{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:41:26Z","timestamp":1791376886090,"version":"4.3.2"},"reference-count":155,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education Industry-University-Research Cooperation Collaborative Education Project","award":["230906291250446"],"award-info":[{"award-number":["230906291250446"]}]},{"name":"Ministry of Education Industry-University-Research Cooperation Collaborative Education Project","award":["Yz2022296"],"award-info":[{"award-number":["Yz2022296"]}]},{"name":"Hubei Province Higher Education Institutions Undergraduate Innovation and Entrepreneurship Training Program Project","award":["230906291250446"],"award-info":[{"award-number":["230906291250446"]}]},{"name":"Hubei Province Higher Education Institutions Undergraduate Innovation and Entrepreneurship Training Program Project","award":["Yz2022296"],"award-info":[{"award-number":["Yz2022296"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Artesunate (ART), an artemisinin-derived semi-synthetic sesquiterpene lactone distinguished by its unique endoperoxide group, has become a cornerstone of clinical antimalarial therapy. Recent research has demonstrated its broad pharmacological profile, including its potent antimalarial, anti-inflammatory, anti-tumor, antidiabetic, immunomodulatory, and anti-fibrotic properties. These discoveries have significantly broadened the therapeutic scope of ART and offer new perspectives for its potential use in treating gastrointestinal disorders. Mechanistically, ART exerts significant therapeutic effects against diverse gastrointestinal pathologies\u2014such as gastric ulcers, ulcerative colitis (UC), hepatic fibrosis (HF), gastric cancer, hepatocellular carcinoma, and colorectal cancer\u2014via multimodal mechanisms, including cell cycle modulation, apoptosis induction, the suppression of tumor cell invasion and migration, proliferation inhibition, ferroptosis activation, and immune regulation. This review evaluates existing evidence on ART\u2019s therapeutic applications and molecular mechanisms in digestive diseases, intending to elucidate its clinical translation potential. ART emerges as a promising multi-target agent with significant prospects for improving the management of gastrointestinal disorders.<\/jats:p>","DOI":"10.3390\/pharmaceutics17030299","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T03:40:12Z","timestamp":1740454812000},"page":"299","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Artesunate: A Review of Its Potential Therapeutic Effects and Mechanisms in Digestive Diseases"],"prefix":"10.3390","volume":"17","author":[{"given":"Mengting","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Pharmacology, The School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou 434023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, The School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou 434023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiulan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, The School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou 434023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1053\/j.gastro.2023.05.050","article-title":"Global Burden of Digestive Diseases: A Systematic Analysis of the Global Burden of Diseases Study, 1990 to 2019","volume":"165","author":"Wang","year":"2023","journal-title":"Gastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1136\/gutjnl-2024-333227","article-title":"Epidemiology of Gastrointestinal Cancers: A Systematic Analysis from the Global Burden of Disease Study 2021","volume":"74","author":"Danpanichkul","year":"2024","journal-title":"Gut"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/JS9.0000000000001902","article-title":"The Global, Regional, and National Patterns of Change in the Burden of Non-Malignant Upper Gastrointestinal Diseases from 1990 to 2019 and the Forecast for the next Decade","volume":"111","author":"Bai","year":"2024","journal-title":"Int. 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