{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:08:07Z","timestamp":1792202887032,"version":"4.4.0"},"reference-count":202,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shaanxi Province, the second batch of Chinese medicine technology backbone talent project","award":["2023-ZQNY-007"],"award-info":[{"award-number":["2023-ZQNY-007"]}]},{"name":"Shaanxi Province, the second batch of Chinese medicine technology backbone talent project","award":["2024SF-YBXM-530"],"award-info":[{"award-number":["2024SF-YBXM-530"]}]},{"name":"Shaanxi Province, the second batch of Chinese medicine technology backbone talent project","award":["SZY-KJCYC-2025-JC-042"],"award-info":[{"award-number":["SZY-KJCYC-2025-JC-042"]}]},{"name":"Shaanxi Provincial Key R&amp;D Program General Project","award":["2023-ZQNY-007"],"award-info":[{"award-number":["2023-ZQNY-007"]}]},{"name":"Shaanxi Provincial Key R&amp;D Program General Project","award":["2024SF-YBXM-530"],"award-info":[{"award-number":["2024SF-YBXM-530"]}]},{"name":"Shaanxi Provincial Key R&amp;D Program General Project","award":["SZY-KJCYC-2025-JC-042"],"award-info":[{"award-number":["SZY-KJCYC-2025-JC-042"]}]},{"name":"Shaanxi Provincial Administration of Traditional Chinese Medicine Research Project","award":["2023-ZQNY-007"],"award-info":[{"award-number":["2023-ZQNY-007"]}]},{"name":"Shaanxi Provincial Administration of Traditional Chinese Medicine Research Project","award":["2024SF-YBXM-530"],"award-info":[{"award-number":["2024SF-YBXM-530"]}]},{"name":"Shaanxi Provincial Administration of Traditional Chinese Medicine Research Project","award":["SZY-KJCYC-2025-JC-042"],"award-info":[{"award-number":["SZY-KJCYC-2025-JC-042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Natural products derived from traditional Chinese medicine have received significant attention as potential treatments for neurodegenerative disorders due to their wide availability, demonstrated efficacy, and favorable safety profiles. Intranasal delivery provides distinct advantages for targeting the central nervous system (CNS), enabling direct therapeutic agent delivery to the brain by bypassing the blood-brain barrier (BBB). This review evaluates natural products administered intranasally for neurodegenerative diseases (NDs), highlighting their therapeutic potential and addressing formulation challenges related to physicochemical properties. Strategic optimization approaches are proposed, including novel carrier systems, molecular modifications, and combination therapies. By discussing current difficulties and offering practical recommendations, this review aims to encourage further scholarly research and clinical application.<\/jats:p>","DOI":"10.3390\/pharmaceutics17050675","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T11:50:31Z","timestamp":1747741831000},"page":"675","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Application of Natural Products in Neurodegenerative Diseases by Intranasal Administration: A Review"],"prefix":"10.3390","volume":"17","author":[{"given":"Yu","family":"Jin","sequence":"first","affiliation":[{"name":"Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Ma","sequence":"additional","affiliation":[{"name":"Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Liu","sequence":"additional","affiliation":[{"name":"Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zong","sequence":"additional","affiliation":[{"name":"Key Laboratory of TCM Drug Delivery, Shaanxi Academy of Traditional Chinese Medicine, Xi\u2019an 710001, China"},{"name":"Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi\u2019an 710001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of TCM Drug Delivery, Shaanxi Academy of Traditional Chinese Medicine, Xi\u2019an 710001, China"},{"name":"Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi\u2019an 710001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang 712046, China"},{"name":"Key Laboratory of TCM Drug Delivery, Shaanxi Academy of Traditional Chinese Medicine, Xi\u2019an 710001, China"},{"name":"Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi\u2019an 710001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunliu","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of TCM Drug Delivery, Shaanxi Academy of Traditional Chinese Medicine, Xi\u2019an 710001, China"},{"name":"Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi\u2019an 710001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5537-4569","authenticated-orcid":false,"given":"Ye","family":"Li","sequence":"additional","affiliation":[{"name":"Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang 712046, China"},{"name":"Key Laboratory of TCM Drug Delivery, Shaanxi Academy of Traditional Chinese Medicine, Xi\u2019an 710001, China"},{"name":"Institute of Traditional Chinese Medicine, Shaanxi Academy of Traditional Chinese Medicine, Xi\u2019an 710001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"ref_1","first-page":"289","article-title":"Preclinical progression of neurodegenerative diseases","volume":"80","author":"Katsuno","year":"2018","journal-title":"Nagoya J. 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