{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:59:53Z","timestamp":1791575993947,"version":"4.3.4"},"reference-count":155,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Para\u00edba State Research Foundation [FAPESQ]","award":["#1866\/2022"],"award-info":[{"award-number":["#1866\/2022"]}]},{"name":"Funda\u00e7\u00e3o Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior [CAPES], Brazil","award":["#1866\/2022"],"award-info":[{"award-number":["#1866\/2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Advances in medical nanobiotechnology have notably enhanced the application of snake venom toxins, facilitating the development of new therapies with animal-derived toxins. The vast diversity of snake species and their venom complexities underline the need for ongoing research. This review is dedicated to exploring the integration of snake venom with nanoparticles to enable their use in human therapies aiming to develop treatments. The complex mixture of snake venom not only inflicts significant pathological effects but also offers valuable insights for the creation of innovative therapies, particularly in the realm of nanobiotechnology. Nanoscale encapsulation not only mitigates the inherent toxicity of snake venom but also amplifies their antitumoral, antimicrobial, and immunomodulatory properties. The synergy between venom-derived macromolecules and nanotechnology offers a novel pathway for augmenting the efficacy and safety of conventional antivenom therapies, extending their applicability beyond treating bites to potentially addressing a myriad of health issues. In conclusion, nanotechnology presents a compelling therapeutic frontier that promises to improve current treatment modalities and ameliorate the adverse effects associated with venomous snakebites.<\/jats:p>","DOI":"10.3390\/pharmaceutics17020204","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T04:47:31Z","timestamp":1738817251000},"page":"204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Emerging Trends in Snake Venom-Loaded Nanobiosystems for Advanced Medical Applications: A Comprehensive Overview"],"prefix":"10.3390","volume":"17","author":[{"given":"\u00c1lisson E. F.","family":"Alves","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Para\u00edba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil"},{"name":"Post-Graduated Program in Natural and Synthetic Bioactive Products, Federal University of Para\u00edba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B. C.","family":"Barros","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Para\u00edba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindomara C. F.","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Para\u00edba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5570-6046","authenticated-orcid":false,"given":"Lucas M. M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Para\u00edba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziela M. A.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Biotechnology (BioTecFarm), Department of Pharmacy, Federal University of Para\u00edba (UFPB), Campus I-Castelo Branco III., Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6872-082X","authenticated-orcid":false,"given":"Ana F. 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(2020). Current knowledge on snake dry bites. Toxins, 12.","DOI":"10.3390\/toxins12110668"},{"key":"ref_3","unstructured":"Williams, D., and World Health Organization (2023, September 06). Snakebite Envenoming. Available online: https:\/\/www.who.int\/health-topics\/snakebite."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17063","DOI":"10.1038\/nrdp.2017.63","article-title":"Snakebite envenoming","volume":"3","author":"Calvete","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Aron, M.B., Mulwafu, M., Mailosi, B., Kreuels, B., Dullie, L., Kachimanga, C., Blessmann, J., Ndarama, E., Sambani, C., and Munyaneza, F. (2023). Experiences and practices of traditional healers on snakebite treatment and prevention in rural Malawi. PLoS Negl. Trop. Dis., 17.","DOI":"10.1371\/journal.pntd.0011653"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"100143","DOI":"10.1016\/j.toxcx.2022.100143","article-title":"Perspectives on snakebite envenoming care needs across different sociocultural contexts and health systems: A comparative qualitative analysis among us and brazilian health providers","volume":"17","author":"Strand","year":"2023","journal-title":"Toxicon X"},{"key":"ref_7","first-page":"12","article-title":"What future for policing? Some reflections on the concept and purpose of policing and their implications for police reform in England and Wales","volume":"2","author":"Williams","year":"2019","journal-title":"Int. J. Law Public Adm."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Schneider, M.C., Min, K., Hamrick, P.N., Montebello, L.R., Ranieri, T.M., Mardini, L., Camara, V.M., Raggio Luiz, R., Liese, B., and Vuckovic, M. (2021). Overview of snakebite in Brazil: Possible drivers and a tool for risk mapping. PLoS Negl. Trop. Dis., 15.","DOI":"10.1371\/journal.pntd.0009044"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e02242023","DOI":"10.1590\/0037-8682-0224-2023","article-title":"Snakebites in northeastern Brazil: Accessing clinical-epidemiological profile as a strategy to deal with neglected tropical diseases","volume":"56","author":"Guedes","year":"2023","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Duque, B.R., Bruno, S.F., Ferreira, V., Guedes, T.B., Machado, C., and Hamdan, B. (2023). Venomous snakes of medical importance in the brazilian state of Rio de Janeiro: Habitat and taxonomy against ophidism. Braz. J. Biol., 83.","DOI":"10.1590\/1519-6984.272811"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Bordon, K.D.C.F., Cologna, C.T., Fornari-Baldo, E.C., Pinheiro-J\u00fanior, E.L., Cerni, F.A., Amorim, F.G., Anjolette, F.A.P., Cordeiro, F.A., Wiezel, G.A., and Cardoso, I.A. (2020). From animal poisons and venoms to medicines: Achievements, challenges and perspectives in drug discovery. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.01132"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"100169","DOI":"10.1016\/j.toxcx.2023.100169","article-title":"Considerations for the development of a field-based medical device for the administration of adjunctive therapies for snakebite envenoming","volume":"20","author":"Werner","year":"2023","journal-title":"Toxicon X"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biologicals.2021.01.003","article-title":"Development and evaluation of polymeric nanoparticles as a delivery system for snake envenoming prevention","volume":"70","author":"Hamzaoui","year":"2021","journal-title":"Biologicals"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.genom.9.081307.164356","article-title":"The toxicogenomic multiverse: Convergent recruitment of proteins into animal venoms","volume":"10","author":"Fry","year":"2009","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jprot.2009.01.009","article-title":"Evolution and diversification of the toxicofera reptile venom system","volume":"72","author":"Fry","year":"2009","journal-title":"J. Proteom."},{"key":"ref_16","unstructured":"Jenner, R., and Undheim, E. (2017). Venom: The Secrets of Nature\u2019s Deadliest Weapon, Smithsonian Books."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Schendel, R., Jenner, R., and Undheim, E. (2019). The diversity of venom: The importance of behavior and venom system morphology in understanding its ecology and evolution. Toxins, 11.","DOI":"10.3390\/toxins11110666"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.tibs.2018.12.004","article-title":"Friends or foes? Emerging impacts of biological toxins","volume":"44","author":"Clark","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s41048-018-0067-x","article-title":"Animal protein toxins: Origins and therapeutic applications","volume":"4","author":"Chen","year":"2018","journal-title":"Biophys. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Singh, S.B., and Pelaez, F. (2008). Biodiversity, chemical diversity and drug discovery. Natural Compounds as Drugs, Volume I, Birkh\u00e4user.","DOI":"10.1007\/978-3-7643-8117-2_4"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/jnc.13975","article-title":"The three-finger toxin fold: A multifunctional structural scaffold able to modulate cholinergic functions","volume":"142","author":"Kessler","year":"2017","journal-title":"J. Neurochem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00018-016-2344-5","article-title":"Convergent evolution of defensin sequence, structure and function","volume":"74","author":"Shafee","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Zhang, S.-K., Song, J., Gong, F., Li, S.-B., Chang, H.-Y., Xie, H.-M., Gao, H.-W., Tan, Y.-X., and Ji, S.-P. (2016). Design of an \u03b1-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. Sci. Rep., 6.","DOI":"10.1038\/srep27394"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.toxicon.2012.09.008","article-title":"Non-enzymatic proteins from snake venoms: A gold mine of pharmacological tools and drug leads","volume":"62","author":"McCleary","year":"2013","journal-title":"Toxicon"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Xiao, H., Pan, H., Liao, K., Yang, M., and Huang, C. (2017). Snake Venom PLA2, a promising target for broad-spectrum antivenom drug development. Biomed. Res. Int., 2017.","DOI":"10.1155\/2017\/6592820"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Tasoulis, T., and Isbister, G. (2017). A review and database of snake venom proteomes. Toxins, 9.","DOI":"10.3390\/toxins9090290"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.tips.2020.05.006","article-title":"Causes and consequences of snake venom variation","volume":"41","author":"Casewell","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00204-022-03420-0","article-title":"A current perspective on snake venom composition and constituent protein families","volume":"97","author":"Tasoulis","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41570-022-00393-7","article-title":"The chemistry of snake venom and its medicinal potential","volume":"6","author":"Oliveira","year":"2022","journal-title":"Nat. Rev. Chem."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Slagboom, J., Mladi\u0107, M., Xie, C., Kazandjian, T.D., Vonk, F., Somsen, G.W., Casewell, N.R., and Kool, J. (2020). high throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches. PLoS Negl. Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0007802"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.toxicon.2011.03.017","article-title":"from snake venom toxins to therapeutics\u2014Cardiovascular examples","volume":"59","author":"Koh","year":"2012","journal-title":"Toxicon"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s001250051314","article-title":"Angiotensin converting-enzyme inhibitor treatment reduces glomerular P16 INK4 and P27 Kip1 expression in diabetic BBdp rats","volume":"42","author":"Wolf","year":"1999","journal-title":"Diabetologia"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/00005072-199612000-00006","article-title":"Myotoxic activity of the toxic phospholipase, notexin, from the venom of the australian tiger snake","volume":"55","author":"Dixon","year":"1996","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.toxicon.2007.08.007","article-title":"Systemic and local myotoxicity induced by snake venom group II Phospholipases A2: Comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue","volume":"51","author":"Marangoni","year":"2008","journal-title":"Toxicon"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4320175","DOI":"10.1155\/2018\/4320175","article-title":"Developing small molecule therapeutics for the initial and adjunctive treatment of snakebite","volume":"2018","author":"Bulfone","year":"2018","journal-title":"J. Trop. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/psb.1837","article-title":"The next generation of venom-based drugs","volume":"31","author":"Greener","year":"2020","journal-title":"Prescriber"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/s10989-023-10543-0","article-title":"Why to study peptides from venomous and poisonous animals?","volume":"29","author":"Oliveira","year":"2023","journal-title":"Int. J. Pept. Res. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmch.2021.01.001","article-title":"Utilisation of compounds from venoms in drug discovery","volume":"60","author":"Trim","year":"2021","journal-title":"Prog. Med. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Lazarovici, P., Marcinkiewicz, C., and Lelkes, P.I. (2019). From snake venom\u2019s disintegrins and C-type lectins to anti-platelet drugs. Toxins, 11.","DOI":"10.3390\/toxins11050303"},{"key":"ref_40","first-page":"117955142110060","article-title":"Therapeutic potential of peptides derived from animal venoms: Current views and emerging drugs for diabetes","volume":"14","author":"McClean","year":"2021","journal-title":"Clin. Med. Insights Endocrinol. Diabetes"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Lan, D., Song, S., Liu, Y., Jiao, B., and Meng, R. (2021). Use of Batroxobin in central and peripheral ischemic vascular diseases: A systematic review. Front. Neurol., 12.","DOI":"10.3389\/fneur.2021.716778"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.3390\/toxins5101799","article-title":"appraisal of antiophidic potential of marine sponges against Bothrops jararaca and Lachesis muta venom","volume":"5","author":"Faioli","year":"2013","journal-title":"Toxins"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Nunes, E., Frihling, B., Barros, E., de Oliveira, C., Verbisck, N., Flores, T., de Freitas J\u00fanior, A., Franco, O., de Macedo, M., and Migliolo, L. (2020). Antibiofilm activity of acidic phospholipase isoform isolated from Bothrops erythromelas snake venom. Toxins, 12.","DOI":"10.20944\/preprints202007.0092.v1"},{"key":"ref_44","unstructured":"Uetz, P. (2024, February 02). The Reptile Database. Available online: http:\/\/www.reptile-database.org\/."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00109-021-02140-9","article-title":"Synthetic polypeptide crotamine: Characterization as a myotoxin and as a target of combinatorial peptides","volume":"100","author":"Pompeia","year":"2022","journal-title":"J. Mol. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e12775","DOI":"10.1111\/micc.12775","article-title":"Effect of the snake venom component crotamine on lymphatic endothelial cell responses and lymph transport","volume":"30","author":"Si","year":"2023","journal-title":"Microcirculation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2021.12.005","article-title":"Toxicon revisiting the potential of south american rattlesnake Crotalus durissus terrificus toxins as therapeutic, theranostic and\/or biotechnological agents","volume":"206","author":"Hayashi","year":"2022","journal-title":"Toxicon"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Giardini, A.C., Evangelista, B.G., Sant\u2019Anna, M.B., Martins, B.B., Lancellotti, C.L.P., Ciena, A.P., Chacur, M., Pagano, R.L., Ribeiro, O.G., and Zambelli, V.O. (2021). Crotalphine attenuates pain and neuroinflammation induced by experimental autoimmune encephalomyelitis in mice. Toxins, 13.","DOI":"10.3390\/toxins13110827"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.peptides.2008.04.003","article-title":"Crotalphine, a novel potent analgesic peptide from the venom of the south american rattlesnake Crotalus durissus terrificus","volume":"29","author":"Konno","year":"2008","journal-title":"Peptides"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/BST20190739","article-title":"Current research into snake antivenoms, their mechanisms of action and applications","volume":"48","author":"Silva","year":"2020","journal-title":"Biochem. Soc. Trans."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Silva, S.L., Rowan, E.G., Albericio, F., St\u00e1beli, R.G., Calderon, L.A., and Soares, A.M. (2014). Animal toxins and their advantages in biotechnology and pharmacology. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/951561"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Peigneur, S., and Tytgat, J. (2018). Toxins in drug discovery and pharmacology. Toxins, 10.","DOI":"10.3390\/toxins10030126"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.toxicon.2018.04.022","article-title":"Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling","volume":"148","author":"Slagboom","year":"2018","journal-title":"Toxicon"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"King, G.F. (2015). Venoms-based drug discovery: Proteomic and transcriptomic approaches. Venom to Drugs, Royal Society of Chemistry.","DOI":"10.1039\/9781849737876"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/jms.1351","article-title":"Peptide fingerprinting of snake venoms by direct infusion nanoelectrospray ionization mass spectrometry: Potential use in venom identification and taxonomy","volume":"43","author":"Souza","year":"2008","journal-title":"J. Mass Spec."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/psc.2965","article-title":"An unexpected cell-penetrating peptide from Bothrops jararaca venom identified through a novel size exclusion chromatography screening","volume":"23","author":"Sciani","year":"2017","journal-title":"J. Pept. Sci."},{"key":"ref_57","first-page":"15","article-title":"Nanoparticle-conjugated animal venom-toxins and their possible therapeutic potential","volume":"3","author":"Biswas","year":"2012","journal-title":"J. Venom. Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Munawar, A., Ali, S., Akrem, A., and Betzel, C. (2018). Snake venom peptides: Tools of biodiscovery. Toxins, 10.","DOI":"10.3390\/toxins10110474"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Hamimed, S., Abdeljelil, N., Landoulsi, A., Chatti, A., Aljabali, A.A.A., and Barhoum, A. (2022). Bacterial cellulose nanofibers. Handbook of Nanocelluloses, Springer.","DOI":"10.1007\/978-3-030-89621-8_15"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1001\/jama.2014.16315","article-title":"Nanotechnology","volume":"313","author":"Langer","year":"2015","journal-title":"JAMA"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"133","DOI":"10.2147\/IJN.S596","article-title":"Drug delivery and nanoparticles: Applications and hazards","volume":"3","author":"Jong","year":"2008","journal-title":"Int. J. Nanomed."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Patra, J.K., Das, G., Fraceto, L.F., Campos, E.V.R., Rodriguez-Torres, M.D.P., Acosta-Torres, L.S., Diaz-Torres, L.A., Grillo, R., Swamy, M.K., and Sharma, S. (2018). Nano based drug delivery systems: Recent developments and future prospects. J. Nanobiotech., 16.","DOI":"10.1186\/s12951-018-0392-8"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mtchem.2018.05.002","article-title":"Biopolymer based nanomaterials in drug delivery systems: A review","volume":"9","author":"Jacob","year":"2018","journal-title":"Mater. Today Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1096\/fj.04-2747rev","article-title":"Nanomedicine: Current status and future prospects","volume":"19","author":"Moghimi","year":"2005","journal-title":"FASEB J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4331\/wjbc.v8.i1.4","article-title":"Modern trends in animal venom research\u2014Omics and nanomaterials","volume":"8","author":"Utkin","year":"2017","journal-title":"World J. Biol. Chem."},{"key":"ref_66","first-page":"707","article-title":"Nanotechnology in snake venom research\u2014An overview","volume":"56","author":"Gomes","year":"2018","journal-title":"Indian J. Exp. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Soares, K., Gl\u00e1ucia-Silva, F., Silva, A.D., Torres-R\u00eago, M., Ara\u00fajo, N., Menezes, Y., Damasceno, I., Tambourgi, D., Silva-J\u00fanior, A., and Fernandes-Pedrosa, M. (2018). Antivenom production against Bothrops jararaca and Bothrops erythromelas snake venoms using cross-linked chitosan nanoparticles as an immunoadjuvant. Toxins, 10.","DOI":"10.3390\/toxins10040158"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Santos-Silva, E.d., Torres-R\u00eago, M., Gl\u00e1ucia-Silva, F., Feitosa, R.C., Lacerda, A.F., Rocha, H.A.d.O., Fernandes-Pedrosa, M.d.F., and Silva-J\u00fanior, A.A. (2022). Cationic PLGA nanoparticle formulations as biocompatible immunoadjuvant for serum production and immune response against Bothrops jararaca venom. Toxins, 14.","DOI":"10.3390\/toxins14120888"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1080\/01480545.2018.1478850","article-title":"Activity of silver nanoparticles on prokaryotic cells and Bothrops jararacussu snake venom","volume":"42","author":"Oliveira","year":"2019","journal-title":"Drug Chem. Toxicol."},{"key":"ref_70","first-page":"1353","article-title":"Snake venom as therapeutic agents: From toxin to drug development","volume":"40","author":"Pal","year":"2002","journal-title":"Indian J. Exp. Biol."},{"key":"ref_71","first-page":"205","article-title":"Effects du venin de cobra sur les greffes cancereuses et sur le cancer spontane adenocarcinome de la souris","volume":"197","author":"Calmette","year":"1933","journal-title":"Comptes Rendus Acad. Sci."},{"key":"ref_72","first-page":"783","article-title":"Cytotoxic effects of snake venoms on kb and yoshida sarcoma cells","volume":"9","author":"Tu","year":"1974","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"ref_73","first-page":"343","article-title":"Cytolytic activity of cytotoxin isolated from indian cobra venom against experimental tumor cells","volume":"10","author":"Iwaguchi","year":"1985","journal-title":"Biochem. Int."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.toxicon.2010.05.016","article-title":"A lethal cardiotoxic\u2013cytotoxic protein from the indian monocellate cobra Naja kaouthia venom","volume":"56","author":"Debnath","year":"2010","journal-title":"Toxicon"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.toxrep.2014.04.007","article-title":"In vivo and in vitro toxicity of nanogold conjugated snake venom protein toxin GNP-NKCT1","volume":"1","author":"Saha","year":"2014","journal-title":"Toxicol. Rep."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Aubin-Tam, M.-E. (2013). Conjugation of nanoparticles to proteins. Nanomaterial Interfaces in Biology, Humana Press. Methods in Molecular Biology.","DOI":"10.1007\/978-1-62703-462-3_3"},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Aubin-Tam, M.-E., and Hamad-Schifferli, K. (2008). Structure and function of nanoparticle\u2013protein conjugates. Biomed. Mater., 33.","DOI":"10.1088\/1748-6041\/3\/3\/034001"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1517\/17425247.2013.769956","article-title":"Poly-\u0190-caprolactone microcapsules and nanocapsules in drug delivery","volume":"10","author":"Pohlmann","year":"2013","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1002\/app.27511","article-title":"Release of highly hydrophilic drugs from Poly-\u0190-caprolactone matrices","volume":"107","author":"Rosenberg","year":"2008","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1002\/jps.21297","article-title":"Novel biodegradable blend matrices for controlled drug release","volume":"97","author":"Lin","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1016\/j.vaccine.2016.04.035","article-title":"Development and characterization of a new carrier for vaccine delivery based on calcium-alginate nanoparticles: Safe immunoprotective approach against scorpion envenoming","volume":"34","year":"2016","journal-title":"Vaccine"},{"key":"ref_82","first-page":"4391","article-title":"Biodegradable polycaprolactone PCL based polymer and composites","volume":"8","author":"Archer","year":"2023","journal-title":"Phys. Sci. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"0063","DOI":"10.1038\/s41570-017-0063","article-title":"Evolution of macromolecular complexity in drug delivery systems","volume":"1","author":"Kakkar","year":"2017","journal-title":"Nat. Rev. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Lotocki, V., and Kakkar, A. (2020). Miktoarm star polymers: Branched architectures in drug delivery. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12090827"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0168-3659(03)00367-5","article-title":"Effects of crystalline microstructure on drug release behavior of poly\u03b5-caprolactone microspheres","volume":"92","author":"Jeong","year":"2003","journal-title":"J. Control. Release"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jconrel.2003.12.021","article-title":"Self-porating polymersomes of PEG\u2013PLA and PEG\u2013PCL: Hydrolysis-triggered controlled release vesicles","volume":"96","author":"Ahmed","year":"2004","journal-title":"J. Control. Release"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2011.09.064","article-title":"Poly-\u0454-caprolactone based formulations for drug delivery and tissue engineering: A review","volume":"158","author":"Dash","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.biopha.2016.08.060","article-title":"Overview on experimental models of interactions between nanoparticles and the immune system","volume":"83","author":"Mohammadi","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1021\/acs.molpharmaceut.7b00826","article-title":"Enhancing mucosal immune response of newcastle disease virus DNA vaccine using n-2-hydroxypropyl trimethylammonium chloride chitosan and n,o-carboxymethyl chitosan nanoparticles as delivery carrier","volume":"151","author":"Zhao","year":"2018","journal-title":"Mol. Pharm."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.2147\/IJN.S317113","article-title":"chitosan nanovaccines as efficient carrier adjuvant system for il-12 with enhanced protection against hbv","volume":"16","author":"Zhao","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.toxicon.2019.06.134","article-title":"Evaluation of self-assembled Bothrops jararacussu snake venom proteins cross-linked chitosan nanoparticles activity for use as a potential antibacterial","volume":"168","author":"Soares","year":"2019","journal-title":"Toxicon"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Tsuruta, L.R., Moro, A.M., Tambourgi, D.V., and Sant\u2019Anna, O.A. (2021). Oral tolerance induction by Bothrops jararaca venom in a murine model and cross-reactivity with toxins of other snake venoms. Toxins, 13.","DOI":"10.3390\/toxins13120865"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.iac.2017.09.003","article-title":"Oral tolerance development and maintenance","volume":"38","author":"Wambre","year":"2018","journal-title":"Immunol. Allergy Clin. N. Am."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2174\/156720112803529747","article-title":"A rational design for the nanoencapsulation of poisonous animal venoms in liposomes prepared with natural phospholipids","volume":"9","author":"Costa","year":"2012","journal-title":"Curr. Drug Deliv."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0176-1617(97)80280-5","article-title":"Evidence of phospholipase activity in phospholipid bilayers under conditions of low hydration","volume":"150","author":"Oliver","year":"1997","journal-title":"J. Plant Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.toxicon.2009.05.025","article-title":"The interaction of bothropstoxin-I Lys49-PLA2 with liposome membranes","volume":"54","author":"Ferreira","year":"2009","journal-title":"Toxicon"},{"key":"ref_97","first-page":"515","article-title":"Characterization of the snake venoms from seven brazilian species of Bothrops by FPLC anion-exchange chromatography","volume":"102","author":"Leite","year":"1992","journal-title":"Comp. Biochem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0005-2760(96)00031-8","article-title":"Arbutin inhibits PLA2 in partially hydrated model systems","volume":"1302","author":"Oliver","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0041-0101(99)00201-9","article-title":"Immunization with liposome-encapsulated Bothrops jararaca venom","volume":"38","author":"Carvalho","year":"2000","journal-title":"Toxicon"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nbt1184-979","article-title":"Dehydration-rehydration vesicles: A simple method for high yield drug entrapment in liposomes","volume":"2","author":"Kirby","year":"1984","journal-title":"Nat. Biotechnol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.intimp.2016.04.025","article-title":"Liposomes containing an ASP49-Phospholipase A2 from Bothrops jararacussu snake venom as experimental therapy against cutaneous leishmaniasis","volume":"36","author":"Barros","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.intimp.2017.12.012","article-title":"ASP49-Phospholipase A2-loaded liposomes as experimental therapy in cutaneous leishmaniasis model","volume":"55","author":"Barros","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.ijbiomac.2018.09.203","article-title":"A biotechnological approach to immunotherapy: Antivenom against Crotalus durissus cascavella snake venom produced from biodegradable nanoparticles","volume":"120","author":"Damasceno","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40409-018-0178-3","article-title":"immunotherapeutic potential of crotoxin: Anti-inflammatory and immunosuppressive properties","volume":"24","author":"Sartim","year":"2018","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Sant\u2019Anna, M.B., Giardini, A.C., Ribeiro, M.A.C., Lopes, F.S.R., Teixeira, N.B., Kimura, L.F., Bufalo, M.C., Ribeiro, O.G., Borrego, A., and Cabrera, W.H.K. (2020). The Crotoxin:SBA-15 complex down-regulates the incidence and intensity of experimental autoimmune encephalomyelitis through peripheral and central actions. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.591563"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Sant\u2019Anna, M.B., Lopes, F.S.R., Kimura, L.F., Giardini, A.C., Sant\u2019Anna, O.A., and Picolo, G. (2019). Crotoxin conjugated to SBA-15 nanostructured mesoporous silica induces long-last analgesic effect in the neuropathic pain model in mice. Toxins, 11.","DOI":"10.3390\/toxins11120679"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/smll.201000538","article-title":"Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals","volume":"6","author":"Lu","year":"2010","journal-title":"Small"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.colsurfb.2017.12.013","article-title":"Design and characterization of crotamine-functionalized gold nanoparticles","volume":"163","author":"Karpel","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_109","first-page":"233","article-title":"Cytotoxic activity of a northern black-tailed rattlesnake Crotalus molossus molossus venom-loaded in chitosan nanoparticles as a potential antitumoral system","volume":"69","year":"2022","journal-title":"Acta Biochim. Pol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/BA20000080","article-title":"Effect of membrane composition and of coencapsulation of immunostimulants in a liposome-entrapped crotoxin","volume":"33","author":"Viotti","year":"2001","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0041-0101(96)00061-X","article-title":"encapsulation of native crotoxin in liposomes: A safe approach for the production of antivenom and vaccination against Crotalus durissus terrificus venom","volume":"35","author":"Freitas","year":"1997","journal-title":"Toxicon"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Baudou, F.G., Fusco, L., Giorgi, E., Diaz, E., Municoy, S., Desimone, M.F., Leiva, L., and De Marzi, M.C. (2020). Physicochemical and biological characterization of nanovenoms, a new tool formed by silica nanoparticles and Crotalus durissus terrificus venom. Colloids Surf. B Biointerfaces, 193.","DOI":"10.1016\/j.colsurfb.2020.111128"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1532-0456(02)00002-9","article-title":"Comparison of the biodistribution of free or liposome-entrapped Crotalus durissus terrificus south american rattlesnake venom in mice","volume":"131","author":"Gomes","year":"2002","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Stransky, S., Costal-Oliveira, F., -Souza, L.L., Duarte, C.G., Ch\u00e1vez-Ol\u00f3rtegui, C., and Braga, V.M.M. (2018). In vitro assessment of cytotoxic activities of Lachesis muta muta snake venom. PLoS Negl. Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006427"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1055\/s-0038-1665414","article-title":"Mechanism of inhibitory action on platelet activation of a phospholipase A2 isolated from Lachesis muta bushmaster snake venom","volume":"78","author":"Fuly","year":"1997","journal-title":"Thromb. Haemost."},{"key":"ref_116","first-page":"261","article-title":"Venoms, toxins and derivatives from the brazilian fauna: Valuable sources for drug discovery","volume":"67","author":"Almeida","year":"2015","journal-title":"Sheng Li Xue Bao"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1096\/fj.03-1459fje","article-title":"Crotamine is a novel cellpenetrating protein from the venom of rattlesnake Crotalus durissus terrificus","volume":"18","author":"Kerkis","year":"2004","journal-title":"FASEB J."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/15216540500494508","article-title":"Properties of cell penetrating peptides CPPs","volume":"58","author":"Kerkis","year":"2006","journal-title":"IUBMB Life"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Porta, L.C., Campeiro, J.D., and Hayashi, M.A.F. (2022). A native CPP from rattlesnake with therapeutic and theranostic properties. Cell Penetrating Peptides, Humana. Methods in Molecular Biology.","DOI":"10.1007\/978-1-0716-1752-6_6"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"21349","DOI":"10.1074\/jbc.M604876200","article-title":"Crotamine mediates gene delivery into cells through the binding to heparan sulfate proteoglycans","volume":"282","author":"Nascimento","year":"2007","journal-title":"J. Bio. Chem."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.toxicon.2008.06.029","article-title":"Cytotoxic effects of crotamine are mediated through lysosomal membrane permeabilization","volume":"52","author":"Hayashi","year":"2008","journal-title":"Toxicon"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbamem.2016.11.002","article-title":"CyLoP-1: Membrane-active peptide with cell-penetrating and antimicrobial properties","volume":"1859","author":"Ponnappan","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"7041","DOI":"10.1021\/jm8009475","article-title":"A Novel Cell-penetrating peptide sequence derived by structural minimization of a snake toxin exhibits preferential nucleolar localization","volume":"51","author":"LaTorre","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1021\/bc200421z","article-title":"efficient cellular delivery of \u03b2-galactosidase mediated by NrTPs, a new family of cell-penetrating peptides","volume":"22","author":"Rodrigues","year":"2011","journal-title":"Bioconjug. Chem."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1016\/j.bbamem.2012.06.014","article-title":"molecular characterization of the interaction of crotamine-derived nucleolar targeting peptides with lipid membranes","volume":"1818","author":"Rodrigues","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1002\/jcb.27943","article-title":"New generation cpps show distinct selectivity for cancer and noncancer cells","volume":"120","author":"Tansi","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1007\/s00726-014-1801-4","article-title":"Vipericidins: A novel family of cathelicidin-related peptides from the venom gland of south american pit vipers","volume":"46","author":"Falcao","year":"2014","journal-title":"Amino Acids"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"170234","DOI":"10.1016\/j.peptides.2019.170234","article-title":"Crotamine and Crotalicidin, membrane active peptides from Crotalus durissus terrificus rattlesnake venom, and their structurally-minimized fragments for applications in medicine and biotechnology","volume":"126","author":"Falcao","year":"2020","journal-title":"Peptides"},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Peinado, C.P., Defaus, S., and Andreu, D. (2020). Hitchhiking with nature: Snake venom peptides to fight cancer and superbugs. Toxins, 12.","DOI":"10.3390\/toxins12040255"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/ph7060723","article-title":"Antimicrobial peptides in reptiles","volume":"7","author":"VanHoek","year":"2014","journal-title":"Pharmaceuticals"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.peptides.2011.04.002","article-title":"The antibacterial activity of bf-30 in vitro and in infected burned rats is through interference with cytoplasmic membrane integrity","volume":"32","author":"Zhou","year":"2011","journal-title":"Peptides"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.bbamem.2015.01.007","article-title":"Helical cationic antimicrobial peptide length and its impact on membrane disruption","volume":"1848","author":"Juba","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1099\/jmm.0.000652","article-title":"Insights into the candidacidal mechanism of ctn[15\u201334]\u2014A carboxyl-terminal, crotalicidin-derived peptide related to cathelicidins","volume":"67","author":"Cavalcante","year":"2018","journal-title":"J. Med. Microbiol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1074\/jbc.RA117.000125","article-title":"Mechanisms of bacterial membrane permeabilization by crotalicidin ctn and its fragment ctn15\u201334, antimicrobial peptides from rattlesnake venom","volume":"293","author":"Dias","year":"2018","journal-title":"J. Bio. Chem."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Aguiar, F.L.L.D., Santos, N.C., de Paula Cavalcante, C.S., Andreu, D., Baptista, G.R., and Gon\u00e7alves, S. (2020). Antibiofilm activity on candida albicans and mechanism of action on biomembrane models of the antimicrobial peptide Ctn[15\u201334]. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218339"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"8553","DOI":"10.1021\/acs.jmedchem.5b01142","article-title":"Structural dissection of crotalicidin, a rattlesnake venom cathelicidin, retrieves a fragment with antimicrobial and antitumor activity","volume":"58","author":"Falcao","year":"2015","journal-title":"J. Med. Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.bbagen.2015.02.013","article-title":"rhodamine b-conjugated encrypted vipericidin nonapeptide is a potent toxin to zebrafish and associated with in vitro cytotoxicity","volume":"1850","author":"Wang","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"115004","DOI":"10.1016\/j.carbpol.2019.115004","article-title":"advances in chitosan-based nanoparticles for oncotherapy","volume":"222","author":"Zhang","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Mendes, B., Almeida, J.R., Vale, N., Gomes, P., Gadelha, F.R., Silva, S.L., and Miguel, D.C. (2019). Potential use of 13-mer peptides based on phospholipase and oligoarginine as leishmanicidal agents. Comp. Biochem. Physiol., 226.","DOI":"10.1016\/j.cbpc.2019.108612"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Aguilar, A., Twardowski, T., and Wohlgemuth, R. (2019). Bioeconomy for sustainable development. Biotechnol. J., 14.","DOI":"10.1002\/biot.201800638"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.nbt.2020.07.004","article-title":"Bioeconomy development factors in the european union and poland","volume":"60","author":"Tyczewska","year":"2021","journal-title":"New Biotechnol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.eist.2020.10.003","article-title":"Entrepreneurship and the sustainable bioeconomy transformation","volume":"37","author":"Kuckertz","year":"2020","journal-title":"Environ. Innov. Soc. Transit."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Bugge, M., Hansen, T., and Klitkou, A. (2016). What is the bioeconomy? a review of the literature. Sustainability, 8.","DOI":"10.3390\/su8070691"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nbt.2017.04.002","article-title":"The origins of the bioeconomy in the european union","volume":"40","author":"Patermann","year":"2018","journal-title":"New Biotechnol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ecolecon.2019.01.027","article-title":"The hijacking of the bioeconomy","volume":"159","author":"Vivien","year":"2019","journal-title":"Ecol. Econ."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Alamgir, A.N.M. (2018). Biotechnology, in vitro production of natural bioactive compounds, herbal preparation, and disease management (treatment and prevention). Therapeutic Use of Medicinal Plants and their Extracts: Volume 2, Springer. Progress in Drug Research.","DOI":"10.1007\/978-3-319-92387-1_7"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1476-5381.1965.tb02091.x","article-title":"A bradykinin-potentiating factor BPF present in the venom of Bothrops jararaca","volume":"24","author":"Ferreira","year":"1965","journal-title":"Br. J. Pharmacol. Chemother."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.toxicon.2011.07.013","article-title":"Bradykinin-potentiating peptides: Beyond captopril","volume":"59","author":"Camargo","year":"2012","journal-title":"Toxicon"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Boldrini-Fran\u00e7a, J., Pinheiro-Junior, E.L., Peigneur, S., Pucca, M.B., Cerni, F.A., Borges, R.J., Costa, T.R., Carone, S.E.I., Fontes, M.R.D.M., and Sampaio, S.V. (2020). Beyond hemostasis: A snake venom serine protease with potassium channel blocking and potential antitumor activities. Sci. Rep., 10.","DOI":"10.1038\/s41598-020-61258-x"},{"key":"ref_150","unstructured":"USPTO (2024, March 06). Cooperative Patent Classification\u2014CPC, Available online: https:\/\/www.uspto.gov\/web\/patents\/classification\/cpc\/html\/cpc.html."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Oliveira, \u00c1.S., Fantinel, A.L., Artuzo, F.D., Oliveira, L., Singer, R.B., da Frota J\u00fanior, M.L.C., Dewes, H., and Talamini, E. (2021). Applications of venom biodiversity in agriculture. EFB Bioecon. J., 1.","DOI":"10.1016\/j.bioeco.2021.100010"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0140-6736(09)61754-2","article-title":"Snake Bite","volume":"375","author":"Warrell","year":"2010","journal-title":"Lancet"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/vr.g1178","article-title":"Snake antivenom trial","volume":"174","author":"Bolton","year":"2014","journal-title":"Vet. 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