{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T17:13:06Z","timestamp":1783617186567,"version":"3.55.0"},"reference-count":56,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: To improve the potential therapeutic efficacy of albendazole (ABZ), its low solubility in alkaline environments should be addressed. Spray drying has been widely applied to increase the solubility of poorly soluble drugs. Eudragit\u00ae E PO (EudE) has previously been used to increase the solubility of weakly basic drugs, alone and in combination with organic acids. In the present work, we aimed to demonstrate that EudE and tartaric acid (TA) significantly increase the solubility of ABZ via spray drying. Furthermore, a colon-delivery formulation was applied to deliver ABZ at pH 7.2. Methods: This study developed spray-dried formulations of ABZ-TA-EudE. The formulation with the best solubility profile was selected and loaded into the EUDRACAP\u00ae colon to achieve colon-delivery of the ABZ formulation with enhanced solubility at basic pH. The physicochemical characteristics and in vitro drug release were evaluated and compared with those of the respective physical mixtures. Results: The addition of TA further enhanced the solubility of ABZ-EudE formulations. Both EudE and TA significantly increase ABZ solubility. The ternary ABZ-TA-EudE formulation with the best solubility, when delivered into the EUDRACAP\u00ae colon, showed enhanced ABZ release at pH 7.2. Enhanced in vitro drug release at basic pH and physicochemical characteristics were observed for the spray-dried formulation of ABZ-TA-EudE compared with the corresponding physical mixture and the ABZ powder. Conclusions: TA and EudE significantly enhance the solubility of the weakly basic drug, ABZ, in a spray-dried formulation. Furthermore, the application of EUDRACAP\u00ae colon is effective for colon-delivery of ABZ, as it ensures ABZ release at pH 7.2, thereby providing enhanced formulation\u2019s solubility at its site of action.<\/jats:p>","DOI":"10.3390\/pharmaceutics18070838","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:16:44Z","timestamp":1783613804000},"page":"838","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tailored Drug Release with Improved Solubility via Spray Drying and Functional Ready-to-Fill Capsules"],"prefix":"10.3390","volume":"18","author":[{"given":"Kristina","family":"Vlahovic","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, H\u0151gyes Endre Street 7, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilla Dorottya","family":"K\u00f3r\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, H\u0151gyes Endre Street 7, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bence D\u00e1vid","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, H\u0151gyes Endre Street 7, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1vid","family":"Hamar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, H\u0151gyes Endre Street 7, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8164-3993","authenticated-orcid":false,"given":"Nikolett","family":"K\u00e1llai-Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, H\u0151gyes Endre Street 7, 1092 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, \u00dcll\u0151i Street. 26, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s J\u00f3zsef","family":"Laki","sequence":"additional","affiliation":[{"name":"Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Pr\u00e1ter Street 50\/A, 1083 Budapest, Hungary"},{"name":"Department of Biophysics and Radiation Biology, Semmelweis University, T\u0171zolt\u00f3 Street 37-47, 1094 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5434-201X","authenticated-orcid":false,"given":"Istv\u00e1n","family":"Antal","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, H\u0151gyes Endre Street 7, 1092 Budapest, Hungary"},{"name":"Center for Pharmacology and Drug Research & Development, Semmelweis University, \u00dcll\u0151i Street. 26, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8865-054X","authenticated-orcid":false,"given":"Mil\u00e9na","family":"Lengyel","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Semmelweis University, H\u0151gyes Endre Street 7, 1092 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.rvsc.2003.08.005","article-title":"Benzimidazole drugs and modulation of biotransformation enzymes","volume":"76","author":"Bull","year":"2004","journal-title":"Res. 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