{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:54:05Z","timestamp":1781679245938,"version":"3.54.5"},"reference-count":219,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Cutaneous infections and chronic inflammatory wounds remain difficult to treat because antimicrobial resistance, polymicrobial biofilms, excessive protease activity, oxidative stress, and impaired barrier repair collectively reduce the effectiveness of conventional topical therapies. Plant-derived antimicrobial peptides (AMPs) and peptide-associated bioactives offer antimicrobial, antibiofilm, immunomodulatory, and tissue reparative potential; however, their clinical translation is limited by proteolytic instability, poor stratum corneum penetration, short cutaneous residence time, formulation variability, cytotoxicity risks and limited human evidence. The key research gap is the lack of an integrated translational framework linking plant-derived peptide bioactivity with polymer engineering, advanced delivery systems, skin microenvironment biology, manufacturability, and regulatory feasibility. This review aims to critically evaluate the design principles, therapeutic mechanisms, delivery platforms, and translational barriers of plant-based peptide\u2013polymer therapeutics for cutaneous infection and inflammation. We summarize major classes of plant-derived antimicrobial peptides, including defensins, cyclotides, thionins, hevein-like peptides, snakins, lipid transfer proteins, and knottin-type scaffolds, and examine engineering strategies such as self-assembly, aromatic N-capping, PEGylation, lipidation, dendritic architectures, and stimuli-responsive conjugation. We further discuss topical matrices, nanocarriers, liposomes, electrospun fibers, and surface-tethered biomaterials as delivery platforms for improving peptide stability, local retention, and controlled release. Finally, we identify key translational bottlenecks, including selectivity, toxicity, scalability, batch reproducibility, regulatory classification, and insufficient clinical validation. Mechanism-driven peptide optimization, quality-by-design manufacturing, standardized preclinical models, and controlled clinical trials will be essential for advancing these systems toward safe and effective dermatological therapies.<\/jats:p>","DOI":"10.3390\/pharmaceutics18060729","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:56:31Z","timestamp":1781675791000},"page":"729","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plant-Derived Peptide\u2013Polymer Therapeutics for Cutaneous Infections and Inflammation: Mechanistic Basis, Delivery Design and Translational Considerations"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5562-6703","authenticated-orcid":false,"given":"Adnan","family":"Amin","sequence":"first","affiliation":[{"name":"Department of Life Sciences, Yeungnam University, Gyeongsan 38541, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-2443","authenticated-orcid":false,"given":"Mozaniel","family":"Santana de Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology of Inflammation and Behavior, Graduate Program in Pharmaceutical Sciences, Institute of Health Sciences, Federal University of Par\u00e1, Bel\u00e9m 66075-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Touseef","family":"Nawaz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Qurtuba University of Science and Information Technology, Peshawar 25100, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7881-8625","authenticated-orcid":false,"given":"Oberdan Oliveira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Program in Biotechnology, Federal University of Par\u00e1 (UFPA), Bel\u00e9m 66075-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41572-022-00377-3","article-title":"Chronic Wounds","volume":"8","author":"Falanga","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.4239\/wjd.v13.i12.1014","article-title":"Diabetic Foot Ulcer: Challenges and Future","volume":"13","author":"Yang","year":"2022","journal-title":"World J. Diabetes"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Zhao, R., Liang, H., Clarke, E., Jackson, C., and Xue, M. (2016). Inflammation in Chronic Wounds. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17122085"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/acs.accounts.0c00864","article-title":"Strategy for Treatment of Infected Diabetic Foot Ulcers","volume":"54","author":"Chang","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s13671-018-0234-9","article-title":"Immunology of Wound Healing","volume":"7","author":"Ellis","year":"2018","journal-title":"Curr. Dermatol. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Panda, S.K., Buroni, S., Swain, S.S., Bonacorsi, A., da Fonseca Amorim, E.A., Kulshrestha, M., Da Silva, L.C.N., and Tiwari, V. (2022). Recent Advances to Combat Eskape Pathogens with Special Reference to Essential Oils. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.1029098"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mulani, M.S., Kamble, E.E., Kumkar, S.N., Tawre, M.S., and Pardesi, K.R. (2019). Emerging Strategies to Combat Eskape Pathogens in the Era of Antimicrobial Resistance: A Review. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.00539"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"eaaz6992","DOI":"10.1126\/scitranslmed.aaz6992","article-title":"Biology of Antimicrobial Resistance and Approaches to Combat it","volume":"12","author":"Schrader","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2002129","DOI":"10.1002\/adma.202002129","article-title":"Advances in Antimicrobial Microneedle Patches for Combating Infections","volume":"32","author":"Jamaledin","year":"2020","journal-title":"Adv. Mater."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"13313","DOI":"10.1073\/pnas.1403995111","article-title":"Ionic Liquids as a Class of Materials for Transdermal Delivery and Pathogen Neutralization","volume":"111","author":"Zakrewsky","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/adhm.201500634","article-title":"De Novo Design of Skin-Penetrating Peptides for Enhanced Transdermal Delivery of Peptide Drugs","volume":"5","author":"Menegatti","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Panza, S., Pellegrini, B., Fiore, D., Tarsitano, M., Mancuso, A., Cristiano, M.C., and Paolino, D. (2026). Botanical and Upcycled Bioactives for Advanced Topical Formulations: Mechanistic Pathways, Cutaneous Delivery, and Sustainability-by-Design. Pharmaceutics, 18.","DOI":"10.3390\/pharmaceutics18030375"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4251091","DOI":"10.1155\/ijbm\/4251091","article-title":"Topical Delivery Systems for Plant-Derived Antimicrobial Agents: A Review of Current Advances","volume":"2025","author":"Hashempur","year":"2025","journal-title":"Int. J. Biomater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"562","DOI":"10.22214\/ijraset.2018.4098","article-title":"Synthesis and Characterization of Nisin Loaded TPP Cross Linked Chitosan Nanoparticles","volume":"6","author":"Paari","year":"2018","journal-title":"Int. J. Res. Appl. Sci. Eng. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1080\/15583724.2025.2485902","article-title":"Synthesis and Characterization of Peptide-Chitosan Engineered Nanoparticles as an Ideal Platform for Food Preservation, Cosmetics, and Pharmaceutical Applications","volume":"65","author":"Tahmasebi","year":"2025","journal-title":"Polym. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Mazurkiewicz-Pisarek, A., Baran, J., and Ciach, T. (2023). Antimicrobial Peptides: Challenging Journey to the Pharmaceutical, Biomedical, and Cosmeceutical Use. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24109031"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"578261","DOI":"10.2147\/DDDT.S578261","article-title":"Biopolymer Hydrogel-Based Nanocomposites Functionalized with Natural Products for Wound Dressings: Translational Advances in Drug Design, Development, and Therapeutic Wound Care","volume":"20","author":"Ranatunga","year":"2026","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"101701","DOI":"10.1016\/j.cocis.2023.101701","article-title":"Skin and Wound Delivery Systems for Antimicrobial Peptides","volume":"65","author":"Caselli","year":"2023","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3201\/eid0809.020063","article-title":"Biofilms: Microbial Life on Surfaces","volume":"8","author":"Donlan","year":"2002","journal-title":"Emerg. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s13346-020-00740-5","article-title":"Challenges in Nanomedicine Clinical Translation","volume":"10","author":"Metselaar","year":"2020","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_21","first-page":"1657","article-title":"Peptides in Wound Healing: A Comprehensive Review of Their Roles, Challenges, and Hydrogel-Based Delivery Systems","volume":"24","author":"Kamil","year":"2025","journal-title":"EXCLI J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s12223-013-0280-4","article-title":"Plant Antimicrobial Peptides","volume":"59","author":"Nawrot","year":"2014","journal-title":"Folia Microbiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/ph8040711","article-title":"Antimicrobial Peptides from Plants","volume":"8","author":"Tam","year":"2015","journal-title":"Pharmaceuticals"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"de Oliveira, S.S., Cherene, M.B., Taveira, G.B., de Oliveira Mello, \u00c9., de Oliveira Carvalho, A., and Gomes, V.M. (2025). Plant Antimicrobial Peptides and Their Main Families and Roles: A Review of the Literature. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47010001"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.peptides.2015.04.017","article-title":"Cysteine-Stabilized A\u03b2 Defensins: From a Common Fold to Antibacterial Activity","volume":"72","author":"Franco","year":"2015","journal-title":"Peptides"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.fbr.2012.08.004","article-title":"Plant Defensins: Common Fold, Multiple Functions","volume":"26","author":"Anderson","year":"2013","journal-title":"Fungal Biol. Rev."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/bip.22570","article-title":"Psd1 Binding Affinity toward Fungal Membrane Components as Assessed by Spr: The Role of Glucosylceramide in Fungal Recognition and Entry","volume":"102","author":"Domitrovic","year":"2014","journal-title":"Biopolymers"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1093\/jxb\/erw210","article-title":"Discovery, Structure, Function, and Applications of Cyclotides: Circular Proteins from Plants","volume":"67","author":"Weidmann","year":"2016","journal-title":"J. Exp. Bot."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1176935119832910","DOI":"10.1177\/1176935119832910","article-title":"Clinically Relevant Biomarker Discovery in High-Risk Recurrent Neuroblastoma","volume":"18","author":"Utnes","year":"2019","journal-title":"Cancer Inf."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"27033","DOI":"10.1074\/jbc.M112.370841","article-title":"Cyclotides Associate with Leaf Vasculature and Are the Products of a Novel Precursor in Petunia (Solanaceae)","volume":"287","author":"Poth","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"H\u00f6ng, K., Austerlitz, T., Bohlmann, T., and Bohlmann, H. (2021). The Thionin Family of Antimicrobial Peptides. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0254549"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40529-021-00312-x","article-title":"Plant Antimicrobial Peptides: Structures, Functions, and Applications","volume":"62","author":"Li","year":"2021","journal-title":"Bot. Stud."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1007\/s12602-024-10421-1","article-title":"Production, Delivery, and Regulatory Aspects for Application of Plant-Based Anti-Microbial Peptides: A Comprehensive Review","volume":"17","author":"Nagella","year":"2025","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"8683","DOI":"10.1007\/s11033-023-08734-5","article-title":"Snakins: Antimicrobial Potential and Prospects of Genetic Engineering for Enhanced Disease Resistance in Plants","volume":"50","author":"Iqbal","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1002\/psc.2895","article-title":"Anti-Biofilm and Sporicidal Activity of Peptides Based on Wheat Puroindoline and Barley Hordoindoline Proteins","volume":"22","author":"Shagaghi","year":"2016","journal-title":"J. Pept. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"667","DOI":"10.18699\/VJ18.409","article-title":"Plant Thionins: Structure, Biological Functions and Potential Use in Biotechnology","volume":"22","author":"Odintsova","year":"2018","journal-title":"Vavilov J. Genet. Breed."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Barashkova, A., Sadykova, V., Salo, V., Zavriev, S., and Rogozhin, E. (2021). Nigellothionins from Black Cumin (Nigella sativa L.) Seeds Demonstrate Strong Antifungal and Cytotoxic Activity. Antibiotics, 10.","DOI":"10.3390\/antibiotics10020166"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Noonan, J., Williams, W., and Shan, X. (2017). Investigation of Antimicrobial Peptide Genes Associated with Fungus and Insect Resistance in Maize. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091938"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1038\/s41598-018-38301-z","article-title":"Identification of Non-Specific Lipid Transfer Protein Gene Family Members in Solanum lycopersicum and Insights into the Features of Sola L 3 Protein","volume":"9","author":"Buonanno","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_40","first-page":"250349","article-title":"Antibacterial Peptides from Plants: What They are and How They Probably Work","volume":"2011","author":"Pelegrini","year":"2011","journal-title":"Biochem. Res. Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100438","DOI":"10.1016\/j.jbc.2021.100438","article-title":"Amino Acid\u2013Derived Defense Metabolites from Plants: A Potential Source to Facilitate Novel Antimicrobial Development","volume":"296","author":"Parthasarathy","year":"2021","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Slavokhotova, A.A., and Rogozhin, E.A. (2020). Defense Peptides from the A-Hairpinin Family Are Components of Plant Innate Immunity. Front. Plant Sci., 11.","DOI":"10.3389\/fpls.2020.00465"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Parisi, M., Oz\u00f3n, B., Gonz\u00e1lez, S.V., Garc\u00eda-Pardo, J., and Obreg\u00f3n, W. (2024). Plant Protease Inhibitors as Emerging Antimicrobial Peptide Agents: A Comprehensive Review. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16050582"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kaur, K.D., and Habimana, O. (2022). Death at the Interface: Nanotechnology\u2019s Challenging Frontier against Microbial Surface Colonization. Front. Chem., 10.","DOI":"10.3389\/fchem.2022.1003234"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Vaara, M. (2019). Polymyxins and Their Potential Next Generation as Therapeutic Antibiotics. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01689"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Moretta, A., Scieuzo, C., Petrone, A.M., Salvia, R., Manniello, M.D., Franco, A., Lucchetti, D., Vassallo, A., Vogel, H., and Sgambato, A. (2021). Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.668632"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.2174\/138161209788682325","article-title":"The Roles of Antimicrobial Peptides in Innate Host Defense","volume":"15","author":"Diamond","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s12951-022-01315-x","article-title":"Nanoarchitectured Prototypes of Mesoporous Silica Nanoparticles for Innovative Biomedical Applications","volume":"20","author":"Kankala","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.it.2008.12.003","article-title":"Amped up Immunity: How Antimicrobial Peptides Have Multiple Roles in Immune Defense","volume":"30","author":"Lai","year":"2009","journal-title":"Trends Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.bbamem.2008.06.007","article-title":"Toroidal Pores Formed by Antimicrobial Peptides Show Significant Disorder","volume":"1778","author":"Sengupta","year":"2008","journal-title":"Biochim. Biophys. Acta (BBA) Biomembr."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ha-Tran, D.M., and Huang, C.-C. (2025). Peptides from Plants and Microorganisms: A Defense Strategy for Biotic and Abiotic Stresses. Front. Plant Sci., 16.","DOI":"10.3389\/fpls.2025.1649512"},{"key":"ref_52","first-page":"48","article-title":"Antimicrobial Peptides: Mechanism of Action, Activity and Clinical Potential","volume":"8","author":"Zhang","year":"2021","journal-title":"Mil. Med. Res."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Zhou, J., Cai, Y., Liu, Y., An, H., Deng, K., Ashraf, M.A., Zou, L., and Wang, J. (2022). Breaking Down the Cell Wall: Still an Attractive Antibacterial Strategy. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.952633"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Nadar, S., Khan, T., Patching, S.G., and Omri, A. (2022). Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance. Microorganisms, 13.","DOI":"10.3390\/microorganisms10020303"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Saleh, H.A., Yousef, M.H., and Abdelnaser, A. (2021). The Anti-Inflammatory Properties of Phytochemicals and Their Effects on Epigenetic Mechanisms Involved in Tlr4\/Nf-\u039ab-Mediated Inflammation. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.606069"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Jazvin\u0161\u0107ak Jembrek, M., Or\u0161oli\u0107, N., Mandi\u0107, L., Sad\u017eak, A., and \u0160egota, S. (2021). Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, Nf-\u039ab and P53 Pathways in Neurodegeneration. Antioxidants, 10.","DOI":"10.3390\/antiox10101628"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"106440","DOI":"10.1016\/j.jff.2024.106440","article-title":"Combination of Network Pharmacology, in vitro Experiments and Molecular Dynamic Simulations Revealed Anti-Inflammatory Molecular Mechanism of the Shrub Metapanax Delavayi","volume":"121","author":"Zhao","year":"2024","journal-title":"J. Funct. Foods"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Lamponi, S. (2026). Plant-Based Biomaterials as Bio-Instructive Immunomodulators: Design Principles, Mechanisms, and Translational Challenges. Life, 16.","DOI":"10.20944\/preprints202603.0368.v1"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.fct.2007.12.021","article-title":"Early Identification Systems for Emerging Foodborne Hazards","volume":"47","author":"Marvin","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Yin, Z., Song, R., Yu, T., Fu, Y., Ding, Y., and Nie, H. (2025). Natural Compounds Regulate Macrophage Polarization and Alleviate Inflammation against Ali\/Ards. Biomolecules, 15.","DOI":"10.3390\/biom15020192"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.3390\/ijms26115206","article-title":"Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications","volume":"26","author":"Nakadate","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1172\/JCI124615","article-title":"The Role of Macrophages in the Resolution of Inflammation","volume":"129","author":"Watanabe","year":"2019","journal-title":"J. Clin. Investig."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1016\/j.drudis.2019.05.026","article-title":"Peptide-Based Protease Inhibitors from Plants","volume":"24","author":"Hellinger","year":"2019","journal-title":"Drug Discov. Today"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"915368","DOI":"10.3389\/fimmu.2022.915368","article-title":"Antimicrobial Peptide Mimics for Clinical Use: Does Size Matter?","volume":"13","author":"Svenson","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_65","first-page":"1","article-title":"Challenges and Strategies for Topical and Transdermal Delivery of Bioactive Peptides","volume":"39","year":"2022","journal-title":"Crit. Rev. Ther. Drug Carr. Syst."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"118817","DOI":"10.1016\/j.ijpharm.2019.118817","article-title":"Transferosomes as Nanocarriers for Drugs across the Skin: Quality by Design from Lab to Industrial Scale","volume":"573","author":"Lalatsa","year":"2020","journal-title":"Int. J. Pharm."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e00485","DOI":"10.1002\/mabi.202500485","article-title":"From Bioactive Peptides to Transdermal Peptides: An Emerging Strategy for Revolutionizing Drug Delivery","volume":"26","author":"Yang","year":"2026","journal-title":"Macromol. Biosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1007\/s12602-024-10354-9","article-title":"The Roadmap of Plant Antimicrobial Peptides under Environmental Stress: From Farm to Bedside","volume":"16","author":"Ghanbarzadeh","year":"2024","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00284-024-03839-x","article-title":"Purification, Structural Characterization, and Anticandidal Activity of a Chitin-Binding Peptide with High Similarity to Hevein and Endochitinase Isolated from Pepper Seeds","volume":"81","author":"Taveira","year":"2024","journal-title":"Curr. Microbiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1016\/j.bbamem.2013.03.023","article-title":"Mechanism of Action of Puroindoline Derived Tryptophan-Rich Antimicrobial Peptides","volume":"1828","author":"Haney","year":"2013","journal-title":"Biochim. Biophys. Acta (BBA)-Biomembr."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.bbamem.2008.09.013","article-title":"Control of Cell Selectivity of Antimicrobial Peptides","volume":"1788","author":"Matsuzaki","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Cavallo, I., Sivori, F., Mastrofrancesco, A., Abril, E., Pontone, M., Di Domenico, E.G., and Pimpinelli, F. (2024). Bacterial Biofilm in Chronic Wounds and Possible Therapeutic Approaches. Biology, 13.","DOI":"10.3390\/biology13020109"},{"key":"ref_73","first-page":"1177932220952739","article-title":"Plant Antimicrobial Peptides: State of the Art, in Silico Prediction and Perspectives in the Omics Era","volume":"14","author":"Zupin","year":"2020","journal-title":"Bioinform. Biol. Insights"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00726-025-03454-5","article-title":"Therapeutic Peptides: Chemical Strategies Fortify Peptides for Enhanced Disease Treatment Efficacy","volume":"57","author":"Li","year":"2025","journal-title":"Amino Acids"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.drudis.2014.10.003","article-title":"Peptide Therapeutics: Current Status and Future Directions","volume":"20","author":"Fosgerau","year":"2015","journal-title":"Drug Discov. Today"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Yu, D., Han, N., Son, H., Kim, S.J., and Kweon, S. (2026). Functional Peptide-Based Biomaterials for Pharmaceutical Application: Sequences, Mechanisms, and Optimization Strategies. J. Funct. Biomater., 17.","DOI":"10.3390\/jfb17010037"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nchem.2202","article-title":"Common Origins of RNA, Protein and Lipid Precursors in a Cyanosulfidic Protometabolism","volume":"7","author":"Patel","year":"2015","journal-title":"Nat. Chem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"100644","DOI":"10.1016\/j.mtbio.2023.100644","article-title":"Self-Assembled Short Peptides: Recent Advances and Strategies for Potential Pharmaceutical Applications","volume":"20","author":"Yang","year":"2023","journal-title":"Mater. Today Bio"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1021\/acsabm.2c01041","article-title":"Self-Assembly, Bioactivity, and Nanomaterials Applications of Peptide Conjugates with Bulky Aromatic Terminal Groups","volume":"6","author":"Hamley","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1021\/bm900584m","article-title":"Self-Assembled Fmoc-Peptides as a Platform for the Formation of Nanostructures and Hydrogels","volume":"10","author":"Orbach","year":"2009","journal-title":"Biomacromolecules"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Das, S., and Das, D. (2021). Rational Design of Peptide-Based Smart Hydrogels for Therapeutic Applications. Front. Chem., 9.","DOI":"10.3389\/fchem.2021.770102"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.theriogenology.2012.08.012","article-title":"Genome Resource Banking of Biomedically Important Laboratory Animals","volume":"78","author":"Agca","year":"2012","journal-title":"Theriogenology"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1021\/acs.bioconjchem.6b00540","article-title":"Site-Specific Polymer Attachment to Hr2 Peptide Fusion Inhibitors against Hiv-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity","volume":"28","author":"Danial","year":"2017","journal-title":"Bioconjug. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2411753","DOI":"10.1002\/advs.202411753","article-title":"Enhancing the Therapeutic Potential of Peptide Antibiotics Using Bacteriophage Mimicry Strategies","volume":"12","author":"Wan","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1039\/D4TB01897D","article-title":"Evolution of Branched Peptides as Novel Biomaterials","volume":"13","author":"Little","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"19","DOI":"10.29245\/2578-3009\/2021\/1.1206","article-title":"The Impact of Nanoparticles on the Immune System: A Gray Zone of Nanomedicine","volume":"5","author":"Ray","year":"2021","journal-title":"J. Immunol. Sci."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s40259-023-00608-3","article-title":"Going Beyond Host Defence Peptides: Horizons of Chemically Engineered Peptides for Multidrug-Resistant Bacteria","volume":"37","author":"Li","year":"2023","journal-title":"BioDrugs"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"7820","DOI":"10.1039\/D0CS00729C","article-title":"The Multifaceted Nature of Antimicrobial Peptides: Current Synthetic Chemistry Approaches and Future Directions","volume":"50","author":"Gan","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1039\/D4ME00021H","article-title":"Engineering the Interaction of Short Antimicrobial Peptides with Bacterial Barriers","volume":"9","author":"Montis","year":"2024","journal-title":"Mol. Syst. Des. Eng."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1007\/s00253-023-12562-9","article-title":"Optimization of Antimicrobial Peptides for the Application against Biocorrosive Bacteria","volume":"107","author":"Stillger","year":"2023","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Li, J., Koh, J.-J., Liu, S., Lakshminarayanan, R., Verma, C.S., and Beuerman, R.W. (2017). Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design. Front. Neurosci., 11.","DOI":"10.3389\/fnins.2017.00073"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00232-024-00315-2","article-title":"A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs","volume":"257","author":"Ramirez","year":"2024","journal-title":"J. Membr. Biol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Hadjicharalambous, A., Bournakas, N., Newman, H., Skynner, M.J., and Beswick, P. (2022). Antimicrobial and Cell-Penetrating Peptides: Understanding Penetration for the Design of Novel Conjugate Antibiotics. Antibiotics, 11.","DOI":"10.3390\/antibiotics11111636"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e70054","DOI":"10.1002\/agt2.70054","article-title":"Cell Membrane-Coated Lipid Nanoparticles for Drug Delivery","volume":"6","author":"Zewail","year":"2025","journal-title":"Aggregate"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Ko\u0142ody\u0144ska, K., Kamysz, W., and Kleczkowska, P. (2026). Peptide-Based Approaches for Pain Relief and Healing in Wounds. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27020685"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Gunasekera, S., Muhammad, T., Str\u00f6mstedt, A.A., Rosengren, K.J., and G\u00f6ransson, U. (2020). Backbone Cyclization and Dimerization of Ll-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.00168"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"10863","DOI":"10.1007\/s10853-022-07266-w","article-title":"Peptide-Coating Combating Antimicrobial Contaminations: A Review of Covalent Immobilization Strategies for Industrial Applications","volume":"57","author":"Stillger","year":"2022","journal-title":"J. Mater. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1007\/s00018-021-03784-z","article-title":"Insect Antimicrobial Peptides: Potential Weapons to Counteract the Antibiotic Resistance","volume":"78","author":"Manniello","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1021\/acs.joc.5c00083","article-title":"Time-Reduced N-Methylation: Exploring a Faster Synthesis Technique","volume":"90","author":"Glavas","year":"2025","journal-title":"J. Org. Chem."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"eaax6601","DOI":"10.1126\/scitranslmed.aax6601","article-title":"A Dual-Action Peptide-Containing Hydrogel Targets Wound Infection and Inflammation","volume":"12","author":"Puthia","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Copling, A., Akantibila, M., Kumaresan, R., Fleischer, G., Cortes, D., Tripathi, R.S., Carabetta, V.J., and Vega, S.L. (2023). Recent Advances in Antimicrobial Peptide Hydrogels. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24087563"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40824-023-00379-6","article-title":"Advanced Polymer Hydrogels That Promote Diabetic Ulcer Healing: Mechanisms, Classifications, and Medical Applications","volume":"27","author":"Xu","year":"2023","journal-title":"Biomater. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"119767","DOI":"10.1016\/j.carbpol.2022.119767","article-title":"New Injectable Chitosan-Hyaluronic Acid Based Hydrogels for Hemostasis and Wound Healing","volume":"294","author":"Weng","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/s41427-022-00444-x","article-title":"A Cyclic Heptapeptide-Based Hydrogel Boosts the Healing of Chronic Skin Wounds in Diabetic Mice and Patients","volume":"14","author":"Fu","year":"2022","journal-title":"NPG Asia Mater."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Mahlapuu, M., H\u00e5kansson, J., Ringstad, L., and Bj\u00f6rn, C. (2016). Antimicrobial Peptides: An Emerging Category of Therapeutic Agents. Front. Cell Infect. Microbiol., 6.","DOI":"10.3389\/fcimb.2016.00194"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1021\/cr9603892","article-title":"Dendrimers in Supramolecular Chemistry: From Molecular Recognition to Self-Assembly","volume":"97","author":"Zeng","year":"1997","journal-title":"Chem. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"444","DOI":"10.2174\/1567201816666190201143457","article-title":"Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies","volume":"16","author":"Benson","year":"2019","journal-title":"Curr. Drug Deliv."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Liu, B., and Chen, K. (2024). Advances in Hydrogel-Based Drug Delivery Systems. Gels, 10.","DOI":"10.3390\/gels10040262"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Dabbaghi, M., Namjoshi, S., Panchal, B., Grice, J.E., Prakash, S., Roberts, M.S., and Mohammed, Y. (2021). Viscoelastic and Deformation Characteristics of Structurally Different Commercial Topical Systems. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13091351"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Zhao, L., Chen, J., Bai, B., Song, G., Zhang, J., Yu, H., Huang, S., Wang, Z., and Lu, G. (2024). Topical Drug Delivery Strategies for Enhancing Drug Effectiveness by Skin Barriers, Drug Delivery Systems and Individualized Dosing. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1333986"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Khubiev, O.M., Egorov, A.R., Kirichuk, A.A., Khrustalev, V.N., Tskhovrebov, A.G., and Kritchenkov, A.S. (2023). Chitosan-Based Antibacterial Films for Biomedical and Food Applications. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310738"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Pfalzgraff, A., Brandenburg, K., and Weindl, G. (2018). Antimicrobial Peptides and Their Therapeutic Potential for Bacterial Skin Infections and Wounds. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00281"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/20415990.2024.2411943","article-title":"Strategies for Transportation of Peptides across the Skin for Treatment of Multiple Diseases","volume":"16","author":"Bhavsar","year":"2025","journal-title":"Ther. Deliv."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/0109298665292469240228064739","article-title":"Enhancement of Oral Bioavailability of Protein and Peptide by Polysaccharide-Based Nanoparticles","volume":"31","author":"Islam","year":"2024","journal-title":"Protein Pept. Lett."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000491497","article-title":"Design and Assessment of Anti-Biofilm Peptides: Steps toward Clinical Application","volume":"11","author":"Dostert","year":"2019","journal-title":"J. Innate Immun."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Alford, M.A., Baquir, B., Santana, F.L., Haney, E.F., and Hancock, R.E.W. (2020). Cathelicidin Host Defense Peptides and Inflammatory Signaling: Striking a Balance. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.01902"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"88","DOI":"10.22159\/ijap.2022v14i4.44564","article-title":"Nanostructured Lipid Carriers for Transdermal Drug Delivery","volume":"14","author":"Hassan","year":"2022","journal-title":"Int. J. Appl. Pharm."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Liu, M., Fang, X., Yang, Y., and Wang, C. (2021). Peptide-Enabled Targeted Delivery Systems for Therapeutic Applications. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.701504"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Lee, N.-H., You, S., Taghizadeh, A., Taghizadeh, M., and Kim, H.S. (2022). Cell Membrane-Cloaked Nanotherapeutics for Targeted Drug Delivery. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23042223"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1021\/acs.accounts.6b00553","article-title":"Self-Assembling Multidomain Peptide Nanofibers for Delivery of Bioactive Molecules and Tissue Regeneration","volume":"50","author":"Moore","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"5867","DOI":"10.1039\/C7OB01092C","article-title":"Self-Assembly of Bioactive Peptides, Peptide Conjugates, and Peptide Mimetic Materials","volume":"15","author":"Hamley","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"14878","DOI":"10.1039\/D5RA09767C","article-title":"Smart Microdevices for Biomedical Drug Delivery: Endogenous Stimuli as the Key to Safer Therapeutics","volume":"16","author":"Datta","year":"2026","journal-title":"RSC Adv."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"8644","DOI":"10.1039\/D0SC02937H","article-title":"Tumor Microenvironment-Oriented Adaptive Nanodrugs Based on Peptide Self-Assembly","volume":"11","author":"Li","year":"2020","journal-title":"Chem. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Wang, Z., Xu, F.-J., and Yu, B. (2021). Smart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.783354"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Huan, Y., Kong, Q., Mou, H., and Yi, H. (2020). Antimicrobial Peptides: Classification, Design, Application and Research Progress in Multiple Fields. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.582779"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Ye, K., Kuang, H., You, Z., Morsi, Y., and Mo, X. (2019). Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11040182"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Song, Y., Zheng, X., Hu, J., Ma, S., Li, K., Chen, J., Xu, X., Lu, X., and Wang, X. (2023). Recent Advances of Cell Membrane-Coated Nanoparticles for Therapy of Bacterial Infection. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1083007"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1080\/07388551.2020.1828810","article-title":"Strategies for Antimicrobial Peptide Coatings on Medical Devices: A Review and Regulatory Science Perspective","volume":"41","author":"Cheng","year":"2021","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Nicolas, M., Beito, B., Oliveira, M., Martins, M.T., Gallas, B., Salmain, M., Boujday, S., and Humblot, V. (2021). Strategies for Antimicrobial Peptides Immobilization on Surfaces to Prevent Biofilm Growth on Biomedical Devices. Antibiotics, 11.","DOI":"10.3390\/antibiotics11010013"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1021\/acsapm.1c00125","article-title":"Polymer-Based Coatings with Integrated Antifouling and Bactericidal Properties for Targeted Biomedical Applications","volume":"3","author":"Mitra","year":"2021","journal-title":"ACS Appl. Polym. Mater."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/451234a","article-title":"Genomics Sizes up","volume":"451","author":"Qiu","year":"2008","journal-title":"Nature"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.biopsych.2006.04.025","article-title":"Association of Fatty Acid Desaturase Genes with Attention-Deficit\/Hyperactivity Disorder","volume":"60","author":"Brookes","year":"2006","journal-title":"Biol. Psychiatry"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"10853","DOI":"10.1038\/s41598-022-14463-9","article-title":"Efficient Transdermal Delivery of Functional Protein Cargoes by a Hydrophobic Peptide Mtd 1067","volume":"12","author":"Shin","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acsabm.3c00659","article-title":"Transdermal Properties of Cell-Penetrating Peptides: Applications and Skin Penetration Mechanisms","volume":"7","author":"Shin","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_135","first-page":"65","article-title":"Transfersomes and Ethosomes for Enhanced Transdermal Drug Delivery: Mechanistic Insights and Comparative Evaluation","volume":"3","author":"Gaddam","year":"2026","journal-title":"Int. J. Sci. Res. Technol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/acs.accounts.1c00544","article-title":"Chemistry of Lipid Nanoparticles for RNA Delivery","volume":"55","author":"Eygeris","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4103\/1735-5362.235156","article-title":"Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Novel Drug Delivery Systems: Applications, Advantages and Disadvantages","volume":"13","author":"Ghasemiyeh","year":"2018","journal-title":"Res. Pharm. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/acs.chemrev.3c00705","article-title":"Polymeric Nanoparticles for Drug Delivery","volume":"124","author":"Beach","year":"2024","journal-title":"Chem. Rev."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Moazzami Goudarzi, Z., Zaszczy\u0144ska, A., Kowalczyk, T., and Sajkiewicz, P. (2024). Electrospun Antimicrobial Drug Delivery Systems and Hydrogels Used for Wound Dressings. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16010093"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"e2104165","DOI":"10.1002\/advs.202104165","article-title":"Self-Assembling Peptide-Based Hydrogels for Wound Tissue Repair","volume":"9","author":"Guan","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2200514","DOI":"10.1002\/mabi.202200514","article-title":"Hydrogel Complex Containing the Antimicrobial Peptide Hx-12c Accelerates Healing of Infected Wounds","volume":"23","author":"Chen","year":"2023","journal-title":"Macromol. Biosci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"213238","DOI":"10.1016\/j.bioadv.2022.213238","article-title":"Tailored Anti-Biofilm Activity\u2014Liposomal Delivery for Mimic of Small Antimicrobial Peptide","volume":"145","author":"Hemmingsen","year":"2023","journal-title":"Biomater. Adv."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Sankar, S., O\u2019Neill, K., D\u2019Arc, M.B., Rebeca, F., Buffier, M., Aleksi, E., Fan, M., Matsuda, N., Gil, E.S., and Spirio, L. (2021). Clinical Use of the Self-Assembling Peptide Rada16: A Review of Current and Future Trends in Biomedicine. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.679525"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Negut, I., Bita, B., and Groza, A. (2022). Polymeric Coatings and Antimicrobial Peptides as Efficient Systems for Treating Implantable Medical Devices Associated-Infections. Polymers, 14.","DOI":"10.3390\/polym14081611"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1021\/acsabm.1c01132","article-title":"Antimicrobial Peptides and Macromolecules for Combating Microbial Infections: From Agents to Interfaces","volume":"5","author":"Yu","year":"2022","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Jadi, P.K., Sharma, P., Bhogapurapu, B., and Roy, S. (2021). Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis. Front. Chem., 9.","DOI":"10.3389\/fchem.2021.694998"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"2203291","DOI":"10.1002\/advs.202203291","article-title":"Biofilms: Formation, Research Models, Potential Targets, and Methods for Prevention and Treatment","volume":"9","author":"Su","year":"2022","journal-title":"Adv. Sci."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s43556-023-00164-w","article-title":"Biofilm Formation: Mechanistic Insights and Therapeutic Targets","volume":"4","author":"Wang","year":"2023","journal-title":"Mol. Biomed."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2102330","DOI":"10.1002\/advs.202102330","article-title":"Engineered Cell Membrane-Derived Nanoparticles in Immune Modulation","volume":"8","author":"Yang","year":"2021","journal-title":"Adv. Sci."},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Liu, X., Su, J., Wang, G., Zheng, L., Wang, G., Sun, Y., Bao, Y., Wang, S., and Huang, Y. (2021). Discovery of Phenolic Glycoside from Hyssopus Cuspidatus Attenuates Lps-Induced Inflammatory Responses by Inhibition of Inos and Cox-2 Expression through Suppression of Nf-\u039ab Activation. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212128"},{"key":"ref_151","first-page":"1","article-title":"Models for the Study of Skin Wound Healing. The Role of Nrf2 and Nf-\u039ab","volume":"161","year":"2017","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc Czechoslov."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Saha, S., Buttari, B., Panieri, E., Profumo, E., and Saso, L. (2020). An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation. Molecules, 25.","DOI":"10.3390\/molecules25225474"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"109","DOI":"10.59298\/NIJPP\/2025\/63109113","article-title":"Oxidative Stress as a Central Mediator of Chronic Inflammation: Mechanistic Insights and Therapeutic Targets","volume":"6","author":"Julius","year":"2025","journal-title":"Newport Int. J. Public Health Pharm. (NIJPP)"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"tkac051","DOI":"10.1093\/burnst\/tkac051","article-title":"Macrophage Polarization in Diabetic Wound Healing","volume":"10","author":"Wu","year":"2022","journal-title":"Burn. Trauma."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"P\u00e9rez, S., and Rius-P\u00e9rez, S. (2022). Macrophage Polarization and Reprogramming in Acute Inflammation: A Redox Perspective. Antioxidants, 11.","DOI":"10.3390\/antiox11071394"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Ross, A., Sauce-Guevara, M.A., Alarcon, E.I., and Mendez-Rojas, M.A. (2022). Peptide Biomaterials for Tissue Regeneration. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.893936"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/s12951-023-02193-7","article-title":"Plant-Derived Nanovesicles: Harnessing Nature\u2019s Power for Tissue Protection and Repair","volume":"21","author":"Chen","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-020-00755-7","article-title":"Nanocomposite Scaffolds for Accelerating Chronic Wound Healing by Enhancing Angiogenesis","volume":"19","author":"Nosrati","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"ref_159","doi-asserted-by":"crossref","unstructured":"Kim, H.-S., Hwang, H.-J., Kim, H.-J., Choi, Y., Lee, D., Jung, H.-H., and Do, S.H. (2022). Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.865545"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"666","DOI":"10.33594\/000000818","article-title":"Knee Joint Response to Mechanical Load-Ing: Bounding Mechanotransduction with Rehabilitation","volume":"59","author":"Swinnena","year":"2025","journal-title":"Cell Physiol. Biochem."},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Fourni\u00e8re, M., Latire, T., Souak, D., Feuilloley, M., and Bedoux, G. (2020). Staphylococcus Epidermidis and Cutibacterium Acnes: Two Major Sentinels of Skin Microbiota and the Influence of Cosmetics. Microorganisms, 8.","DOI":"10.3390\/microorganisms8111752"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s00414-025-03610-2","article-title":"The Human Skin Microbiome: Factors Affecting Individuality and Application in Forensic Investigations","volume":"140","author":"Dass","year":"2025","journal-title":"Int. J. Leg. Med."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s40257-020-00536-w","article-title":"Skin Microbiota and Its Interplay with Wound Healing","volume":"21","author":"Burgess","year":"2020","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"tkad059","DOI":"10.1093\/burnst\/tkad059","article-title":"The Role of the Skin Microbiome in Wound Healing","volume":"12","author":"Yang","year":"2024","journal-title":"Burn. Trauma"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1111\/exd.14433","article-title":"Antimicrobial Peptides and Proteins: Interaction with the Skin Microbiota","volume":"30","author":"Rademacher","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jpra.2024.01.006","article-title":"Impact of Nutrition on Skin Wound Healing and Aesthetic Outcomes: A Comprehensive Narrative Review","volume":"39","author":"Seth","year":"2024","journal-title":"JPRAS Open"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Stanescu, C., Chiscop, I., Mihalache, D., Boev, M., Tamas, C., and Stoleriu, G. (2025). The Roles of Micronutrition and Nutraceuticals in Enhancing Wound Healing and Tissue Regeneration: A Systematic Review. Molecules, 30.","DOI":"10.3390\/molecules30173568"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/15347346231153531","article-title":"The Role of Nutrients and Diet Characteristics in the Management of Diabetic Foot Ulcers: A Systematic Review","volume":"24","author":"Apergi","year":"2023","journal-title":"Int. J. Low. Extrem. Wounds"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"8523","DOI":"10.2147\/DDDT.S543233","article-title":"Application of Antimicrobial Peptides in Wound Dressings","volume":"19","author":"Zhu","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1038\/s41598-019-39219-w","article-title":"Cationic Intrinsically Disordered Antimicrobial Peptides (Cidamps) Represent a New Paradigm of Innate Defense with a Potential for Novel Anti-Infectives","volume":"9","author":"Latendorf","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Acevedo-Fani, A., Dave, A., and Singh, H. (2020). Nature-Assembled Structures for Delivery of Bioactive Compounds and Their Potential in Functional Foods. Front. Chem., 8.","DOI":"10.3389\/fchem.2020.564021"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Yusuf, A., Almotairy, A.R.Z., Henidi, H., Alshehri, O.Y., and Aldughaim, M.S. (2023). Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles\u2019 Physicochemical Properties on Responses in Biological Systems. Polymers, 15.","DOI":"10.3390\/polym15071596"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41392-023-01642-x","article-title":"Smart Nanoparticles for Cancer Therapy","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"13206","DOI":"10.1038\/s41598-020-69995-9","article-title":"Correlation between Hemolytic Activity, Cytotoxicity and Systemic in Vivo Toxicity of Synthetic Antimicrobial Peptides","volume":"10","author":"Greco","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11051-023-05867-3","article-title":"Potential and Risks of Nanotechnology Applications in COVID-19-Related Strategies for Pandemic Control","volume":"25","author":"Araste","year":"2023","journal-title":"J. Nanoparticle Res."},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Ma, X., Aminov, R., Franco, O., De La Fuente-Nunez, C., Wang, G., and Wang, J. (2024). Editorial: Antimicrobial Peptides and Their Druggability, Bio-Safety, Stability, and Resistance. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1425952"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Miron, A., Giurcaneanu, C., Mihai, M., Beiu, C., Voiculescu, V., Popescu, M., Soare, E., and Popa, L. (2023). Antimicrobial Biomaterials for Chronic Wound Care. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15061606"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.bbamem.2008.10.020","article-title":"Antimicrobial Peptide Mimics for Improved Therapeutic Properties","volume":"1788","author":"Rotem","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"15140","DOI":"10.1021\/acs.jmedchem.0c01082","article-title":"Chemical Protein Synthesis in Medicinal Chemistry: Miniperspective","volume":"63","author":"Agouridas","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40880-017-0217-4","article-title":"Cancer Chemoprevention through Dietary Flavonoids: What\u2019s Limiting?","volume":"36","author":"Amawi","year":"2017","journal-title":"Chin. J. Cancer"},{"key":"ref_181","doi-asserted-by":"crossref","unstructured":"Cheng, X., Xie, Q., and Sun, Y. (2023). Advances in Nanomaterial-Based Targeted Drug Delivery Systems. Front. Bioeng. Biotechnol., 11.","DOI":"10.3389\/fbioe.2023.1177151"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Lee, Y.-C.J., Javdan, B., Cowan, A., and Smith, K. (2023). More Than Skin Deep: Cyclic Peptides as Wound Healing and Cytoprotective Compounds. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1195600"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Bilal, M., Usman, M., Ali, M., Shaukat, F., Arslan, M., Li, Z., Zou, X., Guo, Y., and Sun, X. (2026). Turning Trash into Treasure: Bioactive Peptides from Food Waste\u2013a Decade of Progress in Extraction, Purification, and Applications: A Systematic Review. Crit. Rev. Food Sci. Nutr., 1\u201329.","DOI":"10.1080\/10408398.2026.2643761"},{"key":"ref_184","doi-asserted-by":"crossref","unstructured":"J\u00fanior, E.R., Nascimento, S.F.D., De Pontes, J.T.C., Takada, K.Y., De Jesus Silva, V., Pavan, F.R., and Roque-Borda, C.A. (2026). Structural Modification and Conjugation Strategies of Antimicrobial Peptides for Topical Anti-Infective Applications. Antibiotics, 15.","DOI":"10.3390\/antibiotics15040390"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2637282","DOI":"10.1080\/07853890.2026.2637282","article-title":"Navigating the Potential of Algal Peptides: Health Effects, Market Applications, and Scientific Challenges","volume":"58","author":"Khaliq","year":"2026","journal-title":"Ann. Med."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1086\/593185","article-title":"Topical Versus Systemic Antimicrobial Therapy for Treating Mildly Infected Diabetic Foot Ulcers: A Randomized, Controlled, Double-Blinded, Multicenter Trial of Pexiganan Cream","volume":"47","author":"Lipsky","year":"2008","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"ref_187","doi-asserted-by":"crossref","unstructured":"Rousel, J., Saghari, M., Pagan, L., N\u0103d\u0103ban, A., Gambrah, T., Theelen, B., de Kam, M.L., Haakman, J., van der Wall, H.E.C., and Feiss, G.L. (2023). Treatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis Versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241814315"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"e2200433","DOI":"10.1002\/mabi.202200433","article-title":"Dendritic Nanogels Directed Dual-Encapsulation Topical Delivery System of Antimicrobial Peptides Targeting Skin Infections","volume":"23","author":"Zhang","year":"2023","journal-title":"Macromol. Biosci."},{"key":"ref_189","doi-asserted-by":"crossref","unstructured":"Fadaka, A., Sibuyi, N., Madiehe, A., and Meyer, M. (2021). Nanotechnology-Based Delivery Systems for Antimicrobial Peptides. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111795"},{"key":"ref_190","first-page":"7740","article-title":"Synergy between Antimicrobial Peptides and Lipid Nanoparticles for Skin Infection Control","volume":"18","author":"Rosseto","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"e1800488","DOI":"10.1002\/mabi.201800488","article-title":"Antimicrobial Peptide-Based Electrospun Fibers for Wound Healing Applications","volume":"19","author":"Dart","year":"2019","journal-title":"Macromol. Biosci."},{"key":"ref_192","first-page":"854","article-title":"Topical Anti-Microbial Peptide Omiganan Recovers Cutaneous Dysbiosis but Does not Improve Clinical Symptoms in Patients with Mild-to-Moderate Atopic Dermatitis in a Phase 2 Randomized Controlled Trial","volume":"86","author":"Buters","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1080\/07388551.2020.1796576","article-title":"Antimicrobial Peptides as Therapeutic Agents: Opportunities and Challenges","volume":"40","author":"Mahlapuu","year":"2020","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00217-025-04955-z","article-title":"Tenebrio Molitor as a Sustainable Source of Proteins and Bioactive Peptides: Extraction Techniques, Functional Properties, and Applications","volume":"252","author":"Omar","year":"2026","journal-title":"Eur. Food Res. Technol."},{"key":"ref_195","doi-asserted-by":"crossref","unstructured":"Hua, S., De Matos, M.B.C., Metselaar, J.M., and Storm, G. (2018). Current Trends and Challenges in the Clinical Translation of Nanoparticulate Nanomedicines: Pathways for Translational Development and Commercialization. Front. Pharmacol., 9.","DOI":"10.3389\/fphar.2018.00790"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1479-5876-2-14","article-title":"Lost in Translation: Obstacles to Translational Medicine","volume":"2","author":"Mankoff","year":"2004","journal-title":"J. Transl. Med."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Reis, M., Bettencourt, A., and Ribeiro, H. (2022). The Regulatory Challenges of Innovative Customized Combination Products. Front. Med., 9.","DOI":"10.3389\/fmed.2022.821094"},{"key":"ref_198","doi-asserted-by":"crossref","unstructured":"Racchi, M., and Govoni, S. (2020). The Concept of Non-Pharmacological Mechanism of Action in Medical Devices Made of Substances in Practice: What Pharmacology Can do to Promote the Scientific Implementation of the European Medical Device Regulation. Pharm. Adv., 1.","DOI":"10.36118\/pharmadvances.01.2020.02s"},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s13346-022-01262-y","article-title":"Nanomedicines and Nanocarriers in Clinical Trials: Surfing through Regulatory Requirements and Physico-Chemical Critical Quality Attributes","volume":"13","author":"Dri","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_200","doi-asserted-by":"crossref","unstructured":"Chen, C., and Lu, T. (2020). Development and Challenges of Antimicrobial Peptides for Therapeutic Applications. Antibiotics, 9.","DOI":"10.3390\/antibiotics9010024"},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Dijksteel, G., Ulrich, M., Middelkoop, E., and Boekema, B. (2021). Review: Lessons Learned from Clinical Trials Using Antimicrobial Peptides (Amps). Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.616979"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"315","DOI":"10.4155\/fmc.12.213","article-title":"Peptides as the Next Generation of Anti-Infectives","volume":"5","author":"Mercer","year":"2013","journal-title":"Future Med. Chem."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1111\/pbi.14344","article-title":"Molecular Farming for Sustainable Production of Clinical-Grade Antimicrobial Peptides","volume":"22","author":"Chaudhary","year":"2024","journal-title":"Plant Biotechnol. J."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2217\/nnm-2017-0039","article-title":"Challenges Associated and Approaches for Successful Translation of Nanomedicines into Commercial Products","volume":"12","author":"Agrahari","year":"2017","journal-title":"Nanomedicine"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1096\/fj.06-6075com","article-title":"Kallikrein-Mediated Proteolysis Regulates the Antimicrobial Effects of Cathelicidins in Skin","volume":"20","author":"Yamasaki","year":"2006","journal-title":"Faseb J."},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.actbio.2019.12.025","article-title":"Topical Antimicrobial Peptide Formulations for Wound Healing: Current Developments and Future Prospects","volume":"103","author":"Thapa","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_207","doi-asserted-by":"crossref","unstructured":"Gugleva, V., Ivanova, N., Sotirova, Y., and Andonova, V. (2021). Dermal Drug Delivery of Phytochemicals with Phenolic Structure Via Lipid-Based Nanotechnologies. Pharmaceuticals, 14.","DOI":"10.3390\/ph14090837"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"140","DOI":"10.12788\/j.sder.0019","article-title":"Allergic Contact Dermatitis to Plant Extracts in Cosmetics","volume":"32","author":"Jack","year":"2013","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1016\/j.vaccine.2023.04.063","article-title":"Endotoxin Contamination of Nanoparticle Formulations: A Concern in Vaccine Adjuvant Mechanistic Studies","volume":"41","author":"Costa","year":"2023","journal-title":"Vaccine"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41467-024-44968-y","article-title":"Hydrogel Dressings with Intrinsic Antibiofilm and Antioxidative Dual Functionalities Accelerate Infected Diabetic Wound Healing","volume":"15","author":"Pranantyo","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"6360","DOI":"10.1039\/D2GC02319A","article-title":"Advances in Solid-Phase Peptide Synthesis in Aqueous Media (Aspps)","volume":"24","author":"Jaradat","year":"2022","journal-title":"Green Chem."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Noviana, E., Indrayanto, G., and Rohman, A. (2022). Advances in Fingerprint Analysis for Standardization and Quality Control of Herbal Medicines. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.853023"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"107120","DOI":"10.1016\/j.jddst.2025.107120","article-title":"Progress on Drug Nanoparticle Manufacturing: Exploring the Adaptability of Batch Bottom-up Approaches to Continuous Manufacturing","volume":"111","author":"Costa","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/ilar\/ilv016","article-title":"Porcine Models of Cutaneous Wound Healing","volume":"56","author":"Seaton","year":"2015","journal-title":"ILAR J."},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s44222-024-00152-x","article-title":"Machine Learning for Antimicrobial Peptide Identification and Design","volume":"2","author":"Wan","year":"2024","journal-title":"Nat. Rev. Bioeng."},{"key":"ref_216","doi-asserted-by":"crossref","unstructured":"Saleem, N., Kumar, N., El-Omar, E., Willcox, M., and Jiang, X. (2025). Harnessing Machine Learning Approaches for the Identification, Characterization, and Optimization of Novel Antimicrobial Peptides. Antibiotics, 14.","DOI":"10.3390\/antibiotics14121263"},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1016\/j.apsb.2024.08.013","article-title":"Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment","volume":"14","author":"Wu","year":"2024","journal-title":"Acta Pharm. Sinica. B"},{"key":"ref_218","doi-asserted-by":"crossref","first-page":"101321","DOI":"10.1016\/j.mtbio.2024.101321","article-title":"Smart Drug Delivery and Responsive Microneedles for Wound Healing","volume":"29","author":"Liu","year":"2024","journal-title":"Mater. Today Bio"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"eadt0882","DOI":"10.1126\/scitranslmed.adt0882","article-title":"A Microfluidic Wearable Device for Wound Exudate Management and Analysis in Human Chronic Wounds","volume":"17","author":"Wang","year":"2025","journal-title":"Sci. Transl. Med."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/6\/729\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:02:33Z","timestamp":1781676153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/6\/729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":219,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["pharmaceutics18060729"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18060729","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]}}}