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Cerium oxide nanoparticles (CeONPs) exhibit considerable research potential in various oxidative stress injury-related diseases due to their excellent reactive oxygen species (ROS) scavenging capacity; however, its biosafety risk makes direct application in disease treatment a matter of controversy. Methods: Recent evidence suggests that treating cells with nanoparticles can regulate the content of exosomes, enhancing the regenerative potential of exosomes. Accordingly, this study was designed to explore the therapeutic effects and underlying mechanism of exosomes derived from BMSCs treated with CeONPs (BMSC-Ce-exos) in radiation-induced jaw bone injury. Results: In vitro, 25 \u03bcg\/mL CeONPs were identified as the optimal treatment concentration; BMSC-Ce-exos significantly promoted the osteogenic differentiation and reduced the ROS levels of irradiated BMSCs. In vivo, BMSC-Ce-exos notably promoted bone formation and decreased the ROS levels in rats with radiation-induced jaw bone injury. miRNA sequencing revealed that BMSC-Ce-exos were highly enriched with miR-21-5p, which promoted the osteogenic differentiation and reduced the ROS levels of irradiated BMSCs through targeting STAT3. Conclusions: Collectively, these results suggest that BMSC-Ce-exos provided a potential therapeutic approach for radiation-induced jaw bone injury.<\/jats:p>","DOI":"10.3390\/pharmaceutics18020216","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T10:45:31Z","timestamp":1770633931000},"page":"216","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exosomes Derived from BMSCs Treated with CeONPs Ameliorate Radiation-Induced Jaw Bone Injury via miR-21-5p\/STAT3 Axis-Mediated Osteogenesis and ROS Scavenging"],"prefix":"10.3390","volume":"18","author":[{"given":"Zhiyue","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2168-6523","authenticated-orcid":false,"given":"Chong","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Mou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"},{"name":"School of Stomatology, Jiamusi University, Jiamusi 154007, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Tian","sequence":"additional","affiliation":[{"name":"Xi\u2019an Gaoxin No.1 High School, Xi\u2019an 710119, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyang","family":"Ge","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenlu","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiqiang","family":"Dai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1271-8741","authenticated-orcid":false,"given":"Chunlin","family":"Zong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1929-3953","authenticated-orcid":false,"given":"Lei","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi\u2019an 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13014-020-01701-5","article-title":"Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma","volume":"16","author":"Kubota","year":"2021","journal-title":"Radiat. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1002\/hed.25681","article-title":"Quality of life after microvascular mandibular reconstruction for osteoradionecrosis\u2014A prospective study","volume":"41","author":"Danielsson","year":"2019","journal-title":"Head Neck"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3892\/mmr.2015.4539","article-title":"Irradiation alters the differentiation potential of bone marrow mesenchymal stem cells","volume":"13","author":"Wang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kumar, A., Becker, D., Adhikary, A., and Sevilla, M.D. (2019). Reaction of Electrons with DNA: Radiation Damage to Radiosensitization. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20163998"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/09553009414550041","article-title":"Free radicals in biology: Oxidative stress and the effects of ionizing radiation","volume":"65","author":"Riley","year":"1994","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1016\/j.molcel.2021.08.018","article-title":"Redox metabolism: ROS as specific molecular regulators of cell signaling and function","volume":"81","author":"Lennicke","year":"2021","journal-title":"Mol. Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e70306","DOI":"10.1111\/acel.70306","article-title":"FoxO1 Responses to Chronic Oxidative Stress to Participate in Age-Related Osteoporosis by Depriving \u03b2-Catenin from TCF7","volume":"25","author":"Su","year":"2026","journal-title":"Aging Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1200\/JCO.23.02750","article-title":"Prevention and Management of Osteoradionecrosis in Patients with Head and Neck Cancer Treated with Radiation Therapy: ISOO-MASCC-ASCO Guideline","volume":"42","author":"Peterson","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1634\/theoncologist.2016-0298","article-title":"The Use of Hyperbaric Oxygen for the Prevention and Management of Osteoradionecrosis of the Jaw: A Dana-Farber\/Brigham and Women\u2019s Cancer Center Multidisciplinary Guideline","volume":"22","author":"Sultan","year":"2017","journal-title":"Oncologist"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e2001615","DOI":"10.1002\/adhm.202001615","article-title":"Rational Design of Nanomaterials for Various Radiation-Induced Diseases Prevention and Treatment","volume":"10","author":"Xie","year":"2021","journal-title":"Adv. Healthc. Mater."},{"key":"ref_11","first-page":"547","article-title":"A novel approach for the prevention of ionizing radiation-induced bone loss using a designer multifunctional cerium oxide nanozyme","volume":"21","author":"Wei","year":"2023","journal-title":"Bioact. Mater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1089\/ten.tec.2013.0766","article-title":"Effect of high-dose irradiation on human bone-marrow-derived mesenchymal stromal cells","volume":"21","author":"Fekete","year":"2015","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1039\/C4CS00322E","article-title":"Emerging translational research on magnetic nanoparticles for regenerative medicine","volume":"44","author":"Gao","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"174657","DOI":"10.1016\/j.ejphar.2021.174657","article-title":"Mesenchymal stem cell-based nanoparticles and scaffolds in regenerative medicine","volume":"918","author":"Raghav","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.2147\/IJN.S459607","article-title":"Mitochondrial Targeted Cerium Oxide Nanoclusters for Radiation Protection and Promoting Hematopoiesis","volume":"19","author":"Yang","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"21069","DOI":"10.1039\/C8NR04640A","article-title":"Engineered nanoceria cytoprotection in vivo: Mitigation of reactive oxygen species and double-stranded DNA breakage due to radiation exposure","volume":"10","author":"Das","year":"2018","journal-title":"Nanoscale"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2405069","DOI":"10.1002\/adhm.202405069","article-title":"Cerium Dioxide Nanoparticles-Based Inspector Enhances Mitochondrial Quality Control to Maintain Chondrocyte Homeostasis in Osteoarthritis Therapy","volume":"14","author":"Chen","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e2401507","DOI":"10.1002\/adhm.202401507","article-title":"Controlled Release of Ceria and Ferric Oxide Nanoparticles via Collagen Hydrogel for Enhanced Osteoarthritis Therapy","volume":"13","author":"Chen","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e2300123","DOI":"10.1002\/adhm.202300123","article-title":"ROS-Scavenging Hydrogels Synergize with Neural Stem Cells to Enhance Spinal Cord Injury Repair via Regulating Microenvironment and Facilitating Nerve Regeneration","volume":"12","author":"Liu","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1039\/D1NR06043K","article-title":"Cerium oxide nanozyme attenuates periodontal bone destruction by inhibiting the ROS-NF\u03baB pathway","volume":"14","author":"Yu","year":"2022","journal-title":"Nanoscale"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.2147\/IJN.S305676","article-title":"Size-Dependent Cytotoxicity and Reactive Oxygen Species of Cerium Oxide Nanoparticles in Human Retinal Pigment Epithelia Cells","volume":"16","author":"Ma","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9284","DOI":"10.1038\/s41598-017-09430-8","article-title":"Cerium oxide nanoparticles inhibit differentiation of neural stem cells","volume":"7","author":"Gliga","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/s12951-021-00958-6","article-title":"Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: Release of exosomal miR-1260a improves osteogenesis and angiogenesis","volume":"19","author":"Wu","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/s41565-023-01523-y","article-title":"Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model","volume":"18","author":"Koo","year":"2023","journal-title":"Nat. Nanotechnol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.7150\/thno.21945","article-title":"Exosome Theranostics: Biology and Translational Medicine","volume":"8","author":"He","year":"2018","journal-title":"Theranostics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"eaau6977","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Huang, C., Li, H., Zhang, Z., Mou, T., Wang, D., Li, C., Tian, L., and Zong, C. (2025). From Mechanism to Therapy: The Role of MSC-EVs in Alleviating Radiation-Induced Injuries. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17050652"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.1021\/acsami.7b17620","article-title":"Tissue-Engineered Bone Immobilized with Human Adipose Stem Cells-Derived Exosomes Promotes Bone Regeneration","volume":"10","author":"Li","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/s13287-020-01781-w","article-title":"Bone marrow mesenchymal stem cell-derived exosomes protect cartilage damage and relieve knee osteoarthritis pain in a rat model of osteoarthritis","volume":"11","author":"He","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s13287-022-02975-0","article-title":"BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1\/M2 macrophage polarization in rats","volume":"13","author":"Li","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Li, Z., Liu, C., Li, S., Li, T., Li, Y., Wang, N., Bao, X., Xue, P., and Liu, S. (2021). BMSC-Derived Exosomes Inhibit Dexamethasone-Induced Muscle Atrophy via the miR-486-5p\/FoxO1 Axis. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.681267"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s10020-024-00904-w","article-title":"BMSC-derived exosomes promote osteoporosis alleviation via M2 macrophage polarization","volume":"30","author":"Zhang","year":"2024","journal-title":"Mol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e2300315","DOI":"10.1002\/adhm.202300315","article-title":"Treatment with Mesenchymal Stem Cell-Derived Nanovesicle-Containing Gelatin Methacryloyl Hydrogels Alleviates Osteoarthritis by Modulating Chondrogenesis and Macrophage Polarization","volume":"12","author":"Pang","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"105061","DOI":"10.1016\/j.jddst.2023.105061","article-title":"ADSCs-exosomal miR-21-5p modulates neuroinflammatory response by targeting STAT3 in cerebral infarction","volume":"89","author":"Shi","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s11010-023-04775-3","article-title":"M2 macrophage-derived exosomes carry miR-142-3p to restore the differentiation balance of irradiated BMMSCs by targeting TGF-\u03b21","volume":"479","author":"Huang","year":"2024","journal-title":"Mol. Cell. Biochem."},{"key":"ref_36","first-page":"524","article-title":"Effects of different irradiators on the establishment of osteoradionecrosis model of rat mandible","volume":"39","author":"Chen","year":"2021","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1186\/s13287-025-04508-x","article-title":"Ionizing radiation-mediated dendritic cell maturation exacerbates inflammatory response of bone marrow mesenchymal stem cells and impairs osteogenesis in radiation-induced jaw injury","volume":"16","author":"Zheng","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13287-018-1121-9","article-title":"BM-MSC-derived exosomes alleviate radiation-induced bone loss by restoring the function of recipient BM-MSCs and activating Wnt\/\u03b2-catenin signaling","volume":"10","author":"Zuo","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Qiu, S., Chen, H., and Jiang, Q. (2025). Sevoflurane pretreatment alleviates hypoxia-reoxygenation-induced myocardial cell injury by upregulating miR-21-5p. Front. Cardiovasc. Med., 12.","DOI":"10.3389\/fcvm.2025.1515160"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e12152","DOI":"10.1002\/jev2.12152","article-title":"Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p","volume":"10","author":"Lee","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Huang, X., Jin, A., Wang, X., Gao, X., Xu, H., Chung, M., Dai, Q., Yang, Y., and Jiang, L. (2021). Napabucasin Induces Mouse Bone Loss by Impairing Bone Formation via STAT3. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.648866"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"156186","DOI":"10.1016\/j.metabol.2025.156186","article-title":"Pharmacologically targeting fatty acid synthase-mediated de novo lipogenesis alleviates osteolytic bone loss by directly inhibiting osteoclastogenesis through suppression of STAT3 palmitoylation and ROS signaling","volume":"167","author":"Xiu","year":"2025","journal-title":"Metabolism"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"123787","DOI":"10.1016\/j.lfs.2025.123787","article-title":"STC1 promotes paclitaxel resistance in oral squamous cell carcinoma by inhibiting oxidative stress via activating the JAK\/STAT signaling pathway","volume":"377","author":"Wu","year":"2025","journal-title":"Life Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"114709","DOI":"10.1016\/j.colsurfb.2025.114709","article-title":"Immunomodulatory peptide DP7-C mediates macrophage-derived exosomal miR-21b to promote bone regeneration via the SOCS1\/JAK2\/STAT3 axis","volume":"253","author":"Lai","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Fu, X., Liu, G., Halim, A., Ju, Y., Luo, Q., and Song, A.G. (2019). Mesenchymal Stem Cell Migration and Tissue Repair. Cells, 8.","DOI":"10.3390\/cells8080784"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/s13287-022-02996-9","article-title":"Bone marrow mesenchymal stem cells facilitate diabetic wound healing through the restoration of epidermal cell autophagy via the HIF-1\u03b1\/TGF-\u03b21\/SMAD pathway","volume":"13","author":"Shi","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1186\/s13287-025-04587-w","article-title":"Exosomes derived from umbilical cord mesenchymal stem cells alleviate jaw bone marrow mesenchymal stem cells senescence and restore osteogenic differentiation potential","volume":"16","author":"Li","year":"2025","journal-title":"Stem Cell Res. Ther."},{"key":"ref_48","first-page":"239","article-title":"A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis: Antibacterial, hemostasis, immune reprogramming, pro-osteo-\/angiogenesis and recruitment","volume":"41","author":"Yang","year":"2024","journal-title":"Bioact. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1631\/jzus.B2300854","article-title":"Ceria nanoparticles: Biomedical applications and toxicity","volume":"25","author":"Fu","year":"2024","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6525","DOI":"10.1039\/D5BM01308A","article-title":"Exploring exosomes in osteoarthritis: Biogenesis, functional roles, and recent hydrogel-based delivery strategies","volume":"13","author":"Singhmar","year":"2025","journal-title":"Biomater. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2147\/IJN.S291138","article-title":"Platinum Nanoparticles Enhance Exosome Release in Human Lung Epithelial Adenocarcinoma Cancer Cells (A549): Oxidative Stress and the Ceramide Pathway are Key Players","volume":"16","author":"Gurunathan","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1021\/acsami.3c12680","article-title":"Inorganic Nanoparticles Change Cancer-Cell-Derived Extracellular Vesicle Secretion Levels and Cargo Composition, Resulting in Secondary Biological Effects","volume":"16","author":"Buttiens","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"13095","DOI":"10.2147\/IJN.S484751","article-title":"miR-21-5p Enriched Exosomes from Human Embryonic Stem Cells Promote Osteogenesis via YAP1 Modulation","volume":"19","author":"Huang","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"7979","DOI":"10.2147\/IJN.S275650","article-title":"Exosomes Derived from Bone Mesenchymal Stem Cells with the Stimulation of Fe3O4 Nanoparticles and Static Magnetic Field Enhance Wound Healing Through Upregulated miR-21-5p","volume":"15","author":"Wu","year":"2020","journal-title":"Int. J. Nanomed."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.gendis.2022.09.010","article-title":"The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by changing macrophage phenotype","volume":"10","author":"Qin","year":"2023","journal-title":"Genes Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"119721","DOI":"10.1016\/j.lfs.2021.119721","article-title":"The role of melatonin on radiation-induced pneumonitis and lung fibrosis: A systematic review","volume":"281","author":"Sheikholeslami","year":"2021","journal-title":"Life Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"197","DOI":"10.32725\/jab.2024.021","article-title":"Syringin protects high glucose-induced BMSC injury, cell senescence, and osteoporosis by inhibiting JAK2\/STAT3 signaling","volume":"22","author":"Zou","year":"2024","journal-title":"J. Appl. Biomed."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s10735-025-10424-4","article-title":"Nobiletin ameliorates hormone-induced osteoblast apoptosis by modulating JAK2\/STAT3 signaling","volume":"56","author":"Li","year":"2025","journal-title":"J. Mol. Histol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s12672-023-00644-z","article-title":"NRF2 and STAT3: Friends or foes in carcinogenesis?","volume":"14","author":"Arena","year":"2023","journal-title":"Discov. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"100224","DOI":"10.1016\/j.aohep.2020.06.010","article-title":"STAT3: A key regulator in liver fibrosis","volume":"21","author":"Zhao","year":"2021","journal-title":"Ann. Hepatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13046-024-02949-5","article-title":"Unraveling the complexity of STAT3 in cancer: Molecular understanding and drug discovery","volume":"43","author":"Hu","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Butturini, E., Carcereri de Prati, A., and Mariotto, S. (2020). Redox Regulation of STAT1 and STAT3 Signaling. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21197034"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"C1005","DOI":"10.1152\/ajpcell.00520.2019","article-title":"Irradiation-induced senescence of bone marrow mesenchymal stem cells aggravates osteogenic differentiation dysfunction via paracrine signaling","volume":"318","author":"Bai","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41419-025-07965-7","article-title":"Targeting Irgm1 to combat osteoporosis: Suppressing ROS and restoring bone remodeling","volume":"16","author":"Cui","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref_65","first-page":"477","article-title":"Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair","volume":"24","author":"Sun","year":"2023","journal-title":"Bioact. Mater."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/2\/216\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T10:47:37Z","timestamp":1770634057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/2\/216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,9]]},"references-count":65,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["pharmaceutics18020216"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18020216","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,9]]}}}