{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:04:41Z","timestamp":1774001081234,"version":"3.50.1"},"reference-count":44,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq","award":["308388\/2023-2"],"award-info":[{"award-number":["308388\/2023-2"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq","award":["CDS-RED-00007-14"],"award-info":[{"award-number":["CDS-RED-00007-14"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq","award":["88881370874\/2019-01"],"award-info":[{"award-number":["88881370874\/2019-01"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq","award":["Me 978-20"],"award-info":[{"award-number":["Me 978-20"]}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais\u2014FAPEMIG","award":["308388\/2023-2"],"award-info":[{"award-number":["308388\/2023-2"]}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais\u2014FAPEMIG","award":["CDS-RED-00007-14"],"award-info":[{"award-number":["CDS-RED-00007-14"]}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais\u2014FAPEMIG","award":["88881370874\/2019-01"],"award-info":[{"award-number":["88881370874\/2019-01"]}]},{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de Minas Gerais\u2014FAPEMIG","award":["Me 978-20"],"award-info":[{"award-number":["Me 978-20"]}]},{"name":"CAPES-COFECUB","award":["308388\/2023-2"],"award-info":[{"award-number":["308388\/2023-2"]}]},{"name":"CAPES-COFECUB","award":["CDS-RED-00007-14"],"award-info":[{"award-number":["CDS-RED-00007-14"]}]},{"name":"CAPES-COFECUB","award":["88881370874\/2019-01"],"award-info":[{"award-number":["88881370874\/2019-01"]}]},{"name":"CAPES-COFECUB","award":["Me 978-20"],"award-info":[{"award-number":["Me 978-20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: Visceral leishmaniasis remains a serious public health issue, with current antimonial therapies limited by systemic toxicity. Liposomal drug delivery systems offer a promising strategy to improve therapeutic outcomes. In this context, we previously demonstrated the antileishmanial efficacy of the liposomal formulation containing tartar emetic (Lip-TE) in reducing the parasite load in the spleen and liver of animals experimentally infected with Leishmania (Leishmania) infantum, this being an interesting alternative for the treatment of visceral leishmaniasis. In this study, we aimed to evaluate the physicochemical properties, biodistribution, pharmacokinetics, and cardiotoxicity of Lip-TE. Methods: Both Lip-Blank and Lip-TE exhibited monodisperse size distributions (PDI &lt; 0.3), with Lip-TE having an increased particle size (205.1 \u00b1 4.5 nm) compared to Lip-Blank (137.5 \u00b1 0.8 nm). Both formulations demonstrated a positive zeta potential of about +17.0 mV. Biodistribution and cardiotoxicity studies were performed using female BALB\/c mice, approximately 8 to 10 weeks old. Results: A significantly greater splenic, hepatic, and renal accumulation of Lip-TE was observed, particularly at 120 min post-injection, compared to Free TE treatment. The pharmacokinetic profile of the treatment with Lip-TE showed higher systemic exposure (AUC), extended half-life and mean residence time, and reduced clearance compared to Free TE treatment. Echocardiographic analysis revealed that treatment with Free TE significantly reduced the ejection fraction percentage and QRS complex prolongation after 10 days of treatment. These alterations persisted at 30 days, indicating progressive cardiotoxicity. In contrast, Lip-TE treatment preserved cardiac function, revealing the protective effect of the liposomal encapsulation. Conclusions: These findings highlight the potential of the Lip-TE treatment to enhance safety and efficacy.<\/jats:p>","DOI":"10.3390\/pharmaceutics17091109","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T10:35:17Z","timestamp":1756204517000},"page":"1109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Liposomal Encapsulation of Tartar Emetic Improves Pharmacokinetic Profile and Mitigates Cardiotoxicity in Murine Experimental Model"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4119-8696","authenticated-orcid":false,"given":"Larissa","family":"Coelho","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3820-2842","authenticated-orcid":false,"given":"Marta","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2771-5919","authenticated-orcid":false,"given":"Mirna","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Paiva","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e9sia","family":"Nascentes","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Instituto de Ci\u00eancias Exatas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Coelho","sequence":"additional","affiliation":[{"name":"Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation (FIOCRUZ), Belo Horizonte 30190-009, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Moore-Morris","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 de Montpellier, 34094 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9460-6705","authenticated-orcid":false,"given":"Sylvain","family":"Richard","sequence":"additional","affiliation":[{"name":"Physiologie et M\u00e9decine Experimentale, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 de Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5837-3916","authenticated-orcid":false,"given":"Pierre","family":"Sicard","sequence":"additional","affiliation":[{"name":"Physiologie et M\u00e9decine Experimentale, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Universit\u00e9 de Montpellier, 34295 Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Products, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"114909","DOI":"10.1016\/j.poly.2020.114909","article-title":"Antimony(III) Dithiocarbamates: Crystal Structures, Supramolecular Aggregations, DNA Binding, Antioxidant and Antileishmanial Activities","volume":"194","author":"Hayat","year":"2021","journal-title":"Polyhedron"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Gielen, M., and Tiekink, E.R.T. 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