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Traditional therapeutic approaches, including oral administration and injections, continue to exhibit inherent limitations. Consequently, there is growing interest in exploring alternative drug delivery systems that offer more effective, targeted, and patient-friendly therapeutic options. Transdermal administration emerges as a promising solution for managing inflammatory skin diseases, facilitating sustained drug release, and reducing the frequency of dosing. This review provides a comprehensive overview of the skin barrier and critically summarizes clinically adopted transdermal drug delivery systems (TDDSs), including sonophoresis, iontophoresis, chemical penetration enhancers, and electroporation. Particular emphasis is placed on emerging advances in microneedle- and nanocarrier-facilitated transdermal delivery strategies. Moreover, the article synthesizes recent fundamental evidence regarding the application of TDDSs in the treatment of atopic dermatitis, psoriasis, and acne. This review examines fundamental research evaluating various transdermal drug delivery systems for the treatment of major inflammatory skin diseases, with an emphasis on their mechanisms of action, advantages, challenges, and future directions. Transdermal drug delivery systems hold the potential to deliver more efficient and safer treatment and management strategies for patients afflicted with inflammatory skin diseases.<\/jats:p>","DOI":"10.3390\/pharmaceutics17060746","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T03:52:28Z","timestamp":1749181948000},"page":"746","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Advances in Transdermal Drug Delivery Systems and Clinical Applications in Inflammatory Skin Diseases"],"prefix":"10.3390","volume":"17","author":[{"given":"Sizhuo","family":"Liu","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2331-5780","authenticated-orcid":false,"given":"Tinghan","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Hospital of Sichuan Province, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-8682","authenticated-orcid":false,"given":"Jun","family":"Lu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Wu","sequence":"additional","affiliation":[{"name":"Traditional Chinese Medicine Hospital of Sichuan Province, Chengdu 610072, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0169-409X(01)00158-2","article-title":"Veterinary Drug Delivery: Potential for Skin Penetration Enhancement","volume":"50","author":"Magnusson","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.7150\/thno.69999","article-title":"Advanced Nanocarrier- and Microneedle-Based Transdermal Drug Delivery Strategies for Skin Diseases Treatment","volume":"12","author":"Qu","year":"2022","journal-title":"Theranostics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jconrel.2022.09.025","article-title":"Overcoming Skin Barriers through Advanced Transdermal Drug Delivery Approaches","volume":"351","author":"Phatale","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s13346-021-00909-6","article-title":"Enhancement Strategies for Transdermal Drug Delivery Systems: Current Trends and Applications","volume":"12","author":"Ramadon","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jconrel.2021.11.025","article-title":"Recent Advances in Polymeric Transdermal Drug Delivery Systems","volume":"341","author":"Sabbagh","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1517\/17425247.2014.875528","article-title":"Skin Permeabilization for Transdermal Drug Delivery: Recent Advances and Future Prospects","volume":"11","author":"Schoellhammer","year":"2014","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic Dermatitis","volume":"387","author":"Weidinger","year":"2016","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/jdv.13854","article-title":"A Systematic Review of Worldwide Epidemiology of Psoriasis","volume":"31","author":"Michalek","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bjd.13462","article-title":"A Global Perspective on the Epidemiology of Acne","volume":"172","author":"Tan","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1001\/jamadermatol.2016.5538","article-title":"Global Skin Disease Morbidity and Mortality: An Update from the Global Burden of Disease Study 2013","volume":"153","author":"Karimkhani","year":"2017","journal-title":"JAMA Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta19860","article-title":"Educational Interventions to Improve Quality of Life in People with Chronic Inflammatory Skin Diseases: Systematic Reviews of Clinical Effectiveness and Cost-Effectiveness","volume":"19","author":"Pickett","year":"2015","journal-title":"Health Technol. Assess."},{"key":"ref_12","first-page":"92","article-title":"Diagnostic Cost-Effectiveness of the Skin Biopsy in Inflammatory Diseases of the Skin","volume":"96","author":"Acosta","year":"2005","journal-title":"Actas Dermosifiliogr."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Guo, J.-W., and Jee, S.-H. (2021). Strategies to Develop a Suitable Formulation for Inflammatory Skin Disease Treatment. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116078"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"125118","DOI":"10.1016\/j.ijpharm.2024.125118","article-title":"Advanced Transdermal Drug Delivery System: A Comprehensive Review of Microneedle Technologies, Novel Designs, Diverse Applications, and Critical Challenges","volume":"670","author":"Nguyen","year":"2025","journal-title":"Int. J. Pharm."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.actbio.2020.12.004","article-title":"Microneedle-Mediated Transdermal Drug Delivery for Treating Diverse Skin Diseases","volume":"121","author":"Yang","year":"2021","journal-title":"Acta Biomater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jconrel.2020.09.016","article-title":"Recent Trends, Challenges and Future Outlook of Transdermal Drug Delivery Systems for Rheumatoid Arthritis Therapy","volume":"327","author":"Qindeel","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Xu, P., Xiao, W., Xu, K., He, Y., Miao, X., Dong, Y., and Sun, L. (2024). Potential Strategy of Microneedle-Based Transdermal Drug Delivery System for Effective Management of Skin-Related Immune Disorders. Eur. J. Pharm. Biopharm., 195.","DOI":"10.1016\/j.ejpb.2023.11.013"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2478\/acph-2019-0016","article-title":"Transdermal Patches: Design and Current Approaches to Painless Drug Delivery","volume":"69","author":"Khan","year":"2019","journal-title":"Acta Pharm."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wong, W.F., Ang, K.P., Sethi, G., and Looi, C.Y. (2023). Recent Advancement of Medical Patch for Transdermal Drug Delivery. Medicina, 59.","DOI":"10.3390\/medicina59040778"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/jphp.12334","article-title":"Essential Oils and Their Constituents as Skin Penetration Enhancer for Transdermal Drug Delivery: A Review","volume":"67","author":"Herman","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Bajza, \u00c1., Kocsis, D., Berezvai, O., Laki, A.J., Luk\u00e1cs, B., Imre, T., Iv\u00e1n, K., Szab\u00f3, P., and Erd\u0151, F. (2020). Verification of P-Glycoprotein Function at the Dermal Barrier in Diffusion Cells and Dynamic \u201cSkin-on-a-Chip\u201d Microfluidic Device. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12090804"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"31","DOI":"10.15171\/apb.2016.06","article-title":"The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study","volume":"6","author":"Ghanbarzadeh","year":"2016","journal-title":"Adv. Pharm. Bull."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000351940","article-title":"Drug Delivery with Topically Applied Nanoparticles: Science Fiction or Reality?","volume":"26","author":"Lademann","year":"2013","journal-title":"Skin Pharmacol. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.addr.2011.01.012","article-title":"Nanoparticles and Microparticles for Skin Drug Delivery","volume":"63","author":"Prow","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Gorzelanny, C., Mess, C., Schneider, S.W., Huck, V., and Brandner, J.M. (2020). Skin Barriers in Dermal Drug Delivery: Which Barriers Have to Be Overcome and How Can We Measure Them?. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12070684"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/srt.12968","article-title":"Methods for Evaluating Penetration of Drug into the Skin: A Review","volume":"27","author":"Supe","year":"2021","journal-title":"Skin Res. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/pharmaceutics7030090","article-title":"Transdermal Delivery of Drugs with Microneedles\u2014Potential and Challenges","volume":"7","author":"Ita","year":"2015","journal-title":"Pharmaceutics"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Honari, G., Andersen, R.M., and Maibach, H. (2017). Skin Structure and Function. Sensitive Skin Syndrome, CRC Press.","DOI":"10.1201\/9781315121048"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1002\/biot.201600081","article-title":"Solid-in-oil Nanodispersions for Transdermal Drug Delivery Systems","volume":"11","author":"Kitaoka","year":"2016","journal-title":"Biotechnol. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/exd.12579","article-title":"An Ex Vivo Human Skin Model for Studying Skin Barrier Repair","volume":"24","author":"Danso","year":"2015","journal-title":"Exp. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1606596","DOI":"10.1002\/adma.201606596","article-title":"Getting Drugs across Biological Barriers","volume":"29","author":"Yang","year":"2017","journal-title":"Adv. Mater."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.5021\/ad.2018.30.2.258","article-title":"Basement Membrane Status Is Intact in Urticarial Dermatitis vs. Adult-Onset Atopic Dermatitis","volume":"30","author":"Kim","year":"2018","journal-title":"Ann. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1517\/17425247.2016.1136286","article-title":"Heat Effects on Drug Delivery across Human Skin","volume":"13","author":"Hao","year":"2016","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1526-4637.2000.00030.x","article-title":"Assessing the Impact of Heat on the Systemic Delivery of Fentanyl through the Transdermal Fentanyl Delivery System","volume":"1","author":"Shomaker","year":"2000","journal-title":"Pain Med."},{"key":"ref_35","first-page":"236","article-title":"Effect of Local Controlled Heat on Transdermal Delivery of Nicotine","volume":"3","author":"Petersen","year":"2011","journal-title":"Int. J. Physiol. Pathophysiol. Pharmacol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1461-5347(00)00295-9","article-title":"Transdermal Drug Delivery: Overcoming the Skin\u2019s Barrier Function","volume":"3","author":"Naik","year":"2000","journal-title":"Pharm. Sci. Technol. Today"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Stefanov, S.R., and Andonova, V.Y. (2021). Lipid Nanoparticulate Drug Delivery Systems: Recent Advances in the Treatment of Skin Disorders. Pharmaceuticals, 14.","DOI":"10.3390\/ph14111083"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s40290-024-00537-8","article-title":"Transdermal Drug Delivery Systems: Different Generations and Dermatokinetic Assessment of Drug Concentration in Skin","volume":"38","author":"Kushwaha","year":"2024","journal-title":"Pharm. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"100225","DOI":"10.1016\/j.xjidi.2023.100225","article-title":"Evolution of Transdermal Drug Delivery Devices and Novel Microneedle Technologies: A Historical Perspective and Review","volume":"3","author":"Joshi","year":"2023","journal-title":"JID Innov."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Uchida, N., Yanagi, M., and Hamada, H. (2021). Physical Enhancement? Nanocarrier? Current Progress in Transdermal Drug Delivery. Nanomaterials, 11.","DOI":"10.3390\/nano11020335"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1002\/dmrr.210","article-title":"Glucose Monitoring by Reverse Iontophoresis","volume":"18","author":"Potts","year":"2002","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S1359-6446(04)03170-8","article-title":"Ultrasound and Transdermal Drug Delivery","volume":"9","author":"Lavon","year":"2004","journal-title":"Drug Discov. Today"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.17305\/bjbms.2004.3410","article-title":"Sonophoresis-Mechanisms and Application","volume":"4","year":"2008","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ultras.2013.07.007","article-title":"Sonophoresis in Transdermal Drug Deliverys","volume":"54","author":"Park","year":"2014","journal-title":"Ultrasonics"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1016\/j.ultrasmedbio.2021.06.005","article-title":"Advances in Biological Application of and Research on Low-Frequency Ultrasound","volume":"47","author":"Mei","year":"2021","journal-title":"Ultrasound Med. Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1213\/01.ANE.0000099716.02783.C4","article-title":"Rapid Onset of Cutaneous Anesthesia with EMLA Cream after Pretreatment with a New Ultrasound-Emitting Device","volume":"98","author":"Katz","year":"2004","journal-title":"Anesth. Analg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/17425247.2020.1723543","article-title":"Novel Drug Delivery Approaches for the Management of Hair Loss","volume":"17","author":"Alsalhi","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1247450","DOI":"10.1155\/2024\/1247450","article-title":"Low-frequency Sonophoresis: A Promising Strategy for Enhanced Transdermal Delivery","volume":"2024","author":"Marathe","year":"2024","journal-title":"Adv. Pharmacol. Pharm. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1021\/js970023k","article-title":"Effect of Penetration Enhancers and Iontophoresis on the Ultrastructure and Cholecystokinin-8 Permeability through Porcine Skin","volume":"86","author":"Bhatia","year":"1997","journal-title":"J. Pharm. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Berner, B., and Dinh, S.M. (2019). Iontophoresis of Peptides. Electronically Controlled Drug Delivery, CRC Press.","DOI":"10.1201\/9780429262838"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0378-5173(89)90152-X","article-title":"Examination of Iontophoretic Transport of Ionic Drugs across Skin: Baseline Studies with the Four-Electrode System","volume":"49","author":"Masada","year":"1989","journal-title":"Int. J. Pharm."},{"key":"ref_52","first-page":"1","article-title":"Iontophoresis\u2014An Approach for Controlled Drug Delivery: A Review","volume":"4","author":"Dixit","year":"2007","journal-title":"Curr. Drug Deliv."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jconrel.2017.01.017","article-title":"Time Dependence of the Enhancement Effect of Chemical Enhancers: Molecular Mechanisms of Enhancing Kinetics","volume":"248","author":"Liu","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1517\/17425247.2016.1130034","article-title":"Future of the Transdermal Drug Delivery Market\u2014Have We Barely Touched the Surface?","volume":"13","author":"Watkinson","year":"2016","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jconrel.2017.03.023","article-title":"Assessment of Penetration Potential of pH Responsive Double Walled Biodegradable Nanogels Coated with Eucalyptus Oil for the Controlled Delivery of 5-Fluorouracil: In Vitro and Ex Vivo Studies","volume":"253","author":"Sahu","year":"2017","journal-title":"J. Control. Release"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.jconrel.2013.02.011","article-title":"Co-Encapsulating Nanostructured Lipid Carriers for Transdermal Application: From Experimental Design to the Molecular Detail","volume":"167","author":"Vitorino","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.2174\/1381612821666150428124406","article-title":"Breaking the Skin Barrier: Achievements and Future Directions","volume":"21","author":"Zhang","year":"2015","journal-title":"Curr. Pharm. Des."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jare.2014.01.006","article-title":"A Statistical Experimental Design Approach to Evaluate the Influence of Various Penetration Enhancers on Transdermal Drug Delivery of Buprenorphine","volume":"6","author":"Taghizadeh","year":"2015","journal-title":"J. Adv. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1007\/s13346-021-01044-y","article-title":"Molecular Perspective of Efficiency and Safety Problems of Chemical Enhancers: Bottlenecks and Recent Advances","volume":"12","author":"Zeng","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"105410","DOI":"10.1016\/j.ejps.2020.105410","article-title":"Electroporation-Enhanced Transdermal Drug Delivery: Effects of logP, pKa, Solubility and Penetration Time","volume":"151","author":"Chen","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Tsoneva, I., Semkova, S., Bakalova, R., Zhelev, Z., Nuss, P., Staneva, G., and Nikolova, B. (2022). Electroporation, Electrochemotherapy and Electro-Assisted Drug Delivery in Cancer: A State-of-the-Art Review. Biophys. Chem., 286.","DOI":"10.1016\/j.bpc.2022.106819"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jconrel.2014.04.045","article-title":"Electrical, Magnetic, Photomechanical and Cavitational Waves to Overcome Skin Barrier for Transdermal Drug Delivery","volume":"193","author":"Wong","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/jps.20016","article-title":"Temperature Influences the Postelectroporation Permeability State of the Skin","volume":"93","author":"Sen","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2174\/187221109788452285","article-title":"Enhanced Transdermal Drug Delivery Techniques: An Extensive Review of Patents","volume":"3","author":"Rizwan","year":"2009","journal-title":"Recent Pat. Drug Deliv. Formul."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/10717541003667798","article-title":"Microneedle-Based Drug Delivery Systems: Microfabrication, Drug Delivery, and Safety","volume":"17","author":"Donnelly","year":"2010","journal-title":"Drug Deliv."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2147\/CCID.S142450","article-title":"Review of Applications of Microneedling in Dermatology","volume":"10","author":"Iriarte","year":"2017","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/DSS.0000000000001340","article-title":"Residual Squamous Cell Carcinoma After Shave Biopsy in Solid Organ Transplant Recipients","volume":"44","author":"Ilyas","year":"2018","journal-title":"Dermatol. Surg."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4103\/2229-5178.185494","article-title":"Vitamin E in Dermatology","volume":"7","author":"Keen","year":"2016","journal-title":"Indian Dermatol. Online J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/nbt.1504","article-title":"Transdermal Drug Delivery","volume":"26","author":"Prausnitz","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.addr.2012.04.005","article-title":"Microneedles for Drug and Vaccine Delivery","volume":"64","author":"Kim","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1002\/adfm.201200864","article-title":"Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery","volume":"22","author":"Donnelly","year":"2012","journal-title":"Adv. Funct. Mater."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1021\/js980042+","article-title":"Microfabricated Microneedles: A Novel Approach to Transdermal Drug Delivery","volume":"87","author":"Henry","year":"1998","journal-title":"J. Pharm. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"S-11","DOI":"10.1089\/dia.2009.0002","article-title":"A Tale of Two Compartments: Interstitial Versus Blood Glucose Monitoring","volume":"11","author":"Cengiz","year":"2009","journal-title":"Diabetes Technol. Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jconrel.2011.05.021","article-title":"Kinetics of Skin Resealing after Insertion of Microneedles in Human Subjects","volume":"154","author":"Gupta","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Vinayakumar, K.B., Hegde, G.M., Ramachandra, S.G., Nayak, M.M., Dinesh, N.S., and Rajanna, K. (2015). Development of Cup Shaped Microneedle Array for Transdermal Drug Delivery. Biointerphases, 10.","DOI":"10.1116\/1.4919779"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"40377","DOI":"10.1002\/app.40377","article-title":"Microneedles from Fish Scale Biopolymer","volume":"131","author":"Olatunji","year":"2014","journal-title":"J. Appl. Polym. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ejpb.2013.10.007","article-title":"Microneedle-Assisted Delivery of Verapamil Hydrochloride and Amlodipine Besylate","volume":"86","author":"Kaur","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2174\/2210303104666141001003127","article-title":"Transdermal Delivery of Captopril and Metoprolol Tartrate with Microneedles","volume":"4","author":"Nguyen","year":"2014","journal-title":"Drug Deliv. Lett."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ejps.2014.09.011","article-title":"Investigation on Fabrication Process of Dissolving Microneedle Arrays to Improve Effective Needle Drug Distribution","volume":"66","author":"Wang","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nm.2182","article-title":"Dissolving Polymer Microneedle Patches for Influenza Vaccination","volume":"16","author":"Sullivan","year":"2010","journal-title":"Nat. Med."},{"key":"ref_81","first-page":"945","article-title":"Dissolving and Biodegradable Microneedle Technologies for Transdermal Sustained Delivery of Drug and Vaccine","volume":"2013","author":"Hong","year":"2013","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1039\/D3BM01262J","article-title":"A Transdermal Drug Delivery System Based on Dissolving Microneedles for Boron Neutron Capture Therapy of Melanoma","volume":"11","author":"Li","year":"2023","journal-title":"Biomater. Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"105749","DOI":"10.1016\/j.ejps.2021.105749","article-title":"Combination and Efficiency: Preparation of Dissolving Microneedles Array Loaded with Two Active Ingredients and Its Anti-Pigmentation Effects on Guinea Pigs","volume":"160","author":"Wang","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijpharm.2013.04.045","article-title":"Hydrogel-Forming Microneedle Arrays Exhibit Antimicrobial Properties: Potential for Enhanced Patient Safety","volume":"451","author":"Donnelly","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"119580","DOI":"10.1016\/j.ijpharm.2020.119580","article-title":"Development and Characterisation of Novel Poly (Vinyl Alcohol)\/Poly (Vinyl Pyrrolidone)-Based Hydrogel-Forming Microneedle Arrays for Enhanced and Sustained Transdermal Delivery of Methotrexate","volume":"586","author":"Tekko","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jconrel.2010.10.033","article-title":"Separable Arrowhead Microneedles","volume":"149","author":"Chu","year":"2011","journal-title":"J. Control. Release"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3109\/1061186X.2014.921926","article-title":"Smart Microneedle Coatings for Controlled Delivery and Biomedical Analysis","volume":"22","author":"Khan","year":"2014","journal-title":"J. Drug Target."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3390\/pharmaceutics7040486","article-title":"Microneedle Coating Techniques for Transdermal Drug Delivery","volume":"7","author":"Khan","year":"2015","journal-title":"Pharmaceutics"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nmat3550","article-title":"Polymer Multilayer Tattooing for Enhanced DNA Vaccination","volume":"12","author":"DeMuth","year":"2013","journal-title":"Nat. Mater."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jconrel.2008.02.009","article-title":"Improved Piercing of Microneedle Arrays in Dermatomed Human Skin by an Impact Insertion Method","volume":"128","author":"Verbaan","year":"2008","journal-title":"J. Control. Release"},{"key":"ref_91","first-page":"32","article-title":"The AdminPenTM Microneedle Device for Painless & Convenient Drug Delivery","volume":"10","author":"Yuzhakov","year":"2010","journal-title":"Drug Deliv. Technol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s10544-014-9892-y","article-title":"Fabrication of Carbon Nanotube\u2014Polyimide Composite Hollow Microneedles for Transdermal Drug Delivery","volume":"16","author":"Lyon","year":"2014","journal-title":"Biomed. Microdevices"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.3109\/10717544.2014.986309","article-title":"Microneedles for Drug Delivery: Trends and Progress","volume":"23","author":"Cheung","year":"2016","journal-title":"Drug Deliv."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jconrel.2012.01.042","article-title":"Microneedle Technologies for (Trans)Dermal Drug and Vaccine Delivery","volume":"161","author":"Jiskoot","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Kher, G., Trehan, S., and Misra, A. (2011). Antisense Oligonucleotides and RNA Interference. Challenges in Delivery of Therapeutic Genomics and Proteomics, Elsevier.","DOI":"10.1016\/B978-0-12-384964-9.00007-4"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1517\/17425247.5.9.1003","article-title":"Antibody-Modified Liposomes for Cancer Chemotherapy","volume":"5","author":"Torchilin","year":"2008","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijpharm.2005.11.006","article-title":"Increasing Bioavailability of Silymarin Using a Buccal Liposomal Delivery System: Preparation and Experimental Design Investigation","volume":"308","author":"Afifi","year":"2006","journal-title":"Int. J. Pharm."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1517\/17425247.2013.752354","article-title":"Paclitaxel Drug Delivery Systems","volume":"10","author":"Zhang","year":"2013","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Yi, H., Lu, W., Liu, F., Zhang, G., Xie, F., Liu, W., Wang, L., Zhou, W., and Cheng, Z. (2021). ROS-Responsive Liposomes with NIR Light-Triggered Doxorubicin Release for Combinatorial Therapy of Breast Cancer. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-021-00877-6"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijpharm.2006.04.023","article-title":"Evaluation of Hybrid Liposomes-Encapsulated Silymarin Regarding Physical Stability and in Vivo Performance","volume":"319","author":"Elsamaligy","year":"2006","journal-title":"Int. J. Pharm."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0169-409X(01)00105-3","article-title":"Solid Lipid Nanoparticles Production, Characterization and Applications","volume":"47","author":"Mehnert","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Luo, H., Lu, L., Liu, N., Li, Q., Yang, X., and Zhang, Z. (2021). Curcumin Loaded Sub-30 Nm Targeting Therapeutic Lipid Nanoparticles for Synergistically Blocking Nasopharyngeal Cancer Growth and Metastasis. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-021-00966-6"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"6620","DOI":"10.1039\/c3cs60036j","article-title":"Conjugated Polymer Nanoparticles: Preparation, Properties, Functionalization and Biological Applications","volume":"42","author":"Feng","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.progpolymsci.2011.01.001","article-title":"Polymer Nanoparticles: Preparation Techniques and Size-Control Parameters","volume":"36","author":"Rao","year":"2011","journal-title":"Prog. Polym. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Cai, X., Wang, K.-N., Ma, W., Yang, Y., Chen, G., Fu, H., Cui, C., Yu, Z., and Wang, X. (2021). Multifunctional AIE Iridium (III) Photosensitizer Nanoparticles for Two-Photon-Activated Imaging and Mitochondria Targeting Photodynamic Therapy. J. Nanobiotechnol., 19.","DOI":"10.1186\/s12951-021-01001-4"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.addr.2021.04.005","article-title":"Polymeric Nano- and Microparticulate Drug Delivery Systems for Treatment of Biofilms","volume":"174","author":"Birk","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jconrel.2014.03.055","article-title":"Lipid and Polymer Nanoparticles for Drug Delivery to Bacterial Biofilms","volume":"190","author":"Forier","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s11095-008-9800-3","article-title":"Methods for the Preparation and Manufacture of Polymeric Nanoparticles","volume":"26","author":"Vauthier","year":"2009","journal-title":"Pharm. Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"118238","DOI":"10.1016\/j.carbpol.2021.118238","article-title":"Tacrolimus-Loaded Chitosan Nanoparticles for Enhanced Skin Deposition and Management of Plaque Psoriasis","volume":"268","author":"Fereig","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijpharm.2014.02.023","article-title":"A Novel Nano-Carrier Transdermal Gel against Inflammation","volume":"465","author":"Chaudhary","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"13351","DOI":"10.1073\/pnas.1700099114","article-title":"Molecular Characterization of Water and Surfactant AOT at Nanoemulsion Surfaces","volume":"114","author":"Hensel","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"117153","DOI":"10.1016\/j.ejmech.2024.117153","article-title":"Hydroxyl-Based Acid-Hypersensitive Acetal Ester Bond: Design, Synthesis and the Application Potential in Nanodrugs","volume":"283","author":"Wang","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"159276","DOI":"10.1016\/j.cej.2025.159276","article-title":"Dual Targeting of FR+CD44 Overexpressing Tumors by Self-Assembled Nanoparticles Quantitatively Conjugating Folic Acid-Hyaluronic Acid to the GSH-Sensitively Modified Podophyllotoxin","volume":"505","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-food-030216-025908","article-title":"Edible Nanoemulsions as Carriers of Active Ingredients: A Review","volume":"8","author":"McClements","year":"2017","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1039\/C6SM02603F","article-title":"A New Method for the Formulation of Double Nanoemulsions","volume":"13","author":"Ding","year":"2017","journal-title":"Soft Matter"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00281-015-0524-2","article-title":"The Continuing Evolution of Targeted Therapy for Inflammatory Skin Disease","volume":"38","author":"Schlapbach","year":"2016","journal-title":"Semin. Immunopathol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"84","DOI":"10.2500\/aap.2019.40.4202","article-title":"Pathophysiology of Atopic Dermatitis: Clinical Implications","volume":"40","author":"Kim","year":"2019","journal-title":"Allergy Asthma Proc."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000232305","article-title":"Retinoids, Methotrexate and Cyclosporine","volume":"Volume 38","author":"Yawalkar","year":"2009","journal-title":"Current Problems in Dermatology"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jdin.2024.09.013","article-title":"The Epidemiology of Inflammatory Skin Disease in Older Adults","volume":"18","author":"West","year":"2025","journal-title":"JAAD Int."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1001\/jamadermatol.2024.1987","article-title":"The Global Prevalence of Seborrheic Dermatitis: A Systematic Review and Meta-Analysis","volume":"160","author":"Polaskey","year":"2024","journal-title":"JAMA Dermatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/pai.12309","article-title":"Recent Advances in Epidemiology and Prevention of Atopic Eczema","volume":"25","author":"Cipriani","year":"2014","journal-title":"Pediatr. Allergy Immunol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Gao, J., Shen, X., Ko, R., Huang, C., and Shen, C. (2021). Cognitive Process of Psoriasis and Its Comorbidities: From Epidemiology to Genetics. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.735124"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1080\/09546634.2020.1724250","article-title":"Topical Treatment of Psoriasis: Questionnaire Results on Topical Therapy as Long-Term Continuous Treatment and Use on Specific Body Sites","volume":"32","author":"Hoegsberg","year":"2021","journal-title":"J. Dermatol. Treat."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.jaci.2014.08.005","article-title":"Emollient Enhancement of the Skin Barrier from Birth Offers Effective Atopic Dermatitis Prevention","volume":"134","author":"Simpson","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0140-6736(19)32984-8","article-title":"Daily Emollient during Infancy for Prevention of Eczema: The BEEP Randomised Controlled Trial","volume":"395","author":"Chalmers","year":"2020","journal-title":"Lancet"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaad.2014.03.023","article-title":"Guidelines of Care for the Management of Atopic Dermatitis","volume":"71","author":"Eichenfield","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Zhang, R., Liu, R., Liu, C., Pan, L., Qi, Y., Cheng, J., Guo, J., Jia, Y., Ding, J., and Zhang, J. (2020). A pH\/ROS Dual-Responsive and Targeting Nanotherapy for Vascular Inflammatory Diseases. Biomaterials, 230.","DOI":"10.1016\/j.biomaterials.2019.119605"},{"key":"ref_128","first-page":"734","article-title":"Diagnosis and Treatment of Acne","volume":"86","author":"Titus","year":"2012","journal-title":"Am. Fam. Physician"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3928\/0090-4481-20000101-06","article-title":"The Diagnosis and Management of Acne","volume":"29","author":"Sidbury","year":"2000","journal-title":"Pediatr. Ann."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.2165\/00003088-200342140-00005","article-title":"Transdermal Penetration of Topical Drugs Used in the Treatment of Acne","volume":"42","author":"Krautheim","year":"2003","journal-title":"Clin. Pharmacokinet."},{"key":"ref_131","first-page":"85","article-title":"Polycystic Ovaries and Herbal Remedies: A Systematic Review","volume":"27","author":"Manouchehri","year":"2022","journal-title":"JBRA Assist. Reprod."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ctim.2005.10.007","article-title":"Topical and Oral CAM in Acne: A Review of the Empirical Evidence and a Consideration of Its Context","volume":"14","author":"Magin","year":"2006","journal-title":"Complement. Ther. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/ptr.5125","article-title":"Botanical and Phytochemical Therapy of Acne: A Systematic Review","volume":"28","author":"Fisk","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00403-010-1080-1","article-title":"Definition of Treatment Goals for Moderate to Severe Psoriasis: A European Consensus","volume":"303","author":"Mrowietz","year":"2011","journal-title":"Arch. Dermatol. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/ced.13100","article-title":"HLA-Cw6-Positive Patients with Psoriasis Show Improved Response to Methotrexate Treatment","volume":"42","author":"West","year":"2017","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1067\/mjd.2001.112400","article-title":"Intermittent Short Courses of Cyclosporine Microemulsion for the Long-Term Management of Psoriasis: A 2-Year Cohort Study","volume":"44","author":"Ho","year":"2001","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1111\/j.1476-5381.2009.00559.x","article-title":"Apremilast, a cAMP Phosphodiesterase-4 Inhibitor, Demonstrates Anti-inflammatory Activity in Vitro and in a Model of Psoriasis","volume":"159","author":"Schafer","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jdermsci.2017.04.005","article-title":"The Phosphodiesterase 4 Inhibitor Apremilast Inhibits Th1 but Promotes Th17 Responses Induced by 6-Sulfo LacNAc (Slan) Dendritic Cells","volume":"87","author":"Oehrl","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1038\/sj.jid.5700859","article-title":"Dimethylfumarate Specifically Inhibits the Mitogen and Stress-Activated Kinases 1 and 2 (MSK1\/2): Possible Role for Its Anti-Psoriatic Effect","volume":"127","author":"Gesser","year":"2007","journal-title":"J. Investig. Dermatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0014-4827(88)90396-5","article-title":"Specificity in the Synergism between Retinoic Acid and EGF on the Growth of Adult Human Skin Fibroblasts","volume":"178","author":"Harper","year":"1988","journal-title":"Exp. Cell Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/332850a0","article-title":"Identification of a Second Human Retinoic Acid Receptor","volume":"332","author":"Brand","year":"1988","journal-title":"Nature"},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Rendon, A., and Sch\u00e4kel, K. (2019). Psoriasis Pathogenesis and Treatment. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20061475"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1056\/NEJMra1011040","article-title":"Filaggrin Mutations Associated with Skin and Allergic Diseases","volume":"365","author":"Irvine","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.anai.2017.11.023","article-title":"The Skin as a Target for Prevention of the Atopic March","volume":"120","author":"Lowe","year":"2018","journal-title":"Ann. Allergy. Asthma Immunol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1208\/s12249-021-02204-6","article-title":"Preparation and Evaluation of Polyvinylpyrrolidone Electrospun Nanofiber Patches of Pioglitazone for the Treatment of Atopic Dermatitis","volume":"23","author":"Obaidat","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1002\/jbm.b.34325","article-title":"Topical Film Prepared with Rhus Verniciflua Extract-Loaded Pullulan Hydrogel for Atopic Dermatitis Treatment","volume":"107","author":"Jeong","year":"2019","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Wang, W., Wat, E., Hui, P.C.L., Chan, B., Ng, F.S.F., Kan, C.-W., Wang, X., Hu, H., Wong, E.C.W., and Lau, C.B.S. (2016). Dual-Functional Transdermal Drug Delivery System with Controllable Drug Loading Based on Thermosensitive Poloxamer Hydrogel for Atopic Dermatitis Treatment. Sci. Rep., 6.","DOI":"10.1038\/srep24112"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"31645","DOI":"10.1021\/acsami.2c05952","article-title":"Conductive Microneedle Patch with Electricity-Triggered Drug Release Performance for Atopic Dermatitis Treatment","volume":"14","author":"Yang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Choi, J.-H., Song, Y.-S., Lee, H.-J., Kim, G.-C., and Hong, J.-W. (2017). The Topical Application of Low-Temperature Argon Plasma Enhances the Anti-Inflammatory Effect of Jaun-Ointment on DNCB-Induced NC\/Nga Mice. BMC Complement. Altern. Med., 17.","DOI":"10.1186\/s12906-017-1850-9"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Yang, M., Gu, Y., Yang, D., Tang, X., and Liu, J. (2017). Development of Triptolide-Nanoemulsion Gels for Percutaneous Administration: Physicochemical, Transport, Pharmacokinetic and Pharmacodynamic Characteristics. J. Nanobiotechnol., 15.","DOI":"10.1186\/s12951-017-0323-0"},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Latif, M.S., Al-Harbi, F.F., Nawaz, A., Rashid, S.A., Farid, A., Mohaini, M.A., Alsalman, A.J., Hawaj, M.A.A., and Alhashem, Y.N. (2022). Formulation and Evaluation of Hydrophilic Polymer Based Methotrexate Patches: In Vitro and in Vivo Characterization. Polymers, 14.","DOI":"10.3390\/polym14071310"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Latif, M.S., Azad, A.K., Nawaz, A., Rashid, S.A., Rahman, M.H., Al Omar, S.Y., Bungau, S.G., Aleya, L., and Abdel-Daim, M.M. (2021). Ethyl Cellulose and Hydroxypropyl Methyl Cellulose Blended Methotrexate-Loaded Transdermal Patches: In Vitro and Ex Vivo. Polymers, 13.","DOI":"10.3390\/polym13203455"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"3841","DOI":"10.2147\/IJN.S371183","article-title":"Microneedle Patch Delivery of Methotrexate-Loaded Albumin Nanoparticles to Immune Cells Achieves a Potent Antipsoriatic Effect","volume":"17","author":"Wang","year":"2022","journal-title":"Int. J. Nanomed."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.2174\/0113816128305190240718112945","article-title":"Advancements in the Transdermal Drug Delivery Systems Utilizing Microemulsion-Based Gels","volume":"30","author":"Song","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1208\/s12249-024-02781-2","article-title":"Development and Characterization of Transdermal Patches Using Novel Thymoquinone-L-Arginine-Based Polyamide Nanocapsules for Potential Use in the Management of Psoriasis","volume":"25","author":"Dahmash","year":"2024","journal-title":"AAPS PharmSciTech"},{"key":"ref_156","first-page":"100846","article-title":"Nano Transdermal System Combining Mitochondria-Targeting Cerium Oxide Nanoparticles with All-Trans Retinoic Acid for Psoriasis","volume":"18","author":"Wang","year":"2023","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"111824","DOI":"10.1016\/j.intimp.2024.111824","article-title":"A Therapeutic Strategy of Parthenolide in Improving Imiquimod-Induced Psoriasis-like Skin Inflammation Targeting IL-36\/NETs through Skin Transdermal Therapeutic System","volume":"131","author":"Zhan","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1080\/10717544.2022.2086944","article-title":"ROS-Sensitive Calcipotriol Nano-Micelles Prepared by Methoxypolyethylene Glycol (mPEG)\u2013Modified Polymer for the Treatment of Psoriasis","volume":"29","author":"Hua","year":"2022","journal-title":"Drug Deliv."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jaci.2017.07.028","article-title":"Astrotactin 1\u2013Derived Peptide: A New Skin-Penetrating Peptide against Inflammatory Skin Diseases","volume":"141","author":"Dombrowicz","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"105","DOI":"10.5021\/ad.24.024","article-title":"Additional Use of Hyaluronic Acid-Based Dissolving Microneedle Patches to Treat Psoriatic Plaques: A Randomized Controlled Trial","volume":"37","author":"Ju","year":"2025","journal-title":"Ann. Dermatol."},{"key":"ref_161","first-page":"229","article-title":"Compensatory Effect-Based Oxidative Stress Management Microneedle for Psoriasis Treatment","volume":"46","author":"Wu","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_162","first-page":"61","article-title":"Formulation and Evaluation of Topical Anti Acne Formulation of Coriander Oil","volume":"2","author":"Vats","year":"2012","journal-title":"Int. J. Pharm. Pharm. Sci. Res."},{"key":"ref_163","first-page":"57","article-title":"Novel Drug Delivery Systems of Herbal Constituents Used in Acne","volume":"7","author":"Baghel","year":"2017","journal-title":"Asian J. Res. Pharm. Sci."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4274\/tjps.galenos.2019.98624","article-title":"Development of a Novel Freeze-Dried Mulberry Leaf Extract-Based Transfersome Gel","volume":"18","author":"Nangare","year":"2021","journal-title":"Turk. J. Pharm. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"21595","DOI":"10.1021\/acsami.4c01790","article-title":"Dissolving Hyaluronic Acid-Based Microneedles to Transdermally Deliver Eugenol Combined with Photothermal Therapy for Acne Vulgaris Treatment","volume":"16","author":"Wang","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_166","first-page":"273","article-title":"Microsponges for Dermatological Applications: Perspectives and Challenges","volume":"15","author":"Mahant","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"119256","DOI":"10.1016\/j.ijpharm.2020.119256","article-title":"Development of Flavanone and Its Derivatives as Topical Agents against Psoriasis: The Prediction of Therapeutic Efficiency through Skin Permeation Evaluation and Cell-Based Assay","volume":"581","author":"Alalaiwe","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/cod.12584","article-title":"Allergic Contact Dermatitis Caused by Rotigotine in a Transdermal Therapeutic System","volume":"75","author":"Guillot","year":"2016","journal-title":"Contact Dermat."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1034\/j.1600-0536.2002.460513.x","article-title":"Generalized Allergic Contact Dermatitis from Nitroglycerin in a Transdermal Therapeutic System","volume":"46","year":"2002","journal-title":"Contact Dermat."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.biopha.2018.07.027","article-title":"Novel Drug Delivery Systems for NSAIDs in Management of Rheumatoid Arthritis: An Overview","volume":"106","author":"Thakur","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.ejpb.2007.08.007","article-title":"Bioavailability and Bioequivalence of Topical Glucocorticoids","volume":"68","author":"Wiedersberg","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Cheng, T., Tai, Z., Shen, M., Li, Y., Yu, J., Wang, J., Zhu, Q., and Chen, Z. (2023). Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System. 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