{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T01:15:12Z","timestamp":1778980512230,"version":"3.51.4"},"reference-count":40,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T00:00:00Z","timestamp":1743379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guilin Technology and Application Promotion Plan","award":["No. 20210227-3"],"award-info":[{"award-number":["No. 20210227-3"]}]},{"name":"Guilin Technology and Application Promotion Plan","award":["No. JGY2022205"],"award-info":[{"award-number":["No. JGY2022205"]}]},{"name":"Guilin Technology and Application Promotion Plan","award":["GUI Ke ZY20198002"],"award-info":[{"award-number":["GUI Ke ZY20198002"]}]},{"name":"Guilin Technology and Application Promotion Plan","award":["No. 2024ZZKT001"],"award-info":[{"award-number":["No. 2024ZZKT001"]}]},{"name":"Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation","award":["No. 20210227-3"],"award-info":[{"award-number":["No. 20210227-3"]}]},{"name":"Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation","award":["No. JGY2022205"],"award-info":[{"award-number":["No. JGY2022205"]}]},{"name":"Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation","award":["GUI Ke ZY20198002"],"award-info":[{"award-number":["GUI Ke ZY20198002"]}]},{"name":"Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation","award":["No. 2024ZZKT001"],"award-info":[{"award-number":["No. 2024ZZKT001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Prostate cancer (PCa) is the second most prevalent cancer in males globally, impacting one out of every six males. However, the therapeutic effect of chemotherapy on PCa is restricted. Methods: To address this, we developed a tumor-targeted multifunctional liposomal platform (PTX-PS\/Zn@Lip-Apt) for zinc-enhanced chemo-photodynamic therapy of PCa. Co-delivery of PTX and an aggregation-induced emission photosensitizer (TPEDPD) enables combined chemotherapy and photody-namic therapy. Zinc ions were loaded into liposomes to improve the chemosensitivity of PCa to chemodrugs. Then, the AS1411 aptamer was further modified onto the sur-face of the liposome to enhance its tumor targeting ability. Moreover, to improve the cellular uptake efficiency of the nanoparticles, the photochemical internalization (PCI) strategy was also employed. Results: In vitro experiments indicated that aptamer conjugation and PCI application enhanced the cellular uptake and cytotoxicity of PTX\/PS-Zn@Lip-Apt. The zinc ion enhanced cytotoxicity could also be found. In vivo experiments demonstrated the good antitumor effect and biosafety of PTX\/PS-Zn@Lip-Apt. Conclusions: Our findings provide an important basis for innovatively applying zinc-enhanced combined chemo-photodynamic therapy in prostate cancer.<\/jats:p>","DOI":"10.3390\/pharmaceutics17040448","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T04:21:01Z","timestamp":1743481261000},"page":"448","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prostate Cancer-Targeting Liposome Loaded with Zinc Ion-Coordinated Photosensitizer for Enhanced Chemo-Photodynamic Therapy"],"prefix":"10.3390","volume":"17","author":[{"given":"Li","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau 999078, China"},{"name":"College of Pharmacy, Guilin Medical University, Guilin 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhisheng","family":"Tang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital, Guilin Medical University, Guilin 541199, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongming","family":"Xiao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guilin Medical University, Guilin 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guilin Medical University, Guilin 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7700-8041","authenticated-orcid":false,"given":"Yizhun","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau 999078, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. 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