{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T21:56:27Z","timestamp":1775685387171,"version":"3.50.1"},"reference-count":57,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: Oral administration of active pharmaceutical ingredients (APIs) is the most commonly used route of administration. As dysphagia is a prevalent problem, the size of the swallowed dosage form could negatively influence patient adherence. Orally disintegrating tablets (ODTs) are beneficial dosage forms because they disintegrate within a few seconds in the oral cavity without water. Lactose is one of the most commonly used excipients in the pharmaceutical industry; it served as the central concept of a recent publication on the formulation of milk-based ODTs despite lactose malabsorption being widespread worldwide. Consequently, the plant-based alternative market has grown exponentially and has become a prevailing food trend, with various alternatives to choose from. For this reason, the development of a nonsteroidal anti-inflammatory drug (NSAID)-containing ODT with plant-based drinks (PBDs) was assessed for its innovative potential. Methods: Different PBDs were investigated and compared to traditional and lactose-free milk. The liquids\u2019 viscosity, pH, and particle size were determined, and an electronic tongue was used for the sensory evaluation. The various ODTs were prepared with the freeze-drying method, and then the qualitative characteristics of the dosage form were investigated. Results: Our different measurements show that different plant beverages differ from each other and that these differences have an impact on the technological processing. According to the HPLC-DAD measurements, all values were in the required range. Conclusions: These measurements suggest that the soya drink is the most similar to traditional cow milk and would be the most appropriate choice among the investigated plant-based drinks to be used as a carrier system for an ibuprofen-containing ODT.<\/jats:p>","DOI":"10.3390\/pharmaceutics17020195","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T05:55:22Z","timestamp":1738648522000},"page":"195","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Study on Lyophilised Orodispersible Tablets from Plant-Based Drinks as Bulking Agents"],"prefix":"10.3390","volume":"17","author":[{"given":"Adrienn Katalin","family":"Demeter","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Semmelweis University, H\u0151gyes E. Street 7-9, 1092 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00f3ra","family":"Farkas","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Semmelweis University, H\u0151gyes E. Street 7-9, 1092 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rton","family":"Kir\u00e1ly","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Semmelweis University, H\u0151gyes E. Street 7-9, 1092 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0641-8830","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Food Measurements and Process Control, Institute of Food Science and Technology, Hungarian University of Agriculture and Life Sciences, Soml\u00f3i Street 14-16, 1118 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krisztina","family":"Lud\u00e1nyi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Semmelweis University, H\u0151gyes E. Street 7-9, 1092 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5434-201X","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Antal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Semmelweis University, H\u0151gyes E. Street 7-9, 1092 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8164-3993","authenticated-orcid":false,"given":"Nikolett","family":"K\u00e1llai-Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Semmelweis University, H\u0151gyes E. Street 7-9, 1092 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"key":"ref_1","unstructured":"(2024, December 05). GLOBAL REPORT\u20142017 Global Drug Delivery & Formulation Report: Part 1, a Global Review. Available online: https:\/\/www.proquest.com\/docview\/2008938105\/abstract\/C83043300BCB4024PQ\/1."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00455-017-9852-9","article-title":"Patient Adherence to Dysphagia Recommendations: A Systematic Review","volume":"33","author":"Krekeler","year":"2018","journal-title":"Dysphagia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s40266-023-01056-y","article-title":"Crushed Tablet Administration for Patients with Dysphagia and Enteral Feeding: Challenges and Considerations","volume":"40","author":"Blaszczyk","year":"2023","journal-title":"Drugs Aging"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1007\/s11096-013-9836-2","article-title":"Swallowing Difficulties with Oral Drugs among Polypharmacy Patients Attending Community Pharmacies","volume":"35","author":"Marquis","year":"2013","journal-title":"Int. J. Clin. Pharm."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Drumond, N., and Stegemann, S. (2020). Better Medicines for Older Patients: Considerations between Patient Characteristics and Solid Oral Dosage Form Designs to Improve Swallowing Experience. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13010032"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kir\u00e1ly, M., S\u00e1ntha, K., K\u00e1llai-Szab\u00f3, B., Pencz, K.M., Lud\u00e1nyi, K., K\u00e1llai-Szab\u00f3, N., and Antal, I. (2022). Development and Dissolution Study of a \u03b2-Galactosidase Containing Drinking Straw. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14040769"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"106704","DOI":"10.1016\/j.ejps.2024.106704","article-title":"Microparticles and Multi-Unit Systems for Advanced Drug Delivery","volume":"194","author":"Farkas","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Cornil\u0103, A., Iurian, S., Tomu\u021b\u0103, I., and Porfire, A. (2022). Orally Dispersible Dosage Forms for Paediatric Use: Current Knowledge and Development of Nanostructure-Based Formulations. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14081621"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"K\u00e1llai-Szab\u00f3, N., Lengyel, M., Farkas, D., Barna, \u00c1.T., Fleck, C., Basa, B., and Antal, I. (2022). Review on Starter Pellets: Inert and Functional Cores. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14061299"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1208\/s12248-013-9511-5","article-title":"A Report from the Pediatric Formulations Task Force: Perspectives on the State of Child-Friendly Oral Dosage Forms","volume":"15","author":"Zajicek","year":"2013","journal-title":"AAPS J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1208\/s12249-016-0567-2","article-title":"Buccal Dosage Forms: General Considerations for Pediatric Patients","volume":"18","author":"Velaga","year":"2017","journal-title":"AAPS PharmSciTech"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Alyami, H., Koner, J., Huynh, C., Terry, D., and Mohammed, A.R. (2018). Current Opinions and Recommendations of Paediatric Healthcare Professionals\u2014The Importance of Tablets: Emerging Orally Disintegrating versus Traditional Tablets. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0193292"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.23736\/S0026-4946.18.05453-1","article-title":"Ibuprofen in the Treatment of Children\u2019s Inflammatory Pain: A Clinical and Pharmacological Overview","volume":"71","author":"Barbagallo","year":"2018","journal-title":"Minerva Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Basa, B., Jakab, G., K\u00e1llai-Szab\u00f3, N., Borb\u00e1s, B., F\u00fcl\u00f6p, V., Balogh, E., and Antal, I. (2021). Evaluation of Biodegradable PVA-Based 3D Printed Carriers during Dissolution. Materials, 14.","DOI":"10.3390\/ma14061350"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Ghourichay, M.P., Kiaie, S.H., Nokhodchi, A., and Javadzadeh, Y. (2021). Formulation and Quality Control of Orally Disintegrating Tablets (ODTs): Recent Advances and Perspectives. BioMed Res. Int., 2021.","DOI":"10.1155\/2021\/6618934"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1081\/PDT-120003486","article-title":"Investigation of Excipient Type and Level on Drug Release from Controlled Release Tablets Containing HPMC","volume":"7","author":"Reynolds","year":"2002","journal-title":"Pharm. Dev. Technol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.xphs.2016.03.019","article-title":"An Overview of Pharmaceutical Excipients: Safe or Not Safe?","volume":"105","author":"Abrantes","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00408-020-00390-x","article-title":"What Is the Role of Over 100 Excipients in Over the Counter (OTC) Cough Medicines?","volume":"198","author":"Eccles","year":"2020","journal-title":"Lung"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/jps.24299","article-title":"Excipient Variability and Its Impact on Dosage Form Functionality","volume":"104","author":"Dave","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4155\/tde-2023-0026","article-title":"A Comprehensive Review on Pharmaceutical Excipients","volume":"14","author":"Pockle","year":"2023","journal-title":"Ther. Deliv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ejps.2015.12.018","article-title":"Pharmaceutical Excipients\u2014Quality, Regulatory and Biopharmaceutical Considerations","volume":"87","author":"Elder","year":"2016","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"114139","DOI":"10.1016\/j.addr.2022.114139","article-title":"Opportunities for Milk and Milk-Related Systems as \u2018New\u2019 Low-Cost Excipient Drug Delivery Materials","volume":"183","author":"Salim","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.clnu.2023.10.014","article-title":"Lactose Malabsorption and Intolerance: What Is the Correct Management in Older Adults?","volume":"42","author":"Gallo","year":"2023","journal-title":"Clin. Nutr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1177\/2050640613484463","article-title":"Lactose Malabsorption and Intolerance: Pathogenesis, Diagnosis and Treatment","volume":"1","author":"Misselwitz","year":"2013","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dominici, S., Marescotti, F., Sanmartin, C., Macaluso, M., Taglieri, I., Venturi, F., Zinnai, A., and Facioni, M.S. (2022). Lactose: Characteristics, Food and Drug-Related Applications, and Its Possible Substitutions in Meeting the Needs of People with Lactose Intolerance. Foods, 11.","DOI":"10.3390\/foods11101486"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kir\u00e1ly, M., Kiss, B.D., Horv\u00e1th, P., Drahos, L., Mirzahosseini, A., P\u00e1lfy, G., Antal, I., and Lud\u00e1nyi, K. (2021). Investigating Thermal Stability Based on the Structural Changes of Lactase Enzyme by Several Orthogonal Methods. Biotechnol. Rep., 30.","DOI":"10.1016\/j.btre.2021.e00637"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/MCO.0000000000001045","article-title":"Lactose Malabsorption and Intolerance in Older Adults","volume":"27","author":"Gallo","year":"2024","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1080\/87559129.2021.1952421","article-title":"Plant-Based Milk Alternatives: Types, Processes, Benefits, and Characteristics","volume":"39","year":"2023","journal-title":"Food Rev. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"111648","DOI":"10.1016\/j.foodres.2022.111648","article-title":"An Investigation into Consumer Perception and Attitudes towards Plant-Based Alternatives to Milk","volume":"159","author":"Moss","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"114093","DOI":"10.1016\/j.foodres.2024.114093","article-title":"Sensory Characteristics of Plant-Based Milk Alternatives: Product Characterisation by Consumers and Drivers of Liking","volume":"180","author":"Jaeger","year":"2024","journal-title":"Food Res. Int."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Xie, A., Dong, Y., Liu, Z., Li, Z., Shao, J., Li, M., and Yue, X. (2023). A Review of Plant-Based Drinks Addressing Nutrients, Flavor, and Processing Technologies. Foods, 12.","DOI":"10.3390\/foods12213952"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Vilimi, Z., P\u00e1pay, Z.E., Basa, B., Orekhova, X., K\u00e1llai-Szab\u00f3, N., and Antal, I. (2024). Microfluidic Rheology: An Innovative Method for Viscosity Measurement of Gels and Various Pharmaceuticals. Gels, 10.","DOI":"10.3390\/gels10070464"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Aouadi, B., Zaukuu, J.-L.Z., Vit\u00e1lis, F., Bodor, Z., Feh\u00e9r, O., Gillay, Z., Bazar, G., and Kovacs, Z. (2020). Historical Evolution and Food Control Achievements of Near Infrared Spectroscopy, Electronic Nose, and Electronic Tongue\u2014Critical Overview. Sensors, 20.","DOI":"10.3390\/s20195479"},{"key":"ref_34","unstructured":"(2024, December 09). Documentation of Ibuprofen Sodium Salt. Available online: https:\/\/www.sigmaaldrich.com\/HU\/en\/product\/sial\/i1892."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1080\/17425247.2016.1198767","article-title":"Application of Freeze-Drying in the Development of Oral Drug Delivery Systems","volume":"13","author":"Siow","year":"2016","journal-title":"Expert. Opin. Drug Deliv."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-59745-362-2_2","article-title":"The Principles of Freeze-Drying","volume":"Volume 368","author":"Day","year":"2007","journal-title":"Cryopreservation and Freeze-Drying Protocols"},{"key":"ref_37","unstructured":"Council of Europe 2 (2024). 9.5. Uniformity of Mass of Single-Dose Preparations. Eur. Pharmacopoeia, 11, 4523."},{"key":"ref_38","unstructured":"Council of Europe 2 (2024). 9.1. Disintegration of Tablets and Capsules. Eur. Pharmacopoeia, 11, 4523."},{"key":"ref_39","unstructured":"Council of Europe 2 (2024). 5.32. Water: Micro Determination. Eur. Pharmacopoeia, 11, 4523."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jpba.2015.12.046","article-title":"A New Modified Wetting Test and an Alternative Disintegration Test for Orally Disintegrating Tablets","volume":"120","author":"Hooper","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_41","first-page":"287","article-title":"Effect of a Superdisintegrant on Disintegration of Orally Disintegrating Tablets Determined by Simulated Wetting Test and in Vitro Disintegration Test","volume":"77","author":"Sutthapitaksakul","year":"2022","journal-title":"Pharmazie"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/0975-1483.100021","article-title":"Effect of a Disintegration Mechanism on Wetting, Water Absorption, and Disintegration Time of Orodispersible Tablets","volume":"4","author":"Pabari","year":"2012","journal-title":"J. Young Pharm."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Farkas, D., Madar\u00e1sz, L., Nagy, Z.K., Antal, I., and K\u00e1llai-Szab\u00f3, N. (2021). Image Analysis: A Versatile Tool in the Manufacturing and Quality Control of Pharmaceutical Dosage Forms. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13050685"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Vilimi, Z., Kir\u00e1ly, M., Barna, \u00c1.T., P\u00e1pay, Z.E., Budai, L., Lud\u00e1nyi, K., K\u00e1llai-Szab\u00f3, N., and Antal, I. (2024). Formulation of Emulgels Containing Clotrimazole for the Treatment of Vaginal Candidiasis. Gels, 10.","DOI":"10.3390\/gels10110730"},{"key":"ref_45","unstructured":"Council of Europe 2 (2024). 9.6. Uniformity of Content of Single-Dose Preparations. Eur. Pharmacopoeia, 11, 4523."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Fructuoso, I., Rom\u00e3o, B., Han, H., Raposo, A., Ariza-Montes, A., Araya-Castillo, L., and Zandonadi, R.P. (2021). An Overview on Nutritional Aspects of Plant-Based Beverages Used as Substitutes for Cow\u2019s Milk. Nutrients, 13.","DOI":"10.3390\/nu13082650"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11130-016-0583-0","article-title":"Evaluation of Physicochemical and Glycaemic Properties of Commercial Plant-Based Milk Substitutes","volume":"72","author":"Jeske","year":"2017","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Craig, W.J., and Fres\u00e1n, U. (2021). International Analysis of the Nutritional Content and a Review of Health Benefits of Non-Dairy Plant-Based Beverages. Nutrients, 13.","DOI":"10.3390\/nu13030842"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Katidi, A., Xypolitaki, K., Vlassopoulos, A., and Kapsokefalou, M. (2023). Nutritional Quality of Plant-Based Meat and Dairy Imitation Products and Comparison with Animal-Based Counterparts. Nutrients, 15.","DOI":"10.3390\/nu15020401"},{"key":"ref_50","first-page":"1308","article-title":"Food Allergy\u2014New Risks through Vegan Diet? Overview of New Allergen Sources and Current Data on the Potential Risk of Anaphylaxis","volume":"21","author":"Simon","year":"2023","journal-title":"JDDG J. Der Dtsch. Dermatol. Ges."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"10299","DOI":"10.3168\/jds.2024-25098","article-title":"A Comparison of the Quality of UHT Milk and Its Plant-Based Analogs","volume":"107","author":"Daszkiewicz","year":"2024","journal-title":"J. Dairy Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"115219","DOI":"10.1016\/j.lwt.2023.115219","article-title":"Fusion of Electronic Tongue and NIRS for the Detection of Heat Treatment of Honey","volume":"186","author":"Bodor","year":"2023","journal-title":"LWT"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Podra\u017cka, M., B\u0105czy\u0144ska, E., Kundys, M., Jele\u0144, P.S., and Witkowska Nery, E. (2017). Electronic Tongue\u2014A Tool for All Tastes?. Biosensors, 8.","DOI":"10.3390\/bios8010003"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Kazsoki, A., Palcs\u00f3, B., Omer, S.M., Kovacs, Z., and Zelk\u00f3, R. (2022). Formulation of Levocetirizine-Loaded Core\u2013Shell Type Nanofibrous Orally Dissolving Webs as a Potential Alternative for Immediate Release Dosage Forms. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14071442"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kovacs, Z., Sz\u00f6ll\u0151si, D., Zaukuu, J.-L.Z., Bodor, Z., Vit\u00e1lis, F., Aouadi, B., Zsom-Muha, V., and Gillay, Z. (2020). Factors Influencing the Long-Term Stability of Electronic Tongue and Application of Improved Drift Correction Methods. Biosensors, 10.","DOI":"10.3390\/bios10070074"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"N\u00e9meth, D., Bal\u00e1zs, G., Daood, H.G., Kov\u00e1cs, Z., Bodor, Z., Zinia Zaukuu, J.-L., Szentp\u00e9teri, V., K\u00f3kai, Z., and Kappel, N. (2019). Standard Analytical Methods, Sensory Evaluation, NIRS and Electronic Tongue for Sensing Taste Attributes of Different Melon Varieties. Sensors, 19.","DOI":"10.3390\/s19225010"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1080\/10837450.2023.2194989","article-title":"The Electronic Tongue: An Advanced Taste-Sensing Multichannel Sensory Tool with Global Selectivity for Application in the Pharmaceutical and Food Industry","volume":"28","author":"Imam","year":"2023","journal-title":"Pharm. Dev. Technol."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/17\/2\/195\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:26:41Z","timestamp":1760027201000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/17\/2\/195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":57,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["pharmaceutics17020195"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics17020195","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,4]]}}}