{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:36:10Z","timestamp":1791606970354,"version":"4.3.4"},"reference-count":197,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T00:00:00Z","timestamp":1752969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Transdermal drug delivery (TDD) is an increasingly important non-invasive method for administering active pharmaceutical ingredients (APIs) through the skin barrier, offering advantages such as improved therapeutic efficacy and reduced systemic side effects. As demand increases for patient-friendly and minimally invasive treatment options, TDD has attracted substantial attention in research and clinical practice. This review summarizes recent advances enhancing skin permeability through chemical enhancers (e.g., ethanol, fatty acids, terpenes), physical (e.g., iontophoresis, microneedles, sonophoresis), and nanotechnological methods (e.g., liposomes, ethosomes, solid lipid nanoparticles, and transferosomes). A comprehensive literature analysis, including scientific publications, regulatory guidelines, and patents, was conducted to identify innovative methods and materials used to overcome the barrier properties of the stratum corneum. Special emphasis was placed on in vitro, ex vivo, and in vivo evaluation techniques for such as Franz diffusion cells for assessing drug permeation and skin interactions. The findings highlight the importance of active physical methods, passive nanostructured systems, and chemical penetration enhancers. In conclusion, integrating multiple analytical techniques is essential for the rational design and optimization of effective transdermal drug delivery systems.<\/jats:p>","DOI":"10.3390\/pharmaceutics17070936","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T11:44:05Z","timestamp":1753098245000},"page":"936","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Transdermal Drug Delivery Systems: Methods for Enhancing Skin Permeability and Their Evaluation"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-0346","authenticated-orcid":false,"given":"Elena O.","family":"Bakhrushina","sequence":"first","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4448-2588","authenticated-orcid":false,"given":"Marina M.","family":"Shumkova","sequence":"additional","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9891-6995","authenticated-orcid":false,"given":"Yana V.","family":"Avdonina","sequence":"additional","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsen A.","family":"Ananian","sequence":"additional","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2195-0730","authenticated-orcid":false,"given":"Mina","family":"Babazadeh","sequence":"additional","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazaleh","family":"Pouya","sequence":"additional","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria V.","family":"Grikh","sequence":"additional","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina M.","family":"Zubareva","sequence":"additional","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9337-5917","authenticated-orcid":false,"given":"Svetlana I.","family":"Kosenkova","sequence":"additional","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8557-8829","authenticated-orcid":false,"suffix":"Jr.","given":"Ivan I.","family":"Krasnyuk","sequence":"additional","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan I.","family":"Krasnyuk","sequence":"additional","affiliation":[{"name":"A.P. Nelyubin Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119048, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1111\/bph.13059","article-title":"Transdermal Patches: History, Development and Pharmacology","volume":"172","author":"Pastore","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1134\/S1061933X13050189","article-title":"Colloidochemical Aspects of Transdermal Drug Delivery (Review)","volume":"75","author":"Zadymova","year":"2013","journal-title":"Colloid J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Palmer, B.C., and DeLouise, L.A. (2016). Nanoparticle-Enabled Transdermal Drug Delivery Systems for Enhanced Dose Control and Tissue Targeting. Molecules, 21.","DOI":"10.3390\/molecules21121719"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1080\/17425247.2022.2135700","article-title":"Development and Evaluation of a Drug-in-Adhesive Transdermal Delivery System for Delivery of Olanzapine","volume":"19","author":"Vora","year":"2022","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.2174\/1389201020666191202111534","article-title":"The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities","volume":"21","author":"Xu","year":"2020","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e2123930","DOI":"10.1001\/jamanetworkopen.2021.23930","article-title":"Safety and Tolerability of Transdermal Cannabidiol Gel in Children With Developmental and Epileptic Encephalopathies: A Nonrandomized Controlled Trial","volume":"4","author":"Scheffer","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s11689-019-9277-x","article-title":"A Phase 1\/2, Open-Label Assessment of the Safety, Tolerability, and Efficacy of Transdermal Cannabidiol (ZYN002) for the Treatment of Pediatric Fragile X Syndrome","volume":"11","author":"Heussler","year":"2019","journal-title":"J. Neurodev. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/jtm.12064","article-title":"Efficacy of a Travelers\u2019 Diarrhea Vaccine System in Travelers to India","volume":"20","author":"Steffen","year":"2013","journal-title":"J. Travel Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1016\/j.vaccine.2013.05.028","article-title":"Transcutaneous Immunization of Healthy Volunteers with an Attenuated Listeria Monocytogenes Vaccine Strain and Cholera Toxin Adjuvant","volume":"31","author":"Eypper","year":"2013","journal-title":"Vaccine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.biomaterials.2017.10.013","article-title":"Successful Transdermal Allergen Delivery and Allergen-Specific Immunotherapy Using Biodegradable Microneedle Patches","volume":"150","author":"Kim","year":"2018","journal-title":"Biomaterials"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1001\/jamaneurol.2013.3022","article-title":"Transdermal Application of Myelin Peptides in Multiple Sclerosis Treatment","volume":"70","author":"Walczak","year":"2013","journal-title":"JAMA Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"931","DOI":"10.2147\/DDDT.S60389","article-title":"A Preliminary Study of Painless and Effective Transdermal Botulinum Toxin A Delivery by Jet Nebulization for Treatment of Primary Hyperhidrosis","volume":"8","author":"Iannitti","year":"2014","journal-title":"Drug Des. Devel. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.2047-2927.2012.00018.x","article-title":"Comparison of Transdermal Electromotive Administration of Verapamil and Dexamethasone versus Intra-Lesional Injection for Peyronie\u2019s Disease","volume":"1","author":"Mehrsai","year":"2013","journal-title":"Andrology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.contraception.2014.05.013","article-title":"Acceptability of a Transdermal Gel-Based Male Hormonal Contraceptive in a Randomized Controlled Trial","volume":"90","author":"Roth","year":"2014","journal-title":"Contraception"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kapoor, M.S., D\u2019Souza, A., Aibani, N., Nair, S.S., Sandbhor, P., Kumari, D., and Banerjee, R. (2018). Stable Liposome in Cosmetic Platforms for Transdermal Folic Acid Delivery for Fortification and Treatment of Micronutrient Deficiencies. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-34205-0"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.3762\/bjnano.12.77","article-title":"An Overview of Microneedle Applications, Materials, and Fabrication Methods","volume":"12","author":"Prewett","year":"2021","journal-title":"Beilstein J. Nanotechnol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"101216","DOI":"10.1016\/j.jddst.2019.101216","article-title":"Transdermal Delivery of Potassium Chloride with Solid Microneedles","volume":"53","author":"Abiandu","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.fsc.2017.03.001","article-title":"Anatomy of the Skin and the Pathogenesis of Nonmelanoma Skin Cancer","volume":"25","author":"Losquadro","year":"2017","journal-title":"Facial Plast. Surg. Clin. N. Am."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Pandey, P.C., Shukla, S., Skoog, S.A., Boehm, R.D., and Narayan, R.J. (2019). Current Advancements in Transdermal Biosensing and Targeted Drug Delivery. Sensors, 19.","DOI":"10.3390\/s19051028"},{"key":"ref_20","unstructured":"Murphrey, M.B., Miao, J.H., and Zito, P.M. (2023). Histology, Stratum Corneum. StatPearls, StatPearls Publishing."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1517\/17425247.3.6.727","article-title":"Transfersomes for Transdermal Drug Delivery","volume":"3","author":"Benson","year":"2006","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e08938","DOI":"10.1016\/j.heliyon.2022.e08938","article-title":"Physicochemical and Biopharmaceutical Aspects Influencing Skin Permeation and Role of SLN and NLC for Skin Drug Delivery","volume":"8","author":"Souto","year":"2022","journal-title":"Heliyon"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Brito, S., Baek, M., and Bin, B.-H. (2024). Skin Structure, Physiology, and Pathology in Topical and Transdermal Drug Delivery. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16111403"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3109\/10717544.2014.935532","article-title":"Permeation Enhancer Strategies in Transdermal Drug Delivery","volume":"23","author":"Marwah","year":"2016","journal-title":"Drug Deliv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.4155\/tde.10.16","article-title":"Challenges and Opportunities in Dermal\/Transdermal Delivery","volume":"1","author":"Paudel","year":"2010","journal-title":"Ther. Deliv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.4103\/0973-8398.72115","article-title":"Physical and Chemical Penetration Enhancers in Transdermal Drug Delivery System","volume":"4","author":"Mathur","year":"2010","journal-title":"Asian J. Pharm."},{"key":"ref_27","first-page":"67","article-title":"Penetration Enhancers for Transdermal Drug Delivery System: A Review","volume":"1","author":"Patel","year":"2011","journal-title":"Int. J. Pharm. Innov. J. Pharm. Cosmetol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"535","DOI":"10.15171\/apb.2018.063","article-title":"Transdermal Evaporation Drug Delivery System: Concept to Commercial Products","volume":"8","author":"Parhi","year":"2018","journal-title":"Adv. Pharm. Bull."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lim, D.-J., and Kim, H.-J. (2022). Microneedles in Action: Microneedling and Microneedles-Assisted Transdermal Delivery. Polymers, 14.","DOI":"10.3390\/polym14081608"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1034\/j.1600-0625.2000.009003165.x","article-title":"The 500 Dalton Rule for the Skin Penetration of Chemical Compounds and Drugs","volume":"9","author":"Bos","year":"2000","journal-title":"Exp. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.bbamem.2009.08.015","article-title":"Enhancement of Transdermal Drug Delivery via Synergistic Action of Chemicals","volume":"1788","author":"Karande","year":"2009","journal-title":"Biochim. Biophys. Acta BBA\u2014Biomembr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/jphp.12334","article-title":"Essential Oils and Their Constituents as Skin Penetration Enhancer for Transdermal Drug Delivery: A Review","volume":"67","author":"Herman","year":"2015","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"102007","DOI":"10.1016\/j.jddst.2020.102007","article-title":"Transdermal Delivery of Peptide and Protein Drugs: Strategies, Advantages and Disadvantages","volume":"60","author":"Long","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0378-5173(02)00454-4","article-title":"Skin Permeation Enhancement Effect and Skin Irritation of Saturated Fatty Alcohols","volume":"248","author":"Kanikkannan","year":"2002","journal-title":"Int. J. Pharm."},{"key":"ref_35","first-page":"609","article-title":"Next Generation Intra- and Transdermal Therapeutic Systems: Using Non- and Minimally-Invasive Technologies to Increase Drug Delivery into and across the Skin","volume":"50","author":"Gratieri","year":"2013","journal-title":"Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jconrel.2018.09.012","article-title":"Using Elongated Microparticles to Enhance Tailorable Nanoemulsion Delivery in Excised Human Skin and Volunteers","volume":"288","author":"Yamada","year":"2018","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Liu, S., Deng, T., Cheng, H., Lu, J., and Wu, J. (2025). Advances in Transdermal Drug Delivery Systems and Clinical Applications in Inflammatory Skin Diseases. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17060746"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4155\/tde.14.106","article-title":"Formulation Design for Topical Drug and Nanoparticle Treatment of Skin Disease","volume":"6","author":"Raphael","year":"2015","journal-title":"Ther. Deliv."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"120571","DOI":"10.1016\/j.ijpharm.2021.120571","article-title":"Design of Liposomes as Drug Delivery System for Therapeutic Applications","volume":"601","author":"Nogueira","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"102331","DOI":"10.1016\/j.jddst.2021.102331","article-title":"Advances in Biological Nano-Phospholipid Vesicles for Transdermal Delivery: A Review on Applications","volume":"61","author":"Mirtaleb","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s41120-024-00092-1","article-title":"Effect of Chemical Penetration Enhancers on the Transdermal Delivery of Olanzapine in Human Skin in Vitro","volume":"10","author":"Virani","year":"2024","journal-title":"AAPS Open"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zhao, N., Hao, J., Zhao, Y., Zhao, B., Lin, J., Song, J., Wang, M., and Luo, Z. (2025). A Novel Natural Penetration Enhancer for Transdermal Drug Delivery: In Vitro\/In Vivo Evaluation and Penetration Enhancement Mechanism. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17020254"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1007\/s13346-023-01452-2","article-title":"Kinetic Assessment of Iontophoretic Delivery Efficiency of Niosomal Tetracycline Hydrochloride Incorporated in Electroconductive Gel","volume":"14","author":"Duman","year":"2024","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Rahamathulla, M., Pokale, R., Al-Ebini, Y., Osmani, R.A.M., Thajudeen, K.Y., Gundawar, R., Ahmed, M.M., Farhana, S.A., and Shivanandappa, T.B. (2024). Simvastatin-Encapsulated Topical Liposomal Gel for Augmented Wound Healing: Optimization Using the Box-Behnken Model, Evaluations, and In Vivo Studies. Pharmaceuticals, 17.","DOI":"10.3390\/ph17060697"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Wu, J., Xu, R., Xu, X., Ye, S., and Huang, A. (2024). Preparation and Evaluation of Transdermal Permeation of Huperzine A Ethosomes Gel in Vitro. BMC Pharmacol. Toxicol., 25.","DOI":"10.1186\/s40360-024-00742-w"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Vasyuchenko, E.P., Orekhov, P.S., Armeev, G.A., and Bozdaganyan, M.E. (2021). CPE-DB: An Open Database of Chemical Penetration Enhancers. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13010066"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/ics.12364","article-title":"Effect of Different Alcohols on Stratum Corneum Kallikrein 5 and Phospholipase A2 Together with Epidermal Keratinocytes and Skin Irritation","volume":"39","author":"Cartner","year":"2017","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_48","first-page":"997","article-title":"The trans-dermal therapeutic systems as a convenient alternative of traditional medicinal forms","volume":"27","author":"Gildeeva","year":"2019","journal-title":"Probl. Sotsialnoi Gig. Zdr. Istor. Meditsiny"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kope\u010dn\u00e1, M., Mach\u00e1\u010dek, M., Nov\u00e1\u010dkov\u00e1, A., Paraskevopoulos, G., Roh, J., and V\u00e1vrov\u00e1, K. (2019). Esters of Terpene Alcohols as Highly Potent, Reversible, and Low Toxic Skin Penetration Enhancers. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-51226-5"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1080\/13880209.2017.1312464","article-title":"Development of Essential Oils as Skin Permeation Enhancers: Penetration Enhancement Effect and Mechanism of Action","volume":"55","author":"Jiang","year":"2017","journal-title":"Pharm. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Sim, Y.S., Wong, L.C., Yeoh, S.C., Almashhadani, A., Alrimawi, B.H., and Goh, C.F. (2025). Skin Penetration Enhancers: Mechanistic Understanding and Their Selection for Formulation and Design. Drug Deliv. Transl. Res., 224.","DOI":"10.1007\/s13346-025-01809-9"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1208\/s12249-019-1370-7","article-title":"Investigation of Effect of Isopropyl Palmitate on Drug Release from Transdermal Patch and Molecular Dynamics Study","volume":"20","author":"Ruan","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"ref_53","unstructured":"Blue Cross Blue Shield of Massachusetts (2025, July 19). Medical Policy: Iontophoresis and Phonophoresis as a Transdermal Technique for Drug Delivery. Available online: https:\/\/www.bluecrossma.org\/medical-policies\/sites\/g\/files\/csphws2091\/files\/acquiadam-assets\/095%20Iontophoresis%20and%20Phonophoresis%20as%20a%20Transdermal%20Technique%20for%20Drug%20Delivery%20prn.pdf."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.addr.2018.12.006","article-title":"Advances in Transdermal Insulin Delivery","volume":"139","author":"Zhang","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_55","unstructured":"U.S. Food and Drug Administration (FDA) (2025, July 19). LidoSite\u00ae (Lidocaine and Epinephrine Iontophoretic Patch) Labeling Information; NDA 021504, Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2004\/21504_lidoSite_lbl.pdf."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jconrel.2022.09.025","article-title":"Overcoming Skin Barriers through Advanced Transdermal Drug Delivery Approaches","volume":"351","author":"Phatale","year":"2022","journal-title":"J. Controlled Release"},{"key":"ref_57","first-page":"105410","article-title":"Electroporation-Enhanced Transdermal Drug Delivery: Effects of logP, pKa, Solubility and Penetration Time","volume":"151","author":"Chen","year":"2020","journal-title":"Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ultras.2013.07.007","article-title":"Sonophoresis in Transdermal Drug Deliverys","volume":"54","author":"Park","year":"2014","journal-title":"Ultrasonics"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jconrel.2024.01.036","article-title":"Skin Electroporation for Transdermal Drug Delivery: Electrical Measurements, Numerical Model and Molecule Delivery","volume":"367","author":"Kougkolos","year":"2024","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.jconrel.2013.09.030","article-title":"In Vivo Real-Time Monitoring System of Electroporation Mediated Control of Transdermal and Topical Drug Delivery","volume":"172","author":"Blagus","year":"2013","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"ref_61","unstructured":"(2025, June 27). 510(k) Premarket Notification, Available online: https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfpmn\/pmn.cfm?ID=14526."},{"key":"ref_62","unstructured":"(2025, June 27). 510(k) Premarket Notification, Available online: https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfpmn\/pmn.cfm?ID=k092746."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/ics.12749","article-title":"Elongated Microparticles Tuned for Targeting Hyaluronic Acid Delivery to Specific Skin Strata","volume":"43","author":"Yamada","year":"2021","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jconrel.2014.04.045","article-title":"Electrical, Magnetic, Photomechanical and Cavitational Waves to Overcome Skin Barrier for Transdermal Drug Delivery","volume":"193","author":"Wong","year":"2014","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"ref_65","unstructured":"U.S. Food and Drug Administration (FDA) (2025, July 19). 510(k) Summary: ZETAJET Needle-Free Injection Therapy System, K090003. Silver Spring, MD: FDA, Available online: https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf9\/K090003.pdf."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.biopha.2018.10.021","article-title":"Biomedical Applications of Microemulsion through Dermal and Transdermal Route","volume":"108","author":"Shukla","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Cao, Y., Meng, X., Li, C., Wang, H., and Zhang, S. (2020). Enhancement of Transdermal Delivery of Artemisinin Using Microemulsion Vehicle Based on Ionic Liquid and Lidocaine Ibuprofen. Colloids Surf. B Biointerfaces, 189.","DOI":"10.1016\/j.colsurfb.2020.110886"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"120829","DOI":"10.1016\/j.ijpharm.2021.120829","article-title":"Design, Optimization and Evaluation of a Microemulsion-Based Hydrogel with High Malleability for Enhanced Transdermal Delivery of Levamisole","volume":"605","author":"Hu","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Souza de Araujo, G.R., Mendon\u00e7a da Cruz Macieira, G., Xavier de Oliveira, D., Santos Matos, S., Nery Dos Santos, Q., Otubo, L., Antunes de Souza Ara\u00fajo, A., Cavalcante Duarte, M., Moreira Lira, A.A., and de Souza Nunes, R. (2022). Microemulsions Formed by PPG-5-CETETH-20 at Low Concentrations for Transdermal Delivery of Nifedipine: Structural and in Vitro Study. Colloids Surf. B Biointerfaces, 214.","DOI":"10.1016\/j.colsurfb.2022.112474"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"104473","DOI":"10.1016\/j.jtice.2022.104473","article-title":"A New Application of Surfactant-Free Microemulsion: Solubilization and Transport of Drugs and Its Transdermal Release Properties","volume":"138","author":"Han","year":"2022","journal-title":"J. Taiwan Inst. Chem. Eng."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Nikolaev, B., Yakovleva, L., Fedorov, V., Li, H., Gao, H., and Shevtsov, M. (2023). Nano- and Microemulsions in Biomedicine: From Theory to Practice. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15071989"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Nisini, R., Poerio, N., Mariotti, S., De Santis, F., and Fraziano, M. (2018). The Multirole of Liposomes in Therapy and Prevention of Infectious Diseases. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00155"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1166\/jcsb.2012.1020","article-title":"Preparation, Characterization and Applications of Liposomes: State of the Art","volume":"1","author":"Laouini","year":"2012","journal-title":"J. Colloid Sci. Biotechnol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1126\/science.1255288","article-title":"Lipid Cell Biology. Polyunsaturated Phospholipids Facilitate Membrane Deformation and Fission by Endocytic Proteins","volume":"345","author":"Pinot","year":"2014","journal-title":"Science"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Tsuji, T., Morita, S.-Y., Ikeda, Y., and Terada, T. (2019). Enzymatic Fluorometric Assays for Quantifying All Major Phospholipid Classes in Cells and Intracellular Organelles. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-45185-0"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Inglut, C.T., Sorrin, A.J., Kuruppu, T., Vig, S., Cicalo, J., Ahmad, H., and Huang, H.-C. (2020). Immunological and Toxicological Considerations for the Design of Liposomes. Nanomaterials, 10.","DOI":"10.3390\/nano10020190"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"113851","DOI":"10.1016\/j.addr.2021.113851","article-title":"Liposome Composition in Drug Delivery Design, Synthesis, Characterization, and Clinical Application","volume":"176","author":"Large","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_78","first-page":"10","article-title":"A Complete Review on: Liposomes","volume":"3","author":"Shashi","year":"2012","journal-title":"Int. Res. J. Pharm."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"102900","DOI":"10.1016\/j.jddst.2021.102900","article-title":"Transferrin Conjugated Stealth Liposomes for Sirolimus Active Targeting in Breast Cancer","volume":"66","author":"Nandi","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Huang, M., Pu, Y., Peng, Y., Fu, Q., Guo, L., Wu, Y., and Zheng, Y. (2020). Biotin and Glucose Dual-Targeting, Ligand-Modified Liposomes Promote Breast Tumor-Specific Drug Delivery. Bioorg. Med. Chem. Lett., 30.","DOI":"10.1016\/j.bmcl.2020.127151"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"121080","DOI":"10.1016\/j.ijpharm.2021.121080","article-title":"Design of Long Acting Invasomal Nanovesicles for Improved Transdermal Permeation and Bioavailability of Asenapine Maleate for the Chronic Treatment of Schizophrenia","volume":"608","author":"Geneidi","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.5650\/jos.ess24041","article-title":"Luteolin-Loaded Invasomes Gel for Transdermal Delivery: Development, Optimization, in-Vitro, and Preclinical Evaluation","volume":"73","author":"Zafar","year":"2024","journal-title":"J. Oleo Sci."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"105740","DOI":"10.1016\/j.jddst.2024.105740","article-title":"A Comparative Study between Nanostructured Lipid Carriers and Invasomes for the Topical Delivery of Luteolin: Design, Optimization and Pre-Clinical Investigations for Psoriasis Treatment","volume":"97","author":"Hatem","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"118817","DOI":"10.1016\/j.ijpharm.2019.118817","article-title":"Transferosomes as Nanocarriers for Drugs across the Skin: Quality by Design from Lab to Industrial Scale","volume":"573","author":"Lalatsa","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Khan, M.I., Yaqoob, S., Madni, A., Akhtar, M.F., Sohail, M.F., Saleem, A., Tahir, N., Khan, K.-R., and Qureshi, O.S. (2022). Development and In Vitro\/Ex Vivo Evaluation of Lecithin-Based Deformable Transfersomes and Transfersome-Based Gels for Combined Dermal Delivery of Meloxicam and Dexamethasone. BioMed Res. Int., 2022.","DOI":"10.1155\/2022\/8170318"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.2147\/IJN.S105016","article-title":"Ethosomal Nanocarriers: The Impact of Constituents and Formulation Techniques on Ethosomal Properties, in Vivo Studies, and Clinical Trials","volume":"11","author":"Abdulbaqi","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"122098","DOI":"10.1016\/j.molliq.2023.122098","article-title":"Comparative Study on Ethosomes and Transferosomes for Enhancing Skin Permeability of Sinapic Acid","volume":"383","author":"Malviya","year":"2023","journal-title":"J. Mol. Liq."},{"key":"ref_88","first-page":"135","article-title":"Optimizing Glycerosome Formulations via an Orthogonal Experimental Design to Enhance Transdermal Triptolide Delivery","volume":"72","author":"Zhu","year":"2022","journal-title":"Acta Pharm. Zagreb Croat."},{"key":"ref_89","unstructured":"(2025, April 13). Glycerosomes and Use Thereof in Pharmaceutical and Cosmetic Preparations for Topical Application\u2014Patent WO-2010102770-A1\u2014PubChem, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/patent\/WO-2010102770-A1."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Shahien, M.M., Alshammari, A., Ibrahim, S., Ahmed, E.H., Atia, H.A., Elariny, H.A., and Abdallah, M.H. (2024). Development of Glycerosomal pH Triggered In Situ Gelling System to Ameliorate the Nasal Delivery of Sulpiride for Pediatric Psychosis. Gels, 10.","DOI":"10.3390\/gels10090608"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijpharm.2013.07.060","article-title":"Glycerosomes: A New Tool for Effective Dermal and Transdermal Drug Delivery","volume":"455","author":"Manca","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"103364","DOI":"10.1016\/j.jddst.2022.103364","article-title":"Augmented Local Skin Accumulation Efficiency of Sertaconazole Nitrate via Glycerosomal Hydrogel: Formulation, Statistical Optimization, Ex Vivo Performance and in Vivo Penetration","volume":"72","author":"Younes","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2174\/0126673878245185230919101148","article-title":"Glycerosomes: Novel Nano-Vesicles for Efficient Delivery of Therapeutics","volume":"17","author":"Sharma","year":"2023","journal-title":"Recent Adv. Drug Deliv. Formul."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Md, S., Alhakamy, N.A., Aldawsari, H.M., Husain, M., Khan, N., Alfaleh, M.A., Asfour, H.Z., Riadi, Y., Bilgrami, A.L., and Akhter, M.H. (2021). Plumbagin-Loaded Glycerosome Gel as Topical Delivery System for Skin Cancer Therapy. Polymers, 13.","DOI":"10.3390\/polym13060923"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1007\/s13346-023-01371-2","article-title":"Phytosterol-Mediated Glycerosomes Combined with Peppermint Oil Enhance Transdermal Delivery of Lappaconitine by Modulating the Lipid Composition of the Stratum Corneum","volume":"13","author":"Ruan","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"385","DOI":"10.36468\/pharmaceutical-sciences.661","article-title":"Glycerosomes: Advanced Liposomal Drug Delivery System","volume":"82","author":"Gupta","year":"2020","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Alam, M.S., Sultana, N., Rashid, M.A., Alhamhoom, Y., Ali, A., Waheed, A., Ansari, M.S., Aqil, M., and Mujeeb, M. (2023). Quality by Design-Optimized Glycerosome-Enabled Nanosunscreen Gel of Rutin Hydrate. Gels, 9.","DOI":"10.3390\/gels9090752"},{"key":"ref_98","first-page":"100295","article-title":"Augmented Glycerosomes as a Promising Approach against Fungal Ear Infection: Optimization and Microbiological, Ex Vivo and in Vivo Assessments","volume":"8","author":"Ahmed","year":"2024","journal-title":"Int. J. Pharm. X"},{"key":"ref_99","first-page":"100228","article-title":"Formulation, Optimization and Evaluation of Ocular Gel Containing Nebivolol Hcl-Loaded Ultradeformable Spanlastics Nanovesicles: In Vitro and in Vivo Studies","volume":"7","author":"Yasser","year":"2024","journal-title":"Int. J. Pharm. X"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"119125","DOI":"10.1016\/j.ijpharm.2020.119125","article-title":"Preparation and Optimization of Fisetin Loaded Glycerol Based Soft Nanovesicles by Box-Behnken Design","volume":"578","author":"Moolakkadath","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/ics.12771","article-title":"Improved Stability and Skin Penetration through Glycethosomes Loaded with Glycyrrhetinic Acid","volume":"44","author":"Zhang","year":"2022","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"119302","DOI":"10.1016\/j.ijpharm.2020.119302","article-title":"Investigating the Potential of Utilizing Glycerosomes as a Novel Vesicular Platform for Enhancing Intranasal Delivery of Lacidipine","volume":"582","author":"Naguib","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Zaki, R.M., Alfadhel, M.M., Alossaimi, M.A., Elsawaf, L.A., Devanathadesikan Seshadri, V., Almurshedi, A.S., Yusif, R.M., and Said, M. (2022). Central Composite Optimization of Glycerosomes for the Enhanced Oral Bioavailability and Brain Delivery of Quetiapine Fumarate. Pharmaceuticals, 15.","DOI":"10.3390\/ph15080940"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"123487","DOI":"10.1016\/j.ijpharm.2023.123487","article-title":"Synergistic Approach for Acne Vulgaris Treatment Using Glycerosomes Loaded with Lincomycin and Lauric Acid: Formulation, in Silico, in Vitro, LC-MS\/MS Skin Deposition Assay and in Vivo Evaluation","volume":"646","author":"AbouSamra","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Casula, E., Manca, M.L., Perra, M., Pedraz, J.L., Lopez-Mendez, T.B., Lozano, A., Calvo, E., Zaru, M., and Manconi, M. (2021). Nasal Spray Formulations Based on Combined Hyalurosomes and Glycerosomes Loading Zingiber Officinalis Extract as Green and Natural Strategy for the Treatment of Rhinitis and Rhinosinusitis. Antioxidants, 10.","DOI":"10.3390\/antiox10071109"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Aati, S., Farouk, H.O., Elkarmalawy, M.H., Aati, H.Y., Tolba, N.S., Hassan, H.M., Rateb, M.E., and Hamad, D.S. (2024). Intratracheal Administration of Itraconazole-Loaded Hyaluronated Glycerosomes as a Promising Nanoplatform for the Treatment of Lung Cancer: Formulation, Physiochemical, and In Vivo Distribution. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16111432"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/20415990.2024.2408218","article-title":"Atorvastatin Loaded Glycerosomal Patch as an Effective Transdermal Drug Delivery: Optimization and Evaluation","volume":"15","author":"Patil","year":"2024","journal-title":"Ther. Deliv."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Vanti, G., Ntallis, S.G., Panagiotidis, C.A., Dourdouni, V., Patsoura, C., Bergonzi, M.C., Lazari, D., and Bilia, A.R. (2020). Glycerosome of Melissa Officinalis L. Essential Oil for Effective Anti-HSV Type 1. Molecules, 25.","DOI":"10.3390\/molecules25143111"},{"key":"ref_109","unstructured":"Emelyanova, I.V., and Lopatina, G.P.\u041f. (2025, April 13). Method for Producing Tysole Complex of Tetracoptane hydrotetrakis(oxy -3,4-dihydroxypropyl)titanium with Decane -1,23-trihydroxypropane Having Transcutaneous Conductivity of Medicamentous Additives. Available online: https:\/\/goo.su\/sqsGm."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"13","DOI":"10.17116\/stomat201594213-15","article-title":"Evaluation of the clinical efficacy of a new composition of tizol with triamcinolon in complex treatment of patients with erosive ulcerous form of lichen planus of the oral mucosa","volume":"94","author":"Ron","year":"2015","journal-title":"Stomatologiia"},{"key":"ref_111","first-page":"419","article-title":"Characteristics of the Wound Process in Regional Applications Aquacomplexes Glitserosolvata Titanium and Oxytocin in Experiment","volume":"7","author":"Mokhova","year":"2014","journal-title":"J. Exp. Clin. Surg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12737\/4115","article-title":"Assessment of Efficiency of Complex Treatment of Soft Tissue Wounds by Means of Oxytocin and Titanium Aquacomplex Glycerosolvate in Experiment","volume":"8","author":"Glukhov","year":"2014","journal-title":"J. New Med. Technol. EJournal"},{"key":"ref_113","first-page":"20","article-title":"Status of Liver Enzymes as an Indicator of Local Treatment of Burn Trauma in Experiment","volume":"5","author":"Solovyeva","year":"2013","journal-title":"Sovrem. Tehnol. V Med."},{"key":"ref_114","first-page":"354","article-title":"Clinical-morphological, immunological and immunohistochemical characteristics of lichen red planus","volume":"11","author":"Sadikova","year":"2024","journal-title":"Int. Multidiscip. J. Res. Dev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"59","DOI":"10.19163\/1994-9480-2019-1(69)-59-64","article-title":"Efficiency of topical application of mucoadhesive drugs for treating red flat lichen of the oral cavity","volume":"16","author":"Firsova","year":"2019","journal-title":"J. Volgogr. State Med. Univ."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"65","DOI":"10.19163\/1994-9480-2019-1(69)-65-68","article-title":"Clinical trial of natural combination therapies in the treatment of chronic generalized periodontitis of moderate severity","volume":"16","author":"Sharonova","year":"2019","journal-title":"J. Volgogr. State Med. Univ."},{"key":"ref_117","unstructured":"(2025, April 13). Silicon-Titanium-Containing Derivatives of Polymers and Hydrogels Based on Them. Available online: https:\/\/patents.google.com\/patent\/RU2382046C1\/ru."},{"key":"ref_118","unstructured":"(2025, April 13). RU2255939C2\u2014Silicon Glycerates Eliciting Transcutaneous Conductivity of Medicinal Agents and Glycerohydrogels Based on Thereof. Available online: https:\/\/yandex.ru\/patents\/doc\/RU2255939C2_20050710."},{"key":"ref_119","unstructured":"(2025, April 13). RU2322448C2\u2014Solvate Complexes of Silicon and Titanium Glycerates Manifesting Transcutan Activity and Hydrogels Based Thereon. Available online: https:\/\/yandex.ru\/patents\/doc\/RU2322448C2_20080420."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.46235\/1028-7221-314-PAO","article-title":"Pharmacological assessment of immunotropic activity of new gel metabiotic on cellular and humoral immunity in experimentally modeled thermal skin burns","volume":"23","author":"Zabokritskiy","year":"2020","journal-title":"Russ. J. Immunol."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Gackowski, M., Osma\u0142ek, T., Froelich, A., Otto, F., Schneider, R., and Lulek, J. (2023). Phototoxic or Photoprotective?-Advances and Limitations of Titanium (IV) Oxide in Dermal Formulations-A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098159"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s12668-023-01151-9","article-title":"Theranostic Polymeric Nanoparticles for Cancer","volume":"13","author":"Fernandes","year":"2023","journal-title":"BioNanoScience"},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Varela-Fern\u00e1ndez, R., Garc\u00eda-Otero, X., D\u00edaz-Tom\u00e9, V., Regueiro, U., L\u00f3pez-L\u00f3pez, M., Gonz\u00e1lez-Barcia, M., Isabel Lema, M., and Otero-Espinar, F.J. (2022). Mucoadhesive PLGA Nanospheres and Nanocapsules for Lactoferrin Controlled Ocular Delivery. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14040799"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jconrel.2021.05.010","article-title":"PEG-Polyaminoacid Based Micelles for Controlled Release of Doxorubicin: Rational Design, Safety and Efficacy Study","volume":"335","author":"Brunato","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"123150","DOI":"10.1016\/j.ijpharm.2023.123150","article-title":"Methotrexate and Sulforaphane Loaded PBA-G5-PAMAM Dendrimers as a Combination Therapy for Anti-Inflammatory Response in an Intra-Articular Joint Arthritic Animal Model","volume":"642","author":"Essien","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_126","unstructured":"(2025, June 27). A Facile Method for Anti-Cancer Drug Encapsulation into Polymersomes with a Core-Satellite Structure\u2014PubMed, Available online: https:\/\/pubmed.ncbi.nlm.nih.gov\/35904177\/."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejps.2017.12.012","article-title":"Drug Transport Mechanisms and in Vitro Release Kinetics of Vancomycin Encapsulated Chitosan-Alginate Polyelectrolyte Microparticles as a Controlled Drug Delivery System","volume":"114","author":"Unagolla","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"105801","DOI":"10.1016\/j.ejps.2021.105801","article-title":"Development and Characterization of Chitosan Nanoparticles Loaded Nanofiber Hybrid System for Vaginal Controlled Release of Benzydamine","volume":"161","author":"Saar","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_129","first-page":"100205","article-title":"Enhanced Stability and Skin Permeation of Ibuprofen-Loaded Solid Lipid Nanoparticles Based Binary Solid Lipid Matrix: Effect of Surfactant and Lipid Compositions","volume":"6","author":"Chantaburanan","year":"2023","journal-title":"Int. J. Pharm. X"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"101719","DOI":"10.1016\/j.jddst.2020.101719","article-title":"Preparation and Characterization of Sumatriptan Loaded Solid Lipid Nanoparticles for Transdermal Delivery","volume":"57","author":"Salehi","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jconrel.2021.05.032","article-title":"Solid Lipid Nanoparticles for Hydrophilic Drugs","volume":"335","author":"Mirchandani","year":"2021","journal-title":"J. Controlled Release"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijpharm.2018.11.024","article-title":"Transdermal Drug Delivery of Triptolide-Loaded Nanostructured Lipid Carriers: Preparation, Pharmacokinetic, and Evaluation for Rheumatoid Arthritis","volume":"554","author":"Gu","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_133","first-page":"999","article-title":"Nanostructured Lipid Carriers (NLCs) as Drug Delivery Platform: Advances in Formulation and Delivery Strategies","volume":"29","author":"Elmowafy","year":"2021","journal-title":"Saudi Pharm. J. SPJ Off. Publ. Saudi Pharm. Soc."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"121006","DOI":"10.1016\/j.ijpharm.2021.121006","article-title":"Nanostructured Lipid Carrier to Overcome Stratum Corneum Barrier for the Delivery of Agomelatine in Rat Brain; Formula Optimization, Characterization and Brain Distribution Study","volume":"607","author":"Ahmed","year":"2021","journal-title":"Int. J. Pharm."},{"key":"ref_135","first-page":"106169","article-title":"Nanostructured Lipid Carrier-Embedded Polyacrylic Acid Transdermal Patches for Improved Transdermal Delivery of Capsaicin","volume":"173","author":"Arunprasert","year":"2022","journal-title":"Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"119401","DOI":"10.1016\/j.carbpol.2022.119401","article-title":"Chitosan-Coated Nanostructured Lipid Carriers for Transdermal Delivery of Tetrahydrocurcumin for Breast Cancer Therapy","volume":"288","author":"Truong","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"van Staden, D., Plessis, J.d., and Viljoen, J. (2020). Development of Topical\/Transdermal Self-Emulsifying Drug Delivery Systems, Not as Simple as Expected. Sci. Pharm., 88.","DOI":"10.3390\/scipharm88020017"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Ponto, T., Latter, G., Luna, G., Leite-Silva, V.R., Wright, A., and Benson, H.A.E. (2021). Novel Self-Nano-Emulsifying Drug Delivery Systems Containing Astaxanthin for Topical Skin Delivery. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13050649"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.colsurfa.2015.11.017","article-title":"Non-Aqueous Self-Double-Emulsifying Drug Delivery System: A New Approach to Enhance Resveratrol Solubility for Effective Transdermal Delivery","volume":"489","author":"Hu","year":"2016","journal-title":"Colloids Surf. Physicochem. Eng. Asp."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.colsurfb.2009.10.003","article-title":"Self-Microemulsifying and Microemulsion Systems for Transdermal Delivery of Indomethacin: Effect of Phase Transition","volume":"75","year":"2010","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.molliq.2013.10.015","article-title":"Ultra-Fine Self Nanoemulsifying Drug Delivery System for Transdermal Delivery of Meloxicam: Dependency on the Type of Surfactants","volume":"190","author":"Badran","year":"2014","journal-title":"J. Mol. Liq."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Wang, Y., Wei, Y., Liao, H., Fu, H., Yang, X., Xiang, Q., and Zhang, S. (2023). Plant Exosome-like Nanoparticles as Biological Shuttles for Transdermal Drug Delivery. Bioengineering, 10.","DOI":"10.3390\/bioengineering10010104"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"101800","DOI":"10.1016\/j.tice.2022.101800","article-title":"Beta Vulgaris Juice Contains Biologically Active Exosome-like Nanoparticles","volume":"76","author":"Mahdipour","year":"2022","journal-title":"Tissue Cell"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Abraham, A.M., Wiemann, S., Ambreen, G., Zhou, J., Engelhardt, K., Br\u00fc\u00dfler, J., Bakowsky, U., Li, S.-M., Mandic, R., and Pocsfalvi, G. (2022). Cucumber-Derived Exosome-like Vesicles and PlantCrystals for Improved Dermal Drug Delivery. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14030476"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1039\/D0FO02953J","article-title":"Grapefruit-Derived Extracellular Vesicles as a Promising Cell-Free Therapeutic Tool for Wound Healing","volume":"12","author":"Bozkurt","year":"2021","journal-title":"Food Funct."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1007\/s00403-025-03896-7","article-title":"METTL3-Modified Exosomes from Adipose-Derived Stem Cells Enhance the Proliferation and Migration of Dermal Fibroblasts by Mediating m6A Modification of CCNB1 mRNA","volume":"317","author":"Zhou","year":"2025","journal-title":"Arch. Dermatol. Res."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1016\/j.apsb.2024.08.013","article-title":"Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment","volume":"14","author":"Wu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Leong, M.Y., Kong, Y.L., Burgess, K., Wong, W.F., Sethi, G., and Looi, C.Y. (2023). Recent Development of Nanomaterials for Transdermal Drug Delivery. Biomedicines, 11.","DOI":"10.3390\/biomedicines11041124"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1039\/D2NA00530A","article-title":"Functional Nano-Systems for Transdermal Drug Delivery and Skin Therapy","volume":"5","author":"Liu","year":"2023","journal-title":"Nanoscale Adv."},{"key":"ref_150","unstructured":"Nayak, A.K., Hasnain, M.S., Laha, B., and Maiti, S. (2023). Chapter 18\u2014Iontophoretic Drug Delivery: Concepts, Approaches, and Applications. Advanced and Modern Approaches for Drug Delivery, Academic Press."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/1523-1747.ep12533356","article-title":"Percutaneous Absorption on the Relevance of in Vitro Data","volume":"64","author":"Franz","year":"1975","journal-title":"J. Investig. Dermatol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"106873","DOI":"10.1016\/j.ejps.2024.106873","article-title":"In Vitro Permeation Testing for the Evaluation of Drug Delivery to the Skin","volume":"201","author":"Lane","year":"2024","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1007\/s11095-024-03772-5","article-title":"Impact of Different Packaging Configurations on A Topical Cream Product","volume":"41","author":"Mohammed","year":"2024","journal-title":"Pharm. Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1021\/acs.molpharmaceut.1c00238","article-title":"Skin Pharmacokinetics of Transdermal Scopolamine: Measurements and Modeling","volume":"18","author":"Pensado","year":"2021","journal-title":"Mol. Pharm."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1021\/acs.molpharmaceut.4c01058","article-title":"In Vitro Drug Release and Ex Vivo Dermal Drug Permeation Studies of Selected Commercial Benzoyl Peroxide Topical Formulations: Correlation Between Human and Porcine Skin Models","volume":"22","author":"Brighenti","year":"2025","journal-title":"Mol. Pharm."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1016\/j.xphs.2020.07.013","article-title":"Evaluation of Heat Effects on Fentanyl Transdermal Delivery Systems Using In Vitro Permeation and In Vitro Release Methods","volume":"109","author":"Zhang","year":"2020","journal-title":"J. Pharm. Sci."},{"key":"ref_157","unstructured":"(2025, April 23). In Vitro Permeation Test Studies for Topical Drug Products Submitted in ANDAs, Available online: https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/in-vitro-permeation-test-studies-topical-drug-products-submitted-andas."},{"key":"ref_158","unstructured":"(2025, May 19). Decision of the EEC Council No. 85 Dated 3 November 2016 on the Approval of the Rules for Conducting Bioequivalence Studies of Medicinal Products within the Eurasian Economic Union. Available online: https:\/\/docs.eaeunion.org\/documents\/306\/2592\/."},{"key":"ref_159","unstructured":"(2025, April 24). Quality and Equivalence of Locally Applied, Locally Acting Cutaneous Products\u2014Scientific Guideline | European Medicines Agency (EMA). Available online: https:\/\/www.ema.europa.eu\/en\/quality-equivalence-locally-applied-locally-acting-cutaneous-products-scientific-guideline."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijpharm.2013.02.040","article-title":"Skin Penetration Enhancers","volume":"447","author":"Lane","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref_161","unstructured":"(2025, May 19). Guidance Document for the Conduct of Skin Absorption Studies. Available online: https:\/\/www.oecd.org\/en\/publications\/guidance-document-for-the-conduct-of-skin-absorption-studies_9789264078796-en.html."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1208\/s12249-018-1130-0","article-title":"The Sensitivity of In Vitro Permeation Tests to Chemical Penetration Enhancer Concentration Changes in Fentanyl Transdermal Delivery Systems","volume":"19","author":"Shin","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Ossowicz-Rupniewska, P., Nowak, A., Klebeko, J., Janus, E., Duchnik, W., Adamiak-Giera, U., Kucharski, \u0141., Prowans, P., Petriczko, J., and Czapla, N. (2021). Assessment of the Effect of Structural Modification of Ibuprofen on the Penetration of Ibuprofen from Pentravan\u00ae (Semisolid) Formulation Using Human Skin and a Transdermal Diffusion Test Model. Materials, 14.","DOI":"10.3390\/ma14226808"},{"key":"ref_164","first-page":"106943","article-title":"Towards the Understanding of the IVPT Results Variability-Development, Verification and Validation of the PBPK Model of Caffeine in Vitro Human Skin Permeation","volume":"204","author":"Krumpholz","year":"2025","journal-title":"Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1007\/s11095-024-03736-9","article-title":"Topical Semisolid Drug Product Critical Quality Attributes with Relevance to Cutaneous Bioavailability and Pharmacokinetics: Part I-Bioequivalence of Acyclovir Topical Creams","volume":"41","author":"Mohammed","year":"2024","journal-title":"Pharm. Res."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.addr.2019.10.004","article-title":"Intradermal and Transdermal Drug Delivery Using Microneedles\u2014Fabrication, Performance Evaluation and Application to Lymphatic Delivery","volume":"153","author":"Sabri","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.slast.2021.12.006","article-title":"Comparison Between Franz Diffusion Cell and a Novel Micro-Physiological System for In Vitro Penetration Assay Using Different Skin Models","volume":"27","author":"Pulsoni","year":"2022","journal-title":"SLAS Technol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nbt.2989","article-title":"Microfluidic Organs-on-Chips","volume":"32","author":"Bhatia","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Ponmozhi, J., Dhinakaran, S., Varga-Medveczky, Z., F\u00f3nagy, K., Bors, L.A., Iv\u00e1n, K., and Erd\u0151, F. (2021). Development of Skin-On-A-Chip Platforms for Different Utilizations: Factors to Be Considered. Micromachines, 12.","DOI":"10.3390\/mi12030294"},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Varga-Medveczky, Z., Kocsis, D., Naszlady, M.B., F\u00f3nagy, K., and Erd\u0151, F. (2021). Skin-on-a-Chip Technology for Testing Transdermal Drug Delivery-Starting Points and Recent Developments. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111852"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jiec.2019.09.044","article-title":"Side-Effect Test of Sorafenib Using 3-D Skin Equivalent Based on Microfluidic Skin-on-a-Chip","volume":"82","author":"Jeon","year":"2020","journal-title":"J. Ind. Eng. Chem. Seoul Korea"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Luk\u00e1cs, B., Bajza, \u00c1., Kocsis, D., Csorba, A., Antal, I., Iv\u00e1n, K., Laki, A.J., and Erd\u0151, F. (2019). Skin-on-a-Chip Device for Ex Vivo Monitoring of Transdermal Delivery of Drugs-Design, Fabrication, and Testing. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11090445"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Kim, J., Kim, K., and Sung, G.Y. (2020). Coenzyme Q10 Efficacy Test for Human Skin Equivalents Using a Pumpless Skin-On-A-Chip System. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228475"},{"key":"ref_174","doi-asserted-by":"crossref","unstructured":"Kim, K., Jeon, H.M., Choi, K.C., and Sung, G.Y. (2020). Testing the Effectiveness of Curcuma Longa Leaf Extract on a Skin Equivalent Using a Pumpless Skin-on-a-Chip Model. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21113898"},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Mohamadali, M., Ghiaseddin, A., Irani, S., Amirkhani, M.A., and Dahmardehei, M. (2023). Design and Evaluation of a Skin-on-a-Chip Pumpless Microfluidic Device. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-34796-3"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Jonsdottir, F., Snorradottir, B.S., Gunnarsson, S., Georgsdottir, E., and Sigurdsson, S. (2022). Transdermal Drug Delivery: Determining Permeation Parameters Using Tape Stripping and Numerical Modeling. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14091880"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"102355","DOI":"10.1016\/j.jddst.2021.102355","article-title":"An Insight of Techniques for the Assessment of Permeation Flux across the Skin for Optimization of Topical and Transdermal Drug Delivery Systems","volume":"62","author":"Chaturvedi","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s40262-016-0442-z","article-title":"Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence","volume":"56","author":"Bodenlenz","year":"2017","journal-title":"Clin. Pharmacokinet."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"123269","DOI":"10.1016\/j.ijpharm.2023.123269","article-title":"Detailed Pharmacokinetic Characterization of Advanced Topical Acyclovir Formulations with IVPT and in Vivo Open Flow Microperfusion","volume":"643","author":"Schwagerle","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ejpb.2011.03.005","article-title":"Microdialysis Assessment of Percutaneous Penetration of Ketoprofen after Transdermal Administration to Hairless Rats and Domestic Pigs","volume":"78","author":"Shinkai","year":"2011","journal-title":"Eur. J. Pharm. Biopharm. Off. J. Arbeitsgemeinschaft Pharm. Verfahrenstechnik EV"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"121789","DOI":"10.1016\/j.ijpharm.2022.121789","article-title":"Correlation between in Vivo Microdialysis Pharmacokinetics and Ex Vivo Permeation for Sinomenine Hydrochloride Transfersomes with Enhanced Skin Absorption","volume":"621","author":"Fan","year":"2022","journal-title":"Int. J. Pharm."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3233\/JAD-220530","article-title":"Comparison of Steady-State Pharmacokinetics of Donepezil Transdermal Delivery System with Oral Donepezil","volume":"90","author":"Tariot","year":"2022","journal-title":"J. Alzheimers Dis. JAD"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ijbiomac.2017.10.170","article-title":"Tracking the Transdermal Penetration Pathways of Optimized Curcumin-Loaded Chitosan Nanoparticles via Confocal Laser Scanning Microscopy","volume":"108","author":"Hathout","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"Krombholz, R., Liu, Y., and Lunter, D.J. (2021). In-Line and Off-Line Monitoring of Skin Penetration Profiles Using Confocal Raman Spectroscopy. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13010067"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.saa.2016.11.042","article-title":"In Vivo Confocal Raman Spectroscopy and Molecular Dynamics Analysis of Penetration of Retinyl Acetate into Stratum Corneum","volume":"174","author":"Sousa","year":"2017","journal-title":"Spectrochim. Acta. A Mol. Biomol. Spectrosc."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"75","DOI":"10.6061\/clinics\/2014(02)01","article-title":"Nanostructured Transdermal Hormone Replacement Therapy for Relieving Menopausal Symptoms: A Confocal Raman Spectroscopy Study","volume":"69","author":"Botelho","year":"2014","journal-title":"Clin. Sao Paulo Braz."},{"key":"ref_187","first-page":"10","article-title":"In Vitro Skin Models as a Tool in Optimization of Drug Formulation","volume":"75","author":"Flaten","year":"2015","journal-title":"Eur. J. Pharm. Sci. Off. J. Eur. Fed. Pharm. Sci."},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s11095-024-03707-0","article-title":"Observations on the Tritiated Water and TEWL Skin Integrity Tests: Relevance to In Vitro Permeation Testing (IVPT)","volume":"41","author":"Lehman","year":"2024","journal-title":"Pharm. Res."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Chen, J., Jiang, Q.-D., Chai, Y.-P., Zhang, H., Peng, P., and Yang, X.-X. (2016). Natural Terpenes as Penetration Enhancers for Transdermal Drug Delivery. Molecules, 21.","DOI":"10.3390\/molecules21121709"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"108567","DOI":"10.1016\/j.microc.2023.108567","article-title":"Suitability of Skin-PAMPA and Chromatographic Systems to Emulate Skin Permeation. Influence of pH on Skin-PAMPA Permeability","volume":"190","author":"Fuguet","year":"2023","journal-title":"Microchem. J."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Neupane, R., Boddu, S.H.S., Renukuntla, J., Babu, R.J., and Tiwari, A.K. (2020). Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12020152"},{"key":"ref_192","doi-asserted-by":"crossref","unstructured":"Zsik\u00f3, S., Cs\u00e1nyi, E., Kov\u00e1cs, A., Budai-Sz\u0171cs, M., G\u00e1csi, A., and Berk\u00f3, S. (2019). Methods to Evaluate Skin Penetration In Vitro. Sci. Pharm., 87.","DOI":"10.3390\/scipharm87030019"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"122692","DOI":"10.1016\/j.ijpharm.2023.122692","article-title":"A Comparative Study of the in Vitro Permeation of 2-Phenoxyethanol in the Skin PAMPA Model and Mammalian Skin","volume":"635","author":"Rahma","year":"2023","journal-title":"Int. J. Pharm."},{"key":"ref_194","doi-asserted-by":"crossref","unstructured":"Sink\u00f3, B., B\u00e1rdos, V., Vesztergombi, D., K\u00e1d\u00e1r, S., Malcsiner, P., Moustie, A., Jouy, C., Tak\u00e1cs-Nov\u00e1k, K., and Gr\u00e9goire, S. (2021). Use of an In Vitro Skin Parallel Artificial Membrane Assay (Skin-PAMPA) as a Screening Tool to Compare Transdermal Permeability of Model Compound 4-Phenylethyl-Resorcinol Dissolved in Different Solvents. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111758"},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Zsik\u00f3, S., Cs\u00e1nyi, E., Kov\u00e1cs, A., Budai-Sz\u0171cs, M., G\u00e1csi, A., and Berk\u00f3, S. (2020). Novel In Vitro Investigational Methods for Modeling Skin Permeation: Skin PAMPA, Raman Mapping. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12090803"},{"key":"ref_196","unstructured":"(2025, June 27). ISO 10993-1:2018. Available online: https:\/\/www.iso.org\/ru\/standard\/68936.html."},{"key":"ref_197","unstructured":"(2025, June 27). ISO 14971:2019. Available online: https:\/\/www.iso.org\/ru\/standard\/72704.html."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/17\/7\/936\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:12:52Z","timestamp":1760033572000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/17\/7\/936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,20]]},"references-count":197,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["pharmaceutics17070936"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics17070936","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,20]]}}}