{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:15:18Z","timestamp":1785420918200,"version":"3.56.0"},"reference-count":41,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005669","name":"Para\u00edba State Research Foundation","doi-asserted-by":"publisher","award":["1979\/2023"],"award-info":[{"award-number":["1979\/2023"]}],"id":[{"id":"10.13039\/501100005669","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Paraiba State University","award":["#01\/2026"],"award-info":[{"award-number":["#01\/2026"]}]},{"award":["#01\/2026"],"award-info":[{"award-number":["#01\/2026"]}],"id":[{"id":"https:\/\/ror.org\/02cm65z11","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: Inflammatory bowel diseases (IBD) are conditions of the gastrointestinal tract with treatments linked to side effects and relapses. Spondias mombin L. is a species with anti-inflammatory action, but there is little information in the literature about its application in the treatment of IBD. The aim of this study was to evaluate the intestinal anti-inflammatory activity of hydroalcoholic extract of Spondias mombin L. (HESm) in a rat model of ulcerative colitis (UC). Methods: Hydroalcoholic extract was obtained using the turboextraction technique, followed by identification of its major components using ultra-high performance liquid chromatography (UFLC). Intestinal anti-inflammatory activity was evaluated in an acute model of UC induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Groups received a vehicle, prednisolone (2 mg\/kg), or HESm (125, 250 or 500 mg\/kg) before and after UC induction. Ulcerated area, score, and intestinal weight\/length ratio were analyzed. Histopathological analysis and the extract\u2019s effect on the contractility of the intestinal segment were carried out. Results: UFLC identified the presence of quercetin, a flavonoid widely cited for the species. At doses of 125, 250, and 500 mg\/kg, the extract reduced areas of injury by 86.82, 92.67, and 85.06%, respectively, compared to the control, in addition to reducing scores and weight\/length ratio of the colons. Histopathological analysis confirmed the results. In contractility, the extract at the highest concentration tested reduced the response of the muscarinic agonist carbamylcholine to 53.7 \u00b1 4.2% of control contraction. Conclusions: Results demonstrate the species\u2019 ability to reduce injuries caused by colitis, suggesting its potential to contribute to the clinical management of IBD in the future.<\/jats:p>","DOI":"10.3390\/pharmaceutics18060723","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:56:31Z","timestamp":1781675791000},"page":"723","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Intestinal Anti-Inflammatory Property of Spondias mombin L. in an Experimental Animal Model of Colitis"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2377-8741","authenticated-orcid":false,"given":"Yasmim Vilarim","family":"Barbosa","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"},{"name":"Laborat\u00f3rio de Ensaios Farmacol\u00f3gicos, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elaine Cristina","family":"Araruna","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ensaios Farmacol\u00f3gicos, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"},{"name":"Departamento de Farm\u00e1cia, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lorenna Pessoa","family":"Fons\u00eaca","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ensaios Farmacol\u00f3gicos, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"},{"name":"Departamento de Farm\u00e1cia, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9748-5910","authenticated-orcid":false,"given":"Francisco Jos\u00e9 Batista","family":"de Lima J\u00fanior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ensaios Farmacol\u00f3gicos, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"},{"name":"Centro Universit\u00e1rio Unifacisa, Campina Grande 58408-326, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2380-109X","authenticated-orcid":false,"given":"Cassiano Francisco Weege","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Departamento de Odontologia, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo C\u00e9sar Dantas","family":"da Silva","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Avalia\u00e7\u00e3o e Desenvolvimento de Biomateriais do Nordeste (CertBio), Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Elizandro Batista","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"},{"name":"Laborat\u00f3rio de Ensaios Farmacol\u00f3gicos, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"},{"name":"Departamento de Farm\u00e1cia, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Larissa Barbosa","family":"de Lira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ensaios Farmacol\u00f3gicos, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"},{"name":"Departamento de Farm\u00e1cia, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e1ssia Borges","family":"Costa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ensaios Farmacol\u00f3gicos, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"},{"name":"Departamento de Farm\u00e1cia, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda Lucia","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"},{"name":"Laborat\u00f3rio de Ensaios Farmacol\u00f3gicos, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"},{"name":"Departamento de Farm\u00e1cia, Universidade Estadual da Para\u00edba, Campina Grande 58429-500, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"112653","DOI":"10.1016\/j.jpsychores.2026.112653","article-title":"The association of psychological distress with microbiota alterations in patients suffering from quiescent inflammatory bowel disease","volume":"206","author":"Zito","year":"2026","journal-title":"J. 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