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Methods: This study introduces a modified triaxial electrospinning protocol tailored to the application and benchmarks it against two conventional techniques: single-fluid blending and coaxial electrospinning. Ethylcellulose (EC) served as the polymeric matrix, while curcumin (Cur) was chosen as the model drug. In the triaxial setup, an electrospinnable, drug-free EC solution was introduced as an intermediate sheath to act as a molecular barrier, preventing Cur diffusion from the core fluid. Ethanol alone was used as the outermost fluid to guarantee a stable and continuous jet. Results: This strategy provided a DEE value of 98.74 \u00b1 6.45%, significantly higher than the 93.74 \u00b1 5.39% achieved by coaxial electrospinning and the 88.63 \u00b1 7.36% obtained with simple blending. Sustained-release testing revealed the same rank order: triaxial fibers released Cur the most slowly and exhibited the smallest initial burst release effect, followed by coaxial and then blended fibers. Mechanistic models for both fiber production and drug release are proposed to clarify how the tri-layer core\u2013shell structure translates into superior performance. Conclusions: The modified triaxial electrospinning was able to open a new practical route to produce core-sheath nanofibers. These nanofibers could provide a higher DEE and a better sustained drug release profile than those from the coaxial and blending processes.<\/jats:p>","DOI":"10.3390\/pharmaceutics17091152","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T12:04:28Z","timestamp":1756814668000},"page":"1152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["A Modified Triaxial Electrospinning for a High Drug Encapsulation Efficiency of Curcumin in Ethylcellulose"],"prefix":"10.3390","volume":"17","author":[{"given":"Xingjian","family":"Yang","sequence":"first","affiliation":[{"name":"School of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiling","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Shanghai Experimental School, 300 Dongming Road, Shanghai 200125, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-4498","authenticated-orcid":false,"given":"Deng-Guang","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Materials and Chemistry, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4757-2159","authenticated-orcid":false,"given":"Sim-Wan Annie","family":"Bligh","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Saint Francis University, Hong Kong 999077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cruz-Maya, I., Cirillo, V., Serrano-Bello, J., Serri, C., Alvarez-Perez, M.A., and Guarino, V. (2024). Optimization of Diclofenac-Loaded Bicomponent Nanofibers: Effect of Gelatin on In Vitro and In Vivo Response. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16070925"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Blaj, D.-A., Peptu, C.A., Danu, M., Harabagiu, V., Peptu, C., Bujor, A., Ochiuz, L., and Tuchilus, C.G. (2024). Enrofloxacin Pharmaceutical Formulations through the Polymer-Free Electrospinning of \u03b2-Cyclodextrin\u2013oligolactide Derivatives. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16070903"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"165226","DOI":"10.1016\/j.cej.2025.165226","article-title":"Multi-Level Resource Utilization of Food-Grade Nanomaterials from Brewing Residues: Synergistic Polyphenol-Pullulan Membranes for Litchi Preservation","volume":"519","author":"Lin","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"106323","DOI":"10.1016\/j.jddst.2024.106323","article-title":"A synoptic examination of commercially viable nanofiber-based products","volume":"102","author":"Chaudhari","year":"2024","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s42765-024-00473-x","article-title":"A Biomimetic Asymmetric Structured Intelligent Wound Dressing with Dual-Modality Humidity-Pressure Sensing for Non-Invasive and Real-Time Wound Healing Monitoring","volume":"7","author":"Ding","year":"2025","journal-title":"Adv. Fiber Mater."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Wei, W., Zhang, T., Yuan, B., and Rohani, S. (Curr. Drug Deliv., 2024). Local Delivery of Ginger Extract via A Nanofibrous Membrane Suppresses Human Skin Melanoma B16F10 Cells Growth via Targeting Ras\/ERK and PI3K\/AKT Signaling Pathways: An In Vitro Study, Curr. Drug Deliv., in press.","DOI":"10.2174\/0115672018319584241008075033"},{"key":"ref_7","first-page":"1358","article-title":"Electrospun Nanofiber Films Containing Hesperidin and Ofloxacin for the Inhibition of Inflammation and Psoriasis: A Potential In vitro Study","volume":"22","author":"Thirumal","year":"2025","journal-title":"Curr. Drug Deliv."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Agiba, A.M., Elsayyad, N., ElShagea, H.N., Metwalli, M.A., Mahmoudsalehi, A.O., Beigi-Boroujeni, S., Lozano, O., Aguirre-Soto, A., Arreola-Ramirez, J.L., and Segura-Medina, P. (2024). Advances in Light-Responsive Smart Multifunctional Nanofibers: Implications for Targeted Drug Delivery and Cancer Therapy. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16081017"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"25405","DOI":"10.1021\/acsomega.5c00604","article-title":"Spatial Distribution and Clustering of Glycosaminoglycans in Electrospun Gelatin-Based Scaffolds","volume":"10","author":"Li","year":"2025","journal-title":"ACS Omega"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"107208","DOI":"10.1016\/j.jddst.2025.107208","article-title":"Green Nanocarriers and Biodegradable Systems for Sustainable Drug Delivery Solutions","volume":"111","author":"Shirzad","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.coph.2014.09.003","article-title":"Emulsion-Based Techniques for Encapsulation in Biomedicine, Food and Personal Care","volume":"18","author":"Kakran","year":"2014","journal-title":"Curr. Opinion Pharmacol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Rashid, S., Ijaz, M., Rafique, S., Yasin, H., Mushtaq, M., Khan, A.K., Khan, M., Nasir, B., and Murtaza, G. (Curr. Drug Deliv., 2025). Cefadroxil-Mupirocin Integrated Electrospun Nanofiber Films for Burn Wound Therapy, Curr. Drug Deliv., in press.","DOI":"10.2174\/0115672018374558250607134659"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Gong, W., Wang, M.-L., Liu, Y., Yu, D.-G., and Bligh, S.W.A. (2024). Shell Distribution of Vitamin K3 within Reinforced Electrospun Nanofibers for Improved Photo-Antibacterial Performance. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25179556"},{"key":"ref_14","first-page":"1551","article-title":"Electrospun Probiotics: An Alternative for Encapsulation","volume":"32","author":"Akbar","year":"2018","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/17425247.2025.2497831","article-title":"Recent Developments in Nanofiber-Based Fast-Disintegrating Drug Delivery Systems","volume":"1","author":"Topuz","year":"2025","journal-title":"Expert Opin. Drug Del."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ye, P., Yusufu, R., Guan, Z., Chen, T., Li, S., Feng, Y., Zeng, X., Lu, J., Luo, M., and Wei, F. (2024). Multifunctional Bioactivity Electrospinning Nanofibers Encapsulating Emodin Provide A Potential Postoperative Management Strategy for Skin Cancer. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16091131"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Omer, S., Nagy, N., Pinke, B., M\u00e9sz\u00e1ros, L., Kazsoki, A., and Zelk\u00f3, R. (2024). Development and Evaluation of Different Electrospun Cysteamine-Loaded Nanofibrous Webs: A Promising Option for Treating A Rare Lysosomal Storage Disorder. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16081052"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"106681","DOI":"10.1016\/j.jddst.2025.106681","article-title":"Harnessing Electrospun Nanofibers for Comprehensive Oral Disease Management: Current Trends and Future Perspectives","volume":"106","author":"Gupta","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"163889","DOI":"10.1016\/j.cej.2025.163889","article-title":"Transfluthrin-Loaded Electrospun Nanohybrids for Long-Term Mosquito Control and Efficient Air Filtration","volume":"516","author":"Chen","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"136921","DOI":"10.1016\/j.colsurfa.2025.136921","article-title":"Self-Assembled Janus Structure Nanofiber Membranes for Skin Wound Healing: Synergistic Photothermal and Chemical Antibacterial Strategies","volume":"718","author":"Cheng","year":"2025","journal-title":"Colloid Surf. A"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lv, H., Wang, P., Lv, Y., Dong, L., Li, L., Xu, M., Fu, L., Yue, B., and Yu, D. (2025). Piezo-Photocatalytic Degradation of Ciprofloxacin Based on Flexible BiVO4 PVDF Nanofibers Membrane. Catalysts, 15.","DOI":"10.3390\/catal15020163"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s42765-024-00454-0","article-title":"Recent Advances in Functional Cellulose-Based Materials: Classification, Properties, and Applications","volume":"6","author":"Deng","year":"2024","journal-title":"Adv. Fiber Mater."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijbiomac.2018.10.176","article-title":"Production of Core-shell Nanofibers from Zein and Tragacanth for Encapsulation of Saffron Extract","volume":"122","author":"Dehcheshmeh","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jconrel.2020.10.046","article-title":"Protein Encapsulation by Electrospinning and Electrospraying","volume":"329","author":"Moreira","year":"2021","journal-title":"J. Control. Release."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e00364","DOI":"10.1002\/admi.202500364","article-title":"Coaxial Electrospun ZIF-8@PAN Nanofiber Membranes for Tetracycline and Doxycycline Adsorption in Wastewater: Kinetic, Isothermal and Thermodynamic Studies","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Mater. Interf."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1111\/1750-3841.17425","article-title":"Electrospun Gelatin\/Tea Polyphenol@pullulan Nanofibers for Fast-Dissolving Antibacterial and Antioxidant Applications","volume":"89","author":"Zhou","year":"2024","journal-title":"J. Food Sci."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Alfadhel, M. (2025, June 14). Nanofiber-Based Drug Delivery Systems: A Review on Its Applications, Challenges, and Envisioning Future Perspectives. Curr. Drug Deliv., Available online: https:\/\/www.x-mol.com\/paperRedirect\/1834266114278010880.","DOI":"10.2174\/0115672018325012240902122946"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"122856","DOI":"10.1016\/j.carbpol.2024.122856","article-title":"Medicated Tri-Layer Fibers Based on Cellulose Acetate and Polyvinylpyrrolidone for Enhanced Antibacterial and Wound Healing Properties","volume":"348","author":"Wang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/17435889.2024.2446139","article-title":"Versatility of Electrospun Janus Wound Dressings","volume":"20","author":"Yu","year":"2025","journal-title":"Nanomedicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"100119","DOI":"10.1016\/j.nxmate.2024.100119","article-title":"Electrospun Multi-Chamber Nanostructures for Sustainable Biobased Chemical Nanofibers","volume":"2","author":"Yu","year":"2024","journal-title":"Next Mater."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1021\/acsbiomaterials.5c00142","article-title":"Recent Progress in the Strategies and Applications of Electrospinning Electroactive Tissue Engineering Scaffolds","volume":"11","author":"Li","year":"2025","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.tifs.2017.10.009","article-title":"Electrospinning: A Novel Nano-encapsulation Approach for Bioactive Compounds","volume":"70","author":"Wen","year":"2014","journal-title":"Trends Food Sci. Technol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1021\/acs.jafc.7b02956","article-title":"Encapsulation of Bioactive Bompound in Electrospun Fibers and Its Potential Application","volume":"65","author":"Wen","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"127850","DOI":"10.1016\/j.foodchem.2020.127850","article-title":"Encapsulation in Food Industry with Emerging Electrohydrodynamic Techniques: Electrospinning and Electrospraying-A Review","volume":"339","author":"Coelho","year":"2021","journal-title":"Food Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1021\/bm4017594","article-title":"Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery","volume":"15","author":"Xia","year":"2014","journal-title":"Biomacromolecules"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10622","DOI":"10.1039\/c0jm01328e","article-title":"Electrospun poly (lactic-co-glycolic acid)\/halloysite nanotube composite nanofibers for drug encapsulation and sustained release","volume":"133","author":"Qi","year":"2010","journal-title":"J. Mater. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"160117","DOI":"10.1016\/j.cej.2025.160117","article-title":"Synergistic Improvements of Properties of Cellulose Acetate Based Curcumin@ TiO2 Nanofibers via Triaxial Electrospinning","volume":"506","author":"Deng","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"144388","DOI":"10.1016\/j.foodchem.2025.144388","article-title":"The Novel Nano-Electrospray Delivery of Curcumin via Ultrasound Assisted Balangu (Lallemantia Royleana) Hydrocolloid-Chickpea Protein Interaction","volume":"484","author":"Aliabbasi","year":"2025","journal-title":"Food Chem."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Xu, X.-Y., Meng, X., Li, S., Gan, R.-Y., Li, Y., and Li, H.-B. (2018). Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives. Nutrients, 10.","DOI":"10.3390\/nu10101553"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.lfs.2005.12.007","article-title":"Multiple Biological Activities of Curcumin: A Short Review","volume":"78","author":"Maheshwari","year":"2006","journal-title":"Life Sci."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Xia, Y., Gong, W., Zhou, J., Yu, D.-G., and Xie, Y. (2024). Electrospun Chitosan\/\/Ethylcellulose-Vitamin E\/\/Ethylcellulose-Curcumin Tri-Chamber Eccentric Janus Nanofibers for a Joint Antibacterial and Antioxidant Performance. Int. J. Biol. Macromol., 281.","DOI":"10.1016\/j.ijbiomac.2024.135753"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/S0022-3549(15)00191-4","article-title":"Electrospun poly (N-isopropylacrylamide)\/ethyl cellulose nanofibers as thermoresponsive drug delivery systems","volume":"105","author":"Hu","year":"2016","journal-title":"J. Pharm. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.msec.2017.02.004","article-title":"Electrospun water-stable zein\/ethyl cellulose composite nanofiber and its drug release properties","volume":"74","author":"Lu","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"ref_44","first-page":"12","article-title":"Release kinetics\u2013concepts and applications","volume":"8","author":"Paarakh","year":"2018","journal-title":"Int. J. Pharm. Res. Technol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Blaj, D.-A., Peptu, C.A., Balan-Porcarasu, M., Peptu, C., Tuchilus, C.G., and Ochiuz, L. (2025). Polymer-Free Electrospinning of \u03b2-Cyclodextrin\u2013Oligolactide for Magnolol and Honokiol Pharmaceutical Formulations. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17010130"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Jask\u00f3lski, M., Paczkowska-Walendowska, M., Miklaszewski, A., and Cielecka-Piontek, J. (2025). Ashwagandha: Optimizing the Extraction and Electrospun Nanofiber Production. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17010061"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"AlMotawa, R.Y., Alhamid, G., Badran, M.M., Orfali, R., Alomrani, A.H., Tawfik, E.A., Alzahrani, D.A., Alfassam, H.A., Ghaffar, S., and Fathaddin, A. (2024). Co-Delivery of Dragon\u2019s Blood and Alkanna Tinctoria Extracts Using Electrospun Nanofibers: In Vitro and In Vivo Wound Healing Evaluation in Diabetic Rat Model. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16060704"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ghosh, T., Nemadea, A., and Kumar, V. (Curr. Drug Deliv., 2025). Unlocking the Power of Electrospinning: A Review of Cutting-Edge Polymers and Their Impact on Scaffold Design and Performance, Curr. Drug Deliv., in press.","DOI":"10.2174\/0115672018366586250402144057"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2174\/0115672018279628231221105210","article-title":"Fiber Technology in Drug Delivery and Pharmaceuticals","volume":"22","author":"Dhoundiyal","year":"2025","journal-title":"Curr. Drug Deliv."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Alotaibi, B.S., Khan, M., Ibrahim, N.A., Khan, A.K., Liaqat, R., and Ijaz, M. (Curr. Drug Deliv., 2025). Smart Nanofibers in Wound Healing: Exploring Novel Combinations and Applications, Curr. Drug Deliv., in press.","DOI":"10.2174\/0115672018376778250616113903"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"14374","DOI":"10.1039\/D4RA01514B","article-title":"Recent Progress of Electrospun Nanofibers as Burning Dressings","volume":"14","author":"Zhang","year":"2024","journal-title":"RSC Adv."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"de Freitas, C.F., Souza, P.R., Jacinto, G.S., Braga, T.L., Ricken, Y.S., Souza, G.K., Caetano, W., Radovanovic, E., Arns, C.W., and Rai, M. (2024). Silver Nanoparticles In Situ Synthesized and Incorporated in Uniaxial and Core\u2013Shell Electrospun Nanofibers to Inhibit Coronavirus. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16020268"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zhao, Y.-S., Huang, J., Yang, X., Wang, W., Yu, D.-G., He, H., Liu, P., and Du, K. (2025). Electrospun Nanofibers and Their Application As Sensors for Healthcare. Front. Biotechnol. Bioeng., 13.","DOI":"10.3389\/fbioe.2025.1533367"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"156471","DOI":"10.1016\/j.jallcom.2020.156471","article-title":"Electrospun Tri-Layer Nanodepots for Sustained Release of Acyclovir","volume":"846","author":"Wang","year":"2020","journal-title":"J. Alloys Compd."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2401152","DOI":"10.1002\/marc.202401152","article-title":"Polymeric Nanofibers via Green Electrospinning for Safe Food Engineering","volume":"46","author":"Wang","year":"2025","journal-title":"Macromol. Rapid Comm."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Wang, Y., Liu, L., Zhu, Y., Wang, L., Yu, D.-G., and Liu, L.-y. (2023). Tri-Layer Core\u2013Shell Fibers from Coaxial Electrospinning for a Modified Release of Metronidazole. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15112561"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"127871","DOI":"10.1016\/j.molliq.2025.127871","article-title":"Electrospun MXene Based Functionalized Nanofibers for Water Pollutants Adsorption: Potentials, Challenges and Future Perspective","volume":"433","author":"Raut","year":"2025","journal-title":"J. Mol. Liq."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2100858","DOI":"10.1002\/mame.202100858","article-title":"Management of operational parameters and novel spinneret configurations for the electrohydrodynamic processing of functional polymers","volume":"307","author":"Silva","year":"2022","journal-title":"Macromol. Mater. Eng."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/15583720802022257","article-title":"Co-axial electrospinning for nanofiber structures: Preparation and applications","volume":"48","author":"Moghe","year":"2008","journal-title":"Polym. Rev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3233\/BME-130857","article-title":"Influence of sheath solvents on the quality of ethyl cellulose nanofibers in a coaxial electrospinning process","volume":"24","author":"Yu","year":"2014","journal-title":"Bio-Med. Mater. Eng."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.actbio.2016.02.029","article-title":"Electrospun pH-Sensitive Core\u2013Shell Polymer Nanocomposites Fabricated Using A Triaxial Process","volume":"35","author":"Yang","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5672","DOI":"10.1166\/jnn.2015.10471","article-title":"Fabrication and characterization of antimicrobial ethyl cellulose nanofibers using electrospinning techniques","volume":"15","author":"Park","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1700054","DOI":"10.1002\/mame.201700054","article-title":"Internal structure of amorphous electrospun nanofiber: Oriented molecular chains","volume":"302","author":"Xu","year":"2017","journal-title":"Macromol. Mater. Eng."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1021\/acs.macromol.3c02047","article-title":"Poly (vinyl alcohol) fibrils with highly oriented amorphous chains developed in electrospun nanofibers","volume":"57","author":"Wang","year":"2024","journal-title":"Macromolecules"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1016\/j.polymer.2013.03.019","article-title":"Relationship between the rigid amorphous phase and mesophase in electrospun fibers","volume":"54","author":"Ma","year":"2013","journal-title":"Polymer"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"16951","DOI":"10.1039\/C4RA01237B","article-title":"Characterization of Structural, Mechanical and Nano-Mechanical Properties of Electrospun PGS\/PCL Fibers","volume":"4","author":"Salehi","year":"2014","journal-title":"RSC Adv."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1021\/mp500391y","article-title":"Amorphous Formulations of Indomethacin and Griseofulvin Prepared by Electrospinning","volume":"11","author":"Lopez","year":"2014","journal-title":"Mol. Pharm."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Zhou, J.F., Wang, L.Z., Gong, W.J., Wang, B., Yu, D.G., and Zhu, Y.J. (2025). Correction: Zhou et al. Integrating Chinese Herbs and Western Medicine for New Wound Dressings Through Handheld Electrospinning. Biomedicines, 13.","DOI":"10.3390\/biomedicines13051033"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acs.molpharmaceut.5c00624","article-title":"Correction to Theranostic Fibers for Simultaneous Imaging and Drug Delivery","volume":"22","author":"Jin","year":"2025","journal-title":"Mol. Pharm."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1208\/s12249-025-03137-0","article-title":"Correction: Electrosprayed Janus Particles for Combined Photo-Chemotherapy","volume":"26","author":"Amaral","year":"2025","journal-title":"AAPS PharmSciTech"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Mao, H., Zhou, J., Yan, L., Zhang, S., and Yu, D.-G. (2025). Correction: Hybrid Films Loaded with 5-Fuorouracil and Reglan for Synergistic Treatment of Colon Cancer via Asynchronous Dual-Drug Delivery. Front. Bioeng. Biotech., 13.","DOI":"10.3389\/fbioe.2025.1597014"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Liu, H., Dai, Y., Li, J., Liu, P., Zhou, W., Yu, D.-G., and Ge, R. (2025). Corrigendum: Fast and Convenient Delivery of Fluidextracts Liquorice Through Electrospun Core-shell Nanohybrids. Front. Bioeng. Biotech., 13.","DOI":"10.3389\/fbioe.2025.1596937"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ijpharm.2014.12.024","article-title":"Electrospun nanofibers as a potential controlled-release solid dispersion system for poorly water-soluble drugs","volume":"479","author":"Paaver","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"105945","DOI":"10.1016\/j.arabjc.2024.105945","article-title":"Carboxymethyl cellulose\/polyvinylpyrrolidone bio-composite hydrogels enriched with clove bud extracts for enhanced wound healing","volume":"17","author":"Islam","year":"2024","journal-title":"Arab. J. Chem."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Dong, R., Gong, W., Guo, Q., Liu, H., and Yu, D.-G. (2024). Synergistic Effects of Radical Distributions of Soluble and Insoluble Polymers within Electrospun Nanofibers for an Extending Release of Ferulic Acid. Polymers, 16.","DOI":"10.3390\/polym16182614"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.2174\/0115672018279370240103062944","article-title":"Transdermal Drug Delivery System of Linagliptin Sustained-Release Microparticle Gels: In Vitro Characterization and In Vivo Evaluation","volume":"21","author":"Liu","year":"2024","journal-title":"Curr. Drug Deliv."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Chen, Y., Gong, W., Zhang, Z., Zhou, J., Yu, D.-G., and Yi, T. (2024). Reverse Gradient Distributions of Drug and Polymer Molecules within Electrospun Core\u2013Shell Nanofibers for Sustained Release. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25179524"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Jiang, X., Zhu, S., Song, J., Li, X., Li, C., Hou, G., and Gao, Z. (2025). Cirsium Setosum Extract-Loaded Hybrid Nanostructured Scaffolds Incorporating A Temperature-Sensitive Polymer for Mechanically Assisted Wound Healing. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17050660"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Christodoulou, E., Chondromatidou, A., Bikiaris, N.D., Balla, E., Vlachou, M., Barmpalexis, P., and Bikiaris, D.N. (2025). PLA-Based Electrospun Nanofibrous Mats Towards Application as Antibiotic Carriers: Processing Parameters, Fabrication and Characterization. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17050589"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1080\/20550324.2024.2362477","article-title":"Engineered Beads-on-A-String Nanocomposites for An Improved Drug Fast-Sustained Bi-Stage Release","volume":"10","author":"Gong","year":"2024","journal-title":"Nanocomposites"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.2174\/1567201819666220513122319","article-title":"Preparation of the Chitosan\/Poly-\u03b3-Glutamic Acid\/Glabrid in Hybrid Sanoparticles and Study on Its Releasing Property","volume":"20","author":"Chen","year":"2023","journal-title":"Curr. Drug Deliv."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.ijbiomac.2019.10.074","article-title":"Atomic Force Microscopy Reveals How Relative Humidity Impacts the Young\u2019s Modulus of Lignocellulosic Polymers and Their Adhesion with Cellulose Nanocrystals At the Nanoscale","volume":"147","author":"Marcuello","year":"2020","journal-title":"Int. J. Biolog. Macromol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.2174\/0929867324666170705143308","article-title":"Applications of Cellulose-based Materials in Sustained Drug Delivery Systems","volume":"26","author":"Sun","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/1528083716634033","article-title":"Doxorubicin Release from Optimized Electrospun Polylactic Acid Nanofibers","volume":"47","author":"Doustgani","year":"2017","journal-title":"J. Ind. Text."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Hathout, R.M., and Kassem, D.H. (2020). Positively Charged Electroceutical Spun Chitosan Nanofibers Can Protect Health Care Providers From COVID-19 Infection: An Opinion. Front. Bioeng. Biotechnol., 8.","DOI":"10.3389\/fbioe.2020.00885"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"8813","DOI":"10.1039\/D4TC00397G","article-title":"Bio-Inspired, Robust, and Anti-Swelling Hydrogel Sensors for Underwater Information Transmission","volume":"12","author":"Pan","year":"2024","journal-title":"J. Mater. Chem. C"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1021\/acs.macromol.3c02590","article-title":"Reactive Molecular Simulation with Size Extrapolation to Bridge the Polymerization Mechanism and Kinetics","volume":"57","author":"Chen","year":"2024","journal-title":"Macromolecules"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"136227","DOI":"10.1016\/j.colsurfa.2025.136227","article-title":"One-Step Side-by-Side Electrospraying of Janus Particles for Durable Multifunctional Coatings on Cotton Textiles","volume":"710","author":"Chen","year":"2025","journal-title":"Colloid. Surf. A"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.eng.2021.02.025","article-title":"Fabrication and Applications of Multi-Fluidic Electrospinning Multi-Structure Hollow and Core\u2013Shell Nanofibers","volume":"13","author":"Li","year":"2022","journal-title":"Engineering"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"992","DOI":"10.2174\/1567201819666220418102732","article-title":"Novel Electrospun Polymeric Nanofibers Loaded Different Medicaments as Drug Delivery Systems for Regenerative Endodontics","volume":"20","author":"Brimo","year":"2023","journal-title":"Curr. Drug Deliv."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Bayer, I.S. (2023). Controlled Drug Release from Nanoengineered Polysaccharides. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15051364"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2300361","DOI":"10.1002\/mame.202300361","article-title":"Three EHDA Processes from a Detachable Spinneret for Fabricating Drug Fast Dissolution Composites","volume":"309","author":"Chen","year":"2024","journal-title":"Macromol. Mater. 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