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Photonics)","award":["8887.820460\/2023-00"],"award-info":[{"award-number":["8887.820460\/2023-00"]}]},{"name":"INCT-INFO (National Institute of Photonics)","award":["2023\/11853\u20136"],"award-info":[{"award-number":["2023\/11853\u20136"]}]},{"name":"INCT-INFO (National Institute of Photonics)","award":["GURI-M2303930"],"award-info":[{"award-number":["GURI-M2303930"]}]},{"name":"INCT-INFO (National Institute of Photonics)","award":["CPRIT-RR220054"],"award-info":[{"award-number":["CPRIT-RR220054"]}]},{"name":"INCT-INFO (National Institute of Photonics)","award":["CRI-29034"],"award-info":[{"award-number":["CRI-29034"]}]},{"name":"INCT-INFO (National Institute of Photonics)","award":["201810267001556"],"award-info":[{"award-number":["201810267001556"]}]},{"name":"INCT-INFO (National Institute of Photonics)","award":["2021\/11965-3"],"award-info":[{"award-number":["2021\/11965-3"]}]},{"name":"INCT-INFO (National Institute of Photonics)","award":["2017\/50334-3"],"award-info":[{"award-number":["2017\/50334-3"]}]},{"name":"INCT-INFO (National Institute of Photonics)","award":["309614\/2021-0"],"award-info":[{"award-number":["309614\/2021-0"]}]},{"name":"INCT-INFO (National Institute of Photonics)","award":["406973\/2022-9"],"award-info":[{"award-number":["406973\/2022-9"]}]},{"name":"INCT-INFO (National Institute of Photonics)","award":["406925\/2022-4"],"award-info":[{"award-number":["406925\/2022-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Viral diseases including dengue, zika, chikungunya, and yellow fever remain a significant public health challenge, primarily due to the increasing resistance of these vectors, the Aedes aegypti mosquito, to conventional control methods. Objectives: Herein, a microencapsulated curcumin formulation was developed and characterized using spray-drying technology, with D-mannitol and starch as encapsulating agents. After microencapsulation, photolarvicidal tablet formulations (Formulated Curcumin Tablets\u2014FCT) were prepared, varying the proportions of starch and pectin: FCT1 (60% starch), FCT2 (35% pectin and 25% starch), and FCT3 (42.5% pectin and 17.5% starch), while maintaining 10% curcumin and 30% D-mannitol in all formulations. The main goal was to enhance the stability and efficacy of curcumin as a photolarvicidal agent. Methods: The formulation was characterized by UV-Vis spectroscopy, confocal microscopy, thermal analysis (TG and DSC), scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), and photodegradation assays under fluorescent light. Results: The photodynamic inactivation (PDI) of Ae. aegypti larvae was evaluated under white, fluorescent light exposure, and the formulation exhibited a significantly enhanced larvicidal activity compared to free curcumin, with a 57-fold reduction in LC50 (LC50-24h = 0.27 mg\/L). Additionally, the most effective formulation, FCT2, maintained its residual activity for 27 days, reinforcing that curcumin microencapsulation, combined with PDI, can extend vector control. Release studies under different pH conditions confirmed a controlled release mechanism, favoring environmental stability. Conclusions: The results indicate that microencapsulated curcumin has great potential as a sustainable photoinsecticidal agent, offering stability, efficacy, and a promising alternative for managing Ae. aegypti larval populations.<\/jats:p>","DOI":"10.3390\/pharmaceutics17040496","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T07:49:02Z","timestamp":1744184942000},"page":"496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Curcumin Microcapsule Formulations for Prolong Persistence in the Photodynamic Inactivation of Aedes aegypti Larvae"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9055-205X","authenticated-orcid":false,"given":"Matheus","family":"Garbuio","sequence":"first","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics (IFSC), University of S\u00e3o Paulo (USP), S\u00e3o Carlos 13566-590, SP, Brazil"},{"name":"Environmental Biophotonics Laboratory, S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, S\u00e3o Carlos 13566-590, SP, Brazil"},{"name":"PPG Biotec, Federal University of S\u00e3o Carlos, S\u00e3o Carlos 13565-905, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7884-2011","authenticated-orcid":false,"given":"Larissa","family":"Marila de Souza","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics (IFSC), University of S\u00e3o Paulo (USP), S\u00e3o Carlos 13566-590, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2858-7539","authenticated-orcid":false,"given":"Lucas Danilo","family":"Dias","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Novos Materiais, Universidade Evang\u00e9lica de Goi\u00e1s (UniEvang\u00e9lica), An\u00e1polis 75083-515, GO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Carlos","family":"Ferreira Machado","sequence":"additional","affiliation":[{"name":"Biopolymers and Biomaterials Laboratory (BioPolMat), University of Araraquara\u2014UNIARA, Araraquara 14801-320, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Mayumi","family":"Inada","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics (IFSC), University of S\u00e3o Paulo (USP), S\u00e3o Carlos 13566-590, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hernane da Silva","family":"Barud","sequence":"additional","affiliation":[{"name":"Biopolymers and Biomaterials Laboratory (BioPolMat), University of Araraquara\u2014UNIARA, Araraquara 14801-320, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1446-723X","authenticated-orcid":false,"given":"Edgar Aparecido","family":"Sanches","sequence":"additional","affiliation":[{"name":"Laboratory of Nanostructured Polymers (NANOPOL), Federal University of Amazonas (UFAM), Manaus 69080-005, AM, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Eduardo Gontijo","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics (IFSC), University of S\u00e3o Paulo (USP), S\u00e3o Carlos 13566-590, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"da Silva","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics (IFSC), University of S\u00e3o Paulo (USP), S\u00e3o Carlos 13566-590, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra Ramos","family":"Lima","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics (IFSC), University of S\u00e3o Paulo (USP), S\u00e3o Carlos 13566-590, SP, Brazil"},{"name":"Environmental Biophotonics Laboratory, S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, S\u00e3o Carlos 13566-590, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4833-239X","authenticated-orcid":false,"given":"Vanderlei Salvador","family":"Bagnato","sequence":"additional","affiliation":[{"name":"S\u00e3o Carlos Institute of Physics (IFSC), University of S\u00e3o Paulo (USP), S\u00e3o Carlos 13566-590, SP, Brazil"},{"name":"Environmental Biophotonics Laboratory, S\u00e3o Carlos Institute of Physics, University of S\u00e3o Paulo, S\u00e3o Carlos 13566-590, SP, Brazil"},{"name":"Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1590\/s1518-8787.2017051006889","article-title":"Arboviruses emerging in Brazil: Challenges for clinic and implications for public health","volume":"51","author":"Donalisio","year":"2017","journal-title":"Rev. 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