{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:44:47Z","timestamp":1792806287047,"version":"4.5.0"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031918","name":"State Key Laboratory of Natural and Biomimetic Drugs","doi-asserted-by":"crossref","award":["KF2025034"],"award-info":[{"award-number":["KF2025034"]}],"id":[{"id":"10.13039\/100031918","id-type":"DOI","asserted-by":"crossref"}]},{"award":["KF2025034"],"award-info":[{"award-number":["KF2025034"]}],"id":[{"id":"https:\/\/ror.org\/049mqh532","id-type":"ROR","asserted-by":"publisher"}]},{"name":"the Natural Science Foundation of Inner Mongolia Autonomous Region","award":["2023LHMS08011"],"award-info":[{"award-number":["2023LHMS08011"]}]},{"name":"Education Department of Inner Mongolia Autonomous Region \u201cHigher School Research Program\u201d","award":["NZZ23002"],"award-info":[{"award-number":["NZZ23002"]}],"id":[{"id":"https:\/\/ror.org\/01y40gm27","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81660587"],"award-info":[{"award-number":["81660587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["81660587"],"award-info":[{"award-number":["81660587"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Education Department of Inner Mongolia Autonomous Region \u201cYoung Science and Technology Talent Support Program\u201d","award":["NJYT-20-B26"],"award-info":[{"award-number":["NJYT-20-B26"]}],"id":[{"id":"https:\/\/ror.org\/01y40gm27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"University-level Project of Inner Mongolia Medical University","award":["YKD2023MS074"],"award-info":[{"award-number":["YKD2023MS074"]}],"id":[{"id":"https:\/\/ror.org\/01mtxmr84","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Oral colon-targeted delivery for inflammatory bowel disease (IBD) faces significant challenges, including limited gastrointestinal stability, premature drug release, and insufficient mucosal retention. Methods: To address these limitations, a mucoadhesive polysaccharide-based composite hydrogel incorporating prednisolone-loaded polymeric micelles was developed to enhance colonic delivery and promote mucosal repair. Amphiphilic oxidized dextran\u2013oleylamine (ODEX-OA) copolymers were synthesized to self-assemble into prednisolone-loaded micelles. These micelles were subsequently embedded within a thiolated chitosan (CSSH) hydrogel through a Schiff base reaction, yielding the ODEX-OA-Pred-CSSH composite. The resulting system was comprehensively characterized for particle size, mucoadhesion, degradation, and pH\/ROS dual-responsive drug release. Its colon-targeting capability and therapeutic efficacy were subsequently assessed in a dextran sulfate sodium (DSS)-induced colitis mouse model. Results: In vitro, the composite hydrogel demonstrated nanoscale micellar size, enhanced drug release kinetics under simulated inflammatory colonic conditions, and prolonged colonic retention for up to 24 h following oral administration. In vivo, studies confirmed that ODEX-OA-Pred-CSSH significantly alleviated colitis, evidenced by a reduced disease activity index, diminished pro-inflammatory cytokine levels, restored colon length, decreased spleen index, and improved histological mucosal repair. Conclusions: These findings collectively suggest that this mucoadhesive micelle\u2013hydrogel composite represents a promising and effective oral colon-targeted platform for the treatment of IBD.<\/jats:p>","DOI":"10.3390\/pharmaceutics18050602","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:39:34Z","timestamp":1779295174000},"page":"602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Disulfide Cross-Linked Thiolated Chitosan\/Oxidized Dextran\u2013Oleylamine Micelle\u2013Hydrogel System with pH\/ROS Dual-Responsive Cascade Drug Release for Integrated Colon Targeting and Mucosal Repair in Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"18","author":[{"given":"Jiangtao","family":"He","sequence":"first","affiliation":[{"name":"College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Gan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongxia","family":"Chi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuya","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China"},{"name":"Inner Mongolia Autonomous Region Engineering Research Center of New Pharmaceutical Screening, Inner Mongolia Medical University, Hohhot 010110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wu","sequence":"additional","affiliation":[{"name":"Shanghai Wei Er Lab, No. 358, Tian Chen Road, Qingpu District, Shanghai 201707, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6278-0379","authenticated-orcid":false,"given":"Guodong","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3076-9840","authenticated-orcid":false,"given":"Ruijuan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3206-4259","authenticated-orcid":false,"given":"Yuheng","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167648","DOI":"10.1016\/j.bbadis.2024.167648","article-title":"Biological agents as attractive targets for inflammatory bowel disease therapeutics","volume":"1871","author":"Xue","year":"2025","journal-title":"Biochim. 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