{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:56:22Z","timestamp":1779198982474,"version":"3.51.4"},"reference-count":28,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANII\u2013Agencia Nacional de Investigaci\u00f3n","award":["POS-NAC-2018-1-151231"],"award-info":[{"award-number":["POS-NAC-2018-1-151231"]}]},{"name":"ANII\u2013Agencia Nacional de Investigaci\u00f3n","award":["FMV-3-2020-1-162645"],"award-info":[{"award-number":["FMV-3-2020-1-162645"]}]},{"name":"ANII\u2013Agencia Nacional de Investigaci\u00f3n","award":["POS-NAC-2022-1-174042"],"award-info":[{"award-number":["POS-NAC-2022-1-174042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: We report the development of a novel intraocular sustained-release implantable pharmaceutical formulation, designed to be placed in the anterior chamber of the eye after cataract surgery. The device is intended to reduce postoperative inflammation, and to prevent opportunistic bacterial infections that may lead to endophthalmitis. Methods: The implants were produced via hot-melt extrusion, using a twin-screw extruder to process a homogeneous mixture of polylactide-co-glycolic acid, moxifloxacin hydrochloride (MOX HCl) and dexamethasone (DEX). Quality control tests included drug content determination, release rate profile evaluation, and several instrumental characterization techniques (scanning electron microscopy (SEM), confocal Raman microscopy, differential scanning calorimetry, and X-ray diffraction). Long-term and accelerated stability tests were also performed, following ICH guidelines. Sterilization was achieved by exposing samples to gamma radiation. In vivo exploratory studies were carried out in healthy rabbits to evaluate the safety and overall performance of the implantable formulation. Results: In terms of quality control, drug content was found to be homogeneously distributed throughout the implants, and it also met the label claim. In vitro release rate was constant for MOX HCl, but non-linear for DEX, increasing over time. In vivo preliminary tests showed that the inserts completely biodegraded within approximately 20 days. No clinical signs of anterior segment toxic syndrome or statistically significant intraocular pressure differences were found between treatment and control groups. Conclusions: The implants developed in this study can act as sustained-release depots for the delivery of both DEX and MOX HCl, and are biocompatible with ocular structures.<\/jats:p>","DOI":"10.3390\/pharmaceutics17091191","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:56:51Z","timestamp":1757923011000},"page":"1191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sustained-Release Biodegradable Intracameral Implants Containing Dexamethasone and Moxifloxacin: Development and In Vivo Primary Assessment"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-3144","authenticated-orcid":false,"given":"Pablo","family":"Miranda","sequence":"first","affiliation":[{"name":"Laboratorio de Nanotecnolog\u00eda, Instituto Polo Tecnol\u00f3gico de Pando, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica, Canelones 91000, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7183-3881","authenticated-orcid":false,"given":"Luis Ignacio","family":"T\u00e1rtara","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de F\u00edsica Biom\u00e9dica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba X5016JXA, Argentina"},{"name":"Unidad de Investigaci\u00f3n y Desarrollo en Tecnolog\u00eda Farmac\u00e9utica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba X5016JXA, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8226-1364","authenticated-orcid":false,"given":"Anal\u00eda","family":"Castro","sequence":"additional","affiliation":[{"name":"Laboratorio de Nanotecnolog\u00eda, Instituto Polo Tecnol\u00f3gico de Pando, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica, Canelones 91000, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7225-6836","authenticated-orcid":false,"given":"Patricia","family":"Zimet","sequence":"additional","affiliation":[{"name":"Laboratorio de Nanotecnolog\u00eda, Instituto Polo Tecnol\u00f3gico de Pando, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica, Canelones 91000, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1650-7677","authenticated-orcid":false,"given":"Ricardo","family":"Faccio","sequence":"additional","affiliation":[{"name":"\u00c1rea F\u00edsica, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica, Montevideo 11800, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2767-9087","authenticated-orcid":false,"given":"Santiago Daniel","family":"Palma","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n y Desarrollo en Tecnolog\u00eda Farmac\u00e9utica, Facultad de Ciencias Qu\u00edmicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba X5016JXA, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7795-2638","authenticated-orcid":false,"given":"\u00c1lvaro W.","family":"Mombr\u00fa","sequence":"additional","affiliation":[{"name":"\u00c1rea F\u00edsica, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica, Montevideo 11800, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0986-4580","authenticated-orcid":false,"given":"Helena","family":"Pardo","sequence":"additional","affiliation":[{"name":"Laboratorio de Nanotecnolog\u00eda, Instituto Polo Tecnol\u00f3gico de Pando, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica, Canelones 91000, Uruguay"},{"name":"\u00c1rea F\u00edsica, Facultad de Qu\u00edmica, Universidad de la Rep\u00fablica, Montevideo 11800, Uruguay"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rumelt, S. 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