{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T10:19:58Z","timestamp":1785406798078,"version":"3.56.0"},"reference-count":55,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016971","name":"Lomonosov Moscow State University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100016971","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/010pmpe69","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Central Tuberculosis Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background: Pulmonary tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis). Drug-resistant TB remains a major public health challenge and calls for new approaches to drug development. Targeted delivery of antibacterial agents using nanoscale carriers represents one such approach. A decisive factor for efficient targeting is the judicious selection of the carrier platform. Methods: In the present study, diamond nanoparticles were evaluated as a prospective vehicle for conveying anti-TB drugs to lung cells. Conventional and analytical transmission electron microscopy were used to analyze the localization of the nanodiamonds (NDs) in the lungs of M. tuberculosis-infected mice 30 days after nanoparticle administration and 44 days post-infection. Results: The study shows that the NDs co-localize with M. tuberculosis in foamy macrophages of the lung, residing in the same cellular compartments\u2014phagosomes\/phagolysosomes and lipid droplets. These in vivo results demonstrate a high degree of macrophage-specific accumulation of NDs relative to M. tuberculosis. Conclusions: Consequently, NDs can be considered a promising carrier for targeted delivery of anti-TB therapeutics to the lungs during TB-induced inflammation.<\/jats:p>","DOI":"10.3390\/pharmaceutics18060671","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:58:38Z","timestamp":1780473518000},"page":"671","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanodiamonds Co-Localize with Mycobacterium tuberculosis in Foamy Macrophages of Infected Mouse Lungs"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7256-4679","authenticated-orcid":false,"given":"Maria V.","family":"Erokhina","sequence":"first","affiliation":[{"name":"Department of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119991, Russia"},{"name":"Central Tuberculosis Research Institute, 2 Yauzskaya Alleya, Moscow 107564, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8067-4261","authenticated-orcid":false,"given":"Alexander G.","family":"Masyutin","sequence":"additional","affiliation":[{"name":"Department of Biology, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119991, Russia"},{"name":"Central Tuberculosis Research Institute, 2 Yauzskaya Alleya, Moscow 107564, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgii V.","family":"Lisichkin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel G.","family":"Mingalev","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-8432","authenticated-orcid":false,"given":"Gennadii A.","family":"Badun","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Lomonosov Moscow State University, 1-12 Leninskie Gory, Moscow 119234, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa N.","family":"Lepekha","sequence":"additional","affiliation":[{"name":"Central Tuberculosis Research Institute, 2 Yauzskaya Alleya, Moscow 107564, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina V.","family":"Bocharova","sequence":"additional","affiliation":[{"name":"Central Tuberculosis Research Institute, 2 Yauzskaya Alleya, Moscow 107564, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina K.","family":"Tarasova","sequence":"additional","affiliation":[{"name":"Central Tuberculosis Research Institute, 2 Yauzskaya Alleya, Moscow 107564, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atadzhan E.","family":"Ergeshov","sequence":"additional","affiliation":[{"name":"Central Tuberculosis Research Institute, 2 Yauzskaya Alleya, Moscow 107564, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref_1","unstructured":"IHME Pathogen Core Group (2024). 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