{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T23:06:09Z","timestamp":1782774369960,"version":"3.54.5"},"reference-count":50,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82071367"],"award-info":[{"award-number":["82071367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Guangdong Province of China","award":["2023A1515011135"],"award-info":[{"award-number":["2023A1515011135"]}]},{"name":"Science and Technology Program of Guangzhou, China","award":["2023A03J0525"],"award-info":[{"award-number":["2023A03J0525"]}]},{"name":"Clinical Characteristic Technology Project of Guangzhou Municipal Health Commission in Guangzhou Area","award":["2023C-TS41"],"award-info":[{"award-number":["2023C-TS41"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Polysaccharide-based dynamic hydrogels are promising for wound management due to their biocompatibility, injectability, and tunable biofunctionality. The integration of therapeutic gasotransmitter donors offers a strategy to modulate the wound microenvironment. Objectives: This study aimed to develop an injectable, self-healing carbohydrate hydrogel capable of sustained hydrogen sulfide (H2S) release for burn wound therapy, and to evaluate its physicochemical properties, in vivo efficacy, and mechanism of action. Methods: A dynamic hydrogel (ACMOD) was fabricated via Schiff-base crosslinking between oxidized dextran (OD) and carboxymethyl chitosan (CMCS), incorporating the H2S donor 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT-OH). Rheological and recovery tests characterized its mechanical and self-healing properties. Efficacy and mechanisms were assessed in a rat full-thickness burn model, analyzing wound closure, histology, oxidative stress, macrophage polarization, angiogenesis, and collagen deposition. Results: ACMOD exhibited shear-thinning, rapid self-healing, and strong tissue adherence. Sustained H2S release from ACMOD significantly accelerated wound closure and improved tissue regeneration compared to controls. Mechanistically, H2S attenuated oxidative stress, promoted a pro-regenerative M2 macrophage phenotype, enhanced angiogenesis via VEGF upregulation, and fostered organized collagen deposition and extracellular matrix remodeling. Conclusions: This work demonstrates a versatile, carbohydrate-based dynamic hydrogel platform that synergizes polymer network dynamics with bioactive H2S delivery to effectively promote burn wound healing. The findings underscore the potential of polysaccharide hydrogels with integrated gasotransmitter release for regenerative therapy and biomaterials applications.<\/jats:p>","DOI":"10.3390\/pharmaceutics18030370","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T09:35:57Z","timestamp":1773740157000},"page":"370","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oxidized Dextran\/Carboxymethyl Chitosan Dynamic Schiff-Base Hydrogel for Sustained Hydrogen Sulfide Delivery and Burn Wound Microenvironment Remodeling"],"prefix":"10.3390","volume":"18","author":[{"given":"Zhishan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510006, China"},{"name":"College of Pharmacy, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0857-633X","authenticated-orcid":false,"given":"Ying","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510006, China"},{"name":"College of Pharmacy, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoya","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510006, China"},{"name":"College of Pharmacy, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510006, China"},{"name":"College of Pharmacy, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510006, China"},{"name":"College of Pharmacy, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youfu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0946-5552","authenticated-orcid":false,"given":"Ping","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510006, China"},{"name":"College of Pharmacy, Jinan University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/s41590-025-02145-3","article-title":"Cutaneous T cell immunity","volume":"26","author":"Zareie","year":"2025","journal-title":"Nat. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Siu, W.S., Ma, H., and Leung, P.C. (2025). Review on Current Advancements in Facilitation of Burn Wound Healing. Bioengineering, 12.","DOI":"10.3390\/bioengineering12040428"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wang, Z., Qi, F., Luo, H., Xu, G., and Wang, D. (2022). Inflammatory Microenvironment of Skin Wounds. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.789274"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"6536","DOI":"10.1007\/s10853-022-07056-4","article-title":"Dressings for burn wound: A review","volume":"57","author":"Noor","year":"2022","journal-title":"J. Mater. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.burns.2022.01.006","article-title":"Bismuth\/petroleum gauze plus high density polyethylene vs. bismuth\/petroleum gauze: A comparison of donor site healing and patient comfort","volume":"48","author":"Craig","year":"2022","journal-title":"Burns"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41536-025-00427-w","article-title":"Human iPSCs-derived mesenchymal stem cells promote skin regeneration and burn wound healing","volume":"10","author":"Farahat","year":"2025","journal-title":"NPJ Regen. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Li, S., Pan, W., Zhang, M., Song, K., Zhou, Z., Zhao, Q., Li, G.-Z., and Zhu, C. (2025). Chitosan-Based Dressing Materials for Burn Wound Healing. 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Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"164934","DOI":"10.1016\/j.cej.2025.164934","article-title":"Nasal delivery of self-imaging ROS-responsive H2S donors for enhanced neuroprotection in cerebral ischemia-reperfusion injury","volume":"519","author":"Zeng","year":"2025","journal-title":"Chem. Eng. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"107428","DOI":"10.1016\/j.phrs.2024.107428","article-title":"Mitochondria-targeted hydrogen sulfide donor reduces fatty liver and obesity in mice fed a high fat diet by inhibiting de novo lipogenesis and inflammation via mTOR\/SREBP-1 and NF-\u03baB signaling pathways","volume":"209","author":"Stachowicz","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Corsello, T., Komaravelli, N., and Casola, A. (2018). Role of Hydrogen Sulfide in NRF2- and Sirtuin-Dependent Maintenance of Cellular Redox Balance. Antioxidants, 7.","DOI":"10.3390\/antiox7100129"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e13374","DOI":"10.1111\/cpr.13374","article-title":"Role of hydrogen sulphide in physiological and pathological angiogenesis","volume":"56","author":"Zhang","year":"2022","journal-title":"Cell Prolif."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e14972","DOI":"10.1111\/exd.14972","article-title":"Endogenous hydrogen sulphide deficiency and exogenous hydrogen sulphide supplement regulate skin fibroblasts proliferation via necroptosis","volume":"33","author":"Li","year":"2023","journal-title":"Exp. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41419-020-2222-9","article-title":"ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD","volume":"11","author":"Cai","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"114894","DOI":"10.1016\/j.ejpb.2025.114894","article-title":"Gas-based therapies in chronic wounds: A scoping review of preclinical and clinical data","volume":"217","author":"Kasha","year":"2025","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"153391","DOI":"10.1016\/j.cej.2024.153391","article-title":"Injectable hydrogels for bioelectronics: A viable alternative to traditional hydrogels","volume":"495","author":"Shu","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"7156","DOI":"10.1038\/s41467-021-27529-5","article-title":"Hydrogel tapes for fault-tolerant strong wet adhesion","volume":"12","author":"Xue","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1021\/acsnano.1c11040","article-title":"pH\/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing","volume":"16","author":"Liang","year":"2022","journal-title":"ACS Nano"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"120838","DOI":"10.1016\/j.biomaterials.2021.120838","article-title":"A physicochemical double cross-linked multifunctional hydrogel for dynamic burn wound healing: Shape adaptability, injectable self-healing property and enhanced adhesion","volume":"276","author":"Yuan","year":"2021","journal-title":"Biomaterials"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"102906","DOI":"10.1016\/j.apmt.2025.102906","article-title":"Self-healing, adhesive, hemostasis and anti-inflammation with a Schiff base-Crosslinked injectable hydrogel for burn wound healing","volume":"46","author":"Mao","year":"2025","journal-title":"Appl. Mater. Today"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.actbio.2023.04.021","article-title":"Hyaluronate- and gelatin-based hydrogels encapsulating doxycycline as a wound dressing for burn injury therapy","volume":"164","author":"Hu","year":"2023","journal-title":"Acta Biomater."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e2401152","DOI":"10.1002\/smll.202401152","article-title":"Copper Ion-Inspired Dual Controllable Drug Release Hydrogels for Wound Management: Driven by Hydrogen Bonds","volume":"20","author":"Wang","year":"2024","journal-title":"Small"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"114282","DOI":"10.1016\/j.jconrel.2025.114282","article-title":"Multifunctional self-healing hydrogels for chronic wound repair: Design, mechanisms, and applications","volume":"388","author":"Ning","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e2500264","DOI":"10.1002\/adhm.202500264","article-title":"Dual-Network Hydrogel Loaded With ROS-activated Hydrogen Sulfide Donor to Accelerate Wound Healing and Inhibit Scar Production","volume":"14","author":"Zhou","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"120213","DOI":"10.1016\/j.carbpol.2022.120213","article-title":"Oxidized hydroxypropyl cellulose\/carboxymethyl chitosan hydrogels permit pH-responsive, targeted drug release","volume":"300","author":"Zhou","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41579-024-01035-z","article-title":"The wound microbiota: Microbial mechanisms of impaired wound healing and infection","volume":"22","author":"Uberoi","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"123144","DOI":"10.1016\/j.biomaterials.2025.123144","article-title":"Multifunctional injectable hydrogel with self-supplied H2S release and bacterial inhibition for the wound healing with enhanced macrophages polarization via interfering with PI3K\/Akt pathway","volume":"318","author":"Gong","year":"2025","journal-title":"Biomaterials"},{"key":"ref_32","first-page":"196","article-title":"Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty","volume":"8","author":"Zhao","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Xu, L., Zhou, Z., Chen, Y., Lu, H., and Hu, P. (2022). Resina Draconis Particles Encapsulated in a Hyaluronic-Acid-Based Hydrogel to Treat Complex Burn Wounds. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14102087"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1002\/pola.28099","article-title":"Dextran oxidized by a malaprade reaction shows main chain scission through a maillard reaction triggered by schiff base formation between aldehydes and amines","volume":"54","author":"Chimpibul","year":"2016","journal-title":"J. Polym. Sci. Part A Polym. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"118949","DOI":"10.1016\/j.carbpol.2021.118949","article-title":"Elucidating the degradation mechanism of a self-degradable dextran-based medical adhesive","volume":"278","author":"Hyon","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.polymer.2010.11.058","article-title":"Insight on the periodate oxidation of dextran and its structural vicissitudes","volume":"52","author":"Maia","year":"2011","journal-title":"Polymer"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e2308701","DOI":"10.1002\/adma.202308701","article-title":"Injectable Self-Expanding\/Self-Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management","volume":"36","author":"Zhao","year":"2024","journal-title":"Adv. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12034-024-03342-w","article-title":"Oxidized dextran-modified cotton gauze for application as a fouling-resistant wound dressing","volume":"47","author":"Sahoo","year":"2024","journal-title":"Bull. Mater. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1021\/acs.jpca.0c10788","article-title":"Reactivity Dynamics","volume":"125","author":"Sarkar","year":"2021","journal-title":"J. Phys. Chem. A"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s10965-023-03705-7","article-title":"Preparation of carboxymethylchitosan based rapid self-healing injectable hydrogels","volume":"30","author":"Shi","year":"2023","journal-title":"J. Polym. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"043302","DOI":"10.1103\/PhysRevFluids.8.043302","article-title":"Rapid wetting of shear-thinning fluids","volume":"8","author":"Yada","year":"2023","journal-title":"Phys. Rev. Fluids"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"052013","DOI":"10.1063\/5.0268503","article-title":"Quantitative description of self-, Maxwell\u2013Stefan, and Fick diffusion coefficients in sucrose and citric acid solution based on molecular dynamics simulations","volume":"37","author":"Bao","year":"2025","journal-title":"Phys. Fluids"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2147\/DDDT.S242521","article-title":"Hydrogen Sulfide Protects Against High Glucose-Induced Human Umbilical Vein Endothelial Cell Injury Through Activating PI3K\/Akt\/eNOS Pathway","volume":"14","author":"Lin","year":"2020","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"101976","DOI":"10.1016\/j.apmt.2023.101976","article-title":"Hydrogen sulfide releasing and carboxybetaine modified vascular graft with enhanced anticoagulant, anticalcification, and pro-endothelialization properties","volume":"35","author":"Wang","year":"2023","journal-title":"Appl. Mater. Today"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e202502917","DOI":"10.1002\/anie.202502917","article-title":"Tandem Biocatalysis to Generate Hydrogen Sulfide and Promote Endogenous Antioxidant Response","volume":"64","author":"Manna","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.7150\/ijbs.47595","article-title":"Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome","volume":"16","author":"Wang","year":"2020","journal-title":"Int. J. Biol. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/s41586-024-08022-7","article-title":"Gasdermin D-mediated metabolic crosstalk promotes tissue repair","volume":"634","author":"Chi","year":"2024","journal-title":"Nature"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"141887","DOI":"10.1016\/j.ijbiomac.2025.141887","article-title":"Bilayer vascular grafts separately composited with nitric oxide-releasing keratin conjugates and hydrogen sulfide-releasing heparin conjugates","volume":"307","author":"Wang","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Alberts, A., Bratu, A.G., Niculescu, A.-G., and Grumezescu, A.M. (2025). Collagen-Based Wound Dressings: Innovations, Mechanisms, and Clinical Applications. Gels, 11.","DOI":"10.3390\/gels11040271"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41392-025-02249-0","article-title":"Vascular endothelial growth factor signaling in health and disease: From molecular mechanisms to therapeutic perspectives","volume":"10","author":"Lee","year":"2025","journal-title":"Signal Transduct. Target. Ther."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/3\/370\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:19:21Z","timestamp":1773897561000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/3\/370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":50,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["pharmaceutics18030370"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18030370","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,17]]}}}