{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:09Z","timestamp":1760060709068,"version":"build-2065373602"},"reference-count":99,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CACMS Innovation Fund","award":["CI2024E003-XY-06","CI2023E002-Y-54","CI2023E005TS07","ZZ13-YQ-108"],"award-info":[{"award-number":["CI2024E003-XY-06","CI2023E002-Y-54","CI2023E005TS07","ZZ13-YQ-108"]}]},{"name":"Fundamental Research Funds for the Central Public Welfare Research Institutes","award":["CI2024E003-XY-06","CI2023E002-Y-54","CI2023E005TS07","ZZ13-YQ-108"],"award-info":[{"award-number":["CI2024E003-XY-06","CI2023E002-Y-54","CI2023E005TS07","ZZ13-YQ-108"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Psoriasis is a chronic inflammatory skin disorder for which topical medications are the preferred treatment option. However, current therapies are limited by adverse reactions, drug resistance, and economic burdens. Dictamni Cortex (DC; the root bark of Dictamnus dasycarpus Turcz.) has a long history in the treatment of psoriasis, with its transdermal bioactive constituents serving as the pharmacodynamic foundation for topical anti-psoriatic therapy. Methods: Building on the separation of DC\u2019s chemical constituents, this study integrated ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and network pharmacology, along with activity verification, to investigate the anti-psoriatic active components among the transdermal constituents of DC. Results: Forty-one chemical constituents were characterized in DC, including 26 transdermally permeable compounds, predominantly alkaloids and limonoids. Network pharmacological analysis revealed core targets, including MMP9 and TLR4, as well as multiple pathways related to inflammatory and immune responses. Molecular docking studies identified dictamnine, jangomolide, rutaevin, and other key transdermal constituents that exhibited high binding affinity to core targets. In vitro validation showed that these compounds significantly suppressed cellular proliferation (p &lt; 0.05) and downregulated Ki67 mRNA expression (p &lt; 0.05) in the psoriasis-like HaCaT cell model. Concurrently, they significantly reduced secretion of key pro-inflammatory cytokines, including IL-17A, IL-22, IL-1\u03b2, IL-6, and IL-8 (p &lt; 0.05). Comprehensive comparative analyses confirmed that dictamnine exhibited ideal anti-psoriatic efficacy. Conclusions: These results provide a pharmacological substance basis for the development of external preparations of DC for treating psoriasis and provide novel research concepts for investigating the pharmacodynamic material basis of Traditional Chinese Medicine topical drugs.<\/jats:p>","DOI":"10.3390\/pharmaceutics17091195","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T07:56:51Z","timestamp":1757923011000},"page":"1195","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-Psoriatic Pharmacodynamic Material Basis of Dictamni Cortex Based on Transdermal Constituents Group"],"prefix":"10.3390","volume":"17","author":[{"given":"Zhaoyu","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Beijing 100700, China"},{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7776-8556","authenticated-orcid":false,"given":"Mengting","family":"Pi","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Beijing 100700, China"},{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4894-4280","authenticated-orcid":false,"given":"Ziang","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Beijing 100700, China"},{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"},{"name":"School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maobo","family":"Du","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Gu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Beijing 100700, China"},{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzhi","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, Beijing 100700, China"},{"name":"Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,14]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"Zhan, Z.Y., Jiang, M., Zhang, Z.H., An, Y.M., Wang, X.Y., Wu, Y.L., Nan, J.X., and Lian, L.H. (2024). NETs contribute to psoriasiform skin inflammation: A novel therapeutic approach targeting IL-36 cytokines by a small molecule tetrahydroxystilbene glucoside. Phytomedicine, 131.","key":"ref_1","DOI":"10.1016\/j.phymed.2024.155783"},{"doi-asserted-by":"crossref","unstructured":"Sugumaran, D., Yong, A.C.H., and Stanslas, J. (2024). Advances in psoriasis research: From pathogenesis to therapeutics. Life Sci., 355.","key":"ref_2","DOI":"10.1016\/j.lfs.2024.122991"},{"key":"ref_3","first-page":"2942","article-title":"New advances in the pathogenesis and drug research of psoriasis","volume":"58","author":"Liu","year":"2023","journal-title":"Acta Pharm. Sin."},{"doi-asserted-by":"crossref","unstructured":"Li, X., Yan, Z., Lan, H., Wu, Y., Chen, S., Qiu, G., and Wu, Y. (2025). Genetic Comorbidity of Psoriasis and Four Cardiovascular Diseases: Uncovering Shared Mechanisms and Potential Therapeutic Targets. Exp. Dermatol., 34.","key":"ref_4","DOI":"10.1111\/exd.70158"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/jdv.18044","article-title":"Psoriasis and metabolic syndrome: Implications for the management and treatment of psoriasis","volume":"36","author":"Wu","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1111\/1346-8138.16941","article-title":"Association of psoriasis with depression, anxiety, and suicidality: A bidirectional two-sample Mendelian randomization study","volume":"50","author":"Chu","year":"2023","journal-title":"J. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/13651501.2019.1659372","article-title":"Depression and sleep quality in psoriatic patients: Impact of psoriasis severity","volume":"24","author":"Luca","year":"2020","journal-title":"Int. J. Psychiatry Clin. Pract."},{"unstructured":"Committee on Psoriasis. Chinese Society of Dermatology (2023). Guideline for the diagnosis and treatment of psoriasis in China (2023 edition). Chin. J. Dermatol., 56, 573\u2013625.","key":"ref_8"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"19267","DOI":"10.1021\/acs.jmedchem.4c01681","article-title":"Discovery of Janus Kinase and Histone Deacetylase Dual Inhibitors as a New Strategy to Treat Psoriasis","volume":"67","author":"Hu","year":"2024","journal-title":"J. Med. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2147\/DDDT.S504485","article-title":"Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation","volume":"19","author":"Wang","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"doi-asserted-by":"crossref","unstructured":"Lee, H.J., and Kim, M. (2023). Challenges and Future Trends in the Treatment of Psoriasis. Int. J. Mol. Sci., 24.","key":"ref_11","DOI":"10.3390\/ijms241713313"},{"key":"ref_12","first-page":"35","article-title":"Analysis of the characteristics and clinical application of Liangxue Wuhua Decoction in treating psoriasis based on the theory of \u201cblood-heat as the root cause\u201d","volume":"45","author":"Wu","year":"2024","journal-title":"Yunnan J. Tradit. Chin. Med. Mater. Med."},{"key":"ref_13","first-page":"353","article-title":"Research progress on the mechanism and clinical application of traditional Chinese medicine in the treatment of psoriasis","volume":"53","author":"Li","year":"2024","journal-title":"Heilongjiang J. Tradit. Chin. Med."},{"key":"ref_14","first-page":"122","article-title":"Research progress on traditional Chinese medicine treatment of psoriasis","volume":"22","author":"Lin","year":"2024","journal-title":"Chin. J. Geriatr. Care."},{"unstructured":"Chinese Pharmacopoeia Commission (2020). Pharmacopoeia of the People\u2019s Republic of China, China Medical Science Press. [2020 ed.].","key":"ref_15"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.2174\/0115734013345775241113092201","article-title":"Functional Properties and Quality Control of Cortex Dictamni: A Review","volume":"21","author":"Steven","year":"2025","journal-title":"Curr. Nutr. Food Sci."},{"key":"ref_17","first-page":"799","article-title":"Research progress in chemical composition, pharmacological effects, toxicology of Dictamni cortex and predictive analysis of its quality markers","volume":"32","author":"Liu","year":"2023","journal-title":"Chin. New Drug J."},{"key":"ref_18","first-page":"18","article-title":"Research progress of traditional Chinese medicine in the blood-heat stage of psoriasis vulgaris","volume":"42","author":"Xu","year":"2021","journal-title":"Shanghai Med. Pharm. J."},{"key":"ref_19","first-page":"142","article-title":"Analysis of Medication Rules About External Traditional Chinese Medicine Preparations in National Patent Database for Psoriasis","volume":"20","author":"Yao","year":"2024","journal-title":"Asia-Pac. Tradit. Med."},{"key":"ref_20","first-page":"150","article-title":"Wang Yuxi\u2019s experience in treating psoriasis with Chinese herbal external washing therapy","volume":"28","author":"Xu","year":"2022","journal-title":"Guide J. Tradit. Chin. Med."},{"doi-asserted-by":"crossref","unstructured":"Choi, M., Yi, J.K., Kim, S.Y., Ryu, J.H., Lee, J., Kwon, W., Jang, S., Kim, D., Kim, M., and Kim, H. (2019). Anti-inflammatory effects of a methanol extract of Dictamnus dasycarpus Turcz. root bark on imiquimod-induced psoriasis. BMC Complement. Altern. Med., 19.","key":"ref_21","DOI":"10.1186\/s12906-019-2767-2"},{"key":"ref_22","first-page":"2328","article-title":"Mechanism of Dictamni Cortex aqueous extract in improving psoriasis-like rats based on Akt1, TP53, and Caspase-3 targets","volume":"47","author":"Gao","year":"2024","journal-title":"J. Chin. Med. Mater."},{"unstructured":"Li, Y. (2020). Effect and Molecular Mechanisms of Dictamnine in Treating Psoriasis. [Master\u2019s Thesis, South-Central Minzu University].","key":"ref_23"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"W32","DOI":"10.1093\/nar\/gku293","article-title":"SwissTargetPrediction: A web server for target prediction of bioactive small molecules","volume":"42","author":"Gfeller","year":"2014","journal-title":"Nucleic Acids Res."},{"unstructured":"Liu, H.J., Jiang, L., Cheng, X.H., Zeng, J., and Li, Q. (2025). Exploring the pharmacodynamic material basis of Heibu Yaogao in treating keloids based on transdermal component spectrum and network pharmacology. J. Shaanxi Univ. Chin. Med., 1\u20139. (In Chinese).","key":"ref_26"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"doi-asserted-by":"crossref","unstructured":"Wang, Y., Cai, S., Wen, W., Tan, Y., Wang, W., Xu, J., and Xiong, P. (2025). A Network Pharmacology Study and In Vitro Evaluation of the Bioactive Compounds of Kadsura coccinea Leaf Extract for the Treatment of Type 2 Diabetes Mellitus. Molecules, 30.","key":"ref_28","DOI":"10.3390\/molecules30051157"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"D1265","DOI":"10.1093\/nar\/gkad976","article-title":"DrugBank 6.0: The DrugBank Knowledgebase for 2024","volume":"52","author":"Knox","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1.30.1","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinform."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1002\/ajmg.a.62407","article-title":"Online Mendelian Inheritance in Man (OMIM): Victor McKusick\u2019s magnum opus","volume":"185","author":"Hamosh","year":"2021","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"D1465","DOI":"10.1093\/nar\/gkad751","article-title":"TTD: Therapeutic Target Database describing target druggability information","volume":"52","author":"Zhou","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"ref_33","first-page":"2053","article-title":"Mechanism of Cortex Dictamni in the Treatment of Eczema by LC-MS Combined with Network Pharmacology","volume":"24","author":"Shi","year":"2022","journal-title":"World Sci. Technol. Mod. Tradit. Chin. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.2147\/DDDT.S467066","article-title":"Based on UPLC-Q-TOF\/MS and Network Pharmacology to Explore the Mechanism of Qingre Lishi Decoction in the Treatment of Psoriasis","volume":"18","author":"Wei","year":"2024","journal-title":"Drug Des. Dev. Ther."},{"unstructured":"Oliveros, J.C. (2025, June 15). (2007\u20132015) Venny. An Interactive Tool for Comparing Lists with Venn\u2019s Diagrams. Available online: https:\/\/bioinfogp.cnb.csic.es\/tools\/venny\/.","key":"ref_35"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: Protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"ref_37","first-page":"112","article-title":"Investigation of Transdermal Constituents and Molecular Mechanism of Euodiae Fructus in Treatment of Diarrhea by Transdermal Drug Delivery Based on Integrated Pharmacology and UPLC-Q-TOF-MS","volume":"27","author":"Zhou","year":"2021","journal-title":"Chin. J. Exp. Tradit. Med. Form."},{"key":"ref_38","first-page":"2035","article-title":"Quality Evaluation of Qinggan Granules Based on UPLC-Q-Exactive-Orbitrap-MS and Network Pharmacology","volume":"19","author":"Wang","year":"2024","journal-title":"World Chin. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_40","first-page":"2072","article-title":"Network Pharmacology and Experimental Validation of Effective Components of Panacis Quinquefolii Radix and Carthamus tinctorius in Treatment of Early Diabetic Nephropathy","volume":"19","author":"Zhou","year":"2024","journal-title":"World Chin. Med."},{"key":"ref_41","first-page":"113","article-title":"Bioinformatics analysis of lymphangiogenesis in myocardial infarction and screening of traditional Chinese medicine for prevention treatment","volume":"43","author":"Qi","year":"2024","journal-title":"J. Tianjin Univ. Tradit. Chin. Med."},{"doi-asserted-by":"crossref","unstructured":"Tang, D., Chen, M., Huang, X., Zhang, G., Zeng, L., Zhang, G., Wu, S., and Wang, Y. (2023). SRplot: A free online platform for data visualization and graphing. PLoS ONE, 18.","key":"ref_42","DOI":"10.1371\/journal.pone.0294236"},{"doi-asserted-by":"crossref","unstructured":"Ma, M., Du, Q., Shi, S., Lv, J., Zhang, W., Ge, D., Xing, L., and Yu, N. (2024). Integrating UPLC-Q-TOF-MS and Network Pharmacology to Explore the Potential Mechanisms of Paeonia lactiflora Pall. in the Treatment of Blood Stasis Syndrome. Molecules, 29.","key":"ref_43","DOI":"10.3390\/molecules29133019"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/978-1-4939-7000-1_26","article-title":"Protein Data Bank (PDB): The Single Global Macromolecular Structure Archive","volume":"1607","author":"Burley","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"doi-asserted-by":"crossref","unstructured":"Wikan, N., Hankittichai, P., Thaklaewphan, P., Potikanond, S., and Nimlamool, W. (2021). Oxyresveratrol Inhibits TNF-\u03b1-Stimulated Cell Proliferation in Human Immortalized Keratinocytes (HaCaT) by Suppressing AKT Activation. Pharmaceutics, 14.","key":"ref_46","DOI":"10.3390\/pharmaceutics14010063"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/st9.0000000000000041","article-title":"MicroRNA-32-5p inhibits metastasis by directly targeting VPS4B and increases sensitivity to dihydroartemisinin in neuroblastoma","volume":"2","author":"Chen","year":"2024","journal-title":"Sci. Tradit. Chin. Med."},{"key":"ref_48","first-page":"2409","article-title":"Chemical constituents from the root barks of Dictamnus dasycarpus","volume":"38","author":"Guo","year":"2016","journal-title":"Chin. Tradit. Pat. Med."},{"unstructured":"Liu, X. (2020). Chemical Constituents Research of Dictamnus dasycarpus. [Master\u2019s Thesis, China Medical University].","key":"ref_49"},{"key":"ref_50","first-page":"4869","article-title":"Chemical constituents from root barks of Dictamnus dasycarpus and their cytotoxic activities","volume":"43","author":"Guo","year":"2018","journal-title":"Chin. J. Chin. Mater Med."},{"unstructured":"Wang, X.X. (2013). Active Constituents and Quality Research of Euodia Rutaecarpa. [Ph.D. Dissertation, Shenyang Pharmaceutical University].","key":"ref_51"},{"key":"ref_52","first-page":"263","article-title":"Chemical Constituents from Root Bark of Dictamnus dasycarpus","volume":"37","author":"Bai","year":"2014","journal-title":"Chin. Med. Mat."},{"key":"ref_53","first-page":"23","article-title":"Studies on chemical constituents in bark of Dictamnus dasycarpus","volume":"21","author":"Du","year":"2005","journal-title":"Chin. J. Chin. Mater Med."},{"unstructured":"Zhao, Q.Q. (2015). Isolation and Structural Identification of Chemical Constituents from Traditional Chinese Medicine Dictamnus dasycarpus. [Master\u2019s Thesis, Northwest University].","key":"ref_54"},{"key":"ref_55","first-page":"528","article-title":"Study on chemical constituents of Jiu-zishen","volume":"40","author":"Duan","year":"2009","journal-title":"Chin. Tradit. Herb. Drugs"},{"doi-asserted-by":"crossref","unstructured":"Gao, P., Wang, L., Zhao, L., Lu, Y.Y., Zeng, K.W., Zhao, M.B., Jiang, Y., Tu, P.F., and Guo, X.Y. (2021). Rapid identification, isolation, and evaluation on anti-neuroinflammatory activity of limonoids derivatives from the root bark of Dictamnus dasycarpus. J. Pharm. Biomed. Anal., 200.","key":"ref_56","DOI":"10.1016\/j.jpba.2021.114079"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1021\/np070588o","article-title":"Neuroprotective limonoids of root bark of Dictamnus dasycarpus","volume":"71","author":"Yoon","year":"2008","journal-title":"J. Nat. Prod."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.fitote.2019.03.026","article-title":"Anti-inflammatory constituents from Cortex Dictamni","volume":"134","author":"Yang","year":"2019","journal-title":"Fitoterapia"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"490","DOI":"10.3109\/14756366.2011.598151","article-title":"Inhibitory alkaloids from Dictamnus dasycarpus root barks on lipopolysaccharide-induced nitric oxide production in BV2 cells","volume":"27","author":"Yoon","year":"2012","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/BF00574243","article-title":"Coumarin glycosides of Haplophyllum performatum. structures of haploperosides C, D, and E","volume":"21","author":"Yuldashev","year":"1985","journal-title":"Chem. Nat. Compd."},{"doi-asserted-by":"crossref","unstructured":"Zhang, J.L., Song, S.C., Liu, J.C., Ni, P.-H., Liu, L., Ma, Y.-K., Sun, Y., Liu, Q., and Guo, L.-N. (2019). Chemical constituents from the root bark of Dictamnus dasycarpus Turcz. (Rutaceae) and their chemotaxonomic significance. Biochem. Syst. Ecol., 86.","key":"ref_61","DOI":"10.1016\/j.bse.2019.103931"},{"key":"ref_62","first-page":"2118","article-title":"A new lignan from stems of Sargentodoxa cuneata","volume":"38","author":"Yuan","year":"2013","journal-title":"Chin. J. Chin. Mater Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/BF02977397","article-title":"Antimicrobial property of (+)-lyoniresinol-3alpha-O-beta-D- glucopyranoside isolated from the root bark of Lycium chinense Miller against human pathogenic microorganisms","volume":"28","author":"Lee","year":"2005","journal-title":"Arch. Pharmacal Res."},{"doi-asserted-by":"crossref","unstructured":"Chang, K., Gao, P., Lu, Y.Y., Tu, P.F., Jiang, Y., and Guo, X.Y. (2021). Identification and characterization of quinoline alkaloids from the root bark of Dictamnus dasycarpus and their metabolites in rat plasma, urine and feces by UPLC\/Qtrap-MS and UPLC\/Q-TOF-MS. J. Pharm. Biomed. Anal., 204.","key":"ref_64","DOI":"10.1016\/j.jpba.2021.114229"},{"key":"ref_65","first-page":"3887","article-title":"Mass spectrometry guided strategy based on feature fragment ions forguided-separation on quinoline alkaloids from root barks of Dictamnus dasycarpus","volume":"43","author":"Guo","year":"2018","journal-title":"Chin. J. Chin. Mater Med."},{"key":"ref_66","first-page":"330","article-title":"Analysis of Absorbed Components of Rhizoma Anemarrhenae-Cortex Phellodendri Chinesis Herb-Pair Based on UPLC-Q-Exactive Orbitrap-MS","volume":"59","author":"Xia","year":"2024","journal-title":"Chin. Pharm. J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1002\/rcm.7026","article-title":"Species-related difference between limonin and obacunone among five liver microsomes and zebrafish using ultra-high-performance liquid chromatography coupled with a LTQ-Orbitrap mass spectrometer","volume":"28","author":"Ren","year":"2014","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"ref_68","first-page":"113","article-title":"Analysis of Chemical Constituents in Euodiae Fructus by UPLC-Q-TOF-MS\/MS","volume":"27","author":"Zhao","year":"2021","journal-title":"Chin. J. Exp. Tradit. Med. Form."},{"key":"ref_69","first-page":"3723","article-title":"Chemical constituents and pharmacological effects of Dictamni Cortex:a review","volume":"47","author":"Gao","year":"2022","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_70","first-page":"2225","article-title":"Rapid identification of the components in Phellodendri chinensis Cortex based on UPLC-Q-TOF-MS","volume":"42","author":"Shi","year":"2022","journal-title":"Chin. J. Hosp. Pharm."},{"key":"ref_71","first-page":"2953","article-title":"Characterization and identification of chemical components from Euodiae Fructus based on UHPLC-Q-TOF-MS","volume":"49","author":"Wang","year":"2024","journal-title":"China J. Chin. Mater. Med."},{"key":"ref_72","first-page":"1206","article-title":"Exploration of the Mechanism of Yangxue Qingnao Granules in the Treatment of Hypertension Based on Network Pharmacology and Molecular Docking","volume":"35","author":"Shi","year":"2024","journal-title":"Tradit. Chin. Drug Res. Clin. Pharmacol."},{"doi-asserted-by":"crossref","unstructured":"Liu, L., Zhang, H., Tang, X., Zhang, M., Wu, Y., Zhao, Y., Lu, C., and Zhao, R. (2024). Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4\/MyD88\/NF-\u03baB p65 signaling pathway and MMP9. Int. Immunopharmacol., 133.","key":"ref_73","DOI":"10.1016\/j.intimp.2024.112082"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/CCID.S350711","article-title":"Inhibition of miR-155 Attenuates CD14+ Monocyte-Mediated Inflammatory Response and Oxidative Stress in Psoriasis Through TLR4\/MyD88\/NF-\u03baB Signaling Pathway","volume":"15","author":"Li","year":"2022","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.joim.2023.11.004","article-title":"Ethanol extract of Herpetospermum caudigerum Wall ameliorates psoriasis-like skin inflammation and promotes degradation of keratinocyte-derived ICAM-1 and CXCL9","volume":"21","author":"Zhong","year":"2023","journal-title":"J. Integr. Med."},{"doi-asserted-by":"crossref","unstructured":"Shih, C.M., Hsieh, C.K., Huang, C.Y., Huang, C.Y., Wang, K.H., Fong, T.H., Trang, N.T.T., Liu, K.T., and Lee, A.W. (2020). Lycopene Inhibit IMQ-Induced Psoriasis-Like Inflammation by Inhibiting ICAM-1 Production in Mice. Polymers, 12.","key":"ref_76","DOI":"10.3390\/polym12071521"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/eji.202149706","article-title":"EGFR ligands synergistically increase IL-17A-induced expression of psoriasis signature genes in human keratinocytes via I\u03baB\u03b6 and Bcl3","volume":"52","author":"Dai","year":"2022","journal-title":"Eur. J. Immunol."},{"key":"ref_78","first-page":"520","article-title":"Recent advances on the roles of epidermal growth factor receptor in psoriasis","volume":"11","author":"Wang","year":"2019","journal-title":"Am. J. Transl. Res."},{"doi-asserted-by":"crossref","unstructured":"Yang, J. (2018). Cereblon Suppresses LPS-Induced Inflammatory Response and Apoptosis Through Promoting the Ubiquitination and Degradation of c-Jun. [Master\u2019s Thesis, Soochow University].","key":"ref_79","DOI":"10.1074\/jbc.RA118.002246"},{"key":"ref_80","first-page":"214","article-title":"Exploration of the effects of Tuhuaidan Siwu Decoction on proliferation and inflammation of HaCaT Cells based on network pharmacology and molecular docking technology","volume":"23","author":"Zhang","year":"2022","journal-title":"J. Shanxi Univ. Chin. Med."},{"key":"ref_81","first-page":"1488","article-title":"Network Pharmacology Study and Cellular Validation of Dictamni Cortex and Wogonin in the Treatment of Psoriasis","volume":"40","author":"Lin","year":"2023","journal-title":"J. Guangzhou Univ. Tradit. Chin. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"22","DOI":"10.15586\/aei.v52i6.1157","article-title":"Gypenosides alleviates HaCaT keratinocyte hyperproliferation and ameliorates imiquimod-induced psoriasis in mice","volume":"52","author":"Liu","year":"2024","journal-title":"Allergol. Immunopathol."},{"doi-asserted-by":"crossref","unstructured":"Ma, C., Gu, C., Lian, P., Wazir, J., Lu, R., Ruan, B., Wei, L., Li, L., Pu, W., and Peng, Z. (2023). Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling. Cell Death Dis., 14.","key":"ref_83","DOI":"10.1038\/s41419-023-06234-9"},{"doi-asserted-by":"crossref","unstructured":"Veerasubramanian, P.K., Wynn, T.A., Quan, J., and Karlsson, F.J. (2024). Targeting TNF\/TNFR superfamilies in immune-mediated inflammatory diseases. J. Exp. Med., 221.","key":"ref_84","DOI":"10.1084\/jem.20240806"},{"doi-asserted-by":"crossref","unstructured":"Wu, J., Liu, S., Zhang, H., Zhang, X., Xue, J., Li, Z., Zhang, Y., Jiang, Y., Zhang, P., and Yang, M. (2025). Amlexanox ameliorates imiquimod-induced psoriasis-like dermatitis by inhibiting Th17 cells and the NF-\u03baB signal pathway. Biomed. Pharmacother., 184.","key":"ref_85","DOI":"10.1016\/j.biopha.2025.117922"},{"doi-asserted-by":"crossref","unstructured":"Zhang, W., Zhu, G., Sun, H., and Jiang, C. (2025). NLRC3 affects the development of psoriasis by modulating the NF-\u03baB signaling pathway mediated inflammatory response through its interaction with TRAF6. Immunol. Lett., 272.","key":"ref_86","DOI":"10.1016\/j.imlet.2024.106949"},{"doi-asserted-by":"crossref","unstructured":"Yu, H., Lin, L., Zhang, Z., Zhang, H., and Hu, H. (2020). Targeting NF-\u03baB pathway for the therapy of diseases: Mechanism and clinical study. Signal Transduct. Target. Ther., 5.","key":"ref_87","DOI":"10.1038\/s41392-020-00312-6"},{"doi-asserted-by":"crossref","unstructured":"Adamczyk, M., Bartosi\u0144ska, J., Raczkiewicz, D., Michalak-Stoma, A., and Krasowska, D. (2023). The Impact of Biologic Treatment on PD-1\/PD-L1 Pathway Disturbances in Psoriasis. J. Clin. Med., 12.","key":"ref_88","DOI":"10.20944\/preprints202305.1476.v1"},{"doi-asserted-by":"crossref","unstructured":"Emre, S., S\u00fcng\u00fc, N., Hayran, Y., Demirseren, D.D., Aktas, A., and Duman, T.\u00d6. (2023). Investigation of the PD-1\/PD-L1 Expression in the Lesional Skins of Patients with Psoriasis. Dermatol. Pract. Concept., 13.","key":"ref_89","DOI":"10.5826\/dpc.1302a134"},{"doi-asserted-by":"crossref","unstructured":"Swindell, W.R., Johnston, A., Xing, X., Voorhees, J.J., Elder, J.T., and Gudjonsson, J.E. (2013). Modulation of epidermal transcription circuits in psoriasis: New links between inflammation and hyperproliferation. PLoS ONE, 8.","key":"ref_90","DOI":"10.1371\/journal.pone.0079253"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.intimp.2019.01.054","article-title":"Genistein suppresses psoriasis-related inflammation through a STAT3-NF-\u03baB-dependent mechanism in keratinocytes","volume":"69","author":"Wang","year":"2019","journal-title":"Int. Immunopharmacol."},{"doi-asserted-by":"crossref","unstructured":"Gao, J., Chen, F., Fang, H., Mi, J., Qi, Q., and Yang, M. (2020). Daphnetin inhibits proliferation and inflammatory response in human HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice. Biol. Res., 53.","key":"ref_92","DOI":"10.1186\/s40659-020-00316-0"},{"key":"ref_93","first-page":"154","article-title":"Expression and significance of Ki67 in psoriatic lesions","volume":"32","author":"Lin","year":"2011","journal-title":"Sichuan Med. J."},{"doi-asserted-by":"crossref","unstructured":"Choi, D.H., and Hwang, H.S. (2019). Anti-inflammation activity of brazilin in TNF-\u03b1 induced human psoriasis dermatitis skin model. Appl. Biol. Chem., 62.","key":"ref_94","DOI":"10.1186\/s13765-019-0455-z"},{"doi-asserted-by":"crossref","unstructured":"Takuathung, M.N., Potikanond, S., Sookkhee, S., Mungkornasawakul, P., Jearanaikulvanich, T., Chinda, K., Wikan, N., and Nimlamool, W. (2021). Anti-psoriatic and anti-inflammatory effects of Kaempferia parviflora in keratinocytes and macrophage cells. Biomed. Pharmacother., 143.","key":"ref_95","DOI":"10.1016\/j.biopha.2021.112229"},{"doi-asserted-by":"crossref","unstructured":"Tokuyama, M., and Mabuchi, T. (2020). New Treatment Addressing the Pathogenesis of Psoriasis. Int. J. Mol. Sci., 21.","key":"ref_96","DOI":"10.3390\/ijms21207488"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.intimp.2018.04.018","article-title":"Glabridin, an isoflavan from licorice root, ameliorates imiquimod-induced psoriasis-like inflammation of BALB\/c mice","volume":"59","author":"Li","year":"2018","journal-title":"Int. Immunopharmacol."},{"doi-asserted-by":"crossref","unstructured":"Lin, Y., Yin, X., Ma, S., Xue, Y., Hu, C., Xie, Y., Zeng, Y., Zhao, X., Du, C., and Sun, Y. (2024). Cang-ai volatile oil ameliorates imiquimod-induced psoriatic skin lesions by suppressing the ILC3s. J. Ethnopharmacol., 326.","key":"ref_98","DOI":"10.1016\/j.jep.2024.117867"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1080\/08923973.2023.2229510","article-title":"TNF-\u03b1 promotes CXCL-1\/8 production in keratinocytes by downregulating galectin-3 through NF-\u03baB and hsa-miR-27a-3p pathway to contribute psoriasis development","volume":"45","author":"Qiu","year":"2023","journal-title":"Immunopharmacol. Immunotoxicol."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/17\/9\/1195\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:45:25Z","timestamp":1760035525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/17\/9\/1195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,14]]},"references-count":99,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["pharmaceutics17091195"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics17091195","relation":{},"ISSN":["1999-4923"],"issn-type":[{"type":"electronic","value":"1999-4923"}],"subject":[],"published":{"date-parts":[[2025,9,14]]}}}