{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:15:11Z","timestamp":1783055711254,"version":"3.54.6"},"reference-count":202,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"Postdoctoral Research Foundation of China","doi-asserted-by":"publisher","award":["2023M743945"],"award-info":[{"award-number":["2023M743945"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ5507"],"award-info":[{"award-number":["2024JJ5507"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2024JJ7625"],"award-info":[{"award-number":["2024JJ7625"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Open Foundation of Shandong Key Laboratory of Oral Diseases","award":["SDKQ202502"],"award-info":[{"award-number":["SDKQ202502"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["GZC20233163"],"award-info":[{"award-number":["GZC20233163"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Oral diseases, encompassing conditions such as periodontitis, head and neck squamous cell carcinoma, pulpitis, and mucosal infections, remain a major global health burden due to their high prevalence and complex, multifactorial pathophysiology. The unique anatomical structure of the oral cavity, together with persistent microbial challenges and dynamic immune responses, imposes substantial limitations on conventional drug delivery strategies. Biomimetic cell membrane-based materials have recently emerged as a promising class of delivery platforms, leveraging natural biological interfaces to confer inherent biocompatibility, immune evasion, prolonged circulation, specific targeting, and biofilm-interactive capabilities. These features position them as a transformative approach for improving therapeutic precision and efficacy in oral disease management. In this review, we provide a systematic and materials-oriented overview of biomimetic cell membrane-based drug delivery systems. Specifically, we discuss: (1) the biological sources, classification, and physicochemical properties of membrane-coated systems, along with their fabrication and engineering strategies; (2) the mechanistic basis of targeting, immune modulation, and nanobiointerface interactions, and their applications across representative oral diseases; and (3) current challenges, including scalable manufacturing, functional controllability, biosafety, and clinical translation. Furthermore, we highlight emerging directions such as stimuli-responsive membrane systems and multifunctional integrated platforms, aiming to provide a conceptual framework for the rational design and clinical advancement of biomimetic drug delivery systems in complex disease settings.<\/jats:p>","DOI":"10.3390\/pharmaceutics18070799","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T08:26:15Z","timestamp":1782807975000},"page":"799","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Cell Membrane-Based Drug Delivery Systems for Oral Diseases: Engineering Strategies, Targeting Mechanisms, and Translational Challenges"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4515-1806","authenticated-orcid":false,"given":"Zeyuan","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Orthodontics, Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha 410008, China"},{"name":"Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine, Changsha 410008, China"},{"name":"Hunan Key Laboratory of Oral Health Research, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1014-7543","authenticated-orcid":false,"given":"Lingling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha 410008, China"},{"name":"Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine, Changsha 410008, China"},{"name":"Hunan Key Laboratory of Oral Health Research, Changsha 410008, China"},{"name":"Department of Dermatology, National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"FuRong Laboratory, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0385-2017","authenticated-orcid":false,"given":"Chengcheng","family":"Yin","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Jilin University, Changchun 130021, China"},{"name":"Jilin Provincial Key Laboratory of Oral and Craniofacial Diseases & Tissue Reconstruction, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4479-7659","authenticated-orcid":false,"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Xiangya Hospital, Central South University, Changsha 410008, China"},{"name":"FuRong Laboratory, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7958-6504","authenticated-orcid":false,"given":"Yanqin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Xiangya Stomatological Hospital and Xiangya School of Stomatology, Central South University, Changsha 410008, China"},{"name":"Hunan Engineering Research Center for Oral Digital Intelligence and Personalized Medicine, Changsha 410008, China"},{"name":"Hunan Key Laboratory of Oral Health Research, Changsha 410008, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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