{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:10:41Z","timestamp":1778908241160,"version":"3.51.4"},"reference-count":225,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:00:00Z","timestamp":1777507200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The treatment of skin diseases remains a significant clinical challenge. Cellulose and its derivatives have emerged as research hotspots in skin-related applications due to their excellent biocompatibility, structural modifiability, and biomimetic properties. This review systematically summarizes the diverse construction forms of cellulose-based materials, including films, nanofibrous scaffolds, hydrogels, and aerogels, with a focus on smart responsive systems tailored to various microenvironmental conditions. Their application progresses in acute\/chronic wound healing, bacterial infections, burns, scar prevention, immunomodulation, and smart wearable monitoring are highlighted. The underlying mechanisms involving anti-infection, pro-regeneration, microenvironment modulation, and sensing are analyzed, aiming to provide insights for further exploration of cellulose-based materials in skin disease therapy and even smart wearable devices.<\/jats:p>","DOI":"10.3390\/pharmaceutics18050562","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:33:17Z","timestamp":1777627997000},"page":"562","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cellulose and Its Derivatives-Based Skin Dressings: Design, Smart Advances and Applications"],"prefix":"10.3390","volume":"18","author":[{"given":"Shiyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengran","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e009283","DOI":"10.1136\/bmjopen-2015-009283","article-title":"Health economic burden that wounds impose on the National Health Service in the UK","volume":"5","author":"Guest","year":"2015","journal-title":"BMJ Open"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/QCO.0000000000000239","article-title":"Epidemiology and microbiology of skin and soft tissue infections","volume":"29","author":"Esposito","year":"2016","journal-title":"Curr. 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