{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:46:05Z","timestamp":1782816365363,"version":"3.54.5"},"reference-count":153,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The biggest challenge faced by classical anticancer therapy is drug resistance, which causes cancer recurrence and metastasis. Two underlying mechanisms could be responsible, including the stemness of pro-survival autophagy-associated cancer stem cells (CSCs). Background\/Objectives: The relationship between CSCs and autophagy in gynecological cancer is still unknown. However, it has been shown that CSCs\u2019 in vitro self-renewal ability is decreased when autophagy is inhibited. Helping to maintain normal tissue homeostasis, autophagy is a catabolic process involved in degrading long-lived proteins and cytoplasmic organelles. Autophagy acts as a key player in the human body\u2019s self-regenerating tissues. It also has a reproductive function, contributing to decidualization for a successful pregnancy. The aim of our review is to identify similarities and differences between these processes, using these findings to discover new therapeutic strategies through nanotechnology. Method: We conducted a narrative review, identifying heterogeneity in the data in the literature, and found 153 relevant articles. Discussions: While autophagy has been proven to be capable of acting as a tumor suppressor, it also promotes tumor progression. Moreover, it has been linked to cancer stem cell regulation, therapy resistance, cancer invasion, and metastasis. Several molecular mechanisms have been linked to autophagy. Remarkably, some cellular processes required for proper placentation, including autophagy, are common between placental development and tumor growth. Just as trophoblast cells invade and migrate, so do cancer cells. While in the trophoblast, this phenomenon is programmed and controlled; in cancer, this regulation is lost. As shown, we thus observed commonalities and discrepancies in the phenotypes and underlying molecular mechanisms of autophagy regulation in preeclampsia versus cancer contexts. Translational applicability of nanomedicine research strategies and design paradigms between preeclampsia intervention and cancer therapy has been sought. Conclusions: Autophagy-based nanotechnology seems to be feasible in both placental ischemia in preeclampsia and cancers. This review draws parallels between targeted treatments in malignancies and placenta-derived PE. Comparing these diseases provides a novel molecular rationale and the possibility of identifying treatment through autophagy modulation.<\/jats:p>","DOI":"10.3390\/pharmaceutics18070809","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:01:17Z","timestamp":1782813677000},"page":"809","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanomedicine-Mediated Autophagy Modulation in Placental Impairment Versus Cancers: A Narrative Review"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-6353","authenticated-orcid":false,"given":"Melinda Ildiko","family":"Mitranovici","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Emergency County Hospital Hunedoara, 331057 Hunedoara, Romania"},{"name":"Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-4911","authenticated-orcid":false,"given":"Viviana","family":"Ivan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6684-1759","authenticated-orcid":false,"given":"Adrian","family":"Apostol","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liviu","family":"Moraru","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Medicine, Pharmacy, Sciences and Technology \u201cGeorge Emil Palade\u201d, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6467-6275","authenticated-orcid":false,"given":"Septimiu","family":"Voidazan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9016-5412","authenticated-orcid":false,"given":"Raluca","family":"Niculescu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 38 Gheorghe Marinescu Street, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-2384","authenticated-orcid":false,"given":"Ioana Cristina","family":"Rotar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology I, Mother and Child Department, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin","family":"Bobirca","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-5706","authenticated-orcid":false,"given":"Andreea Taisia","family":"Tiron","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7756-9670","authenticated-orcid":false,"given":"Laura Georgiana","family":"Caravia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Carvajal, L., Guti\u00e9rrez, J., Morselli, E., and Leiva, A. (2021). Autophagy process in trophoblast cells invasion and differentiation: Similitude and differences with cancer cells. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.637594"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41427-022-00422-3","article-title":"Autophagy-targeted nanoparticles for effective cancer treatment: Advances and outlook","volume":"14","author":"Long","year":"2022","journal-title":"NPG Asia Mater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s00018-011-0865-5","article-title":"Microautophagy: Lesser-known self-eating","volume":"69","author":"Li","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/cr.2013.153","article-title":"Chaperone-mediated autophagy: Roles in disease and aging","volume":"24","author":"Cuervo","year":"2014","journal-title":"Cell Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nrd.2017.22","article-title":"Pharmacological modulation of autophagy: Therapeutic potential and persisting obstacles","volume":"16","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mitranovici, M.I., Costachescu, D., Voidazan, S., Munteanu, M., Buicu, C.F., Oal\u0103, I.E., Ivan, V., Apostol, A., Melinte, I.M., and Crisan, A. (2024). Exploring the shared pathogenesis mechanisms of endometriosis and cancer: Stemness and targeted treatments of its molecular pathways\u2014A narrative review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252312749"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mitranovici, M.I., Caravia, L.G., Moraru, L., and Pu\u0219ca\u0219iu, L. (2025). Targeting Cancer Stemness Using Nanotechnology in a Holistic Approach: A Narrative Review. Pharmaceutics, 17.","DOI":"10.3390\/pharmaceutics17030277"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Hoosen, Y., Pradeep, P., Kumar, P., Du Toit, L.C., Choonara, Y.E., and Pillay, V. (2018). Nanotechnology and glycosaminoglycans: Paving the way forward for ovarian cancer intervention. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19030731"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1080\/17460441.2022.2077329","article-title":"Advances in nanotechnology-based platforms for survivin-targeted drug discovery","volume":"17","author":"George","year":"2022","journal-title":"Expert Opin. Drug Discov."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13578-023-00986-9","article-title":"Nanomedicine for autophagy modulation in cancer therapy: A clinical perspective","volume":"13","author":"Trionfetti","year":"2023","journal-title":"Cell Biosci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1007\/s13346-022-01125-6","article-title":"Nanotherapeutics in autophagy: A paradigm shift in cancer treatment","volume":"12","author":"Negi","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e12283","DOI":"10.1590\/1414-431x2022e12283","article-title":"Down-regulation of autophagy proteins is associated with higher mTOR expression in the placenta of pregnant women with preeclampsia","volume":"55","author":"Weel","year":"2023","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00441-022-03587-z","article-title":"Esomeprazole inhibits hypoxia\/endothelial dysfunction\u2013induced autophagy in preeclampsia","volume":"388","author":"Gu","year":"2022","journal-title":"Cell Tissue Res."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Iurciuc, M., Buleu, F., Iurciuc, S., Petre, I., Popa, D., Moleriu, R.D., Bordianu, A., Suciu, O., Tasdemir, R., and Dragomir, R.-E. (2024). Effect of vitamin D deficiency on arterial stiffness in pregnant women with preeclampsia and pregnancy-induced hypertension and implications for fetal development. Biomedicines, 12.","DOI":"10.3390\/biomedicines12071595"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2445556","DOI":"10.1080\/10641955.2024.2445556","article-title":"Targeting oxidative stress in preeclampsia","volume":"44","author":"Afrose","year":"2025","journal-title":"Hypertens. Pregnancy"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5653\/cerm.2014.41.3.97","article-title":"The role of autophagy in the placenta as a regulator of cell death","volume":"41","author":"Gong","year":"2014","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.humimm.2022.02.005","article-title":"Increase of autophagy marker p62 in the placenta from pregnant women with preeclampsia","volume":"83","author":"Ribeiro","year":"2022","journal-title":"Hum. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.placenta.2008.11.003","article-title":"Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia","volume":"30","author":"Burton","year":"2009","journal-title":"Placenta"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1530\/JOE-17-0402","article-title":"Trophoblast lineage specification, differentiation and their regulation by oxygen tension","volume":"236","author":"Chang","year":"2018","journal-title":"J. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Han, C., Huang, P., Lyu, M., and Dong, J. (2020). Oxidative stress and preeclampsia-associated prothrombotic state. Antioxidants, 9.","DOI":"10.3390\/antiox9111139"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.31083\/j.ceog4908170","article-title":"An update review of the pathogenesis hypothesis in Preeclampsia","volume":"49","author":"Lian","year":"2022","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.placenta.2020.11.012","article-title":"Placental mitochondrial function in response to gestational exposures","volume":"104","author":"Lu","year":"2021","journal-title":"Placenta"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Cano, A.M., Calzada-Mendoza, C.C., Estrada-Gutierrez, G., Mendoza-Ortega, J.A., and Perichart-Perera, O. (2020). Nutrients, Mitochondrial Function, And Perinatal Health. Nutrients, 12.","DOI":"10.3390\/nu12072166"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1007\/s43032-021-00464-y","article-title":"Placental mitochondrial abnormalities in preeclampsia","volume":"28","author":"Vangrieken","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/1440-1681.13172","article-title":"Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy","volume":"47","author":"Fisher","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.mito.2020.08.008","article-title":"Placental mitochondrial DNA mutations and copy numbers in intrauterine growth restricted (IUGR) pregnancy","volume":"55","author":"Naha","year":"2020","journal-title":"Mitochondrion"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1083\/jcb.201002100","article-title":"The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy","volume":"191","author":"Corazzari","year":"2010","journal-title":"J. Cell Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.cell.2010.04.009","article-title":"Mitochondria supply membranes for autophagosome biogenesis during starvation","volume":"141","author":"Hailey","year":"2010","journal-title":"Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/sj.cdd.4401751","article-title":"Autophagy and signaling: Their role in cell survival and cell death","volume":"12","author":"Codogno","year":"2005","journal-title":"Cell Death Differ."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4161\/auto.22927","article-title":"Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia","volume":"9","author":"Nakashima","year":"2013","journal-title":"Autophagy"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5653\/cerm.2012.39.2.73","article-title":"Effects of hypoxia inducible factors-1\u03b1 on autophagy and invasion of trophoblasts","volume":"39","author":"Choi","year":"2012","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2249.2007.03397.x","article-title":"Proportion of peripheral blood and decidual CD4+ CD25bright regulatory T cells in pre-eclampsia","volume":"149","author":"Sasaki","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.1038\/s41598-017-06605-1","article-title":"UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization","volume":"7","author":"Nakashima","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5653\/cerm.2013.40.1.33","article-title":"Autophagy-related protein LC3 and Beclin-1 in the first trimester of pregnancy","volume":"40","author":"Chifenti","year":"2013","journal-title":"Clin. Exp. Reprod. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1038\/sj.onc.1202722","article-title":"Bcl-2\/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2\/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability","volume":"18","author":"Imazu","year":"1999","journal-title":"Oncogene"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jri.2013.06.002","article-title":"A review of the mechanism for poor placentation in early-onset preeclampsia: The role of autophagy in trophoblast invasion and vascular remodeling","volume":"101\u2013102","author":"Saito","year":"2014","journal-title":"J. Reprod. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhao, X., He, B., Wu, W., Zhang, H., Yang, X., and Cheng, W. (2021). Autophagy activation by hypoxia regulates angiogenesis and apoptosis in oxidized low-density lipoprotein-induced preeclampsia. Front. Mol. Biosci., 8.","DOI":"10.3389\/fmolb.2021.709751"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"20469","DOI":"10.1038\/s41598-021-99837-1","article-title":"Impaired placental mitophagy and oxidative stress are associated with dysregulated BNIP3 in preeclampsia","volume":"11","author":"Zhou","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wan, R., Yao, P., Wang, Y., Zhang, L., Guo, W., Du, M., Wang, Y., Shi, W., and Li, W. (2024). Autophagy-related biomarkers in preeclampsia: The underlying mechanism, correlation to the immune microenvironment and drug screening. BMC Pregnancy Childbirth, 24.","DOI":"10.1186\/s12884-023-06211-2"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1111\/febs.14388","article-title":"Functions of autophagy in the tumor microenvironment and cancer metastasis","volume":"285","author":"Mowers","year":"2018","journal-title":"FEBS J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4155\/fmc.09.155","article-title":"Autophagy: Cancer therapy\u2019s friend or foe?","volume":"2","author":"Panaretakis","year":"2010","journal-title":"Future Med. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.tjog.2016.06.019","article-title":"Molecular regulation and role of angiogenesis in reproduction","volume":"56","author":"Rizov","year":"2017","journal-title":"Taiwan. J. Obstet. Gynecol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Corrado, C., and Fontana, S. (2020). Hypoxia and HIF signaling: One axis with divergent effects. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21165611"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez-Cort\u00e9s, M., Delgado-Bellido, D., and Oliver, F.J. (2019). Vasculogenic mimicry: Become an endothelial cell \u201cbut not so much\u201d. Front. Oncol., 9.","DOI":"10.3389\/fonc.2019.00803"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.acthis.2007.02.008","article-title":"Vasculogenesis and angiogenesis in the early human placenta","volume":"109","author":"Demir","year":"2007","journal-title":"Acta Histochem."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2019.08.011","article-title":"Hallmarks of endothelial cell metabolism in health and disease","volume":"30","author":"Li","year":"2019","journal-title":"Cell Metab."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Daskalaki, I., Gkikas, I., and Tavernarakis, N. (2018). Hypoxia and selective autophagy in cancer development and therapy. Front. Cell Dev. Biol., 6.","DOI":"10.3389\/fcell.2018.00104"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jalouli, M. (2025). Emerging role of hypoxia-inducible factors (hifs) in modulating autophagy: Perspectives on cancer therapy. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26041752"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1158\/1535-7163.MCT-11-0047","article-title":"The role of autophagy in cancer: Therapeutic implications","volume":"10","author":"Yang","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Cheng, S., Huang, Z., Jash, S., Wu, K., Saito, S., Nakashima, A., and Sharma, S. (2022). Hypoxia-reoxygenation impairs autophagy-lysosomal machinery in primary human trophoblasts mimicking placental pathology of early-onset preeclampsia. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105644"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/humrep\/det353","article-title":"Distribution of decidual natural killer cells and macrophages in the neighbourhood of the trophoblast invasion front: A quantitative evaluation","volume":"29","author":"Helige","year":"2014","journal-title":"Hum. Reprod."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"S185","DOI":"10.1016\/j.semcancer.2015.03.004","article-title":"Immune evasion in cancer: Mechanistic basis and therapeutic strategies","volume":"35","author":"Vinay","year":"2015","journal-title":"Semin. Cancer Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12964-020-00579-w","article-title":"Autophagy suppression of trophoblast cells induces pregnancy loss by activating decidual NK cytotoxicity and inhibiting trophoblast invasion","volume":"18","author":"Tan","year":"2020","journal-title":"Cell Commun. Signal."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Janji, B., Berchem, G., and Chouaib, S. (2018). Targeting autophagy in the tumor microenvironment: New challenges and opportunities for regulating tumor immunity. Front. Immunol., 9.","DOI":"10.3389\/fimmu.2018.00887"},{"key":"ref_55","first-page":"27","article-title":"HLA-G intracellular expression in decidua trophoblasts in a normal term placenta: A confocal and transmission electron microscopy study","volume":"28","author":"Chifenti","year":"2016","journal-title":"Ital. J. Gynaecol. Obstet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"a008821","DOI":"10.1101\/cshperspect.a008821","article-title":"Autophagy and cancer","volume":"4","author":"Mah","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13045-020-00936-9","article-title":"Crosstalks between inflammasome and autophagy in cancer","volume":"13","author":"Chung","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1205406","article-title":"Autophagy in human health and disease","volume":"368","author":"Choi","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12958-018-0421-3","article-title":"Shifting perspectives from \u201concogenic\u201d to oncofetal proteins; how these factors drive placental development","volume":"16","author":"West","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0025-6196(11)60669-1","article-title":"Cancer and pregnancy: Parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents","volume":"84","author":"Holtan","year":"2009","journal-title":"Mayo Clin. Proc."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1007\/s00204-026-04301-6","article-title":"Autophagy in cancer nanomedicine: An implication of nanomaterials\u2019 impact on the evolutionarily conservative catabolic processes in human tumors","volume":"100","author":"Wiktorowski","year":"2026","journal-title":"Arch. Toxicol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Petre, I., Vernic, C., Petre, I., Vlad, C.S., Sipos, S.I., Bordianu, A., Luciana, M., Dragomir, R.D., Fizedean, C.M., and Daliborca, C.V. (2024). Systematic review on the effectiveness and outcomes of nivolumab treatment schemes in advanced and metastatic cervical cancer. Diseases, 12.","DOI":"10.3390\/diseases12040077"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1038\/s12276-024-01234-x","article-title":"Exploiting sweet relief for preeclampsia by targeting autophagy-lysosomal machinery and proteinopathy","volume":"56","author":"Huang","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Li, A., Zhao, M., Yang, Z., Fang, Z., Qi, W., Zhang, C., Zhou, M., Guo, J., Li, S., and Wang, X. (2023). 6-Gingerol alleviates placental injury in preeclampsia by inhibiting oxidative stress via BNIP3\/LC3 signaling-mediated trophoblast mitophagy. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1243734"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Bertozzi, S., Corradetti, B., Seriau, L., Diaz \u00d1a\u00f1ez, J.A., Cedolini, C., Fruscalzo, A., Cesselli, D., Cagnacci, A., and Londero, A.P. (2022). Nanotechnologies in obstetrics and cancer during pregnancy: A narrative review. J. Pers. Med., 12.","DOI":"10.3390\/jpm12081324"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12951-022-01477-8","article-title":"Nanoparticle classification, physicochemical properties, characterization, and applications: A comprehensive review for biologists","volume":"20","author":"Joudeh","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/14728222.2022.2134779","article-title":"Emerging pharmacologic interventions for pre-eclampsia treatment","volume":"26","author":"Zhang","year":"2022","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e24291","DOI":"10.1161\/HYPERTENSIONAHA.124.24291","article-title":"Modulating placental functionality in preeclampsia with siRNA nanocomplexes","volume":"83","author":"Peng","year":"2026","journal-title":"Hypertension"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"100076","DOI":"10.1016\/j.ntm.2025.100076","article-title":"Bio-nanomaterials: Promising anticancer properties and treatment strategies","volume":"4","author":"Elemike","year":"2025","journal-title":"Nano TransMed"},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Yao, Y., Zhou, Y., Liu, L., Xu, Y., Chen, Q., Wang, Y., Wu, S., Deng, Y., Zhang, J., and Shao, A. (2020). Nanoparticle-based drug delivery in cancer therapy and its role in overcoming drug resistance. Front. Mol. Biosci., 7.","DOI":"10.3389\/fmolb.2020.00193"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ejps.2012.12.006","article-title":"A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics","volume":"48","author":"Steichen","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"168","DOI":"10.14336\/AD.2024.0206-1","article-title":"Nanomaterials in medicine: Understanding cellular uptake, localization, and retention for enhanced disease diagnosis and therapy","volume":"16","author":"Peng","year":"2024","journal-title":"Aging Dis."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.jcis.2023.05.031","article-title":"Autophagy-induced intracellular signaling fractional nano-drug system for synergistic anti-tumor therapy","volume":"645","author":"Yan","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Rahman, M.A., Jalouli, M., Bhajan, S.K., Al-Zharani, M., and Harrath, A.H. (2025). A comprehensive review of nanoparticle-based drug delivery for modulating PI3K\/AKT\/mTOR-mediated autophagy in cancer. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26051868"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Rotar, I.C., Bernad, E., Moraru, L., Ivan, V., Apostol, A., Bernad, S.I., Muresan, D., and Mitranovici, M.I. (2025). Therapeutic and Prognostic Relevance of Cancer Stem Cell Populations in Endometrial Cancer: A Narrative Review. Diagnostics, 15.","DOI":"10.3390\/diagnostics15151872"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1016\/j.apsb.2024.03.019","article-title":"Nanotherapeutics targeting autophagy regulation for improved cancer therapy","volume":"14","author":"Liu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s12020-020-02228-1","article-title":"Increased autophagy\/mitophagy levels in primary tumours of patients with pancreatic neuroendocrine neoplasms","volume":"68","author":"Daskalakis","year":"2020","journal-title":"Endocrine"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1158\/1538-7445.AM2024-478","article-title":"Abstract 478: Targeted combination nano-drug delivery system to enhance anti-cancer efficacy and reduce side effects","volume":"84","author":"Rashidi","year":"2024","journal-title":"Cancer Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"8899","DOI":"10.24294\/can8899","article-title":"Nanoparticles\u2019 classification, synthesis, characterization and applications\u2014A review","volume":"8","author":"Awan","year":"2024","journal-title":"Charact. Appl. Nanomater."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"29827","DOI":"10.1021\/acsami.3c03068","article-title":"ROS responsive nanoparticles encapsulated with natural medicine remodel autophagy homeostasis in breast cancer","volume":"15","author":"Zhang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.7150\/thno.13181","article-title":"Interplay of oxidative stress and autophagy in PAMAM dendrimers-induced neuronal cell death","volume":"5","author":"Li","year":"2015","journal-title":"Theranostics"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ncb0910-814","article-title":"Eaten alive: A history of macroautophagy","volume":"12","author":"Yang","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nature06639","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"Mizushima","year":"2008","journal-title":"Nature"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Caravia, L.G., Mitranovici, M.I., Oala, I.E., Tiron, A.T., Simionescu, A.A., Borcan, A.M., and Craina, M. (2025). The Importance of Cancer Stem Cells and Their Pathways in Endometrial Cancer: A Narrative Review. Cells, 14.","DOI":"10.3390\/cells14080594"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Moraru, L., Mitranovici, M.I., Moraru, R., Voidazan, S., Munteanu, M., Georgescu, R., Costachescu, D., and Turdean, S.G. (2024). Combining molecular and traditional prognostic factors: A holistic approach to breast cancer prognostication. Diagnostics, 14.","DOI":"10.3390\/diagnostics14131449"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1534-5807(04)00099-1","article-title":"Development by self-digestion: Molecular mechanisms and biological functions of autophagy","volume":"6","author":"Levine","year":"2004","journal-title":"Dev. Cell"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Hara","year":"2006","journal-title":"Nature"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.placenta.2021.11.003","article-title":"Cyclosporin A alleviates trophoblast apoptosis and senescence by promoting autophagy in preeclampsia","volume":"117","author":"Hu","year":"2022","journal-title":"Placenta"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.placenta.2020.08.022","article-title":"Novel approaches to combat preeclampsia: From new drugs to innovative delivery","volume":"102","author":"Binder","year":"2020","journal-title":"Placenta"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s10620-011-1940-3","article-title":"The safety of fetal exposure to proton-pump inhibitors during pregnancy","volume":"57","author":"Matok","year":"2012","journal-title":"Dig. Dis. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/HYPERTENSIONAHA.116.08408","article-title":"Proton pump inhibitors decrease soluble fms-like tyrosine kinase-1 and soluble endoglin secretion, decrease hypertension, and rescue endothelial dysfunction","volume":"69","author":"Onda","year":"2017","journal-title":"Hypertension"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1080\/15548627.2019.1707494","article-title":"Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia","volume":"16","author":"Nakashima","year":"2020","journal-title":"Autophagy"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1161\/HYPERTENSIONAHA.121.18916","article-title":"Evidence From Human Placenta, Endoplasmic Reticulum\u2013Stressed Trophoblasts, and Transgenic Mice Links Transthyretin Proteinopathy to Preeclampsia","volume":"79","author":"Cheng","year":"2022","journal-title":"Hypertension"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"5641","DOI":"10.1074\/jbc.M609532200","article-title":"Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and \u03b1-synuclein","volume":"282","author":"Sarkar","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"101312","DOI":"10.1016\/j.omtm.2024.101312","article-title":"Combination AAV therapy with galectin-1 and SOD1 downregulation demonstrates superior therapeutic effect in a severe ALS mouse model","volume":"32","author":"Baird","year":"2024","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"16517","DOI":"10.1021\/acsnano.4c18731","article-title":"Gestational Exposure to Black Phosphorus Nanoparticles Induces Placental Trophoblast Dysfunction by Triggering Reactive Oxygen Species-Regulated Mitophagy","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1073\/pnas.1011293108","article-title":"Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model","volume":"108","author":"Kumasawa","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","first-page":"1203","article-title":"INOVASIA study: A multicenter randomized clinical trial of pravastatin to prevent preeclampsia in high-risk patients","volume":"41","author":"Akbar","year":"2022","journal-title":"Am. J. Perinatol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1042\/BJ20040885","article-title":"Metformin inhibits mitochondrial permeability transition and cell death: A pharmacological in vitro study","volume":"382","author":"Guigas","year":"2004","journal-title":"Biochem. J."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Kaitu\u2019u-Lino, T.J., Brownfoot, F.C., Beard, S., Cannon, P., Hastie, R., Nguyen, T.V., Binder, N.K., Tong, S., and Hannan, N.J. (2018). Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction\u2014Implications for treating preeclampsia. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0188845"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"993","DOI":"10.7150\/ijms.73012","article-title":"SIRT1: A novel protective molecule in pre-eclampsia","volume":"19","author":"Liu","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Hannan, N.J., Binder, N.K., Beard, S., Nguyen, T.-V., Kaitu\u2019U-Lino, T.J., and Tong, S. (2018). Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0187082"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"R1495","DOI":"10.1152\/ajpregu.00325.2011","article-title":"Induction of heme oxygenase-1 attenuates sFlt-1-induced hypertension in pregnant rats","volume":"301","author":"George","year":"2011","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"e13297","DOI":"10.1111\/aji.13297","article-title":"Placental extracellular vesicles and pre-eclampsia","volume":"85","author":"Schuster","year":"2021","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijgo.2008.11.033","article-title":"Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia","volume":"105","author":"Teran","year":"2009","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1016\/j.ajpath.2018.07.027","article-title":"Placental adaptation to early-onset hypoxic pregnancy and mitochondria-targeted antioxidant therapy in a rodent model","volume":"188","author":"Nuzzo","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Hu, X.Q., and Zhang, L. (2021). Hypoxia and mitochondrial dysfunction in pregnancy complications. Antioxidants, 10.","DOI":"10.3390\/antiox10030405"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"94907706","DOI":"10.26599\/NR.2025.94907706","article-title":"Innovative nanoparticle-based approach for preeclampsia treatment through inhibition of KAT7-mediated histone modifications","volume":"18","author":"Zhu","year":"2025","journal-title":"Nano Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.placenta.2020.07.023","article-title":"Oxidative stress markers in preeclamptic placentas: A systematic review with meta-analysis","volume":"99","author":"Ferreira","year":"2020","journal-title":"Placenta"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1039\/C9TB02266J","article-title":"Mitochondria-targeted tetrahedral DNA nanostructures for doxorubicin delivery and enhancement of apoptosis","volume":"8","author":"Yan","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"100704","DOI":"10.1016\/j.drup.2020.100704","article-title":"Nanomedicine to target multidrug resistant tumors","volume":"52","author":"Lepeltier","year":"2020","journal-title":"Drug Resist. Updates"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.addr.2013.08.006","article-title":"Rationally designed nanovehicles to overcome cancer chemoresistance","volume":"65","author":"Livney","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"7289","DOI":"10.1039\/c3cs60048c","article-title":"Functional block copolymer assemblies responsive to tumor and intracellular microenvironments for site-specific drug delivery and enhanced imaging performance","volume":"42","author":"Ge","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1021\/mp5000423","article-title":"Sequential release of autophagy inhibitor and chemotherapeutic drug with polymeric delivery system for oral squamous cell carcinoma therapy","volume":"11","author":"Saiyin","year":"2014","journal-title":"Mol. Pharm."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1021\/acsami.7b16522","article-title":"MOF nanoparticles with encapsulated autophagy inhibitor in controlled drug delivery system for antitumor","volume":"10","author":"Chen","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"128222","DOI":"10.1016\/j.cej.2020.128222","article-title":"In-situ drug generation and controllable loading: Rational design of copper-based nanosystems for chemo-photothermal cancer therapy","volume":"409","author":"Pan","year":"2021","journal-title":"Chem. Eng. J."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Domagala, A., Stachura, J., Gabrysiak, M., Muchowicz, A., Zagozdzon, R., Golab, J., and Firczuk, M. (2018). Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy. BMC Cancer, 18.","DOI":"10.1186\/s12885-018-4126-y"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1039\/C9NH00643E","article-title":"Endosome\/lysosome-detained supramolecular nanogels as an efflux retarder and autophagy inhibitor for repeated photodynamic therapy of multidrug-resistant cancer","volume":"5","author":"Zhang","year":"2020","journal-title":"Nanoscale Horiz."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"27701","DOI":"10.1021\/acsami.8b10167","article-title":"Blocking autophagic flux enhances iron oxide nanoparticle photothermal therapeutic efficiency in cancer treatment","volume":"10","author":"Ren","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10103-007-0470-x","article-title":"Plasmonic photothermal therapy (PPTT) using gold nanoparticles","volume":"23","author":"Huang","year":"2008","journal-title":"Lasers Med. Sci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"101374","DOI":"10.1016\/j.nantod.2022.101374","article-title":"Self-cycling redox nanoplatform in synergy with mild magnetothermal and autophagy inhibition for efficient cancer therapy","volume":"43","author":"Wang","year":"2022","journal-title":"Nano Today"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"EMBJ201899847","DOI":"10.15252\/embj.201899847","article-title":"A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex","volume":"38","author":"Forrester","year":"2019","journal-title":"EMBO J."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1039\/C8MH00993G","article-title":"Nanodiamond-based non-canonical autophagy inhibitor synergistically induces cell death in oxygen-deprived tumors","volume":"5","author":"Chen","year":"2018","journal-title":"Mater. Horiz."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1802337","DOI":"10.1002\/smll.201802337","article-title":"Photosensitizer and autophagy promoter coloaded ROS-responsive dendrimer-assembled carrier for synergistic enhancement of tumor growth suppression","volume":"14","author":"Wang","year":"2018","journal-title":"Small"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature20815","article-title":"Microenvironmental autophagy promotes tumour growth","volume":"541","author":"Katheder","year":"2017","journal-title":"Nature"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2011171","DOI":"10.1002\/adfm.202011171","article-title":"Nanomedicine-boosting tumor immunogenicity for enhanced immunotherapy","volume":"31","author":"Huang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-022-05426-1","article-title":"Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation","volume":"612","author":"Schmitt","year":"2022","journal-title":"Nature"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmet.2007.11.001","article-title":"FoxO3 controls autophagy in skeletal muscle in vivo","volume":"6","author":"Mammucari","year":"2007","journal-title":"Cell Metab."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nrc3262","article-title":"Deconvoluting the context-dependent role for autophagy in cancer","volume":"12","author":"White","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1101\/gad.1545107","article-title":"Autophagy suppresses tumor progression by limiting chromosomal instability","volume":"21","author":"Mathew","year":"2007","journal-title":"Genes Dev."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1038\/s41467-020-17395-y","article-title":"Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1097\/JTO.0b013e318262de4a","article-title":"A phase I study of erlotinib and hydroxychloroquine in advanced non-small-cell lung cancer","volume":"7","author":"Goldberg","year":"2012","journal-title":"J. Thorac. Oncol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0140-6736(08)61039-9","article-title":"Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial","volume":"372","author":"Motzer","year":"2008","journal-title":"Lancet"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1158\/1078-0432.CCR-12-0351","article-title":"Counteracting autophagy overcomes resistance to everolimus in mantle cell lymphoma","volume":"18","author":"Rosich","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrm3028","article-title":"Mechanisms of mitophagy","volume":"12","author":"Youle","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1039\/D1TB02583J","article-title":"Verteporfin-loaded supramolecular micelles for enhanced cisplatin-based chemotherapy via autophagy inhibition","volume":"10","author":"Ye","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.celrep.2019.03.037","article-title":"Autophagy regulation of metabolism is required for CD8+ T cell anti-tumor immunity","volume":"27","author":"DeVorkin","year":"2019","journal-title":"Cell Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1021\/acsnano.2c02183","article-title":"Efficient immunotherapy of drug-free layered double hydroxide nanoparticles via neutralizing excess acid and blocking tumor cell autophagy","volume":"16","author":"Zhang","year":"2022","journal-title":"ACS Nano"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.1158\/1078-0432.CCR-04-0361","article-title":"Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells","volume":"10","author":"Mondesire","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1158\/1535-7163.MCT-09-0763","article-title":"Dual inhibition of akt\/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma","volume":"9","author":"Cirstea","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.nano.2018.05.019","article-title":"HER2-targeted gold nanoparticles potentially overcome resistance to trastuzumab in gastric cancer","volume":"14","author":"Kubota","year":"2018","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"61083","DOI":"10.18632\/oncotarget.17854","article-title":"Cuprous oxide nanoparticles inhibit the growth of cervical carcinoma by inducing autophagy","volume":"8","author":"Xia","year":"2017","journal-title":"Oncotarget"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41565-021-00898-0","article-title":"The current landscape of nucleic acid therapeutics","volume":"16","author":"Kulkarni","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"ref_145","first-page":"1125","article-title":"The downregulation of ATG4B mediated by microRNA-34a\/34c-5p suppresses rapamycin-induced autophagy","volume":"20","author":"Wu","year":"2017","journal-title":"Iran. J. Basic Med. Sci."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejphar.2019.01.071","article-title":"miR-34a inhibits progression of neuroblastoma by targeting autophagy-related gene 5","volume":"850","author":"Cheng","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11357-011-9324-3","article-title":"MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9","volume":"35","author":"Yang","year":"2013","journal-title":"Age"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12951-020-00615-4","article-title":"Treatment of breast cancer with autophagy inhibitory microRNAs carried by AGO2-conjugated nanoparticles","volume":"18","author":"Unal","year":"2020","journal-title":"J. Nanobiotechnol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.ajpath.2018.09.001","article-title":"Autophagy-based diagnosis of pregnancy hypertension and pre-eclampsia","volume":"188","author":"Sharma","year":"2018","journal-title":"Am. J. Pathol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e838","DOI":"10.1038\/cddis.2013.350","article-title":"Autophagy and chemotherapy resistance: A promising therapeutic target for cancer treatment","volume":"4","author":"Sui","year":"2013","journal-title":"Cell Death Dis."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"578148","DOI":"10.2147\/IJN.S578148","article-title":"Nano-Enabled Therapeutics: Novel Strategies for Preeclampsia Treatment","volume":"21","author":"Huang","year":"2026","journal-title":"Int. J. Nanomed."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Pang, H., Lei, D., Guo, Y., Yu, Y., Liu, T., Liu, Y., Chen, T., and Fan, C. (2022). Three categories of similarities between the placenta and cancer that can aid cancer treatment: Cells, the microenvironment, and metabolites. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.977618"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s11671-021-03628-6","article-title":"Nanoparticles for cancer therapy: Current progress and challenges","volume":"16","author":"Gavas","year":"2021","journal-title":"Nanoscale Res. Lett."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/7\/809\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T10:14:43Z","timestamp":1782814483000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/7\/809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":153,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["pharmaceutics18070809"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18070809","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}