{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:31:48Z","timestamp":1792758708528,"version":"4.5.0"},"reference-count":201,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Cancer is still one of the world\u2019s major causes of morbidity and mortality; thus, safer and more efficient treatment approaches are required. The structural variety, multitargeted mechanisms, and generally good safety profiles of plant-derived polyphenols have made them attractive anticancer medicines. Flavonoids (like quercetin), stilbenes (like resveratrol), phenolic acids and curcuminoids (like curcumin) are major classes that have shown strong anticancer action against a variety of cancers, including prostate, colorectal and breast cancers. Through targets including PI3K\/Akt, MAPK, NF-\u03baB, and p53 signaling networks, these substances influence important molecular pathways involved in tumor initiation and development, including oxidative stress, inflammation, apoptosis, cell cycle control, angiogenesis and metastasis. The clinical translation of polyphenols is still constrained by poor bioavailability, fast metabolism, low aqueous solubility and inefficient pharmacokinetic characteristics, which lead to insufficient systemic exposure and therapeutic efficacy despite strong preclinical data. Their therapeutic applicability is further complicated by variations in absorption and possible dose-related restrictions. To overcome these limitations, the anticancer efficacy of polyphenols has been enhanced via delivery technologies like polymeric nanoparticles, lipid-based carriers, nanoemulsions and phytosome complexes, which have shown improved stability, increased bioavailability and targeted delivery to tumor tissues. This review provides a comprehensive and integrative analysis of plant-derived polyphenols by linking molecular mechanisms, pharmacokinetic limitations and emerging delivery strategies within a translational framework. By bridging these interconnected domains, this review highlights the potential of polyphenols as viable candidates in next-generation cancer therapeutics and underscores the need for well-designed clinical studies to facilitate their successful integration into oncology practice.<\/jats:p>","DOI":"10.3390\/pharmaceutics18060737","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T05:56:31Z","timestamp":1781675791000},"page":"737","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Plant-Derived Polyphenols in Cancer Therapy: Bridging Molecular Mechanisms and Bioavailability Toward Clinical Translation"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-8158","authenticated-orcid":false,"given":"Syed Arman","family":"Rabbani","sequence":"first","affiliation":[{"name":"RAK College of Pharmacy, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah P.O. Box 11172, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrestha","family":"Sharma","sequence":"additional","affiliation":[{"name":"Amity Institute of Pharmacy, Amity University, Gurugram 122413, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"El-Tanani","sequence":"additional","affiliation":[{"name":"RAK College of Pharmacy, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah P.O. Box 11172, United Arab Emirates"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-7535","authenticated-orcid":false,"given":"Suman","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Panipat Institute of Engineering and Technology (PIET), Panipat 132102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4157-1166","authenticated-orcid":false,"given":"Manita","family":"Saini","sequence":"additional","affiliation":[{"name":"Geeta Institute of Pharmacy, Geeta University, Panipat 132145, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monu","family":"Yadav","sequence":"additional","affiliation":[{"name":"Amity Institute of Pharmacy, Amity University, Gurugram 122413, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1252-5990","authenticated-orcid":false,"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Jagannath University, Bahadurgarh 124507, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahia","family":"El-Tanani","sequence":"additional","affiliation":[{"name":"Royal Cornwall Hospital Trust, NHS, Truro TR1 3LJ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,13]]},"reference":[{"key":"ref_1","unstructured":"(2025, February 06). GLOBOCAN. All Cancers Fact Sheet. Available online: https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/cancers\/39-all-cancers-fact-sheet.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Choudhari, A.S., Mandave, P.C., Deshpande, M., Ranjekar, P., and Prakash, O. (2020). Phytochemicals in cancer treatment: From preclinical studies to clinical practice. Front. Pharmacol., 10.","DOI":"10.3389\/fphar.2019.01614"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Singaravelan, N., and Tollefsbol, T.O. (2025). Polyphenol-based prevention and treatment of cancer through epigenetic and combinatorial mechanisms. Nutrients, 17.","DOI":"10.3390\/nu17040616"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10549-016-3794-z","article-title":"Effect of polyphenols on glucose and lactate transport by breast cancer cells","volume":"157","author":"Martel","year":"2016","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"02601060251411197","DOI":"10.1177\/02601060251411197","article-title":"Dietary polyphenols as anticancer agents: A review of recent advances and mechanisms","volume":"32","author":"Meer","year":"2026","journal-title":"Nutr. Health"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Lyubitelev, A., and Studitsky, V. (2023). Inhibition of Cancer Development by Natural Plant Polyphenols: Molecular Mechanisms. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310663"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.2147\/IJN.S131973","article-title":"Polyphenol Nanoformulations for Cancer Therapy: Experimental Evidence and Clinical Perspective","volume":"12","author":"Masoomzadeh","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Ahmed, Z.S., Khan, E., Elias, N., Elshebiny, A., and Dou, Q. (2025). Updated review on natural polyphenols: Molecular mechanisms, biological effects, and clinical applications for cancer management. Biomolecules, 15.","DOI":"10.3390\/biom15050629"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Jia, W., Zhou, L., Li, L., Zhou, P., and Shen, Z. (2023). Nano-Based Drug Delivery of Polyphenolic Compounds for Cancer Treatment: Progress, Opportunities, and Challenges. Pharmaceuticals, 16.","DOI":"10.3390\/ph16010101"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.5740\/jaoacint.19-0133","article-title":"Natural polyphenols: Chemical classification, definition of classes, subcategories, and structures","volume":"102","author":"Singla","year":"2019","journal-title":"J. AOAC Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/1471-0307.12515","article-title":"A review on polyphenols: Classification, beneficial effects and their application in dairy products","volume":"71","author":"Cutrim","year":"2018","journal-title":"Int. J. Dairy Technol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Tariq, H., Asif, S., Andleeb, A., Hano, C., and Abbasi, B.H. (2023). Flavonoid production: Current trends in plant metabolic engineering and de novo microbial production. Metabolites, 13.","DOI":"10.3390\/metabo13010124"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Liga, S., Paul, C., and P\u00e9ter, F. (2023). Flavonoids: Overview of biosynthesis, biological activity, and current extraction techniques. Plants, 12.","DOI":"10.3390\/plants12142732"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"113128","DOI":"10.1016\/j.phytochem.2022.113128","article-title":"Stilbenes: Source plants, chemistry, biosynthesis, pharmacology, application and problems related to their clinical application\u2014A comprehensive review","volume":"197","author":"Teka","year":"2022","journal-title":"Phytochemistry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s40104-022-00822-z","article-title":"Biological function of resveratrol and its application in animal production: A review","volume":"14","author":"Meng","year":"2023","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1038\/s41467-018-07338-z","article-title":"Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap","volume":"9","author":"Lee","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Garc\u00eda, C., S\u00e1nchez-Quesada, C., and Gaforio, J.J. (2019). Dietary flavonoids as cancer chemopreventive agents: An updated review of human studies. Antioxidants, 8.","DOI":"10.3390\/antiox8050137"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Arena, A., Romeo, M.A., Benedetti, R., Masuelli, L., Bei, R., Gilardini Montani, M.S., and Cirone, M. (2021). New insights into curcumin- and resveratrol-mediated anti-cancer effects. Pharmaceuticals, 14.","DOI":"10.3390\/ph14111068"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Abotaleb, M., Samuel, S.M., Varghese, E., Varghese, S., Kubatka, P., Liskova, A., and B\u00fcsselberg, D. (2019). Flavonoids in cancer and apoptosis. Cancers, 11.","DOI":"10.3390\/cancers11010028"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.tcb.2018.02.003","article-title":"Apoptotic caspases: Multiple or mistaken identities?","volume":"28","author":"McArthur","year":"2018","journal-title":"Trends Cell Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"205","DOI":"10.15171\/apb.2019.024","article-title":"Understanding apoptosis and apoptotic pathways targeted cancer therapeutics","volume":"9","author":"Jan","year":"2019","journal-title":"Adv. Pharm. Bull."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"11365","DOI":"10.1007\/s13277-016-5013-2","article-title":"Naringenin inhibits proliferation, migration, and invasion as well as induces apoptosis of gastric cancer SGC7901 cell line by downregulation of AKT pathway","volume":"37","author":"Bao","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3892\/etm.2015.2912","article-title":"Enhanced anticancer effect of ABT-737 in combination with naringenin on gastric cancer cells","volume":"11","author":"Zhang","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4347","DOI":"10.7314\/APJCP.2013.14.7.4347","article-title":"Molecular mechanism underlying hesperetin-induced apoptosis by in silico analysis and in prostate cancer PC-3 cells","volume":"14","author":"Sambantham","year":"2013","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.fct.2013.08.022","article-title":"Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells","volume":"60","author":"Park","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"4701275","DOI":"10.1155\/2018\/4701275","article-title":"Till death do us part: The marriage of autophagy and apoptosis","volume":"2018","author":"Cooper","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Li, Y., Xie, S., Ying, J., Wei, W., and Gao, K. (2018). Chemical structures of lignans and neolignans isolated from Lauraceae. Molecules, 23.","DOI":"10.3390\/molecules23123164"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Pang, X., Zhang, X., Jiang, Y., Su, Q., Li, Q., and Li, Z. (2021). Autophagy: Mechanisms and therapeutic potential of flavonoids in cancer. Biomolecules, 11.","DOI":"10.3390\/biom11020135"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/ptr.6577","article-title":"Therapeutic effects of kaempferol affecting autophagy and endoplasmic reticulum stress","volume":"34","author":"Ashrafizadeh","year":"2020","journal-title":"Phytother. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Wei, R., Cortez Penso, N.E., Hackman, R.M., Wang, Y., and Mackenzie, G.G. (2019). Epigallocatechin-3-gallate (EGCG) suppresses pancreatic cancer cell growth, invasion, and migration partly through the inhibition of Akt pathway and epithelial\u2013mesenchymal transition: Enhanced efficacy when combined with gemcitabine. Nutrients, 11.","DOI":"10.3390\/nu11081856"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s12272-025-01578-6","article-title":"Effects of polyphenols on cancer cell progression mediated by inhibition of cyclin-dependent kinases (CDKs): The emerging drug targets in cancer","volume":"48","author":"Basit","year":"2025","journal-title":"Arch. Pharm. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Liskova, A., Koklesova, L., Samec, M., Smejkal, K., Samuel, S.M., Varghese, E., Abotaleb, M., Biringer, K., Kudela, E., and Danko, J. (2020). Flavonoids in cancer metastasis. Cancers, 12.","DOI":"10.3390\/cancers12061498"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Yaskolka Meir, A., Keller, M., Hoffmann, A., Rinott, E., Tsaban, G., Kaplan, A., Zelicha, H., Hagemann, T., Ceglarek, U., and Isermann, B. (2023). The effect of polyphenols on DNA methylation-assessed biological age attenuation: The DIRECT PLUS randomized controlled trial. BMC Med., 21.","DOI":"10.1186\/s12916-023-03067-3"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13148-015-0095-z","article-title":"Epigenetic activities of flavonoids in the prevention and treatment of cancer","volume":"7","author":"Busch","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yahfoufi, N., Alsadi, N., Jambi, M., and Matar, C. (2018). The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients, 10.","DOI":"10.3390\/nu10111618"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1264074","DOI":"10.1155\/2018\/1264074","article-title":"Regulation of immune function by polyphenols","volume":"2018","author":"Ding","year":"2018","journal-title":"J. Immunol. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4162\/nrp.2015.9.2.137","article-title":"Effects of quercetin derivatives from mulberry leaves: Improved gene expression related hepatic lipid and glucose metabolism in short-term high-fat fed mice","volume":"9","author":"Sun","year":"2015","journal-title":"Nutr. Res. Pract."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Gupta, S.C., Kunnumakkara, A.B., Aggarwal, S., and Aggarwal, B.B. (2018). Inflammation, a double-edge sword for cancer and other age-related diseases. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.02160"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hosseinzade, A., Sadeghi, O., Naghdipour Biregani, A., Soukhtehzari, S., Brandt, G.S., and Esmaillzadeh, A. (2019). Immunomodulatory effects of flavonoids: Possible induction of T CD4+ regulatory cells through suppression of mTOR pathway signaling activity. Front. Immunol., 10.","DOI":"10.3389\/fimmu.2019.00051"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Gong, J., Zhou, S., and Yang, S. (2019). Vanillic acid suppresses HIF-1\u03b1 expression via inhibition of mTOR\/p70S6K\/4E-BP1 and Raf\/MEK\/ERK pathways in human colon cancer HCT116 cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030465"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12291-016-0605-6","article-title":"Preventive efficacy of vanillic acid on regulation of redox homeostasis, matrix metalloproteinases and cyclin D1 in rats bearing endometrial carcinoma","volume":"32","author":"Bhavani","year":"2017","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Punvittayagul, C., Chariyakornkul, A., Jarukamjorn, K., and Wongpoomchai, R. (2021). Protective role of vanillic acid against diethylnitrosamine- and 1,2-dimethylhydrazine-induced hepatocarcinogenesis in rats. Molecules, 26.","DOI":"10.3390\/molecules26092718"},{"key":"ref_43","first-page":"e14366","article-title":"Vanillic acid attenuates cell proliferation, xenobiotic enzyme activity, and the status of pulmonary mitochondrial enzymes in lung carcinoma","volume":"46","author":"Sk","year":"2022","journal-title":"J. Food Biochem."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"115618","DOI":"10.1016\/j.bcp.2023.115618","article-title":"STING activation in macrophages by vanillic acid exhibits antineoplastic potential","volume":"213","author":"Zhu","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_45","first-page":"BF01","article-title":"Assessment of lipid peroxidation and antioxidant status in vanillic acid treated 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis","volume":"11","author":"Anbalagan","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3892\/or.2015.4354","article-title":"Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN\/AKT\/HIF-1\u03b1\/VEGF signaling pathway in ovarian cancer cells","volume":"35","author":"He","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.3892\/ijo.2015.2864","article-title":"Gallic acid exerts a protective or an anti-proliferative effect on glioma T98G cells via dose-dependent epigenetic regulation mediated by miRNAs","volume":"46","author":"Paolini","year":"2015","journal-title":"Int. J. Oncol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.3892\/or.2016.5335","article-title":"Gallic acid induces HeLa cell death via increasing GSH depletion rather than ROS levels","volume":"37","author":"Park","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.biopha.2016.09.046","article-title":"The reduction of IL-6 gene expression, pAKT, pERK1\/2, pSTAT3 signaling pathways and invasion activity by gallic acid in prostate cancer PC3 cells","volume":"84","author":"Heidarian","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Sanchez-Martin, V., Plaza-Calonge, M.D., Soriano-Lerma, A., Ortiz-Gonzalez, M., Linde-Rodriguez, A., Perez-Carrasco, V., Ramirez-Macias, I., Cuadros, M., Gutierrez-Fernandez, J., and Murciano-Calles, J. (2022). Gallic acid: A natural phenolic compound exerting antitumoral activities in colorectal cancer via interaction with G-quadruplexes. Cancers, 14.","DOI":"10.3390\/cancers14112648"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s11033-019-04658-1","article-title":"Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells","volume":"46","author":"Pelinson","year":"2019","journal-title":"Mol. Biol. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1248\/bpb.b17-00892","article-title":"Biochemical characterization of ferulic acid and caffeic acid which effectively inhibit melanin synthesis via different mechanisms in B16 melanoma cells","volume":"41","author":"Maruyama","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1177\/1534735418801521","article-title":"Caffeic acid versus caffeic acid phenethyl ester in the treatment of breast cancer MCF-7 cells: Migration rate inhibition","volume":"17","author":"Kubina","year":"2018","journal-title":"Integr. Cancer Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.18632\/oncotarget.3246","article-title":"Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1","volume":"6","author":"Lin","year":"2015","journal-title":"Oncotarget"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00432-003-0520-0","article-title":"Sulindac sulfide and caffeic acid phenethyl ester suppress the motility of lung adenocarcinoma cells promoted by transforming growth factor-\u03b2 through Akt inhibition","volume":"130","author":"Shigeoka","year":"2004","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"10748","DOI":"10.3390\/ijms160510748","article-title":"Caffeic acid phenethyl ester is a potential therapeutic agent for oral cancer","volume":"16","author":"Kuo","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.biopha.2018.01.129","article-title":"Caffeic acid phenethyl ester inhibits the progression of ovarian cancer by regulating NF-\u03baB signaling","volume":"99","author":"Liu","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Chiang, K.C., Yang, S.W., Chang, K.P., Feng, T.H., Chang, K.S., Tsui, K.H., Shin, Y.S., Chen, C.C., Chao, M., and Juang, H.H. (2018). Caffeic acid phenethyl ester induces N-myc downstream regulated gene 1 to inhibit cell proliferation and invasion of human nasopharyngeal cancer cells. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051397"},{"key":"ref_59","first-page":"2758","article-title":"Resveratrol inhibited the progression of human hepatocellular carcinoma by inducing autophagy via regulating p53 and the phosphoinositide 3-kinase\/protein kinase B pathway","volume":"40","author":"Zhang","year":"2018","journal-title":"Oncol. Rep."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"100167","DOI":"10.1016\/j.crphar.2023.100167","article-title":"Flavonoids as promising molecules in cancer therapy: An insight","volume":"6","author":"Mir","year":"2024","journal-title":"Curr. Res. Pharmacol. Drug Discov."},{"key":"ref_61","first-page":"100010","article-title":"Therapeutic role of flavonoids and flavones in cancer prevention: Current trends and future perspectives","volume":"3","author":"Khan","year":"2021","journal-title":"Eur. J. Med. Chem. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1512745","DOI":"10.1155\/2017\/1512745","article-title":"Oxidative stress triggered by apigenin induces apoptosis in a comprehensive panel of human cervical cancer-derived cell lines","volume":"2017","author":"Souza","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.taap.2016.09.016","article-title":"Downregulation of NEDD9 by apigenin suppresses migration, invasion, and metastasis of colorectal cancer cells","volume":"311","author":"Dai","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/tox.22247","article-title":"Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2\/M arrest and histone H3 acetylation-mediated p21WAF1\/CIP1 expression","volume":"32","author":"Tseng","year":"2017","journal-title":"Environ. Toxicol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/CAD.0000000000000479","article-title":"Apigenin inhibits cell proliferation, migration, and invasion by targeting Akt in the A549 human lung cancer cell line","volume":"28","author":"Zhou","year":"2017","journal-title":"Anticancer. Drugs"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lfs.2016.08.019","article-title":"The flavonoid apigenin reduces prostate cancer CD44+ stem cell survival and migration through PI3K\/Akt\/NF-\u03baB signaling","volume":"162","author":"Erdogan","year":"2016","journal-title":"Life Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.tiv.2018.04.001","article-title":"Tangeretin inhibits the proliferation of human breast cancer cells via CYP1A1\/CYP1B1 enzyme induction and CYP1A1\/CYP1B1-mediated metabolism to the product 4\u2032 hydroxy tangeretin","volume":"50","author":"Surichan","year":"2018","journal-title":"Toxicol. Vitr."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"121749","DOI":"10.1016\/j.lfs.2023.121749","article-title":"Role of NF-\u03baB\/ICAM-1, JAK\/STAT-3, and apoptosis signaling in the anticancer effect of tangeretin against urethane-induced lung cancer in BALB\/c mice","volume":"325","author":"Mohamed","year":"2023","journal-title":"Life Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jff.2013.01.003","article-title":"Induction of GADD45\u03b1 expression contributes to the anti-proliferative effects of polymethoxyflavones on colorectal cancer cells","volume":"5","author":"Lee","year":"2013","journal-title":"J. Funct. Foods"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"103404","DOI":"10.1016\/j.jff.2019.06.006","article-title":"Bitter orange peel extract induces endoplasmic reticulum-mediated autophagy in human hepatoma cells","volume":"60","author":"Lu","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"111811","DOI":"10.1016\/j.fct.2020.111811","article-title":"Polymethoxyflavones from citrus inhibited gastric cancer cell proliferation through inducing apoptosis by upregulating RAR\u03b2, both in vitro and in vivo","volume":"146","author":"Wang","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.biopha.2018.07.005","article-title":"MicroRNA-1469, a p53-responsive microRNA promotes genistein induced apoptosis by targeting Mcl1 in human laryngeal cancer cells","volume":"106","author":"Ma","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_73","first-page":"178","article-title":"Genistein induces apoptosis and inhibits proliferation of HT29 colon cancer cells","volume":"5","author":"Shafiee","year":"2016","journal-title":"Int. J. Mol. Cell. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3109\/13880209.2015.1014921","article-title":"Genistein induces activation of the mitochondrial apoptosis pathway by inhibiting phosphorylation of Akt in colorectal cancer cells","volume":"54","author":"Qin","year":"2016","journal-title":"Pharm. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1016\/j.biocel.2013.07.002","article-title":"Genistein modulates oxidative stress in breast cancer cell lines according to ER\u03b1\/ER\u03b2 ratio: Effects on mitochondrial functionality, sirtuins, uncoupling protein 2 and antioxidant enzymes","volume":"45","author":"Pons","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Sundaram, M.K., Unni, S., Somvanshi, P., Bhardwaj, T., Mandal, R.K., Hussain, A., and Haque, S. (2019). Genistein modulates signaling pathways and targets several epigenetic markers in HeLa cells. Genes, 10.","DOI":"10.3390\/genes10120955"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1002\/ptr.6155","article-title":"Anticancer potential of quercetin: A comprehensive review","volume":"32","author":"Rauf","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1080\/01635581.2018.1559929","article-title":"Regulation of the intracellular ROS level is critical for the antiproliferative effect of quercetin in the hepatocellular carcinoma cell line HepG2","volume":"71","author":"Jeon","year":"2019","journal-title":"Nutr. Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/tox.22623","article-title":"Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells","volume":"33","author":"Shang","year":"2018","journal-title":"Environ. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Ranganathan, S., Halagowder, D., and Sivasithambaram, N.D. (2015). Quercetin suppresses twist to induce apoptosis in MCF-7 breast cancer cells. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0141370"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biopha.2017.05.044","article-title":"Effects of quercetin on proliferation and migration of human glioblastoma U251 cells","volume":"92","author":"Liu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.4103\/0973-1296.182154","article-title":"Quercetin suppresses the migration and invasion in human colon cancer Caco-2 cells through regulating toll-like receptor 4\/nuclear factor-kappa B pathway","volume":"12","author":"Han","year":"2016","journal-title":"Pharmacogn. Mag."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Kim, S.R., Lee, E.Y., Kim, D.J., Kim, H.J., and Park, H.R. (2020). Quercetin inhibits cell survival and metastatic ability via the EMT-mediated pathway in oral squamous cell carcinoma. Molecules, 25.","DOI":"10.3390\/molecules25030757"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1021\/acs.jafc.8b02656","article-title":"Reactive oxygen species and p53 mediated activation of p38 and caspases is critically involved in kaempferol induced apoptosis in colorectal cancer cells","volume":"66","author":"Choi","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Wu, P., Meng, X., Zheng, H., Zeng, Q., Chen, T., Wang, W., Zhang, X., and Su, J. (2018). Kaempferol attenuates ROS-induced hemolysis and the molecular mechanism of its induction of apoptosis on bladder cancer. Molecules, 23.","DOI":"10.3390\/molecules23102592"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.biopha.2017.02.061","article-title":"Kaempferol increases apoptosis in human cervical cancer HeLa cells via PI3K\/AKT and telomerase pathways","volume":"89","author":"Kashafi","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/s41419-018-0930-1","article-title":"Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells","volume":"9","author":"Kim","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/10286020.2017.1327949","article-title":"Hesperetin induces an apoptosis-triggered extrinsic pathway and a p53-independent pathway in human lung cancer H522 cells","volume":"20","author":"Elango","year":"2018","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"119957","DOI":"10.1016\/j.lfs.2021.119957","article-title":"Protective effects of hesperidin through attenuation of Ki67 expression against DMBA-induced breast cancer in female rats","volume":"285","author":"Patel","year":"2021","journal-title":"Life Sci."},{"key":"ref_90","first-page":"5569","article-title":"Hesperidin inhibits ovarian cancer cell viability through endoplasmic reticulum stress signaling pathways","volume":"14","author":"Zhao","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.lfs.2017.07.026","article-title":"Hepatoprotective effect of hesperidin in hepatocellular carcinoma: Involvement of Wnt signaling pathways","volume":"185","author":"Zaghloul","year":"2017","journal-title":"Life Sci."},{"key":"ref_92","first-page":"795","article-title":"Galangin induced antitumor effects in human kidney tumor cells mediated via mitochondrial mediated apoptosis, inhibition of cell migration and invasion and targeting PI3K\/AKT\/mTOR signalling pathway","volume":"23","author":"Zhu","year":"2018","journal-title":"J. BUON"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.2147\/OTT.S264209","article-title":"Galangin suppresses proliferation, migration, and invasion of human glioblastoma cells by targeting Skp2-induced epithelial\u2013mesenchymal transition (EMT)","volume":"13","author":"Xiong","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_94","first-page":"1377","article-title":"Galangin induces p53-independent S-phase arrest and apoptosis in human nasopharyngeal carcinoma cells through inhibiting PI3K\u2013AKT signaling pathway","volume":"38","author":"Lee","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3892\/or.2017.5767","article-title":"Galangin suppresses human laryngeal carcinoma via modulation of caspase-3 and AKT signaling pathways","volume":"38","author":"Wang","year":"2017","journal-title":"Oncol. Rep."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.biopha.2017.09.144","article-title":"Galangin inhibits the cell progression and induces cell apoptosis through activating PTEN and Caspase-3 pathways in retinoblastoma","volume":"97","author":"Zou","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5546","DOI":"10.1002\/cam4.3195","article-title":"Galangin promotes cell apoptosis through suppression of H19 expression in hepatocellular carcinoma cells","volume":"9","author":"Zhong","year":"2020","journal-title":"Cancer Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ptr.6201","article-title":"Cyanidin-3-glucoside attenuates the angiogenesis of breast cancer via inhibiting STAT3\/VEGF pathway","volume":"33","author":"Ma","year":"2019","journal-title":"Phytother. Res."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Chen, J., Zhu, Y., Zhang, W., Peng, X., Zhou, J., Li, F., Han, B., Liu, X., Ou, Y., and Yu, X. (2018). Delphinidin induced protective autophagy via mTOR pathway suppression and AMPK pathway activation in HER-2 positive breast cancer cells. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4231-y"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3892\/ol.2017.6232","article-title":"Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K\/AKT and ERK1\/2 MAPK signal transduction","volume":"14","author":"Lim","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"110","DOI":"10.15430\/JCP.2016.21.2.110","article-title":"Suppression of \u03b2-catenin signaling pathway in human prostate cancer PC3 cells by delphinidin","volume":"21","author":"Lee","year":"2016","journal-title":"J. Cancer Prev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1016\/j.bmcl.2017.09.024","article-title":"Delphinidin inhibits BDNF-induced migration and invasion in SKOV3 ovarian cancer cells","volume":"27","author":"Lim","year":"2017","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/tox.23152","article-title":"Delphinidin modulates JAK\/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells","volume":"36","author":"Zhang","year":"2021","journal-title":"Environ. Toxicol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4196\/kjpp.2020.24.5.413","article-title":"Delphinidin enhances radio-therapeutic effects via autophagy induction and JNK\/MAPK pathway activation in non-small cell lung cancer","volume":"24","author":"Kang","year":"2020","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_105","first-page":"1427","article-title":"Resveratrol induced reactive oxygen species and endoplasmic reticulum stress-mediated apoptosis, and cell cycle arrest in the A375SM malignant melanoma cell line","volume":"42","author":"Heo","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6781872","DOI":"10.1155\/2017\/6781872","article-title":"The repeated administration of resveratrol has measurable effects on circulating T-cell subsets in humans","volume":"2017","author":"Espinoza","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12937-015-0050-z","article-title":"Effects of a grape-supplemented diet on proliferation and Wnt signaling in the colonic mucosa are greatest for those over age 50 and with high arginine consumption","volume":"14","author":"Holcombe","year":"2015","journal-title":"Nutr. J."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1039\/C5MD00197H","article-title":"Inhibitory effect of cytotoxic nitrogen-containing heterocyclic stilbene analogues on VEGF protein secretion and VEGF, hTERT and c-Myc gene expression","volume":"6","author":"Murga","year":"2015","journal-title":"MedChemComm"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.1038\/s41598-021-83924-4","article-title":"Pterostilbene inhibits gallbladder cancer progression by suppressing the PI3K\/Akt pathway","volume":"11","author":"Tong","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1007\/s13277-015-3793-4","article-title":"Resveratrol inhibits oral squamous cell carcinoma through induction of apoptosis and G2\/M phase cell cycle arrest","volume":"37","author":"Yu","year":"2016","journal-title":"Tumor Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"110645","DOI":"10.1016\/j.cbi.2023.110645","article-title":"Resveratrol triggers the ER stress-mediated intrinsic apoptosis of neuroblastoma cells coupled with suppression of Rho-dependent migration and consequently prolongs mouse survival","volume":"382","author":"Sun","year":"2023","journal-title":"Chem. Biol. Interact."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3892\/mmr.2020.11809","article-title":"Resveratrol induces human colorectal cancer cell apoptosis by activating the mitochondrial pathway via increasing reactive oxygen species","volume":"23","author":"Fu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3892\/ijo.2017.3859","article-title":"Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells","volume":"50","author":"Takashina","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.taap.2019.03.008","article-title":"Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress","volume":"370","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_115","first-page":"697","article-title":"Resveratrol integrates metabolic and growth effects in PC3 prostate cancer cells: Involvement of prolyl hydroxylase and hypoxia inducible factor 1","volume":"17","author":"Fonseca","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/bab.2332","article-title":"Pterostilbene regulates cell proliferation and apoptosis in non-small-cell lung cancer via targeting COX-2","volume":"70","author":"Wang","year":"2023","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jnutbio.2015.01.005","article-title":"Pterostilbene inhibits triple-negative breast cancer metastasis via inducing microRNA-205 expression and negatively modulates epithelial-to-mesenchymal transition","volume":"26","author":"Su","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1177\/0960327110368739","article-title":"Cytotoxic and antioxidant effects of methoxylated stilbene analogues on HepG2 hepatoma and Chang liver cells: Implications for structure activity relationship","volume":"30","author":"Hasiah","year":"2011","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Hsu, Y.H., Chen, S.Y., Wang, S.Y., Lin, J.A., and Yen, G.C. (2020). Pterostilbene enhances cytotoxicity and chemosensitivity in human pancreatic cancer cells. Biomolecules, 10.","DOI":"10.3390\/biom10050709"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4062\/biomolther.2017.235","article-title":"Gomisin G inhibits the growth of triple-negative breast cancer cells by suppressing AKT phosphorylation and decreasing cyclin D1","volume":"26","author":"Maharjan","year":"2018","journal-title":"Biomol. Ther."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"153147","DOI":"10.1016\/j.phymed.2019.153147","article-title":"Gomisin A ameliorates metastatic melanoma by inhibiting AMPK and ERK\/JNK-mediated cell survival and metastatic phenotypes","volume":"68","author":"Han","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Ko, Y.H., Jeong, M., Jang, D.S., and Choi, J.H. (2021). Gomisin L1, a lignan isolated from Schisandra berries, induces apoptosis by regulating NADPH oxidase in human ovarian cancer cells. Life, 11.","DOI":"10.3390\/life11080858"},{"key":"ref_123","first-page":"711","article-title":"Anticancer activity of gomisin J from Schisandra chinensis fruit","volume":"41","author":"Jung","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"113673","DOI":"10.1016\/j.bcp.2019.113673","article-title":"Schisantherin A induces cell apoptosis through ROS\/JNK signaling pathway in human gastric cancer cells","volume":"173","author":"Wang","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_125","first-page":"1934578X251383035","article-title":"Cytotoxic activity of Schisantherin A against liver cancer cells: In vitro and in silico insights","volume":"20","author":"Nguyen","year":"2025","journal-title":"Nat. Prod. Commun."},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Feng, F., Pan, L., Wu, J., Liu, M., He, L., Yang, L., and Zhou, W. (2022). Schisantherin A inhibits cell proliferation by regulating glucose metabolism pathway in hepatocellular carcinoma. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1019486"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3892\/mmr.2025.13734","article-title":"Schisantherin A induces ferroptosis in non-small cell lung cancer through activation of the YAP\/ACSL4\/TfR signaling pathway","volume":"33","author":"Zhu","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"ref_128","first-page":"677","article-title":"Inhibitory effects of Schisandrin B on human prostate cancer cells","volume":"41","author":"Nasser","year":"2019","journal-title":"Oncol. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.taap.2018.09.005","article-title":"Schisandrin B exhibits potent anticancer activity in triple negative breast cancer by inhibiting STAT3","volume":"58","author":"Dai","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12935-025-03727-9","article-title":"Schisandrin B exerts anti-colorectal cancer effect through CXCL2\/ERK\/DUSP11 signaling pathway","volume":"25","author":"Sun","year":"2025","journal-title":"Cancer Cell Int."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1021\/acsptsci.4c00009","article-title":"Schisandrin B suppresses colon cancer growth by inducing cell cycle arrest and apoptosis: Molecular mechanism and therapeutic potential","volume":"7","author":"Co","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"354","DOI":"10.5530\/ijper.57.2.45","article-title":"Insight into the glycosylation methods of the flavonoids as an approach to enhance its bioavailability and pharmacological activities","volume":"57","author":"Dahiya","year":"2023","journal-title":"Indian J. Pharm. Educ. Res."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Hu, L., Luo, Y., Yang, J., and Cheng, C. (2025). Botanical flavonoids: Efficacy, absorption, metabolism and advanced pharmaceutical technology for improving bioavailability. Molecules, 30.","DOI":"10.3390\/molecules30051184"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e105461","DOI":"10.1136\/bmjopen-2025-105461","article-title":"Effect of plant-based foods and (poly)phenol supplementation on gut-microbiota metabolism in participants with overweight or obesity and cardiometabolic risk: A study protocol for a single-blind, parallel and randomised controlled trial","volume":"15","author":"Lanuza","year":"2025","journal-title":"BMJ Open"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"An, H., Li, G., Yang, Z., Xiong, M., Wang, N., Cao, X., and Yu, A. (2024). Denovo production of resveratrol by engineered rice wine strain Saccharomyces cerevisiae HJ08 and its application in rice wine brewing. J. Fungi, 10.","DOI":"10.3390\/jof10080513"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"26936","DOI":"10.1021\/acs.jafc.4c08435","article-title":"Polyphenols in human nutrition: European regulations and potential classification as a novel food or food additive","volume":"72","author":"Rouault","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"111875","DOI":"10.1016\/j.foodres.2022.111875","article-title":"Comparative study on the phenolic composition and in vitro bioactivity of medicinal and aromatic plants from the Lamiaceae family","volume":"161","author":"Caleja","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"7730","DOI":"10.1080\/10408398.2021.1917508","article-title":"Absorption, metabolism and bioavailability of flavonoids: A review","volume":"62","author":"Chen","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1080\/10408398.2021.1898333","article-title":"The fate of flavonoids after oral administration: A comprehensive overview of its bioavailability","volume":"62","author":"Naeem","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.200900437","article-title":"Resveratrol bioavailability and toxicity in humans","volume":"54","author":"Cottart","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0014-5793(97)01367-7","article-title":"Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man","volume":"418","author":"Hollman","year":"1997","journal-title":"FEBS Lett."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/jn\/131.2.235","article-title":"Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice","volume":"131","author":"Erlund","year":"2001","journal-title":"J. Nutr."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1021\/je4010905","article-title":"Dissociation constants and solubilities of daidzein and genistein in different solvents","volume":"59","author":"Nan","year":"2014","journal-title":"J. Chem. Eng. Data"},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Di Lorenzo, C., Colombo, F., Biella, S., Stockley, C., and Restani, P. (2021). Polyphenols and human health: The role of bioavailability. Nutrients, 13.","DOI":"10.3390\/nu13010273"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"109221","DOI":"10.1016\/j.foodhyd.2023.109221","article-title":"Recent advances in the conjugation approaches for enhancing the bioavailability of polyphenols","volume":"146","author":"Sahraeian","year":"2024","journal-title":"Food Hydrocoll."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bcp.2017.03.012","article-title":"Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols","volume":"139","author":"Williamson","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Wang, X., Qi, Y., and Zheng, H. (2022). Dietary polyphenol, gut microbiota, and health benefits. Antioxidants, 11.","DOI":"10.3390\/antiox11061212"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Aatif, M. (2023). Current understanding of polyphenols to enhance bioavailability for better therapies. Biomedicines, 11.","DOI":"10.3390\/biomedicines11072078"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1021\/acs.molpharmaceut.2c00009","article-title":"Development of poly(lipoic acid) nanoparticles with improved oral bioavailability and hepatoprotective effects of quercetin","volume":"19","author":"Banik","year":"2022","journal-title":"Mol. Pharm."},{"key":"ref_150","first-page":"3921","article-title":"Poly(n-butylcyanoacrylate) nanoparticles for oral delivery of quercetin: Preparation, characterization, and pharmacokinetics and biodistribution studies in Wistar rats","volume":"10","author":"Bagad","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.2147\/IJN.S164235","article-title":"Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: Enhanced bioavailability and in vitro anti-inflammatory activity","volume":"13","author":"Siu","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"112599","DOI":"10.1016\/j.lwt.2021.112599","article-title":"Preparation and characterization of epigallocatechin-3-gallate loaded melanin nanocomposite (EGCG@MNPs) for improved thermal stability, antioxidant and antibacterial activity","volume":"154","author":"Zhao","year":"2022","journal-title":"LWT"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/1750-3841.14405","article-title":"Co-encapsulation of EGCG and quercetin in liposomes for optimum antioxidant activity","volume":"84","author":"Chen","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Russo, C., Valle, M.S., D\u2019Angeli, F., Surdo, S., and Malaguarnera, L. (2024). Resveratrol and vitamin D: Eclectic molecules promoting mitochondrial health in sarcopenia. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25147503"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"115583","DOI":"10.1016\/j.lwt.2023.115583","article-title":"Effect of the incorporation of liposomes loaded with rutin on the transport properties of edible film produced with hydroxypropyl methylcellulose: An in vitro release study","volume":"191","author":"Soto","year":"2024","journal-title":"LWT"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"183","DOI":"10.31557\/apjcb.2024.9.2.183-189","article-title":"Studying the characteristics of curcumin-loaded liposomal nanoparticles","volume":"9","author":"Afyouni","year":"2024","journal-title":"Asian Pac. J. Cancer Biol."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Borges, A., de Freitas, V., Mateus, N., Fernandes, I., and Oliveira, J. (2020). Solid lipid nanoparticles as carriers of natural phenolic compounds. Antioxidants, 9.","DOI":"10.3390\/antiox9100998"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.colsurfb.2015.11.050","article-title":"Improved oral delivery of resveratrol from N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticles","volume":"139","author":"Ramalingam","year":"2016","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"104792","DOI":"10.1016\/j.fbio.2024.104792","article-title":"Nanoemulsification of epigallocatechin gallate for debitterization, antibrowning, and inhibition of intracellular lipid accumulation","volume":"61","author":"Nam","year":"2024","journal-title":"Food Biosci."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"129721","DOI":"10.1016\/j.foodchem.2021.129721","article-title":"Coconut oil-based resveratrol nanoemulsion: Optimization using response surface methodology, stability assessment and pharmacokinetic evaluation","volume":"357","author":"Kotta","year":"2021","journal-title":"Food Chem."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"104890","DOI":"10.1016\/j.chemphyslip.2020.104890","article-title":"Role of rutin nanoemulsion in ameliorating oxidative stress: Pharmacokinetic and pharmacodynamics studies","volume":"228","author":"Sharma","year":"2020","journal-title":"Chem. Phys. Lipids"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Mahadev, M., Nandini, H.S., Ramu, R., Gowda, D.V., Almarhoon, Z.M., Al-Ghorbani, M., and Mabkhot, Y.N. (2022). Fabrication and evaluation of quercetin nanoemulsion: A delivery system with improved bioavailability and therapeutic efficacy in diabetes mellitus. Pharmaceuticals, 15.","DOI":"10.3390\/ph15010070"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"127","DOI":"10.56499\/jppres19.729_8.2.127","article-title":"Preparation and characterization of quercetin-polyvinylpyrrolidone K-30 spray dried solid dispersion","volume":"8","author":"Febriyenti","year":"2020","journal-title":"J. Pharm. Pharmacogn. Res."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.carbpol.2016.09.067","article-title":"Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro","volume":"157","author":"Gilley","year":"2017","journal-title":"Carbohydr. Polym."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Ha, E.S., Choi, D.H., Baek, I.H., Park, H., and Kim, M.S. (2021). Enhanced oral bioavailability of resveratrol by using neutralized Eudragit E solid dispersion prepared via spray drying. Antioxidants, 10.","DOI":"10.3390\/antiox10010090"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Pechanova, O., Dayar, E., and Cebova, M. (2020). Therapeutic potential of polyphenols-loaded polymeric nanoparticles in cardiovascular system. Molecules, 25.","DOI":"10.3390\/molecules25153322"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Enaru, B., Socaci, S., Farcas, A., Socaciu, C., Danciu, C., Stanila, A., and Diaconeasa, Z. (2021). Novel delivery systems of polyphenols and their potential health benefits. Pharmaceuticals, 14.","DOI":"10.3390\/ph14100946"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.56238\/levv16n49-087","article-title":"Trans-resveratrol content in Vitis vinifera L. cultivated in the S\u00e3o Francisco River Valley-Brazil and possible use as a functional ingredient in foods","volume":"16","author":"Lima","year":"2025","journal-title":"Lumen Virtus"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Wang, W., Zhou, M., Xu, Y., Peng, W., Zhang, S., Li, R., Zhang, H., Cheng, S., Wang, Y., and Wei, X. (2021). Resveratrol-loaded TPGS-resveratrol-solid lipid nanoparticles for multidrug-resistant therapy of breast cancer: In vivo and in vitro study. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.762489"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1080\/08982104.2025.2594689","article-title":"Formulation Optimization and Biodistribution of Epigallocatechin Gallate Phospholipid Complex-Loaded NLCs for Rheumatoid Arthritis Treatment","volume":"36","author":"Mangla","year":"2026","journal-title":"J. Liposome Res."},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Ezenabor, E.H., Afolabi, A.A., Ojo, O.A., and Adeyemi, O.S. (2026). Polyphenol-rich formulations and their multi-target interactions with molecular pathways in cancer cells. Pharmacology, Characterizations, Toxicity, and Herb-Drug Interactions of Herbs in Traditional Medicine, IGI Global Scientific Publishing.","DOI":"10.4018\/979-8-3373-5876-5.ch008"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Valenzuela-Bustamante, P., Cornejo, P., Nolan, N., Concepci\u00f3n-Alvarez, A., Bridi, R., Rinc\u00f3n-Cervera, M.\u00c1., Porras, O., de Camargo, A.C., and Arias-Sant\u00e9, M.F. (2025). Valorization of carm\u00e9n\u00e8re grape pomace: Extraction, microencapsulation, and evaluation of the bioactivity of polyphenols in Caco-2 cells. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26167994"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"823206","DOI":"10.1155\/2012\/823206","article-title":"Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson\u2032 s Disease Induced by 6-Hydroxydopamine","volume":"2012","author":"Sriraksa","year":"2012","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1093\/ndt\/gfr195","article-title":"Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumor activity","volume":"26","author":"Morales","year":"2011","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuropharm.2015.01.027","article-title":"The flavonoid quercetin ameliorates Alzheimer\u2019s disease pathology in transgenic mice","volume":"93","author":"Osorio","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/jop.12554","article-title":"DNA ploidy and cell cycle protein expression in oral squamous cell carcinomas with and without lymph node metastases","volume":"46","author":"Zargoun","year":"2017","journal-title":"Oral Pathol. Med."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/ptr.5967","article-title":"Possible therapeutic effect of carvacrol on asthmatic patients: A randomized, double blind, placebo-controlled, Phase II clinical trial","volume":"32","author":"Alavinezhad","year":"2018","journal-title":"Phytother. Res."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.jnutbio.2007.09.003","article-title":"Effects of soy protein and isoflavone on hepatic fatty acid synthesis and oxidation and mRNA expression of uncoupling proteins and peroxisome proliferator-activated receptor \u03b3 in adipose tissues of rats","volume":"19","author":"Takahashi","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"5185","DOI":"10.3892\/mmr.2016.5203","article-title":"Shensong Yangxin capsules prevent ischemic arrhythmias by prolonging action potentials and alleviating Ca2+ overload","volume":"13","author":"Zhao","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1007\/s00204-025-04068-2","article-title":"Protective effects of flavonoids against silver nanoparticles-induced toxicity","volume":"99","author":"Santos","year":"2025","journal-title":"Arch. Toxicol."},{"key":"ref_181","unstructured":"ClinicalTrials.gov (2026, May 10). Resveratrol in Colorectal Cancer (NCT00256334), Available online: https:\/\/clinicaltrials.gov\/study\/NCT00256334."},{"key":"ref_182","unstructured":"ClinicalTrials.gov (2026, May 10). Resveratrol in Lymphangioleiomyomatosis (NCT03253913), Available online: https:\/\/clinicaltrials.gov\/study\/NCT03253913."},{"key":"ref_183","unstructured":"ClinicalTrials.gov (2026, May 10). Resveratrol in PCOS (NCT01720459), Available online: https:\/\/clinicaltrials.gov\/study\/NCT01720459."},{"key":"ref_184","unstructured":"ClinicalTrials.gov (2026, May 10). A Biological Study of Resveratrol\u2019s Effects on Notch-1 Signaling in Subjects with Low Grade Gastrointestinal Tumors (NCT01476592), Available online: https:\/\/clinicaltrials.gov\/study\/NCT01476592."},{"key":"ref_185","unstructured":"ClinicalTrials.gov (2026, May 10). Dietary Polyphenols in Breast Cancer (NCT03482401), Available online: https:\/\/clinicaltrials.gov\/study\/NCT03482401."},{"key":"ref_186","unstructured":"ClinicalTrials.gov (2026, May 10). Quercetin + Green Tea in Prostate Cancer (NCT01912820), Available online: https:\/\/clinicaltrials.gov\/study\/NCT01912820."},{"key":"ref_187","unstructured":"ClinicalTrials.gov (2026, May 10). Quercetin Supplementation in Advanced Cancer Patients with Cachexia and Systemic Inflammation (NCT05680662), Available online: https:\/\/clinicaltrials.gov\/study\/NCT05680662."},{"key":"ref_188","unstructured":"ClinicalTrials.gov (2026, May 10). Phase I Study of Quercetin in Patients with Chronic Hepatitis C (NCT01538316), Available online: https:\/\/clinicaltrials.gov\/study\/NCT01538316."},{"key":"ref_189","unstructured":"ClinicalTrials.gov (2026, May 10). Soy Isoflavones in Prostate Cancer Patients (NCT01985763), Available online: https:\/\/clinicaltrials.gov\/study\/NCT01985763."},{"key":"ref_190","unstructured":"ClinicalTrials.gov (2026, May 10). Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal Women (NCT00099008), Available online: https:\/\/clinicaltrials.gov\/study\/NCT00099008?cond=NCT00099008&viewType=Card&rank=1."},{"key":"ref_191","unstructured":"ClinicalTrials.gov (2026, May 10). Genistein in Treating Patients with Bladder Cancer Undergoing Surgery (NCT00244933), Available online: https:\/\/clinicaltrials.gov\/study\/NCT00244933?cond=Cancer&intr=Genistein&viewType=Card&page=2&rank=15."},{"key":"ref_192","unstructured":"ClinicalTrials.gov (2026, May 10). EGCG (Polyphenon E) in Prostate Cancer (NCT00676780), Available online: https:\/\/clinicaltrials.gov\/study\/NCT00676780."},{"key":"ref_193","unstructured":"ClinicalTrials.gov (2026, May 10). Pomegranate Polyphenols in Colorectal Cancer (NCT01916239), Available online: https:\/\/clinicaltrials.gov\/study\/NCT01916239."},{"key":"ref_194","unstructured":"ClinicalTrials.gov (2026, May 10). Dietary Polyphenols in Cervical Cancer (NCT03994055), Available online: https:\/\/clinicaltrials.gov\/study\/NCT03994055."},{"key":"ref_195","unstructured":"ClinicalTrials.gov (2026, May 10). Chlorogenic Acid in Advanced Cancer (NCT02728349), Available online: https:\/\/clinicaltrials.gov\/study\/NCT02728349."},{"key":"ref_196","unstructured":"ClinicalTrials.gov (2026, May 10). Blueberry Anthocyanins + Docetaxel in NSCLC (NCT01426620), Available online: https:\/\/clinicaltrials.gov\/study\/NCT01426620."},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Cory, H., Passarelli, S., Szeto, J., Tamez, M., and Mattei, J. (2018). The role of polyphenols in human health and food systems: A mini-review. Front. Nutr., 5.","DOI":"10.3389\/fnut.2018.00087"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"2300167","DOI":"10.1002\/mabi.202300167","article-title":"Polyphenol-based nanosystems for next-generation cancer therapy: Multifunctionality, design, and challenges","volume":"23","author":"Feng","year":"2023","journal-title":"Macromol. Biosci."},{"key":"ref_199","first-page":"162","article-title":"Nano-delivery systems for improving therapeutic efficiency of dietary polyphenols","volume":"27","author":"Hendawy","year":"2021","journal-title":"Altern. Ther. Health Med."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"152353","DOI":"10.1016\/j.seminoncol.2025.152353","article-title":"Unlocking the therapeutic potential of polyphenols: Promising advances and future directions in pancreatic cancer treatment","volume":"52","author":"Suhail","year":"2025","journal-title":"Semin. Oncol."},{"key":"ref_201","doi-asserted-by":"crossref","unstructured":"Kim, K.H., Ki, M.R., Min, K.H., and Pack, S.P. (2023). Advanced delivery system of polyphenols for effective cancer prevention and therapy. Antioxidants, 12.","DOI":"10.3390\/antiox12051048"}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/6\/737\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T06:04:27Z","timestamp":1781676267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/6\/737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,13]]},"references-count":201,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["pharmaceutics18060737"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18060737","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,13]]}}}