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Methods: In this study, an integrated multi-omics strategy combining SILAC-based quantitative proteomics, shotgun lipidomics, and targeted metabolomics was applied to characterize the biomolecular response of MDA-MB-231 cells following exposure to the Ag@MSN-Tf-SeNPs nanosystem. Results and Conclusions: The complementary analytical platforms provided a comprehensive and system-level view of the cytotoxic effects induced by the nanosystem, highlighting its potential as an antitumoral nanotherapeutic approach. Exposure resulted in reduced cell growth and metastatic potential, associated with DNA damage-induced cell-cycle arrest, disruption of protein biosynthesis, and impaired protein quality control linked to Ca2+ homeostasis imbalance. In addition, significant alterations in lipid metabolism were observed, including disruption of cholesterol biosynthesis. These changes, together with disturbances in glycolysis and the tricarboxylic acid cycle, and alterations in NAD+\/NADH balance, indicate the induction of oxidative stress driven by reactive oxygen species accumulation. Furthermore, the integration of multi-omics data revealed the activation of compensatory mechanisms aimed at restoring cellular homeostasis, including metabolic rewiring and stress-response pathways, although these responses were insufficient to counteract nanosystem-induced cytotoxicity.<\/jats:p>","DOI":"10.3390\/pharmaceutics18080919","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:11:56Z","timestamp":1785168716000},"page":"919","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systems-Level Multi-Omics Analysis Resolves the Mechanism of Action of a Novel Multifunctional Nanosystem Against Triple-Negative Breast Cancer"],"prefix":"10.3390","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2633-753X","authenticated-orcid":false,"given":"Mar\u00eda Pilar","family":"Buendia-Nacarino","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7628-7368","authenticated-orcid":false,"given":"Dominik","family":"Bulfon","sequence":"additional","affiliation":[{"name":"Cell Death and Metabolism, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Institute, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Tom","sequence":"additional","affiliation":[{"name":"Lipidomics Core Facility, Danish Cancer Institute, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel","family":"Rohde","sequence":"additional","affiliation":[{"name":"Cell Death and Metabolism, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Institute, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesut","family":"Bilgin","sequence":"additional","affiliation":[{"name":"Lipidomics Core Facility, Danish Cancer Institute, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5950-7111","authenticated-orcid":false,"given":"Marja","family":"J\u00e4\u00e4ttel\u00e4","sequence":"additional","affiliation":[{"name":"Cell Death and Metabolism, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Institute, 2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luz","family":"Mena","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Alvarez-Fernandez Garcia","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6273-0349","authenticated-orcid":false,"given":"Jose L.","family":"Luque-Garcia","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Chemical Sciences, Complutense University of Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Freihat, O., Sipos, D., and Kovacs, A. (2025). Global burden and projections of breast cancer incidence and mortality to 2050: A comprehensive analysis of GLOBOCAN data. Front. Public Health, 13.","DOI":"10.3389\/fpubh.2025.1622954"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s12032-025-03066-9","article-title":"Triple-negative breast cancer: Challenges, advances, and promising therapeutic interventions","volume":"42","author":"Sood","year":"2025","journal-title":"Med. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1039\/C8NR07667G","article-title":"Cancer cell targeting and therapeutic delivery of silver nanoparticles by mesoporous silica nanocarriers: Insights into the action mechanisms using quantitative proteomics","volume":"11","author":"Gonzalez","year":"2019","journal-title":"Nanoscale"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: Pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Singal. Transduct. Target. Ther."},{"key":"ref_5","first-page":"100268","article-title":"Nanotechnology-based drug delivery for breast cancer treatment: Current applications and future directions","volume":"14","author":"Samad","year":"2025","journal-title":"Eur. J. Med. Chem. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Shahalaei, M., Azad, A.K., Sulaiman, W.M.A.W., Derakhshani, A., Mofakham, E.B., Mallandrich, M., Kumarasamy, V., and Subramaniyan, V. (2024). A review of metallic nanoparticles: Present issues and prospects focused on the preparation methods, characterization techniques, and their theranostic applications. Front. Chem., 12.","DOI":"10.3389\/fchem.2024.1398979"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"7685","DOI":"10.1002\/chem.202001112","article-title":"Rhodium nanoparticles as a novel photosensitizing agent in photodynamic therapy against cancer","volume":"26","author":"Machuca","year":"2020","journal-title":"Chem. Eur. J."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Aragoneses-Cazorla, G., Buendia-Nacarino, M.P., Mena, M.L., and Luque-Garcia, J.L. (2022). A multi-omics approach to evaluate the toxicity mechanisms associated with silver nanoparticles exposure. Nanomaterials, 12.","DOI":"10.3390\/nano12101762"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1096\/fba.2019-00021","article-title":"Silver nanoparticles selectively treat triple-negative breast cancer cells without affecting non-malignant breast epithelial cells in vitro and in vivo","volume":"1","author":"Swanner","year":"2019","journal-title":"FASEB BioAdv."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Okur, E.E., Akda\u015f\u00e7i, E., Eker, F., Bechelany, M., and Karav, S. (2026). Silver nanoparticles as anticancer agents: Mechanisms insight, current studies, and limitations. Pharmaceuticals, 19.","DOI":"10.3390\/ph19020241"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s00604-023-05712-3","article-title":"Integrated transcriptomics and metabolomics analysis reveals the biomolecular mechanisms associated to the antitumoral potential of a novel silver-based core@shell nanosystem","volume":"190","author":"Gonzalez","year":"2023","journal-title":"Microchim. Acta"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107155","DOI":"10.1016\/j.jddst.2025.107155","article-title":"SILAC-based nuclear proteomics uncovers antitumor mechanisms of selenium nanoparticles with in vivo validation in a melanoma model","volume":"111","author":"Estevez","year":"2025","journal-title":"J. Drug Deliv. Sci. Tech."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Estevez, H., Garcia-Calvo, E., Rivera-Torres, J., Vallet-Regi, M., Gonzalez, B., and Luque-Garcia, J.L. (2021). Transcriptome analysis identifies novel mechanisms associated with the antitumor effect of chitosan-stabilized selenium nanoparticles. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13030356"},{"key":"ref_14","first-page":"e70210","article-title":"Selenium nanoparticles in cancer therapy: Unveiling cytotoxic mechanisms and therapeutic potential","volume":"8","author":"Anjum","year":"2025","journal-title":"Cancer Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2408898","DOI":"10.1002\/smll.202408898","article-title":"Smart mesoporous silica nanoparticles in cancer: Diagnosis, treatment, immunogenicity, and clinical Translation","volume":"21","author":"Yousefiasl","year":"2025","journal-title":"Small"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"140143","DOI":"10.1016\/j.jcis.2026.140143","article-title":"A third-generation rhodium-based nanophotosensitizer for precision photodynamic cancer therapy","volume":"713","author":"Machuca","year":"2026","journal-title":"J. Colloid Interface Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.5306\/wjco.v15.i6.667","article-title":"Silica nanoparticle design for colorectal cancer treatment: Recent progress and clinical potential","volume":"15","author":"Meng","year":"2024","journal-title":"World J. Clin. Oncol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1039\/D1QI00143D","article-title":"A novel hemocompatible core@shell nanosystem for selective targeting and apoptosis induction in cancer cells","volume":"8","author":"Gonzalez","year":"2021","journal-title":"Inorg. Chem. Front."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e202100287","DOI":"10.1002\/tcr.202100287","article-title":"Silver mesoporous silica nanoparticles: Fabrication to combination therapies for cancer and infection","volume":"22","author":"He","year":"2022","journal-title":"Chem. Rec."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"136387","DOI":"10.1016\/j.colsurfa.2025.136387","article-title":"Silver-functionalized mesoporous silica nanoparticle coatings: Optimal thermal stability and ionic activity for antimicrobial applications","volume":"711","author":"Yohai","year":"2025","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"115613","DOI":"10.1016\/j.colsurfb.2026.115613","article-title":"Silver-selenium hybrid nanocomposite with combined cytotoxic and metabolic reprogramming effects in triple-negative breast cancer","volume":"263","author":"Gonzalez","year":"2026","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Machuca, A., Garcia-Calvo, E., Anunciacao, D.S., and Luque-Garcia, J.L. (2021). Integration of transcriptomics and metabolomics to reveal the molecular mechanisms underlying rhodium nanoparticles-based photodynamic cancer therapy. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13101629"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"114992","DOI":"10.1016\/j.addr.2023.114992","article-title":"Omics approaches for the assessment of biological responses to nanoparticles","volume":"200","author":"Abdelkader","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12672-025-04088-5","article-title":"Omics-enhanced nanomedicine: Integrating multi-omics for precision cancer diagnosis and therapy","volume":"17","author":"Yan","year":"2026","journal-title":"Discov. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"100565","DOI":"10.1016\/j.impact.2025.100565","article-title":"Navigating nanotoxicity: Unravelling nanomaterial-induced effects via multi-omics integration","volume":"38","author":"Wang","year":"2025","journal-title":"NanoImpact"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1021\/jasms.9b00136","article-title":"Comprehensive evaluation of a quantitative shotgun lipidomics platform for mammalian sample analysis on a high-resolution mass spectrometer","volume":"31","author":"Nielsen","year":"2020","journal-title":"J. Am. Soc. Mass. Spec."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1080\/15548627.2015.1063871","article-title":"Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin punctual assay","volume":"11","author":"Aits","year":"2015","journal-title":"Autophagy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/nar\/24.3.486","article-title":"Differential effect of H1 variant overexpression on cell cycle progression and gene expression","volume":"24","author":"Brown","year":"1996","journal-title":"Nucleic Acids Res."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Xu, J., Li, Z., Zuo, X., Li, G., Zhang, X., Zhang, B., and Cui, Y. (2022). Knockdown of NAA25 suppresses breast cancer progression by regulating apoptosis and cell cycle. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.755267"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Hooper, N.M., and Lendeckel, Y. (2004). The puromycin-sensitive aminopeptidase proliferative disorders. Aminopeptidases in Biology and Disease, Springer. Proteases in Biology and Disease.","DOI":"10.1007\/978-1-4419-8869-0"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3001922","DOI":"10.1126\/scitranslmed.3001922","article-title":"Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer","volume":"3","author":"Ito","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11003","DOI":"10.1038\/s41598-025-95505-w","article-title":"Predictive and clinicopathological importance of HMGB2 in various carcinomas: A meta and bioinformatic approach","volume":"15","author":"Zhu","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.21037\/jgo-21-628","article-title":"Identification of potential core genes in gastric cancer using bioinformatics analysis","volume":"12","author":"Shao","year":"2021","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"101936","DOI":"10.1016\/j.molmet.2024.101936","article-title":"Roles and therapeutic targeting of ceramide metabolism in cancer","volume":"83","author":"Wajapeyee","year":"2024","journal-title":"Mol. Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41419-017-0143-z","article-title":"Downregulation of annexin A3 inhibits tumor metastasis and decreases drug resistance in breast cancer","volume":"9","author":"Du","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00418-015-1359-6","article-title":"Differential requirements for H\/ACA ribonucleoprotein components in cell proliferation and response to DNA damage","volume":"144","author":"Lin","year":"2015","journal-title":"Histochem. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cellsig.2013.01.016","article-title":"TCEA3 binds to TGF-beta receptor I and induces Smad-independent, JNK-dependent apoptosis in ovarian cancer cells","volume":"25","author":"Cha","year":"2013","journal-title":"Cell. Signal."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"14694","DOI":"10.1038\/s41598-024-64687-0","article-title":"KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells","volume":"14","author":"Paizula","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ceb.2017.05.007","article-title":"Translational control and the cancer cell response to stress","volume":"45","author":"Robichaud","year":"2017","journal-title":"Curr. Opin. Cell Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.ajpath.2020.01.010","article-title":"Endoplasmic reticulum stress signaling in cancer cells","volume":"190","author":"Oakes","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.gene.2017.03.005","article-title":"HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum","volume":"618","author":"Wang","year":"2017","journal-title":"Gene"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41435-023-00205-y","article-title":"Identification of heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver disease","volume":"24","author":"Rehati","year":"2023","journal-title":"Genes Immun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"13884","DOI":"10.1038\/s41598-022-17347-0","article-title":"CRELD2 is a novel modulator of calcium release and calcineurin-NFAT signalling during osteoclast differentiation","volume":"12","author":"Duxfield","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"10157","DOI":"10.1038\/s41467-024-54377-w","article-title":"PDCD6 regulates lactate metabolism to modulate LC3-associated phagocytosis and antibacterial defense","volume":"15","author":"Sun","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1111\/cas.15487","article-title":"Reticulocalbin3: A Ca2+ homeostasis regulator that promotes esophageal squamous cell carcinoma progression and cisplatin resistance","volume":"113","author":"Cai","year":"2022","journal-title":"Cancer Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.canlet.2018.05.018","article-title":"PSMD2 regulates breast cancer cell proliferation and cell cycle progression by modulating p21 and p27 proteasomal degradation","volume":"430","author":"Li","year":"2018","journal-title":"Cancer Lett."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/s41420-025-02621-7","article-title":"CYP51A1 in health and disease: From sterol metabolism to regulated cell death","volume":"11","author":"Chen","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_48","first-page":"1261","article-title":"Transcriptom-based identification of a putative role for the human acyl-CoA-binding-protein (ACBP) in vesicular trafficking","volume":"56","author":"Vock","year":"2010","journal-title":"Cell. Mol. Biol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.7150\/jca.73112","article-title":"Down-regulation of MSMO1 promotes the development and progression of pancreatic cancer","volume":"13","author":"Cao","year":"2022","journal-title":"J. Cancer"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1038\/s41467-019-10279-w","article-title":"Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition","volume":"10","author":"Long","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Zeng, C., Riad, A., and Mach, R.H. (2020). The biological function of sigma-2 receptor\/tmem97 and its utility in pet imaging studies in cancer. Cancers, 12.","DOI":"10.3390\/cancers12071877"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.aag1417","article-title":"Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann pick C1 signaling complex","volume":"355","author":"Castellano","year":"2018","journal-title":"Science"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.brainres.2016.02.051","article-title":"The role of CHMP2BIntron5 in autophagy and frontotemporal dementia","volume":"176","author":"Krasniak","year":"2016","journal-title":"Brain Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"428","DOI":"10.7150\/jca.90113","article-title":"Identification of a PANoptosis-related gene signature for predicting the prognosis, tumor microenvironment and therapy response in breast cancer","volume":"15","author":"Yu","year":"2024","journal-title":"J. Cancer"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s13046-020-01701-z","article-title":"Lysosomal dysfunction and autophagy blockade contribute to autophagy-related cancer suppressing peptide-induced","volume":"39","author":"Yang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.tranon.2018.11.014","article-title":"Exosomal release of L-plastin by breast cancer cells facilitates metastatic bone osteolysis","volume":"12","author":"Tiedemann","year":"2019","journal-title":"Transl. Oncol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1038\/s41467-017-01829-1","article-title":"The IKK\/NF-\u03baB signaling pathway requires Morgana to drive breast cancer metastasis","volume":"8","author":"Fusella","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"101579","DOI":"10.1016\/j.jbc.2022.101579","article-title":"The Rho guanine nucleotide exchange factor PLEKHG1 is activated by interaction with and phosphorylation by Src family kinase member FYN","volume":"298","author":"Nakano","year":"2022","journal-title":"J. Biol. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12192-012-0367-x","article-title":"Downregulation of Hsp27 (HSPB1) in MCF-7 human breast cancer cells induces upregulation of PTEN","volume":"18","author":"Moncalero","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41419-022-04766-0","article-title":"HspBP1 is a dual function regulatory protein that controls both DNA repair and apoptosis in breast cancer cells","volume":"13","author":"Youn","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/cas.15632","article-title":"BAIAP2L1 accelerates breast cancer progression and chemoresistance by activating AKT signaling through binding with ribosomal protein L3","volume":"114","author":"Deng","year":"2023","journal-title":"Cancer Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"S713","DOI":"10.21037\/tcr.2016.10.95","article-title":"Beyond genomics: Biologic insights from the CPTAC proteogenomic analysis of breast cancer","volume":"5","author":"Rajput","year":"2016","journal-title":"Transl. Cancer Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s11033-022-07964-3","article-title":"The expression and clinical significance of STAMBP in breast cancer","volume":"50","author":"Li","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s10565-025-10022-w","article-title":"SDH defective cancers: Molecular mechanisms and treatment strategies","volume":"41","author":"Wang","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1172\/JCI64264","article-title":"Mitochondrial complex I activity and NAD+\/NADH balance regulate breast cancer progression","volume":"123","author":"Santidrian","year":"2013","journal-title":"J. Clin. Investig."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"115500","DOI":"10.1016\/j.biopha.2023.115500","article-title":"Research progress on the pathogenesis of the SDHB mutation and related diseases","volume":"167","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"111869","DOI":"10.1016\/j.cellsig.2025.111869","article-title":"Role of ferroptosis in breast cancer: Molecular mechanisms and therapeutic interventions","volume":"134","author":"Wang","year":"2025","journal-title":"Cell Signal"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"215960","DOI":"10.1016\/j.canlet.2022.215960","article-title":"Sorbitol dehydrogenase induction of cancer cell necroptosis and macrophage polarization in the HCC microenvironment suppresses tumor progression","volume":"551","author":"Lee","year":"2022","journal-title":"Cancer Lett."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"118895","DOI":"10.1016\/j.jep.2024.118895","article-title":"Hippocampal PDHA1 gene knockout inhibits the Warburg effect leading to cognitive dysfunction and attenuates the beneficial effects of ZiBuPiYin recipe on cognition","volume":"337","author":"Zhou","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Wagner, F., Kunz, T.C., Chowdhury, S.R., Thiede, B., Fraunholz, M., Eger, D., and Kozjak-Pavlovic, V. (2019). Armadillo repeat-containing protein 1 is a dual localization protein associated with mitochondrial intermembrane space bridging complex. PLoS ONE, 14.","DOI":"10.1101\/656934"}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/8\/919\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:15:02Z","timestamp":1785168902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/8\/919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":70,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["pharmaceutics18080919"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18080919","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}