{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:31:17Z","timestamp":1789428677318,"version":"build-2803163510"},"reference-count":225,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Inflammation plays a crucial role in defending the body against harmful stimuli and maintaining physiological balance; however, when it becomes chronic, it contributes to the pathogenesis of several long-term diseases, including autoimmune conditions, cardiovascular and neurodegenerative disorders, and various cancers. Although conventional anti-inflammatory drugs provide symptomatic relief, their long-term use is often associated with adverse side effects. This limitation has shifted scientific attention toward naturally occurring bioactive molecules with potent, safer anti-inflammatory activity. Dietary incorporation of phytopharmaceuticals, such as flavonoids, polyphenols, alkaloids, terpenoids, and fatty acids, has been shown to regulate immune and oxidative mechanisms and to modulate key inflammatory signaling cascades, including the NF-\u03baB, mitogen-activated protein kinase (MAPK), and JAK\/STAT pathways. These agents also influence cytokine secretion, NLRP3 inflammasome activation, and antioxidant defense mechanisms involving the Nrf2\/HO-1 axis. The current review emphasizes the relevance of major natural plant products in therapy, like quercetin and rutin, resveratrol, glycyrrhizin, lycopene, and indole-3-carbinol. Moreover, recent progress in anti-inflammatory research has focused on novel resolution-based strategies that extend beyond inflammation and oxidative stress suppression. In addition, the review discusses innovations including nanoformulation-assisted targeted delivery, specialized pro-resolving lipid mediators such as resolvins and protectins, and microbiota-oriented therapeutic approaches. Additionally, the review highlights the integration of personalized medicine supported by multi-omics technologies to enhance treatment precision and clinical outcomes. By synthesizing findings from preclinical studies and clinical investigations, this work emphasizes the synergistic therapeutic potential of bioactive compounds from natural sources and resolution-enhancing techniques in restoring immune homeostasis and effectively mitigating chronic inflammation.<\/jats:p>","DOI":"10.3390\/pharmaceutics18060687","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:33:14Z","timestamp":1780479194000},"page":"687","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bioactive Anti-Inflammatory Compounds and Therapeutic Strategies for Promoting Resolution"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-9352","authenticated-orcid":false,"given":"Dipa K.","family":"Israni","sequence":"first","affiliation":[{"name":"Department of Pharmacology, LJ Institute of Pharmacy, LJ University, Ahmedabad 382210, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, LJ Institute of Pharmacy, LJ University, Ahmedabad 382210, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1470-8604","authenticated-orcid":false,"given":"Heena","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, LJ Institute of Pharmacy, LJ University, Ahmedabad 382210, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mumuxa","family":"Rathod","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, LJ Institute of Pharmacy, LJ University, Ahmedabad 382210, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-4541","authenticated-orcid":false,"given":"Bhupendra G.","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Parul Institute of Pharmacy, Parul University, Waghodia, Vadodara 391760, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3223-1551","authenticated-orcid":false,"given":"Supachoke","family":"Mangmool","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-3322","authenticated-orcid":false,"given":"Sudarshan","family":"Singh","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand"},{"name":"Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-9969","authenticated-orcid":false,"given":"Chuda","family":"Chittasupho","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory Responses and Inflammation-Associated Diseases in Organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jjcc.2018.05.010","article-title":"Critical Roles of Inflammation in Atherosclerosis","volume":"73","author":"Moriya","year":"2019","journal-title":"J. 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