{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:44:30Z","timestamp":1785437070722,"version":"3.56.0"},"reference-count":75,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sakarya University of Applied Sciences","award":["244-2024"],"award-info":[{"award-number":["244-2024"]}]},{"award":["244-2024"],"award-info":[{"award-number":["244-2024"]}],"id":[{"id":"https:\/\/ror.org\/01shwhq58","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Background\/Objectives: An evaluation of the sensitizing properties of chloroindium(III) phthalocyanine complex (InPc) bearing 4-sulfonylphenoxy groups was performed. Methods: The ability to form singlet oxygen under light exposure was assessed, and the quantum yield \u03a6\u0394 was calculated to be 0.82 \u00b1 0.04. Under ultrasound exposure of the sensitizer (1 MHz, 3 W, 40% duty cycle), significant 1,3-diphenylisobenzofuran decomposition was observed. Results: Moreover, the macrocycle was assigned to be a moderate\u2013high photo- and sonostable sensitizer. Density functional theory studies supported experimental results, suggesting the InPc to be a good photochemical agent. From the global reactivity parameters analysis, it can be suggested that InPc would interact easily with electron-excess species, such as various free radicals, in the solution phase, and should also be able to interact with electrophilic species. Conclusions: Studied InPc revealed high photodynamic antimicrobial activity and reached &gt;4 log10 reduction in microbial growth against methicillin-resistant Staphylococcus aureus, and 4.08 \u00b1 0.29 log10 against Candida albicans resistant to fluconazole (for dosimetry of 100 \u03bcM and 50 J\/cm2). Interestingly, the photosensitizer studied was inactive against extended-spectrum \u03b2-lactamase-producing Escherichia coli.<\/jats:p>","DOI":"10.3390\/pharmaceutics18070874","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T12:00:17Z","timestamp":1784548817000},"page":"874","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potent Antimicrobial Chloroindium(III) Phthalocyanine Sensitizer Targeting Drug-Resistant Microbes: Physicochemical, Photobiological Validation and DFT Insights"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1187-5968","authenticated-orcid":false,"given":"Aleksandra","family":"Pawska","sequence":"first","affiliation":[{"name":"Poznan University of Medical Sciences, Department of Inorganic and Analytical Chemistry, Rokietnicka 3, 60-806 Poznan, Poland"},{"name":"Poznan University of Medical Sciences, Department of Genetics and Pharmaceutical Microbiology, Rokietnicka 3, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8857-3118","authenticated-orcid":false,"given":"Aleksey E.","family":"Kuznetsov","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Universidad T\u00e9cnica Federico Santa Mar\u00eda, Av. Santa Mar\u00eda 6400, Vitacura, Santiago 7660251, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5735-5426","authenticated-orcid":false,"given":"Marianna","family":"Szczepaniak","sequence":"additional","affiliation":[{"name":"Poznan University of Medical Sciences, Department of Inorganic and Analytical Chemistry, Rokietnicka 3, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4923-9982","authenticated-orcid":false,"given":"Daniel","family":"Ziental","sequence":"additional","affiliation":[{"name":"Poznan University of Medical Sciences, Department of Inorganic and Analytical Chemistry, Rokietnicka 3, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-3936","authenticated-orcid":false,"given":"Emre","family":"G\u00fczel","sequence":"additional","affiliation":[{"name":"Department of Engineering Fundamental Sciences, Sakarya University of Applied Sciences, 54050 Sakarya, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5062-4503","authenticated-orcid":false,"given":"Lukasz","family":"Sobotta","sequence":"additional","affiliation":[{"name":"Poznan University of Medical Sciences, Department of Inorganic and Analytical Chemistry, Rokietnicka 3, 60-806 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1021\/acsabm.3c01078","article-title":"Hybrid Sono-Photodynamic Combination Therapy Mediated by Water-Soluble Gallium Phthalocyanine Enhances the Cytotoxic Effect against Breast Cancer Cell Lines","volume":"7","author":"Turkkol","year":"2024","journal-title":"ACS Appl. 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