{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:03:25Z","timestamp":1784178205031,"version":"3.55.0"},"reference-count":129,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>The rise of antimicrobial resistance and the persistence of difficult-to-treat infections have stimulated interest in new strategies to overcome these problems. Among these strategies, dendrimers, which are highly branched monodisperse macromolecules, have emerged as innovative antimicrobial and anti-infective platforms. Dendrimers can act as intrinsic antimicrobial agents through multivalent interactions or membrane disruption or serve as nanocarriers for antibiotics, antiviral agents, antibiofilm compounds, gas-releasing active molecules, or photosensitizers. This review analyzes dendrimer-based anti-infective systems for which in vivo or clinical evaluation has been reported. The literature covers diverse platforms, including PAMAM, poly(L-lysine), peptide, carbosilane, phosphorhydrazone, polyglycerol, polyester, and other dendritic architectures. The available evidence includes infected animal models, pharmacokinetic and biodistribution studies, local tolerance studies, and clinical trials. PAMAM systems are the most extensively explored preclinically, whereas poly(L-lysine) dendrimer astodrimer\/SPL7013 remains the most clinically advanced example. Overall, dendrimers provide a chemically tunable and biologically versatile approach to anti-infective research, but the current evidence remains heterogeneous. Direct comparison across studies is limited by differences in dendrimer scaffold, generation, surface chemistry, formulation, pathogen, infection model, administration route, dosing regimen, and biological endpoint. Future development will require better-defined in vivo models, more systematic safety and biodistribution studies, clearer structure\u2013activity relationships, and stronger links between in vitro activity and clinically relevant efficacy.<\/jats:p>","DOI":"10.3390\/pharmaceutics18070851","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T02:34:44Z","timestamp":1783996484000},"page":"851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in Dendrimer-Based Anti-Infective Systems: In Vivo Insights and Perspectives"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4639-4942","authenticated-orcid":false,"given":"Charlotte","family":"Aparici","sequence":"first","affiliation":[{"name":"Univ Toulouse, CNRS, LCC, Toulouse, France"},{"name":"Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077 Toulouse CEDEX 4, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3296-1344","authenticated-orcid":false,"given":"Kevin","family":"Antraygues","sequence":"additional","affiliation":[{"name":"Univ Toulouse, CNRS, LCC, Toulouse, France"},{"name":"Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077 Toulouse CEDEX 4, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2937-6787","authenticated-orcid":false,"given":"Vania","family":"Bernardes-G\u00e9nisson","sequence":"additional","affiliation":[{"name":"Univ Toulouse, CNRS, LCC, Toulouse, France"},{"name":"Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077 Toulouse CEDEX 4, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel S.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Univ Toulouse, CNRS, LCC, Toulouse, France"},{"name":"Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077 Toulouse CEDEX 4, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-8070","authenticated-orcid":false,"given":"C\u00e9dric-Olivier","family":"Turrin","sequence":"additional","affiliation":[{"name":"Univ Toulouse, CNRS, LCC, Toulouse, France"},{"name":"Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077 Toulouse CEDEX 4, France"},{"name":"IMD-Pharma, 205 Route de Narbonne, 31077 Toulouse CEDEX 4, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0900-7332","authenticated-orcid":false,"given":"Val\u00e9rie","family":"Maraval","sequence":"additional","affiliation":[{"name":"Univ Toulouse, CNRS, LCC, Toulouse, France"},{"name":"Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077 Toulouse CEDEX 4, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-3578","authenticated-orcid":false,"given":"Anne-Marie","family":"Caminade","sequence":"additional","affiliation":[{"name":"Univ Toulouse, CNRS, LCC, Toulouse, France"},{"name":"Laboratoire de Chimie de Coordination, 205 Route de Narbonne, 31077 Toulouse CEDEX 4, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/clinids\/2.1.129","article-title":"On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. influenzae","volume":"2","author":"Fleming","year":"1980","journal-title":"Rev. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Aminov, R.I. (2010). A brief history of the antibiotic era: Lessons learned and challenges for the future. Front. Microbiol., 1.","DOI":"10.3389\/fmicb.2010.00134"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Muteeb, G., Rehman, M.T., Shahwan, M., and Aatif, M. (2023). Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review. Pharmaceuticals, 16.","DOI":"10.20944\/preprints202306.1921.v1"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1039\/D2BM01878K","article-title":"Amphiphilic dendrimers against antibiotic resistance: Light at the end of the tunnel?","volume":"11","author":"Galanakou","year":"2023","journal-title":"Biomater. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Alfei, S., and Caviglia, D. (2022). Prevention and eradication of biofilm by dendrimers: A possibility still little explored. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14102016"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Salam, M.A., Al-Amin, M.Y., Salam, M.T., Pawar, J.S., Akhter, N., Rabaan, A.A., and Alqumber, M.A.A. (2023). Antimicrobial resistance: A growing serious threat for global public health. Healthcare, 11.","DOI":"10.20944\/preprints202305.0555.v1"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1016\/S0140-6736(24)00876-6","article-title":"The scope of the antimicrobial resistance challenge","volume":"403","author":"Okeke","year":"2024","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100947","DOI":"10.1016\/j.lanmic.2024.07.010","article-title":"Antimicrobial resistance: A concise update","volume":"6","author":"Ho","year":"2025","journal-title":"Lancet Microbe"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/anie.199001381","article-title":"Starburst dendrimers\u2014Molecular level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter","volume":"29","author":"Tomalia","year":"1990","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1021\/cr970069y","article-title":"About dendrimers: Structure, physical properties, and applications","volume":"99","author":"Bosman","year":"1999","journal-title":"Chem. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1021\/cr900341m","article-title":"Dendrimers derived from 1 -> 3 branching motifs","volume":"110","author":"Newkome","year":"2010","journal-title":"Chem. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1021\/cr900327d","article-title":"Dendrimers designed for functions: From physical, photophysical, and supramolecular properties to applications in sensing, catalysis, molecular electronics, photonics, and nanomedicine","volume":"110","author":"Astruc","year":"2010","journal-title":"Chem. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"5174","DOI":"10.1039\/C6CS00074F","article-title":"Inorganic dendrimers: Recent advances for catalysis, nanomaterials, and nanomedicine","volume":"45","author":"Caminade","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7638","DOI":"10.1021\/ja00177a027","article-title":"Preparation of polymers with controlled molecular architecture\u2014A new convergent approach to dendritic macromolecules","volume":"112","author":"Hawker","year":"1990","journal-title":"J. Am. Chem. Soc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"10","DOI":"10.18433\/jpps29659","article-title":"PAMAM-dendrimer enhanced antibacterial effect of Vancomycin hydrochloride against Gram-negative bacteria","volume":"22","author":"Serri","year":"2018","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1021\/acs.molpharmaceut.0c00083","article-title":"Dendrimer conjugation enhances tumor penetration and efficacy of doxorubicin in extracellular matrix-expressing 3D lung cancer models","volume":"17","author":"Almuqbil","year":"2020","journal-title":"Mol. Pharm."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ejpb.2019.01.006","article-title":"Polyamidoamine dendrimers-based nanomedicine for combination therapy with siRNA and chemotherapeutics to overcome multidrug resistance","volume":"136","author":"Pan","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_18","first-page":"195","article-title":"Peptide dendrimers: Applications and synthesis","volume":"90","author":"Sadler","year":"2002","journal-title":"J. Biotechnol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.2533\/chimia.2021.535","article-title":"Peptide dendrimers: From enzyme models to antimicrobials and transfection reagents","volume":"75","author":"Reymond","year":"2021","journal-title":"Chimia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"114322","DOI":"10.1016\/j.jconrel.2025.114322","article-title":"Peptide dendrimers: Novel therapeutic opportunities for peptide-based biomaterials in biomedicine","volume":"388","author":"Lyu","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Filipczak, N., Yalamarty, S.S.K., Li, X., Parveen, F., and Torchilin, V. (2021). Developments in treatment methodologies using dendrimers for infectious diseases. Molecules, 26.","DOI":"10.3390\/molecules26113304"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13756-023-01241-z","article-title":"Quaternary ammonium disinfectants and antiseptics: Tolerance, resistance and potential impact on antibiotic resistance","volume":"12","author":"Boyce","year":"2023","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ortega, M.A., Guzman Merino, A., Fraile-Martinez, O., Recio-Ruiz, J., Pekarek, L., Guijarro, L.G., Garcia-Honduvilla, N., Alvarez-Mon, M., Bujan, J., and Garcia-Gallego, S. (2020). Dendrimers and dendritic materials: From laboratory to medical practice in infectious diseases. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12090874"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1021\/mp2005033","article-title":"Exploiting dendrimer multivalency to combat emerging and re-emerging infectious diseases","volume":"9","author":"Mintzer","year":"2012","journal-title":"Mol. Pharm."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Garcia-Gallego, S., Franci, G., Falanga, A., Gomez, R., Folliero, V., Galdiero, S., Javier de la Mata, F., and Galdiero, M. (2017). Function oriented molecular design: Dendrimers as novel antimicrobials. Molecules, 22.","DOI":"10.3390\/molecules22101581"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Alfei, S., and Schito, A.M. (2020). From nanobiotechnology, positively charged biomimetic dendrimers as novel antibacterial agents: A review. Nanomaterials, 10.","DOI":"10.3390\/nano10102022"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2400123","DOI":"10.1002\/macp.202400123","article-title":"Recent developments in antimicrobial and antiviral agents based on natural\/synthetic polymers and dendrimers: Design and therapeutic applications","volume":"225","author":"Fouda","year":"2024","journal-title":"Macromol. Chem. Phys."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Sztandera, K., Rodriguez-Garcia, J.L., and Cena, V. (2024). In Vivo Applications of Dendrimers: A Step toward the Future of Nanoparticle-Mediated Therapeutics. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16040439"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1080\/01621459.1976.10480949","article-title":"Science and statistics","volume":"71","author":"Box","year":"1976","journal-title":"J. Amer. Stat. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1295\/polymj.17.117","article-title":"A new class of polymers\u2014Starburst-dendritic macromolecules","volume":"17","author":"Tomalia","year":"1985","journal-title":"Polym. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ijpharm.2010.05.030","article-title":"Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers","volume":"395","author":"Wang","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.actbio.2024.09.010","article-title":"Mussel-inspired bifunctional coating for long-term stability of oral implants","volume":"188","author":"Wang","year":"2024","journal-title":"Acta Biomater."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4012\/dmj.2025-317","article-title":"Borneol-grafted poly(amidoamine) dendrimer with dual antimicrobial and enamel-remineralizing activities against early-stage dental caries","volume":"45","author":"Qin","year":"2026","journal-title":"Dent. Mater. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"10200","DOI":"10.1021\/acsami.2c00658","article-title":"On-demand multifunctional electrostatic complexation for synergistic eradication of MRSA biofilms","volume":"14","author":"Jiang","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1021\/acsnano.0c00269","article-title":"Size and charge adaptive clustered nanoparticles targeting the biofilm microenvironment for chronic lung infection management","volume":"14","author":"Gao","year":"2020","journal-title":"ACS Nano"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1021\/mp200027z","article-title":"Injectable PAMAM dendrimer-PEG hydrogels for the treatment of genital infections: Formulation and in vitro and in vivo evaluation","volume":"8","author":"Navath","year":"2011","journal-title":"Mol. Pharm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1021\/nn404872e","article-title":"Dendrimer brain uptake and targeted therapy for brain injury in a large animal model of hypothermic circulatory arrest","volume":"8","author":"Mishra","year":"2014","journal-title":"ACS Nano"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"eabo2652","DOI":"10.1126\/scitranslmed.abo2652","article-title":"Dendrimer nanotherapy for severe COVID-19 attenuates inflammation and neurological injury markers and improves outcomes in a phase2a clinical trial","volume":"14","author":"Gusdon","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1039\/b913281n","article-title":"\u201cClick\u201d methodologies: Efficient, simple and greener routes to design dendrimers","volume":"39","author":"Franc","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Poh, W.H., and Rice, S.A. (2022). Recent developments in nitric oxide donors and delivery for antimicrobial and anti-biofilm applications. Molecules, 27.","DOI":"10.3390\/molecules27030674"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/10717544.2021.1876183","article-title":"\u0392-Cyclodextrin-graft-poly(amidoamine) dendrons as the nitric oxide deliver system for the chronic rhinosinusitis therapy","volume":"28","author":"Liu","year":"2021","journal-title":"Drug Deliv."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1039\/D1TB02037D","article-title":"Cationic amphiphilic dendrons with effective antibacterial performance","volume":"10","author":"Guo","year":"2022","journal-title":"J. Mater. Chem. B"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9286","DOI":"10.1039\/D2NR02305A","article-title":"Dynamic self-assembling supramolecular dendrimer nanosystems as potent antibacterial candidates against drug-resistant bacteria and biofilms","volume":"14","author":"Dhumal","year":"2022","journal-title":"Nanoscale"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1021\/acsinfecdis.3c00425","article-title":"Amphiphilic dendrimer as potent antibacterial against drug-resistant bacteria in mouse models of human infectious diseases","volume":"10","author":"King","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"8117","DOI":"10.1126\/sciadv.adn8117","article-title":"Targeting the phosphatidylglycerol lipid: An amphiphilic dendrimer as a promising antibacterial candidate","volume":"10","author":"Zhang","year":"2024","journal-title":"Sci. Adv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"115928","DOI":"10.1016\/j.carbpol.2020.115928","article-title":"Chitosan derivatives co-delivering nitric oxide and methicillin for the effective therapy to the methicillin-resistant S. aureus infection","volume":"234","author":"Liu","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6486","DOI":"10.1039\/D1BM01077H","article-title":"Fluorescent carbon dots with a high nitric oxide payload for effective antibacterial activity and bacterial imaging","volume":"9","author":"Liu","year":"2021","journal-title":"Biomater. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"145316","DOI":"10.1016\/j.cej.2023.145316","article-title":"Glutathione-responsive sulfur dioxide-releasing dendronized chitooligosaccharide polymer for effective treatment of multidrug-resistant bacterial infection","volume":"474","author":"Yu","year":"2023","journal-title":"Chem. Eng. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ijpharm.2008.04.045","article-title":"Brain and muscle of Wistar rats are the main targets of intravenous dendrimeric sulfadiazine","volume":"360","author":"Prieto","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1021\/acs.bioconjchem.0c00121","article-title":"Platensimycin-encapsulated poly(lactic-co-glycolic acid) and poly(amidoamine) dendrimers nanoparticles with enhanced anti-staphylococcal activity in vivo","volume":"31","author":"Liu","year":"2020","journal-title":"Bioconjugate Chem."},{"key":"ref_51","unstructured":"(2026, March 25). World Health Organization Global Tuberculosis Report 2025. Available online: https:\/\/www.who.int\/teams\/global-programme-on-tuberculosis-and-lung-health\/tb-reports\/global-tuberculosis-report-2025."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Sanhueza, C., Vergara, D., Chavez-Aravena, C., Galvez-Jiron, F., Chavez-Angel, E., and Castro-Alvarez, A. (2023). Functionalizing dendrimers for targeted delivery of bioactive molecules to macrophages: A potential treatment for Mycobacterium tuberculosis infection\u2014A review. Pharmaceuticals, 16.","DOI":"10.3390\/ph16101428"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.powtec.2015.12.037","article-title":"Pulmonary delivery of rifampicin microspheres using lower generation polyamidoamine dendrimers as a carrier","volume":"291","author":"Rajabnezhad","year":"2016","journal-title":"Powder Technol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"101185","DOI":"10.1016\/j.nantod.2021.101185","article-title":"Adjuvant-like biomimetic nanovesicles combat New Delhi metallo-\u03b2-lactamases (NDMs) producing superbugs infections","volume":"38","author":"Wu","year":"2021","journal-title":"Nano Today"},{"key":"ref_55","first-page":"4568","article-title":"Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitro","volume":"6","author":"Huang","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/j.dental.2021.06.003","article-title":"A novel anticaries agent, honokiol-loaded poly(amido amine) dendrimer, for simultaneous long-term antibacterial treatment and remineralization of demineralized enamel","volume":"37","author":"Tao","year":"2021","journal-title":"Dent. Mater."},{"key":"ref_57","first-page":"254","article-title":"pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats","volume":"18","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"12085","DOI":"10.1039\/D5TB01477H","article-title":"Multifunctional PAMAM nanoparticles with sequential antimicrobial-remineralization therapy for dentin caries management","volume":"13","author":"Liu","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Luo, J., Lin, X., Li, L., Tan, J., and Li, P. (2022). \u03b2-Cyclodextrin and oligoarginine peptide-based dendrimer-entrapped gold nanoparticles for improving drug delivery to the inner ear. Front. Bioeng. Biotechnol., 10.","DOI":"10.3389\/fbioe.2022.921652"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"15163","DOI":"10.1021\/acsami.8b02527","article-title":"A nanocomposite hydrogel with potent and broad-spectrum antibacterial activity","volume":"10","author":"Dai","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s12010-021-03764-w","article-title":"Dendrimer-functionalized metal oxide nanoparticle-mediated self-assembled collagen scaffold for skin regenerative application: Function of metal in metal oxides","volume":"194","author":"Vedhanayagam","year":"2022","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"113850","DOI":"10.1016\/j.jconrel.2025.113850","article-title":"Amphiphilic dendrimer-assisted delivery of antisense nucleic acid mimics against E. coli","volume":"384","author":"Gomes","year":"2025","journal-title":"J. Control. Release"},{"key":"ref_63","unstructured":"Denkewalter, R.G., Jaroslav, K., and Lukasavage, W.J. (1979). Macromolecular Highly Branched Homogeneous Compound Based on Lysine Units. (US4289872A), U.S. Patent."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Caminade, A.-M. (2022). Dendrimers, an emerging opportunity in personalized medicine?. J. Pers. Med., 12.","DOI":"10.3390\/jpm12081334"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1021\/mp050023q","article-title":"Dendrimers as drugs: Discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention","volume":"2","author":"McCarthy","year":"2005","journal-title":"Mol. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1128\/AAC.44.9.2471-2474.2000","article-title":"Dendrimers, a new class of candidate topical microbicides with activity against herpes simplex virus infection","volume":"44","author":"Bourne","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1128\/AAC.47.12.3784-3788.2003","article-title":"Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes","volume":"47","author":"Bernstein","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/aid.2005.21.207","article-title":"SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques","volume":"21","author":"Jiang","year":"2005","journal-title":"AIDS Res. Hum. Retrovir."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1128\/AAC.50.5.1696-1700.2006","article-title":"Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model","volume":"50","author":"Patton","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Tyssen, D., Henderson, S.A., Johnson, A., Sterjovski, J., Moore, K., La, J., Zanin, M., Sonza, S., Karellas, P., and Giannis, M.P. (2010). Structure activity relationship of dendrimer microbicides with dual action antiviral activity. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0012309"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1071\/SH07093","article-title":"Attitudes of men in an Australian male tolerance study towards microbicide use","volume":"5","author":"Holmes","year":"2008","journal-title":"Sex. Health"},{"key":"ref_72","first-page":"125","article-title":"Australian men\u2019s experiences during a microbicide male tolerance study","volume":"21","author":"Rosenthal","year":"2009","journal-title":"AIDS Care-Psychol. Socio-Med. Asp. AIDS\/HIV"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/QAI.0b013e318198a7e6","article-title":"A randomized controlled trial of the safety of candidate microbicide SPL7013 gel when applied to the penis","volume":"50","author":"Chen","year":"2009","journal-title":"JAIDS-J. Acquir. Immune Defic. Syndr."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/OLQ.0b013e3181bc0aac","article-title":"Safety, Tolerability, and pharmacokinetics of SPL7013 gel (VivaGel (R)): A dose ranging, Phase I study","volume":"37","author":"Millwood","year":"2010","journal-title":"Sex. Transm. Dis."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Cohen, C.R., Brown, J., Moscicki, A.B., Bukusi, E.A., Paull, J.R.A., Price, C.F., and Shiboski, S. (2011). A Phase I randomized placebo controlled trial of the safety of 3% SPL7013 gel (VivaGel (R)) in healthy young women administered twice daily for 14 days. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0016258"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/QAI.0b013e31823f2aeb","article-title":"Measurement of mucosal biomarkers in a Phase 1 trial of intravaginal 3% StarPharma LTD 7013 gel (VivaGel) to assess expanded safety","volume":"59","author":"Moscicki","year":"2012","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/aji.12412","article-title":"Soluble immune mediators and vaginal bacteria impact innate genital mucosal antimicrobial activity in young women","volume":"74","author":"Madan","year":"2015","journal-title":"Am. J. Reprod. Immunol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1097\/QAD.0b013e328346bd3e","article-title":"Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004)","volume":"25","author":"McGowan","year":"2011","journal-title":"AIDS"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s10461-011-0028-6","article-title":"\u201cTell Juliana\u201d: Acceptability of the candidate microbicide VivaGel\u00ae and two placebo gels among ethnically diverse, sexually active young women participating in a Phase 1 microbicide study","volume":"16","author":"Giguere","year":"2012","journal-title":"AIDS Behav."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Price, C.F., Tyssen, D., Sonza, S., Davie, A., Evans, S., Lewis, G.R., Xia, S., Spelman, T., Hodsman, P., and Moench, T.R. (2011). SPL7013 gel (VivaGel (R)) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0024095"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Waldbaum, A.S., Schwebke, J.R., Paull, J.R.A., Price, C.F., Edmondson, S.R., Castellarnau, A., McCloud, P., and Kinghorn, G.R. (2020). A phase 2, double-blind, multicenter, randomized, placebo-controlled, dose-ranging study of the efficacy and safety of Astodrimer Gel for the treatment of bacterial vaginosis. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0232394"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejogrb.2019.11.032","article-title":"Two phase 3, double-blind, placebo-controlled studies of the efficacy and safety of Astodrimer 1% Gel for the treatment of bacterial vaginosis","volume":"245","author":"Chavoustie","year":"2020","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_83","first-page":"100121","article-title":"A phase 3, randomized, controlled trial of Astodrimer 1% Gel for preventing recurrent bacterial vaginosis","volume":"10","author":"Schwebke","year":"2021","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol.-X"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00404-022-06429-z","article-title":"Astodrimer sodium and bacterial vaginosis: A mini review","volume":"306","author":"Mendling","year":"2022","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Romanowski, E.G., Yates, K.A., Paull, J.R.A., Heery, G.P., and Shanks, R.M.Q. (2021). Topical Astodrimer sodium, a non-toxic polyanionic dendrimer, demonstrates antiviral activity in an experimental ocular adenovirus infection model. Molecules, 26.","DOI":"10.3390\/molecules26113419"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Paull, J.R.A., Luscombe, C.A., Castellarnau, A., Heery, G.P., Bobardt, M.D., and Gallay, P.A. (2021). Protective effects of Astodrimer sodium 1% nasal spray formulation against SARS-CoV-2 nasal challenge in K18-hACE2 mice. Viruses, 13.","DOI":"10.3390\/v13081656"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"10210","DOI":"10.1038\/s41598-022-14601-3","article-title":"Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial","volume":"12","author":"Castellarnau","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Winchester, S., Castellarnau, A., Jabbar, K., Nadir, M., Ranasinghe, K., Masramon, X., Kinghorn, G.R., John, I., and Paull, J.R.A. (2024). Astodrimer sodium nasal spray versus placebo in non-hospitalised patients with COVID-19: A randomised, double-blinded, placebo-controlled trial. Pharmaceutics, 16.","DOI":"10.3390\/pharmaceutics16091173"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"23659","DOI":"10.1021\/acsnano.5c02488","article-title":"Nanoflower-mediated gallium-protoporphyrin IX complex for intracellular antibacterial and immunomodulatory effects in macrophage-targeted therapy","volume":"19","author":"Zhou","year":"2025","journal-title":"ACS Nano"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2304381","DOI":"10.1002\/adfm.202304381","article-title":"Reactive oxygen species-activated CO versatile nanomedicine with innate gut immune and microbiome remodeling effects for treating inflammatory bowel disease","volume":"33","author":"Zeng","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"ref_91","first-page":"212","article-title":"Saliva-acquired pellicle inspired multifunctional gargle with wet adhesion, photodynamic antimicrobial, and in situ remineralization properties for dental caries prevention","volume":"47","author":"Shi","year":"2025","journal-title":"Bioact. Mater."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"22479","DOI":"10.1021\/acsami.0c01967","article-title":"Ultra-efficient antibacterial system based on photodynamic therapy and CO gas therapy for synergistic antibacterial and ablation biofilms","volume":"12","author":"Ma","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1021\/acsami.9b18720","article-title":"Fast and high strength soft tissue bioadhesives based on a peptide dendrimer with antimicrobial properties and hemostatic ability","volume":"12","author":"Zhu","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"102925","DOI":"10.1016\/j.jddst.2021.102925","article-title":"Synthesis, characterization and topical application of novel bifunctional peptide metallodendrimer","volume":"66","author":"Pukale","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Scorciapino, M.A., Serra, I., Manzo, G., and Rinaldi, A.C. (2017). Antimicrobial dendrimeric peptides: Structure, activity and new therapeutic applications. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18030542"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1021\/acsinfecdis.3c00624","article-title":"Peptide dendrimer-based antibacterial agents: Synthesis and applications","volume":"10","author":"Paul","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5804","DOI":"10.1167\/iovs.10-5388","article-title":"Nanosized dendritic polyguanidilyated translocators for enhanced solubility, permeability, and delivery of gatifloxacin","volume":"51","author":"Durairaj","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1021\/jacs.7b11037","article-title":"Lipidated peptide dendrimers killing multidrug-resistant bacteria","volume":"140","author":"Siriwardena","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"12827","DOI":"10.1002\/anie.201409270","article-title":"Combining topology and sequence design for the discovery of potent antimicrobial peptide dendrimers against multidrug-resistant pseudomonas aeruginosa","volume":"53","author":"Stach","year":"2014","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"8483","DOI":"10.1002\/anie.201802837","article-title":"Optimizing antimicrobial peptide dendrimers in chemical space","volume":"57","author":"Siriwardena","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.2147\/IDR.S168868","article-title":"Peptide dendrimers as \u201clead compounds\u201d for the treatment of chronic lung infections by Pseudomonas aeruginosa in cystic fibrosis patients: In vitro and in vivo studies","volume":"11","author":"Pompilio","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"15824","DOI":"10.1021\/acsnano.1c03301","article-title":"Self-assembling peptide dendron nanoparticles with high stability and a multimodal antimicrobial mechanism of action","volume":"15","author":"Lai","year":"2021","journal-title":"ACS Nano"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"154171","DOI":"10.1016\/j.cej.2024.154171","article-title":"Nontoxic and proteolytic-resistant self-assembled peptide dendrimer aggregates to combat multidrug-resistant gram-negative bacterial infections","volume":"496","author":"Lai","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1021\/acsinfecdis.2c00089","article-title":"Antisense peptide nucleic acid-diaminobutanoic acid dendron conjugates with SbmA-independent antimicrobial activity against Gram-negative bacteria","volume":"8","author":"Iubatti","year":"2022","journal-title":"ACS Infect. Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"116451","DOI":"10.1016\/j.ejmech.2024.116451","article-title":"Arginine and tryptophan-rich dendritic antimicrobial peptides that disrupt membranes for bacterial infection in vivo","volume":"271","author":"Yang","year":"2024","journal-title":"Eur. J. Med. Chem."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1021\/ma00057a013","article-title":"Synthesis of novel carbosilane dendritic macromolecules","volume":"26","author":"Zhou","year":"1993","journal-title":"Macromolecules"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"7669","DOI":"10.1073\/pnas.112058999","article-title":"A therapeutic agent with oriented carbohydrates for treatment of infections by Shiga toxin-producing Escherichia coli O157: H7","volume":"99","author":"Nishikawa","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1002\/anie.199415891","article-title":"A general synthetic strategy for neutral phosphorus-containing dendrimers","volume":"33","author":"Launay","year":"1994","journal-title":"Angew. Chem.-Int. Ed. Engl."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"114296","DOI":"10.1016\/j.eurpolymj.2025.114296","article-title":"Phosphorus-containing dendrimers: Another type of phosphorus polymers, and their properties","volume":"239","author":"Turrin","year":"2025","journal-title":"Eur. Polym. J."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1021\/acs.biomac.1c00355","article-title":"Safe polycationic dendrimers as potent oral in vivo inhibitors of Mycobacterium tuberculosis: A new therapy to take down tuberculosis","volume":"22","author":"Mignani","year":"2021","journal-title":"Biomacromolecules"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"116289","DOI":"10.1016\/j.biopha.2024.116289","article-title":"Polycationic phosphorous dendrimer potentiates multiple antibiotics against drug-resistant mycobacterial pathogens","volume":"173","author":"Imran","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.1021\/acs.biomac.3c00266","article-title":"Low-generation cationic phosphorus dendrimers: Novel approach to tackle drug-resistant S. aureus in vitro and in vivo","volume":"24","author":"Apartsin","year":"2023","journal-title":"Biomacromolecules"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"4240","DOI":"10.1021\/ma990090w","article-title":"Controlled synthesis of hyperbranched polyglycerols by ring-opening multibranching polymerization","volume":"32","author":"Sunder","year":"1999","journal-title":"Macromolecules"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1389-0352(01)00063-0","article-title":"Dendritic polyglycerol: A new versatile biocompatible-material","volume":"90","author":"Frey","year":"2002","journal-title":"Rev. Mol. Biotechnol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/adma.200902144","article-title":"Dendritic polyglycerols for biomedical applications","volume":"22","author":"Calderon","year":"2010","journal-title":"Adv. Mater."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.xphs.2020.04.015","article-title":"Boric acid, a Lewis acid with unique and unusual properties: Formulation implications","volume":"109","author":"Lopalco","year":"2020","journal-title":"J. Pharm. Sci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1163\/156856206777346313","article-title":"Physicochemical and antimicrobial properties of boron-complexed polyglycerol-chitosan dendrimers","volume":"17","author":"Abraham","year":"2006","journal-title":"J. Biomater. Sci.-Polym. Ed."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e202425069","DOI":"10.1002\/anie.202425069","article-title":"Modular synthesis of dendritic oligo-glycerol cationic surfactants for enhanced antibacterial efficacy","volume":"64","author":"Hanheiser","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Zamboulis, A., Nakiou, E.A., Christodoulou, E., Bikiaris, D.N., Kontonasaki, E., Liverani, L., and Boccaccini, A.R. (2019). Polyglycerol hyperbranched polyesters: Synthesis, properties and pharmaceutical and biomedical applications. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246210"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2018.10.005","article-title":"A hybrid of mPEG-b-PCL and G1-PEA dendrimer for enhancing delivery of antibiotics","volume":"290","author":"Omolo","year":"2018","journal-title":"J. Control. Release"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1801619","DOI":"10.1002\/adhm.201801619","article-title":"Antibiotic-free cationic dendritic hydrogels as surgical-site-infection-inhibiting coatings","volume":"8","author":"Andren","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"111683","DOI":"10.1016\/j.jphotobiol.2019.111683","article-title":"Synthesis and effect of pegylation on citric acid dendritic nano architectures anchored with cefotaxime sodium","volume":"201","author":"Valikala","year":"2019","journal-title":"J. Photochem. Photobiol. B-Biol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/acs.biomac.2c01128","article-title":"Facially amphiphilic skeleton-derived antibacterial cationic dendrimers","volume":"24","author":"Le","year":"2023","journal-title":"Biomacromolecules"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5162","DOI":"10.1002\/anie.201200362","article-title":"Biocompatible polyurea dendrimers with pH-dependent fluorescence","volume":"51","author":"Restani","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jconrel.2020.12.021","article-title":"Dendrimers against fungi\u2014A state of the art review","volume":"330","author":"Mlynarczyk","year":"2021","journal-title":"J. Control. Release"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1039\/D2BM00679K","article-title":"Core-shell polycationic polyurea pharmadendrimers: New-generation of sustainable broad-spectrum antibiotics and antifungals","volume":"10","author":"Pinto","year":"2022","journal-title":"Biomater. Sci."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"14360","DOI":"10.1021\/acsomega.9b02221","article-title":"Evolving concept of activity cliffs","volume":"4","author":"Stumpfe","year":"2019","journal-title":"ACS Omega"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1021\/ci060117s","article-title":"On outliers and activity cliffs\u2014Why QSAR often disappoints","volume":"46","author":"Maggiora","year":"2006","journal-title":"J. Chem. Inf. Model."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"7722","DOI":"10.1038\/ncomms8722","article-title":"The key role of the scaffold on the efficiency of dendrimer nanodrugs","volume":"6","author":"Caminade","year":"2015","journal-title":"Nat. Comm."}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/7\/851\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:16:42Z","timestamp":1784175402000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/7\/851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":129,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["pharmaceutics18070851"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18070851","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}