{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:03:44Z","timestamp":1774008224905,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hebei Province Medical Science Research Project Program","award":["20250307"],"award-info":[{"award-number":["20250307"]}]},{"name":"Hebei Province Medical Science Research Project Program","award":["20260052"],"award-info":[{"award-number":["20260052"]}]},{"name":"Research Project on Stability of Intravenous Drug Infusion Special Topic of Hebei Pharmaceutical Society","award":["2024-Hbsyxhdx001"],"award-info":[{"award-number":["2024-Hbsyxhdx001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Maintaining therapeutic meropenem plasma concentrations requires prolonged infusion, but stability concerns exist between preparation and administration. This study compared the stability and operability of ready-to-use powder\u2013liquid double-chamber bag (DCB) infusions versus traditional powder-for-injection (PFI) meropenem under clinical conditions. Methods: Infusions at clinically relevant concentrations were stored at 2\u20138 \u00b0C, 25 \u00b1 5 \u00b0C, and 40 \u00b1 2 \u00b0C for 12 h. Stability assessments included appearance, pH, osmolality, insoluble particle count, meropenem content (HPLC), and impurity A level. Results: DCBs demonstrated superior content uniformity, significantly fewer insoluble particles (p &lt; 0.05), and greater operational simplicity compared to PFI. Refrigeration maintained meropenem content &gt; 95% and effectively suppressed impurity formation for up to 12 h. However, at both room temperature and elevated temperature, impurity A exceeded pharmacopoeial limits within 2 h, particularly at higher concentrations. An innovative bedside solvent volume adjustment method enabled DCBs to deliver high-concentration infusions, facilitating individualized critical care dosing. Conclusions: Compared with traditional powder injection formulations, the Meropenem powder\u2013liquid dual-chamber bag offers more convenient operation under routine preparation conditions and poses a lower risk of contamination during the preparation process. Its stability is more sensitive to storage temperature, requiring strict adherence to refrigeration conditions. When stored under standardized conditions, the dual-chamber bag can better ensure drug efficacy stability and medication safety, making it particularly suitable for clinical emergency use and standardized workflow management.<\/jats:p>","DOI":"10.3390\/pharmaceutics18030382","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:44:41Z","timestamp":1773999881000},"page":"382","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Stability and Quality Assessment of Powder\u2013Liquid Double-Chamber Bag Versus Traditional Meropenem Infusions: Implications for Critical Care and Individualized Dosing"],"prefix":"10.3390","volume":"18","author":[{"given":"Xiaokai","family":"Ren","sequence":"first","affiliation":[{"name":"School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"},{"name":"Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, China"},{"name":"Hebei Key Laboratory of Clinical Pharmacy, Hebei General Hospital, Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, China"},{"name":"Hebei Key Laboratory of Clinical Pharmacy, Hebei General Hospital, Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, China"},{"name":"Hebei Key Laboratory of Clinical Pharmacy, Hebei General Hospital, Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, China"},{"name":"Hebei Key Laboratory of Clinical Pharmacy, Hebei General Hospital, Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, China"},{"name":"Hebei Key Laboratory of Clinical Pharmacy, Hebei General Hospital, Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanjun","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China"},{"name":"Department of Pharmacy, Hebei General Hospital, Shijiazhuang 050051, China"},{"name":"Hebei Key Laboratory of Clinical Pharmacy, Hebei General Hospital, Hebei Medical University, Shijiazhuang 050051, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jcrc.2019.04.013","article-title":"Early target attainment of continuous infusion piperacillin\/tazobactam and meropenem in critically ill patients: A prospective observational study","volume":"52","author":"Dhaese","year":"2019","journal-title":"J. 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