciences, UiT the Artic University of Norway, 9037 Troms\u00f8, Norway"},{"name":"The Public Dental Health Service Competence Center of Northern Norway, 9271 Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Stomatology, Lanzhou University, Lanzhou 730000, China"},{"name":"Key Laboratory of Dental Maxillofacial Reconstruction and Biological Intelligence Manufacturing, Lanzhou University, Lanzhou 730000, China"},{"name":"Clinical Research Center for Oral Diseases, Lanzhou University, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpdogan","family":"Kantarci","sequence":"additional","affiliation":[{"name":"The Forsyth Institute, Cambridge, MA 02142, USA"},{"name":"School of Dental Medicine, Harvard University, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Faculty of Health Sciences, UiT the Artic University of Norway, 9037 Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.gene.2012.12.108","article-title":"Association of TGF-\u03b21-509 C\/T, 29 C\/T and 788 C\/T gene polymorphisms with chronic periodontitis: A case-control study","volume":"518","author":"Heidari","year":"2013","journal-title":"Gene"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"980805","DOI":"10.3389\/fimmu.2022.980805","article-title":"Host and bacterial factors linking periodontitis and rheumatoid arthritis","volume":"13","author":"Strzelec","year":"2022","journal-title":"Front. 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