{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:29:36Z","timestamp":1790627376605,"version":"4.1.0"},"reference-count":101,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH NIAID","award":["1R56AI180213-01A1"],"award-info":[{"award-number":["1R56AI180213-01A1"]}]},{"name":"Institute for Integration of Medicine and Science (IIMS) at UT Health San Antonio by the National Center for Advancing Translational Sciences, National Institutes of Health","award":["UM1 TR004538"],"award-info":[{"award-number":["UM1 TR004538"]}]},{"name":"Office of the Vice President for Research Internal Funding Programs","award":["174597-23092"],"award-info":[{"award-number":["174597-23092"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Schistosomiasis, a neglected tropical disease affecting over 250 million people worldwide, relies on praziquantel (PZQ) as its sole treatment. However, PZQ has significant limitations, including inactivity against juvenile worms, inability to prevent reinfection, and emerging drug resistance. In this review, we outline the development of CIDD-0150303, a novel oxamniquine (OXA) derivative with pan-species and pan-stage activity against Schistosoma mansoni, PZQ-resistant S. mansoni, and S. haematobium. Using a structure-guided design approach, over 350 OXA analogs were synthesized and screened to identify leading drug candidate CIDD-0150303. CIDD-0150303 demonstrates 100% lethality in vitro and up to 80% reduction in worm burden in vivo. CIDD-0150303 is effective against both juvenile and adult parasites as well as PZQ-resistant S. mansoni. This compound represents a promising advance in schistosomiasis treatment to address urgent gaps in control\/elimination strategies and PZQ resistance. However, dedicated safety and toxicity studies are still ongoing, and additional in vivo validation is required.<\/jats:p>","DOI":"10.3390\/pharmaceutics17101268","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:00:32Z","timestamp":1759132832000},"page":"1268","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of a Novel Compound Effective Against Juvenile, Adult, and Drug-Resistant Schistosoma Species"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8701-4859","authenticated-orcid":false,"given":"Sevan N.","family":"Alwan","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-6033","authenticated-orcid":false,"given":"Alexander B.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"},{"name":"Greehey Children\u2019s Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0070-4924","authenticated-orcid":false,"given":"Stanton F.","family":"McHardy","sequence":"additional","affiliation":[{"name":"Center for Innovative Drug Discovery, Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3154-4775","authenticated-orcid":false,"given":"Michael D.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL 33458, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip T.","family":"LoVerde","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Structural Biology, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis","volume":"4","author":"McManus","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0001-706X(03)00029-9","article-title":"Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa","volume":"86","author":"Brooker","year":"2003","journal-title":"Acta Trop."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chitsulo, L., Loverde, P., and Engels, D. (2004). Focus: Schistosomiasis. Nat. Rev. Microbiol., 2.","DOI":"10.1038\/nrmicro801"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pt.2020.06.003","article-title":"Schistosoma\u00a0mansoni","volume":"37","author":"Anderson","year":"2021","journal-title":"Trends Parasitol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.tips.2022.08.007","article-title":"Malnutrition vaccines for an imminent global food catastrophe","volume":"43","author":"Hotez","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/20477724.2021.1975081","article-title":"Schistosoma mansoni infection and the occurrence, characteristics, and survival of patients with hepatocellular carcinoma: An observational study over a decade","volume":"116","author":"Shousha","year":"2022","journal-title":"Pathog. Glob. Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pt.2011.10.008","article-title":"A review of female genital schistosomiasis","volume":"28","author":"Kjetland","year":"2012","journal-title":"Trends Parasitol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1056\/NEJMp1914709","article-title":"Female Genital Schistosomiasis","volume":"381","author":"Hotez","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4103\/aam.aam_48_17","article-title":"A review of bladder cancer in Sub-Saharan Africa: A different disease, with a distinct presentation, assessment, and treatment","volume":"17","author":"Bowa","year":"2018","journal-title":"Ann. Afr. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chala, B., and Torben, W. (2018). An Epidemiological Trend of Urogenital Schistosomiasis in Ethiopia. Front. Public Health, 6.","DOI":"10.3389\/fpubh.2018.00060"},{"key":"ref_11","first-page":"153","article-title":"Schistosomiasis: Still a Cause of Significant Morbidity and Mortality","volume":"10","author":"Verjee","year":"2019","journal-title":"Res. Rep. Trop. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.55460\/KP8A-D310","article-title":"Schistosomiasis: Traverers in Africa","volume":"16","author":"Strohmayer","year":"2016","journal-title":"J. Spec. Oper. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00281-020-00789-x","article-title":"Schistosomiasis\u2014From immunopathology to vaccines","volume":"42","author":"McManus","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S1473-3099(16)00175-4","article-title":"Outbreak of urogenital schistosomiasis in Corsica (France): An epidemiological case study","volume":"16","author":"Boissier","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014","journal-title":"Lancet"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Gurarie, D., Lo, N.C., Ndeffo-Mbah, M.L., Durham, D.P., and King, C.H. (2018). The human-snail transmission environment shapes long term schistosomiasis control outcomes: Implications for improving the accuracy of predictive modeling. PLoS Neglected Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006514"},{"key":"ref_17","first-page":"R1","article-title":"Progress in assesment of morbidity due to Schistosoma mansoni infection: A review of recent literature","volume":"85","author":"Chen","year":"1998","journal-title":"Trop. Dis. Bull."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.12688\/wellcomeopenres.13488.1","article-title":"Transplantation of schistosome sporocysts between host snails: A video guide","volume":"3","author":"Mouahid","year":"2018","journal-title":"Wellcome Open Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Nation, C.S., Da\u2019dara, A.A., Marchant, J.K., and Skelly, P.J. (2020). Schistosome migration in the definitive host. PLoS Neglected Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0007951"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1017\/S0031182000000743","article-title":"Migration of the schistosomula of Schistosoma mansoni from the lungs to the hepatic portal system","volume":"80","author":"Miller","year":"1980","journal-title":"Parasitology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1017\/S0031182000051970","article-title":"Schistosoma mansoni: A histological study of migration in the laboratory mouse","volume":"79","author":"Wheater","year":"1979","journal-title":"Parasitology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0014-4894(03)00024-9","article-title":"Schistosoma mansoni, S. haematobium, and S. japonicum: Early events associated with penetration and migration of schistosomula through human skin","volume":"102","author":"He","year":"2002","journal-title":"Exp. Parasitol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00436-004-1284-4","article-title":"Schistosoma japonicum migration through mouse skin compared histologically and immunologically with S. mansoni","volume":"95","author":"Wang","year":"2005","journal-title":"Parasitol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1645\/0022-3395(2002)088[0003:PASASA]2.0.CO;2","article-title":"Presidential address. Sex and schistosomes: An interesting biological interplay with control implications","volume":"88","author":"LoVerde","year":"2002","journal-title":"J. Parasitol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Wang, J., Chen, R., and Collins, J.J. (2019). Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni. PLoS Biol., 17.","DOI":"10.1371\/journal.pbio.3000254"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"831","DOI":"10.4269\/ajtmh.1956.5.831","article-title":"The relative egg producing capacity of Schistosoma mansoni and Schistosoma japonicum","volume":"5","author":"Moore","year":"1956","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100625","DOI":"10.1016\/j.jhepr.2022.100625","article-title":"Metabolic reprogramming of hepatocytes by Schistosoma mansoni eggs","volume":"5","author":"Gindner","year":"2023","journal-title":"JHEP Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.chom.2020.10.002","article-title":"Schistosoma mansoni Eggs Modulate the Timing of Granuloma Formation to Promote Transmission","volume":"29","author":"Takaki","year":"2021","journal-title":"Cell Host Microbe"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.actatropica.2013.01.001","article-title":"The impact of single versus mixed Schistosoma haematobium and S. mansoni infections on morbidity profiles amongst school-children in Taveta, Kenya","volume":"128","author":"Gouvras","year":"2013","journal-title":"Acta Trop."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Koukounari, A., Donnelly, C.A., Sacko, M., Keita, A.D., Landoure, A., Dembele, R., Bosque-Oliva, E., Gabrielli, A.F., Gouvras, A., and Traore, M. (2010). The impact of single versus mixed schistosome species infections on liver, spleen and bladder morbidity within Malian children pre- and post-praziquantel treatment. BMC Infect. Dis., 10.","DOI":"10.1186\/1471-2334-10-227"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ijpara.2012.02.002","article-title":"Epidemiology of mixed Schistosoma mansoni and Schistosoma haematobium infections in northern Senegal","volume":"42","author":"Meurs","year":"2012","journal-title":"Int. J. Parasitol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.curtheres.2019.06.001","article-title":"Schistosomiasis: Life Cycle, Diagnosis, and Control","volume":"91","author":"Nelwan","year":"2019","journal-title":"Curr. Ther. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/QCO.0b013e328318978f","article-title":"Praziquantel: Mechanisms of action, resistance and new derivatives for schistosomiasis","volume":"21","author":"Doenhoff","year":"2008","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"738","DOI":"10.2471\/BLT.08.058669","article-title":"Global trends in schistosomiasis control","volume":"86","author":"Taylor","year":"2008","journal-title":"Bull. World Health Organ."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"701","DOI":"10.4155\/fmc.15.11","article-title":"What is the mechanism of action of praziquantel and how might resistance strike?","volume":"7","author":"Cupit","year":"2015","journal-title":"Future Med. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1111\/bph.14831","article-title":"Praziquantel ameliorates CCl4-induced liver fibrosis in mice by inhibiting TGF-beta\/Smad signalling via up-regulating Smad7 in hepatic stellate cells","volume":"176","author":"Liu","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1017\/S0031182009990400","article-title":"The Schistosomiasis Control Initiative (SCI): Rationale, development and implementation from 2002\u20132008","volume":"136","author":"Fenwick","year":"2009","journal-title":"Parasitology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e02582-16","DOI":"10.1128\/AAC.02582-16","article-title":"Praziquantel for Schistosomiasis: Single-Drug Metabolism Revisited, Mode of Action, and Resistance","volume":"61","author":"Vale","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990\u20132010: A systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"ref_40","unstructured":"WHO (2025, February 23). Zanzibar: Gearing Up to Eliminate Schistosomiasis. Available online: https:\/\/www.who.int\/news\/item\/07-03-2012-zanzibar-gearing-up-to-eliminate-schistosomiasis?utm_source=chatgpt.com."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00436-009-1656-x","article-title":"The in vitro effect of mefloquine and praziquantel against juvenile and adult Schistosoma japonicum","volume":"106","author":"Xiao","year":"2009","journal-title":"Parasitol. Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.pt.2019.11.002","article-title":"The Journey to Discovering a Flatworm Target of Praziquantel: A Long TRP","volume":"36","author":"Park","year":"2020","journal-title":"Trends Parasitol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"eabj5832","DOI":"10.1126\/scitranslmed.abj5832","article-title":"Mechanism of praziquantel action at a parasitic flatworm ion channel","volume":"13","author":"Park","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"eabj9114","DOI":"10.1126\/scitranslmed.abj9114","article-title":"Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel","volume":"13","author":"Chevalier","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13071-016-1958-7","article-title":"Efficacy and safety of praziquantel 40 mg\/kg in preschool-aged and school-aged children: A meta-analysis","volume":"10","author":"Zwang","year":"2017","journal-title":"Parasites Vectors"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"King, C.H., Olbrych, S.K., Soon, M., Singer, M.E., Carter, J., and Colley, D.G. (2011). Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: A systematic review. PLoS Neglected Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0001321"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1093\/infdis\/jix496","article-title":"A Persistent Hotspot of Schistosoma mansoni Infection in a Five-Year Randomized Trial of Praziquantel Preventative Chemotherapy Strategies","volume":"216","author":"Wiegand","year":"2017","journal-title":"J. Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Mushi, V., Zacharia, A., Shao, M., Mubi, M., and Tarimo, D. (2022). Persistence of Schistosoma haematobium transmission among school children and its implication for the control of urogenital schistosomiasis in Lindi, Tanzania. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0263929"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1017\/S0031182009000493","article-title":"Praziquantel: Its use in control of schistosomiasis in sub-Saharan Africa and current research needs","volume":"136","author":"Doenhoff","year":"2009","journal-title":"Parasitology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"932","DOI":"10.4269\/ajtmh.1999.60.932","article-title":"Resistance to praziquantel: Direct evidence from Schistosoma mansoni isolated from Egyptian villagers","volume":"60","author":"Ismail","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4269\/ajtmh.2006.74.342","article-title":"Failure of standard treatment with praziquantel in two returned travelers with Schistosoma haematobium infection","volume":"74","author":"Alonso","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1590\/S0074-02762011000200006","article-title":"Schistosoma mansoni: A method for inducing resistance to praziquantel using infected Biomphalaria glabrata snails","volume":"106","author":"Couto","year":"2011","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4269\/ajtmh.1994.51.83","article-title":"Drug-resistant schistosomiasis: Resistance to praziquantel and oxamniquine induced in Schistosoma mansoni in mice is drug specific","volume":"51","author":"Fallon","year":"1994","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_54","first-page":"209","article-title":"Epidemiology, immunology and chemotherapy of Schistosoma mansoni infections in a recently exposed community in Senegal","volume":"46","author":"Gryseels","year":"1994","journal-title":"Trop. Geogr. Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1471-4922(01)02209-7","article-title":"Interpreting low praziquantel cure rates of Schistosoma mansoni infections in Senegal","volume":"18","year":"2002","journal-title":"Trends Parasitol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40249-017-0293-3","article-title":"Efficacy of praziquantel on Schistosoma haematobium and re-infection rates among school-going children in the Ndumo area of uMkhanyakude district, KwaZulu-Natal, South Africa","volume":"6","author":"Kabuyaya","year":"2017","journal-title":"Infect. Dis. Poverty"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.trstmh.2008.03.010","article-title":"Efficacy and side effects of praziquantel treatment against Schistosoma haematobium infection among primary school children in Zimbabwe","volume":"102","author":"Midzi","year":"2008","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1017\/S003118201000154X","article-title":"Efficacy of two praziquantel treatments among primary school children in an area of high Schistosoma mansoni endemicity, Nile Delta, Egypt","volume":"138","author":"Barakat","year":"2011","journal-title":"Parasitology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"778","DOI":"10.4269\/ajtmh.2004.71.778","article-title":"Efficacy of praziquantel against Schistosoma haematobium infection in children","volume":"71","author":"Tchuente","year":"2004","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1017\/S0031182000052689","article-title":"A comparative study of the life-histories of mammalian schistosomes","volume":"87","author":"Loker","year":"1983","journal-title":"Parasitology"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Zdesenko, G., and Mutapi, F. (2020). Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental models. PLoS Neglected Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008649"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"101065","DOI":"10.1016\/j.lanmic.2024.101065","article-title":"Population-level impact of mass drug administration against schistosomiasis with anthelmintic drugs targeting juvenile schistosomes: A modelling study","volume":"6","author":"Singer","year":"2025","journal-title":"Lancet Microbe"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1016\/j.bmc.2017.04.031","article-title":"Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine","volume":"25","author":"Campos","year":"2017","journal-title":"Bioorganic Med. Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1756-3305-4-201","article-title":"Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: A systematic review and meta-analysis","volume":"4","author":"Liu","year":"2011","journal-title":"Parasites Vectors"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.phrs.2016.02.017","article-title":"Antischistosomal activity of artemisinin derivatives in vivo and in patients","volume":"110","author":"Saeed","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0163-7258(95)00026-7","article-title":"Antischistosomal drugs: Past, present \u2026 and future?","volume":"68","author":"Cioli","year":"1995","journal-title":"Pharmacol. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.actatropica.2008.05.006","article-title":"Clinical therapy of schistosomiasis mansoni: The Brazilian contribution","volume":"108","author":"Katz","year":"2008","journal-title":"Acta Trop."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pt.2003.11.010","article-title":"Schistosomiasis control: Keep taking the tablets","volume":"20","author":"Hagan","year":"2004","journal-title":"Trends Parasitol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/00034983.1971.11686730","article-title":"The action of UK 3883, a novel 2-aminomethyltetrahydroquinoline derivative, against mature schistosomes in rodents and primates","volume":"65","author":"Foster","year":"1971","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Alwan, S.N., Taylor, A.B., Rhodes, J., Tidwell, M., McHardy, S.F., and LoVerde, P.T. (2023). Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis. PLoS Pathog., 19.","DOI":"10.1101\/2023.05.23.541778"},{"key":"ref_71","first-page":"11","article-title":"Recent developments in the chemotherapy of schistosomiasis","volume":"Volume 16","author":"Archer","year":"1972","journal-title":"Progress in Drug Research"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0022-3565(25)30557-4","article-title":"Long-term hepatocellular effects of hycanthone and of two other anti-Schistosomal drugs in mice infected with Schistosoma mansoni","volume":"197","author":"Haese","year":"1976","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/15287397509529325","article-title":"Genetic activity spectra of some antischistosomal compounds, with particular emphasis on thioxanthenones and benzothiopyranoindazoles","volume":"1","author":"Hartman","year":"1975","journal-title":"J. Toxicol. Environ. Health"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0035-9203(87)90282-3","article-title":"A review of clinical experience with oxamniquine","volume":"81","author":"Foster","year":"1987","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/jac\/19.1.87","article-title":"Oxamniquine pharmacokinetics in hepatosplenic schistosomiasis in the Sudan","volume":"19","author":"Daneshmend","year":"1987","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_76","first-page":"CD000528","article-title":"Drugs for treating Schistosoma mansoni infection","volume":"2013","author":"Olliaro","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_77","first-page":"359","article-title":"Oxamniquine pharmacokinetics in healthy Kenyan African volunteers","volume":"68","author":"Kokwaro","year":"1991","journal-title":"East. Afr. Med. J."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.172.3987.1057","article-title":"Hycanthone resistance: Development in Schistosoma mansoni","volume":"172","author":"Rogers","year":"1971","journal-title":"Science"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1006\/expr.1993.1104","article-title":"Schistosoma mansoni: Genetic complementation analysis shows that two independent hycanthone\/oxamniquine-resistant strains are mutated in the same gene","volume":"77","author":"Dias","year":"1993","journal-title":"Exp. Parasitol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0378-5173(01)00917-6","article-title":"Synthesis and evaluation of new oxamniquine derivatives","volume":"233","author":"Filho","year":"2002","journal-title":"Int. J. Pharm."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.bmc.2006.11.027","article-title":"Design, synthesis, and in vivo evaluation of oxamniquine methacrylate and acrylamide prodrugs","volume":"15","author":"Filho","year":"2007","journal-title":"Bioorganic Med. Chem."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2174\/1389557511313040003","article-title":"The evolution of drugs on schistosoma treatment: Looking to the past to improve the future","volume":"13","author":"Galdino","year":"2013","journal-title":"Mini-Rev. Med. Chem."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1021\/acsinfecdis.7b00054","article-title":"Ferrocenyl, Ruthenocenyl, and Benzyl Oxamniquine Derivatives with Cross-Species Activity against Schistosoma mansoni and Schistosoma haematobium","volume":"3","author":"Hess","year":"2017","journal-title":"ACS Infect. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1186\/s13071-018-3132-x","article-title":"Assessment of tegumental damage to Schistosoma mansoni and S. haematobium after in vitro exposure to ferrocenyl, ruthenocenyl and benzyl derivatives of oxamniquine using scanning electron microscopy","volume":"11","author":"Buchter","year":"2018","journal-title":"Parasites Vectors"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"15232","DOI":"10.1002\/chem.202002856","article-title":"Multidisciplinary Preclinical Investigations on Three Oxamniquine Analogues as New Drug Candidates for Schistosomiasis","volume":"26","author":"Buchter","year":"2020","journal-title":"Chemistry"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1021\/acsmedchemlett.8b00257","article-title":"Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Antischistosomal Agents","volume":"9","author":"Rugel","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1126\/science.1243106","article-title":"Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites","volume":"342","author":"Valentim","year":"2013","journal-title":"Science"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0024-3205(85)90419-9","article-title":"Evidence for the mode of antischistosomal action of hycanthone","volume":"37","author":"Cioli","year":"1985","journal-title":"Life Sci."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Guzman, M.A., Rugel, A., Alwan, S.N., Tarpley, R., Taylor, A.B., Chevalier, F.D., Wendt, G.R., Collins, J.J., Anderson, T.J.C., and McHardy, S.F. (2022). Schistosome Sulfotransferases: Mode of Action, Expression and Localization. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14071416"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.molbiopara.2011.03.001","article-title":"Whole mount in situ hybridization methodology for Schistosoma mansoni","volume":"178","author":"Cogswell","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature11924","article-title":"Adult somatic stem cells in the human parasite Schistosoma mansoni","volume":"494","author":"Collins","year":"2013","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"11154","DOI":"10.1074\/jbc.M116.766527","article-title":"Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy","volume":"292","author":"Taylor","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijpddr.2021.05.002","article-title":"Rational approach to drug discovery for human schistosomiasis","volume":"16","author":"LoVerde","year":"2021","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijpddr.2020.04.001","article-title":"Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?","volume":"13","author":"Rugel","year":"2020","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Guzman, M.A., Rugel, A.R., Tarpley, R.S., Alwan, S.N., Chevalier, F.D., Kovalskyy, D.P., Cao, X., Holloway, S.P., Anderson, T.J.C., and Taylor, A.B. (2020). An iterative process produces oxamniquine derivatives that kill the major species of schistosomes infecting humans. PLoS Neglected Trop. Dis., 14.","DOI":"10.1371\/journal.pntd.0008517"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1017\/S0031182009991600","article-title":"Schistosomiasis and neglected tropical diseases: Towards integrated and sustainable control and a word of caution","volume":"136","author":"Utzinger","year":"2009","journal-title":"Parasitology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jare.2012.05.002","article-title":"Novel therapeutic and prevention approaches for schistosomiasis: Review","volume":"4","author":"Tallima","year":"2013","journal-title":"J. Adv. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijpddr.2023.01.003","article-title":"Addressing the oxamniquine in vitro-in vivo paradox to facilitate a new generation of anti-schistosome treatments","volume":"21","author":"Toth","year":"2023","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/0014-4894(86)90184-0","article-title":"Schistosoma mansoni: Chemotherapy of infections of different ages","volume":"61","author":"Sabah","year":"1986","journal-title":"Exp. Parasitol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.actatropica.2008.09.003","article-title":"Brazilian studies on the genetics of Schistosoma mansoni","volume":"108","author":"Gentile","year":"2008","journal-title":"Acta Trop."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0014-4894(92)90255-9","article-title":"Schistosoma mansoni: Hycanthone\/oxamniquine resistance is controlled by a single autosomal recessive gene","volume":"75","author":"Cioli","year":"1992","journal-title":"Exp. Parasitol."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/17\/10\/1268\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:06:43Z","timestamp":1759133203000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/17\/10\/1268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,27]]},"references-count":101,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,10]]}},"alternative-id":["pharmaceutics17101268"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics17101268","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,27]]}}}