{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:54:44Z","timestamp":1792184084834,"version":"4.4.0"},"reference-count":189,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Alopecia is a concerning dermatological issue and is also known as alopecia. This disease can affect men and women, influencing their confidence and appearance. It targets the scalp or any area of the entire body. Alopecia has become widespread worldwide over the years and has many types and different causes: hereditary, hormonal, immunological, therapeutic, or psychological. This review will present a comprehensive study of the physiological structure of hair and the different growth and shedding phases. It discusses using nano-drug delivery systems that contain natural substances of plant origin, which are effective, less harmful compared to current treatments, and help avoid adverse effects. This review also covers the latest trends in treating alopecia, including drug delivery systems, the materials and methods used to prepare these systems, three-dimensional (3D) bioprinting strategies, and plant extracts that may be utilized for treatment in the coming years.<\/jats:p>","DOI":"10.3390\/pharmaceutics17050584","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:28:11Z","timestamp":1746174491000},"page":"584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Future of Alopecia Treatment: Plant Extracts, Nanocarriers, and 3D Bioprinting in Focus"],"prefix":"10.3390","volume":"17","author":[{"given":"Rana E.","family":"Elnady","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Sinai University\u2014Arish Branch, Arish 45511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar S.","family":"Abdon","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Sinai University\u2014Arish Branch, Arish 45511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagar R.","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Sinai University\u2014Arish Branch, Arish 45511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem M.","family":"Eladawy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University\u2014Arish Branch, Arish 45511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmena O.","family":"Azar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Sinai University\u2014Arish Branch, Arish 45511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seham M.","family":"Al Raish","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, United Arab Emirates University, Al Ain 15551, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41580-023-00662-3","article-title":"Local and systemic mechanisms that control the hair follicle stem cell niche","volume":"25","author":"Zhang","year":"2023","journal-title":"Nat. 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