{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T15:02:40Z","timestamp":1789570960806,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: In this work, expanded electrospun poly(vinyl alcohol) (PVA) nanofiber mats incorporating tetracycline-loaded mesoporous silica nanoparticles (MSNs) were fabricated for antimicrobial wound dressing applications. Methods: MSNs with high surface area were synthesized and efficiently loaded with tetracycline, achieving sustained drug release. These nanoparticles were then embedded into both conventional (2D) and gas-expanded (3D) electrospun PVA mats. Results: The gas-foaming process significantly enhanced the mat\u2019s thickness, promoting improved nanoparticle loading and diffusion properties. Physicochemical characterization confirmed the structural integrity, thermal stability, and successful drug incorporation within the hybrid scaffolds. Antimicrobial tests against Escherichia coli and Staphylococcus aureus demonstrated excellent bactericidal effects, with superior inhibition observed in 3D mats due to their higher drug loading capacity and faster drug release related to the expanded structure. Conclusions: These results highlight the potential of combining electrospinning, gas expansion, and nanocarriers to engineer advanced, drug-loaded fibrous scaffolds for wound healing.<\/jats:p>","DOI":"10.3390\/pharmaceutics17101335","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:12:29Z","timestamp":1760523149000},"page":"1335","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Expanded Nanofibrous Polymeric Mats Incorporating Tetracycline-Loaded Silica Mesoporous Nanoparticles for Antimicrobial Applications"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8784-5695","authenticated-orcid":false,"given":"Federico","family":"Fookes","sequence":"first","affiliation":[{"name":"Group of Polymers and Polymerization Reactors, INTEC (National University of Litoral-CONICET), G\u00fcemes 3450, Santa Fe 3000, Argentina"},{"name":"Health Sciences College, UCSF (Santa Fe Catholic University), Echag\u00fce 7151, Santa Fe 3000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5327-6153","authenticated-orcid":false,"given":"Silvestre","family":"Bongiovanni Abel","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Division, INTEMA (National University of Mar del Plata-CONICET), Av. Col\u00f3n 10850, Mar del Plata 7600, Argentina"},{"name":"Department of Chemical and Food Engineering, Faculty of Engineering, National University of Mar del Plata, Av. Juan B. Justo 4302, Mar del Plata 7600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefa F.","family":"Martucci","sequence":"additional","affiliation":[{"name":"Department of Chemical and Food Engineering, Faculty of Engineering, National University of Mar del Plata, Av. Juan B. Justo 4302, Mar del Plata 7600, Argentina"},{"name":"Sustainable Materials Division, INTEMA (National University of Mar del Plata-CONICET), Av. Col\u00f3n 10850, Mar del Plata 7600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Estenoz","sequence":"additional","affiliation":[{"name":"Group of Polymers and Polymerization Reactors, INTEC (National University of Litoral-CONICET), G\u00fcemes 3450, Santa Fe 3000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-1031","authenticated-orcid":false,"given":"Gustavo A.","family":"Abraham","sequence":"additional","affiliation":[{"name":"Biomedical Polymers Division, INTEMA (National University of Mar del Plata-CONICET), Av. Col\u00f3n 10850, Mar del Plata 7600, Argentina"},{"name":"Department of Chemical and Food Engineering, Faculty of Engineering, National University of Mar del Plata, Av. Juan B. Justo 4302, Mar del Plata 7600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5745-8387","authenticated-orcid":false,"given":"Carlos A.","family":"Busatto","sequence":"additional","affiliation":[{"name":"Group of Polymers and Polymerization Reactors, INTEC (National University of Litoral-CONICET), G\u00fcemes 3450, Santa Fe 3000, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Oliveira, C., Sousa, D., Teixeira, J.A., Ferreira-Santos, P., and Botelho, C.M. (2023). Polymeric biomaterials for wound healing. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1136077"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Luneva, O., Olekhnovich, R., and Uspenskaya, M. (2022). Bilayer hydrogels for wound dressing and tissue engineering. 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