{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:34:12Z","timestamp":1762493652938,"version":"build-2065373602"},"reference-count":12,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009795","name":"Pancreatic Cancer UK","doi-asserted-by":"crossref","award":["PCU014X"],"award-info":[{"award-number":["PCU014X"]}],"id":[{"id":"10.13039\/100009795","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Ultrasound therapy has emerged as a powerful tool for the non-invasive treatment of indications ranging from Parkinson\u2019s disease and essential tremor to malignant solid tumours [...]<\/jats:p>","DOI":"10.3390\/pharmaceutics17111430","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T16:09:47Z","timestamp":1762358987000},"page":"1430","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound-Induced Acoustic Cavitation Takes Centre Stage to Enhance Drug Delivery and the Activation of the Immune System"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7248-6076","authenticated-orcid":false,"given":"Petros","family":"Mouratidis","sequence":"first","affiliation":[{"name":"Division of Radiotherapy and Imaging, The Institute of Cancer Research, London SM2 5NG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Rivens","sequence":"additional","affiliation":[{"name":"Division of Radiotherapy and Imaging, The Institute of Cancer Research, London SM2 5NG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-0775","authenticated-orcid":false,"given":"Gail","family":"ter Haar","sequence":"additional","affiliation":[{"name":"Division of Radiotherapy and Imaging, The Institute of Cancer Research, London SM2 5NG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0022-5347(05)00141-2","article-title":"Pulsed cavitational ultrasound: A noninvasive technology for controlled tissue ablation (histotripsy) in the rabbit kidney","volume":"175","author":"Roberts","year":"2006","journal-title":"J. Urol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.ultrasmedbio.2018.10.033","article-title":"Microbubbles, Nanodroplets and Gas-Stabilizing Solid Particles for Ultrasound-Mediated Extravasation of Unencapsulated Drugs: An Exposure Parameter Optimization Study","volume":"45","author":"Mannaris","year":"2019","journal-title":"Ultrasound Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Endo-Takahashi, Y., and Negishi, Y. (2020). Microbubbles and Nanobubbles with Ultrasound for Systemic Gene Delivery. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12100964"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/02656736.2015.1007538","article-title":"Histotripsy methods in mechanical disintegration of tissue: Towards clinical applications","volume":"31","author":"Khokhlova","year":"2015","journal-title":"Int. J. Hyperth."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.ultrasmedbio.2018.10.035","article-title":"For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy","volume":"45","author":"Bader","year":"2019","journal-title":"Ultrasound Med. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Ter Haar, G., Aubry, J.F., Gr\u00fcll, H., and Lafon, C. (2021). Ultrasound Therapy. EFSUMB Course Book, EFSUMB. [2nd ed.].","DOI":"10.37713\/ECB37"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100445","DOI":"10.1016\/j.dmpk.2022.100445","article-title":"Gene and oligonucleotide delivery via micro- and nanobubbles by ultrasound exposure","volume":"44","author":"Negishi","year":"2022","journal-title":"Drug Metab. Pharmacokinet."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Cohen, G., Chandran, P., Lorsung, R.M., Tomlinson, L.E., Sundby, M., Burks, S.R., and Frank, J.A. (2020). The Impact of Focused Ultrasound in Two Tumor Models: Temporal Alterations in the Natural History on Tumor Microenvironment and Immune Cell Response. Cancers, 12.","DOI":"10.3390\/cancers12020350"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Cohen, G., Chandran, P., Lorsung, R.M., Aydin, O., Tomlinson, L.E., Rosenblatt, R.B., Burks, S.R., and Frank, J.A. (2021). Pulsed-Focused Ultrasound Slows B16 Melanoma and 4T1 Breast Tumor Growth through Differential Tumor Microenvironmental Changes. Cancers, 13.","DOI":"10.3390\/cancers13071546"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/02656736.2022.2112309","article-title":"First-in-man histotripsy of hepatic tumors: The THERESA trial, a feasibility study","volume":"39","author":"Serres","year":"2022","journal-title":"Int. J. Hyperth."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e233051","DOI":"10.1148\/radiol.233051","article-title":"The #HOPE4LIVER Single-Arm Pivotal Trial for Histotripsy of Primary and Metastatic Liver Tumors","volume":"312","author":"Wiggermann","year":"2024","journal-title":"Radiology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41598-018-36340-0","article-title":"Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study","volume":"9","author":"Mainprize","year":"2019","journal-title":"Sci Rep."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/17\/11\/1430\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T05:30:27Z","timestamp":1762493427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/17\/11\/1430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["pharmaceutics17111430"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics17111430","relation":{},"ISSN":["1999-4923"],"issn-type":[{"type":"electronic","value":"1999-4923"}],"subject":[],"published":{"date-parts":[[2025,11,5]]}}}