{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:37:47Z","timestamp":1786534667813,"version":"build-2736575974"},"reference-count":137,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmaceutics"],"abstract":"<jats:p>Kaempferol is a natural flavonol compound widely present in various single-herb remedies and compound formulations used for the treatment of ocular diseases. Despite its inherent pharmaceutical limitations, accumulating evidence indicates that kaempferol exerts broad protective effects against diverse ocular disorders through multiple biological pathways, highlighting its potential as a multi-target therapeutic candidate in ophthalmology. However, current evidence regarding kaempferol-based ophthalmic applications remains fragmented across different ocular diseases and mechanistic investigations, and a comprehensive evaluation of its therapeutic potential, translational challenges, and existing limitations is still lacking. This review systematically summarizes the research progress on kaempferol in the treatment of eye diseases, encompassing its source distribution, structural characteristics, ocular delivery strategies, disease spectrum coverage, molecular mechanisms, and safety profile. By critically evaluating currently available evidence, this review further identifies unresolved issues and translational barriers that hinder the clinical application of kaempferol in ophthalmology. Regarding delivery strategies, carriers such as gelatin nanoparticles, porous bovine serum albumin membranes, platelet-derived extracellular vesicles, and polyvinylpyrrolidone-based nanocomposites have preliminarily improved ocular surface retention and corneal permeability of kaempferol in models of corneal neovascularization and alkali burns. In terms of therapeutic indications, kaempferol has demonstrated protective effects in diverse experimental models, including age-related macular degeneration (AMD), diabetic retinopathy, diabetic cataract, dry eye disease, fungal keratitis, corneal transplant rejection, acute glaucoma, and retinoblastoma. At the mechanistic level, kaempferol exerts comprehensive pharmacological actions\u2014anti-inflammatory, antioxidant, metabolic regulation, anti-angiogenic, and immunomodulatory\u2014by modulating multiple signaling pathways, including MAPK, NF-\u03baB, STAT1\/IRF7, Nrf2\/HO-1, VEGF\/PI3K\/Src\/Akt\/ERK, aldose reductase, estrogen-related receptor alpha (ERR\u03b1), and the NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome. Available safety assessments suggest that kaempferol exhibits a generally favorable safety profile across ocular, cellular, systemic, and genetic evaluations. Despite these advances, the clinical translation of kaempferol in ophthalmology remains limited by insufficient clinical and pharmacokinetic evidence, underdeveloped targeted delivery strategies, and a lack of integrated understanding of its molecular basis in ocular protection. By systematically integrating evidence from ocular disease models, molecular mechanisms, delivery strategies, and safety evaluations, this review bridges fragmented knowledge regarding kaempferol-based ophthalmic applications and provides an integrated framework for understanding its therapeutic potential and translational prospects. Overall, this review highlights kaempferol as a promising multi-target therapeutic candidate for ocular diseases and provides insights into its future translational development.<\/jats:p>","DOI":"10.3390\/pharmaceutics18080996","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:02:11Z","timestamp":1786532531000},"page":"996","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kaempferol\u2019s Therapeutic Applications and Mechanistic Insights in Ocular Diseases: Current Progress, Challenges, and Translational Opportunities"],"prefix":"10.3390","volume":"18","author":[{"given":"Zhirui","family":"Ma","sequence":"first","affiliation":[{"name":"Eye School of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China"},{"name":"Eye Health with Traditional Chinese Medicine Key Laboratory of Sichuan Province, Chengdu 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dazheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye School of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Eye School of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Eye School of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China"},{"name":"Eye Health with Traditional Chinese Medicine Key Laboratory of Sichuan Province, Chengdu 610075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"114770","DOI":"10.1016\/j.addr.2023.114770","article-title":"Polymer-and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives","volume":"196","author":"Han","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Li, C., Zhu, B., Zhang, J., Guan, P., Zhang, G., Yu, H., Yang, X., and Liu, L. (2022). Epidemiology, health policy and public health implications of visual impairment and age-related eye diseases in mainland China. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.966006"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0161-6420(87)33308-1","article-title":"The dimensions of the problem of eye disease among the elderly","volume":"94","author":"Pizzarello","year":"1987","journal-title":"Ophthalmology"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Youssef, A.A.A., Cai, C., Dudhipala, N., and Majumdar, S. (2021). Design of topical ocular ciprofloxacin nanoemulsion for the management of bacterial keratitis. Pharmaceuticals, 14.","DOI":"10.3390\/ph14030210"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"114870","DOI":"10.1016\/j.addr.2023.114870","article-title":"Recent advances and future prospects: Current status and challenges of the intraocular injection of drugs for vitreoretinal diseases","volume":"198","author":"Hashida","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Rusciano, D. (2025). A personal scientific journey in ophthalmology: Twenty-Five years of translating research into novel therapies. Pharmaceuticals, 18.","DOI":"10.3390\/ph18060883"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Martiniakova, M., Sarocka, A., Penzes, N., Biro, R., Kovacova, V., Mondockova, V., Sevcikova, A., Ciernikova, S., and Omelka, R. (2025). Protective role of dietary polyphenols in the management and treatment of type 2 diabetes mellitus. Nutrients, 17.","DOI":"10.3390\/nu17020275"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1055\/a-1109-3405","article-title":"Effects of Ginkgo biloba on diseases related to oxidative stress","volume":"86","author":"Matias","year":"2020","journal-title":"Planta Medica"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.foodchem.2009.03.042","article-title":"Inhibitory effects of Chrysanthemum species extracts on formation of advanced glycation end products","volume":"116","author":"Saeki","year":"2009","journal-title":"Food Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1610751","DOI":"10.1155\/2018\/1610751","article-title":"Protection of Kaempferol on Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage","volume":"2018","author":"Du","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1089\/jop.2022.0128","article-title":"Kaempferol Protects Against Retinal Photoreceptor Degeneration in a Mouse Model of Light-Induced Retinal Injury","volume":"39","author":"Noguchi","year":"2023","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1002\/fsn3.1590","article-title":"Aucuba japonica extract inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy, with its bioactive components preventing VEGF-induced retinal vascular hyperpermeability","volume":"8","author":"Jung","year":"2020","journal-title":"Food Sci. Nutr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/s41433-018-0318-6","article-title":"Kaempferol attenuates retinal ganglion cell death by suppressing NLRP1\/NLRP3 inflammasomes and caspase-8 via JNK and NF-kappaB pathways in acute glaucoma","volume":"33","author":"Lin","year":"2019","journal-title":"Eye"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"108960","DOI":"10.1016\/j.exer.2022.108960","article-title":"Kaempferol ameliorate the prognosis of Aspergillus fumigatus keratitis by reducing fungal load and inhibiting the Dectin-1 and p38 MAPK pathway","volume":"216","author":"Jia","year":"2022","journal-title":"Exp. Eye Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"108627","DOI":"10.1016\/j.exer.2021.108627","article-title":"Kaempferol alleviates corneal transplantation rejection by inhibiting NLRP3 inflammasome activation and macrophage M1 polarization via promoting autophagy","volume":"208","author":"Tian","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Chuang, Y.L., Fang, H.W., Ajitsaria, A., Chen, K.H., Su, C.Y., Liu, G.S., and Tseng, C.L. (2019). Development of Kaempferol-Loaded Gelatin Nanoparticles for the Treatment of Corneal Neovascularization in Mice. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11120635"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11010-025-05412-x","article-title":"Deciphering the therapeutic mechanism of kaempferol in diabetic retinopathy via the P21\/Thioredoxin axis","volume":"481","author":"Zhang","year":"2026","journal-title":"Mol. Cell. Biochem."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chen, H.C., Chen, Z.Y., Wang, T.J., Drew, V.J., Tseng, C.L., Fang, H.W., and Lin, F.H. (2017). Herbal Supplement in a Buffer for Dry Eye Syndrome Treatment. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081697"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2174\/138955711795305335","article-title":"A review on the dietary flavonoid kaempferol","volume":"11","year":"2011","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chen, J., Zhong, H., Huang, Z., Chen, X., You, J., and Zou, T. (2023). A critical review of kaempferol in intestinal health and diseases. Antioxidants, 12.","DOI":"10.3390\/antiox12081642"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"135778","DOI":"10.1016\/j.foodchem.2023.135778","article-title":"Structural characterization and stability of glycated bovine serum albumin-kaempferol nanocomplexes","volume":"415","author":"Ma","year":"2023","journal-title":"Food Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"113027","DOI":"10.1016\/j.fluid.2021.113027","article-title":"Measurement and correlation of the solubility of kaempferol monohydrate in pure and binary solvents","volume":"539","author":"Li","year":"2021","journal-title":"Fluid Phase Equilibria"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.20450\/mjcce.2019.1333","article-title":"Structural characterization of kaempferol: A spectroscopic and computational study","volume":"38","year":"2019","journal-title":"Maced. J. Chem. Chem. Eng."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e202400752","DOI":"10.1002\/cbdv.202400752","article-title":"Antioxidant mechanism, spectroscopic and pharmacological properties of four flavonoids: DFT, docking and molecular dynamics","volume":"21","author":"Lai","year":"2024","journal-title":"Chem. Biodivers."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"132637","DOI":"10.1016\/j.molstruc.2022.132637","article-title":"Experimental Raman, FTIR and UV-vis spectra, DFT studies of molecular structures and barrier heights, thermodynamic functions and bioactivity of kaempferol","volume":"1258","author":"Yadav","year":"2022","journal-title":"J. Mol. Struct."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Deng, S.-P., Yang, Y.-L., Cheng, X.-X., Li, W.-R., and Cai, J.-Y. (2019). Synthesis, spectroscopic study and radical scavenging activity of kaempferol derivatives: Enhanced water solubility and antioxidant activity. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040975"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Wei, X., Wang, W., Hu, R., Gao, X., Li, B., Bai, Y., and Zhang, J. (2025). Advances in Kaempferol: Extraction, Biosynthesis, and Application with Antibacterial Agents. Antibiotics, 14.","DOI":"10.3390\/antibiotics14121254"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9966750","DOI":"10.1155\/2022\/9966750","article-title":"Flavonols and flavones as potential anti-inflammatory, antioxidant, and antibacterial compounds","volume":"2022","author":"Chagas","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"105121","DOI":"10.1016\/j.fitote.2021.105121","article-title":"Biologically active polyphenolic compounds from Lespedeza bicolor","volume":"157","author":"Tarbeeva","year":"2022","journal-title":"Fitoterapia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"109508","DOI":"10.1016\/j.intimp.2022.109508","article-title":"Endoplasmic reticulum as a therapeutic target in type 2 diabetes: Role of phytochemicals","volume":"114","author":"Sajadimajd","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e2100269","DOI":"10.1002\/mabi.202100269","article-title":"Kaempferol Incorporated Bovine Serum Albumin Fibrous Films for Ocular Drug Delivery","volume":"21","author":"Yin","year":"2021","journal-title":"Macromol. Biosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"123205","DOI":"10.1016\/j.biomaterials.2025.123205","article-title":"Platelet-derived extracellular vesicle drug delivery system loaded with kaempferol for treating corneal neovascularization","volume":"319","author":"Liu","year":"2025","journal-title":"Biomaterials"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4103\/2221-1691.387747","article-title":"Kaempferol and its derivatives: Biological activities and therapeutic potential","volume":"13","author":"Parveen","year":"2023","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.foodchem.2007.11.053","article-title":"Flavonols (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants","volume":"108","author":"Sultana","year":"2008","journal-title":"Food Chem."},{"key":"ref_35","first-page":"171","article-title":"A review of chemistry and biological activities of the genus Aerva--a desert plant","volume":"69","author":"Chawla","year":"2012","journal-title":"Acta Pol. Pharm."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8878569","DOI":"10.1155\/2020\/8878569","article-title":"A network pharmacology to explore the mechanism of Astragalus Membranaceus in the treatment of diabetic retinopathy","volume":"2020","author":"Jin","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"D\u0103escu, A.M., Nistor, M., Nicolescu, A., Pop, R., Bunea, A., Rugina, D., and Pintea, A. (2024). Antioxidant, enzyme inhibitory, and protective effect of Amelanchier lamarckii extract. Plants, 13.","DOI":"10.3390\/plants13101347"},{"key":"ref_38","first-page":"1","article-title":"Protection against oxidative stress-induced retinal cell death by compounds isolated from Ehretia asperula","volume":"16","author":"Le","year":"2021","journal-title":"Nat. Prod. Commun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuint.2010.08.005","article-title":"Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells)","volume":"57","author":"Jung","year":"2010","journal-title":"Neurochem. Int."},{"key":"ref_40","first-page":"5814221","article-title":"Phytochemical Profile and Antioxidant and Antiproliferative Activity of Sedum dendroideum on Pterygium Fibroblasts","volume":"2021","author":"Zavala","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejbt.2025.05.006","article-title":"Chufeng Yisun Decoction treat dry eye syndrome by inhibiting the PI3K\/Akt pathway","volume":"18","author":"Du","year":"2025","journal-title":"Electron. J. Biotechnol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"116794","DOI":"10.1016\/j.jpba.2025.116794","article-title":"Yi-qi-yang-yin decoction ameliorates diabetic retinopathy: New and comprehensive evidence from network pharmacology, machine learning, molecular docking and molecular biology experiment","volume":"260","author":"Huang","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e34615","DOI":"10.1097\/MD.0000000000034615","article-title":"Identification of the key mechanisms of action of Si-Ni-San in uveitis using bioinformatics and network pharmacology","volume":"102","author":"Zhang","year":"2023","journal-title":"Medicine"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"5107103","DOI":"10.1155\/2019\/5107103","article-title":"Systems-Pharmacology-Based Identification of Antitumor Necrosis Factor Effect in Mimeng Flower Decoction for the Treatment of Diabetic Retinopathy","volume":"2019","author":"Li","year":"2019","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.2147\/DMSO.S495286","article-title":"Combining network pharmacological analysis and animal experiments to explore the pharmacological mechanism of zhangyanming tablets in diabetic retinopathy","volume":"18","author":"Yang","year":"2025","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8467046","DOI":"10.1155\/2020\/8467046","article-title":"Exploring the Mechanism of Action Compound-Xueshuantong Capsule in Diabetic Retinopathy Treatment Based on Network Pharmacology","volume":"2020","author":"Li","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6657521","DOI":"10.1155\/2021\/6657521","article-title":"Network Pharmacology Analysis of Traditional Chinese Medicine Formula Shuang Di Shou Zhen Tablets Treating Nonexudative Age-Related Macular Degeneration","volume":"2021","author":"Fang","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Razavi, M.S., Ebrahimnejad, P., Fatahi, Y., D\u2019Emanuele, A., and Dinarvand, R. (2022). Recent developments of nanostructures for the ocular delivery of natural compounds. Front. Chem., 10.","DOI":"10.3389\/fchem.2022.850757"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1007\/s13346-023-01357-0","article-title":"Preparation, characterization, and evaluation of the antitumor effect of kaempferol nanosuspensions","volume":"13","author":"He","year":"2023","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_50","first-page":"1","article-title":"Biocompatibility, uptake and anti-cancer activity of doxorubicin loaded gold nanoparticles in MCF-7 breast cancer cell line","volume":"3","author":"Bhuvanasree","year":"2016","journal-title":"Nanosci. Technol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"119303","DOI":"10.1016\/j.saa.2020.119303","article-title":"Kaempferol as an AIE-active natural product probe for selective Al3+ detection in Arabidopsis thaliana","volume":"249","author":"Sun","year":"2021","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"133414","DOI":"10.1016\/j.snb.2023.133414","article-title":"Highly sensitive fluorescent turn-on lateral flow strip for chlorothalonil based on an indicator displacement ratiometric fluorescent assay","volume":"381","author":"Ren","year":"2023","journal-title":"Sens. Actuators B Chem."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Alrumaihi, F., Almatroodi, S.A., Alharbi, H.O.A., Alwanian, W.M., Alharbi, F.A., Almatroudi, A., and Rahmani, A.H. (2024). Pharmacological potential of kaempferol, a flavonoid in the management of pathogenesis via modulation of inflammation and other biological activities. Molecules, 29.","DOI":"10.3390\/molecules29092007"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s40242-013-2352-z","article-title":"Forced degradation of flavonol glycosides extraced from Ginkgo biloba","volume":"29","author":"Jin","year":"2013","journal-title":"Chem. Res. Chin. Univ."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"McKay, T.B., Emmitte, K.A., German, C., and Karamichos, D. (2023). Quercetin and related analogs as therapeutics to promote tissue repair. Bioengineering, 10.","DOI":"10.3390\/bioengineering10101127"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/bkcs.11926","article-title":"Quantification and Distribution Evaluation of Quercetin and Kaempferol in Rat Eyes after Oral Administration of EEDK Using Ultra-Performance Liquid Chromatography\u2013Tandem Mass Spectrometry","volume":"41","author":"Peng","year":"2020","journal-title":"Bull. Korean Chem. Soc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"105289","DOI":"10.1016\/j.ejps.2020.105289","article-title":"Ultra-small nanocomplexes based on polyvinylpyrrolidone K-17PF: A potential nanoplatform for the ocular delivery of kaempferol","volume":"147","author":"Zhang","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_58","first-page":"173","article-title":"Design and Evaluation of Novel in situ Gel Forming Ocular Drug Delivery System of Kaempferol for Sustain Pharmacological Response against Cataract","volume":"14","author":"Chaudhuri","year":"2023","journal-title":"Northeast. Geogr."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1089\/jop.2019.0151","article-title":"Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1","volume":"36","year":"2020","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_60","first-page":"5576","article-title":"Kaempferol targets estrogen-related receptor alpha and suppresses the angiogenesis of human retinal endothelial cells under high glucose conditions","volume":"14","author":"Wu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s13205-019-1581-3","article-title":"Dietary flavonoids inhibit the glycation of lens proteins: Implications in the management of diabetic cataract","volume":"9","author":"Patil","year":"2019","journal-title":"3 Biotech"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"613","DOI":"10.4155\/fmc-2020-0381","article-title":"Kaempferol Ameliorates the Regulatory Effects of PVT1\/miR-214 on Epithelial\u2013Mesenchymal Transition Through the PAK4\/\u03b2-catenin Axis in SRA01\/04 Cells","volume":"13","author":"Huang","year":"2021","journal-title":"Future Med. Chem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1167\/iovs.66.12.50","article-title":"Kaempferol Alleviates Dry Eye Disease Via Modulation of the IDH3B\/CCAR2\/IKBKB Axis","volume":"66","author":"Zhang","year":"2025","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1021\/acs.jmedchem.0c00053","article-title":"In Vitro and In Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria","volume":"63","author":"Lin","year":"2020","journal-title":"J. Med. Chem."},{"key":"ref_65","first-page":"21415","article-title":"Kaempferol targets estrogen-related receptor alpha and inhibits cell proliferation and invasion in retinoblastoma via Wnt\/beta-catenin signaling pathway","volume":"9","author":"Qin","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neuron.2012.06.018","article-title":"Mechanisms of age-related macular degeneration","volume":"75","author":"Ambati","year":"2012","journal-title":"Neuron"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41419-024-07150-2","article-title":"Retinal pigment epithelium-specific ablation of GPx4 in adult mice recapitulates key features of geographic atrophy in age-related macular degeneration","volume":"15","author":"Azuma","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12964-022-00973-6","article-title":"PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models","volume":"20","author":"Zhan","year":"2022","journal-title":"Cell Commun. Signal."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"102231","DOI":"10.1016\/j.coph.2022.102231","article-title":"COVID-19 and retinal degenerative diseases: Promising link \u201cKaempferol\u201d","volume":"64","author":"Firoz","year":"2022","journal-title":"Curr. Opin. Pharmacol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"119328","DOI":"10.1016\/j.jep.2025.119328","article-title":"Fractionation and identification of ocular protective compounds from kochiae fructus against oxidative damage in retinal pigment epithelium cells","volume":"341","author":"Wu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"105797","DOI":"10.1016\/j.jff.2023.105797","article-title":"Attenuation of blue light-induced photo-oxidative stress through inhibition of NF-\u03baB and MAPK signaling pathways, and activation of Nrf2 signaling pathway by djulis and its bioactive compounds","volume":"109","author":"Liu","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e202401257","DOI":"10.1002\/cbdv.202401257","article-title":"Crotalaria quinquefolia L. revealed as a potential source of neuropharmacophore in both experimental and computational studies","volume":"22","author":"Nahar","year":"2025","journal-title":"Chem. Biodivers."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejphar.2006.04.050","article-title":"Effects of quinones and flavonoids on the reduction of all-trans retinal to all-trans retinol in pig heart","volume":"540","author":"Shimada","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Zhang, H., Liu, C., Gu, C., Jiang, J., and Gao, Y. (2024). Kaempferol Alleviates Injury in Human Retinal Pigment Epithelial Cells via STAT1 Ubiquitination-Mediated Degradation of IRF7. Front. Biosci. (Landmark Ed.), 29.","DOI":"10.31083\/j.fbl2907247"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.exer.2007.04.003","article-title":"Protective effects of myricetin and related flavonols against A2E and light mediated-cell death in bovine retinal primary cell culture","volume":"85","author":"Laabich","year":"2007","journal-title":"Exp. Eye Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.lfs.2012.11.022","article-title":"Studies on \u03b1-glucosidase inhibition and anti-glycation potential of Iris loczyi and Iris unguicularis","volume":"92","author":"Mosihuzzman","year":"2013","journal-title":"Life Sci."},{"key":"ref_77","first-page":"2057333","article-title":"Hypoglycemic effects of plant flavonoids: A review","volume":"2021","author":"Darmarajan","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.fct.2017.08.004","article-title":"Biological effects and chemical characterization of Iris schachtii Markgr. extracts: A new source of bioactive constituents","volume":"112","author":"Mocan","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.phytochem.2015.04.004","article-title":"High-resolution bioactivity profiling combined with HPLC\u2013HRMS\u2013SPE\u2013NMR: \u03b1-Glucosidase inhibitors and acetylated ellagic acid rhamnosides from Myrcia palustris DC. (Myrtaceae)","volume":"116","author":"Wubshet","year":"2015","journal-title":"Phytochemistry"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1007\/s11094-021-02329-9","article-title":"Structure\u2013activity relationship and therapeutic benefits of flavonoids in the management of diabetes and associated disorders","volume":"54","author":"Lodhi","year":"2021","journal-title":"Pharm. Chem. J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0140-6736(09)62124-3","article-title":"Diabetic retinopathy","volume":"376","author":"Cheung","year":"2010","journal-title":"Lancet"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Wallsh, J.O., and Gallemore, R.P. (2021). Anti-VEGF-resistant retinal diseases: A review of the latest treatment options. Cells, 10.","DOI":"10.3390\/cells10051049"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/jamaophthalmol.2017.6565","article-title":"Persistent macular thickening following intravitreous aflibercept, bevacizumab, or ranibizumab for central-involved diabetic macular edema with vision impairment: A secondary analysis of a randomized clinical trial","volume":"136","author":"Bressler","year":"2018","journal-title":"JAMA Ophthalmol."},{"key":"ref_84","first-page":"5728408","article-title":"Investigating the mechanisms of pollen typhae in the treatment of diabetic retinopathy based on network pharmacology and molecular docking","volume":"2022","author":"Zhou","year":"2022","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"e5396","DOI":"10.1590\/1414-431x20165396","article-title":"Kaempferol inhibited VEGF and PGF expression and in vitro angiogenesis of HRECs under diabetic-like environment","volume":"50","author":"Xu","year":"2017","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1126\/science.401544","article-title":"Diabetic cataracts and flavonoids","volume":"195","author":"Varma","year":"1977","journal-title":"Science"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"130814","DOI":"10.1016\/j.bbagen.2025.130814","article-title":"Systemically administered mini \u03b1-crystallin peptide delays cataract progression in streptozotocin-induced diabetic rats","volume":"1869","author":"Savitikadi","year":"2025","journal-title":"Biochim. Biophys. Acta (BBA)-Gen. Subj."},{"key":"ref_88","first-page":"915","article-title":"Evaluation of the drug-like properties of kaempferol, chrysophanol and emodin and their interactions with EGFR tyrosine kinase-an in silico approach","volume":"12","author":"Sreelakshmi","year":"2017","journal-title":"Nat. Prod. Commun."},{"key":"ref_89","first-page":"3971","article-title":"Investigating the Mechanism of Action of Qiju Dihuang Pill in Cataract Treatment by Network Pharmacology and Molecular Docking","volume":"5","author":"Hao","year":"2025","journal-title":"Curr. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Hwang, H.S., Kim, H.Y., Guillen Quispe, Y.N., Wang, Z., Zuo, G., and Lim, S.S. (2019). Aldose reductase, protein glycation inhibitory and antioxidant of Peruvian medicinal plants: The case of Tanacetum parthenium L. and its constituents. Molecules, 24.","DOI":"10.3390\/molecules24102010"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jtos.2024.08.001","article-title":"Preservatives and ocular surface disease: A review","volume":"34","author":"Kahook","year":"2024","journal-title":"Ocul. Surf."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jtos.2023.08.009","article-title":"TFOS lifestyle report executive summary: A lifestyle epidemic-ocular surface disease","volume":"30","author":"Craig","year":"2023","journal-title":"Ocul. Surf."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"P286","DOI":"10.1016\/j.ophtha.2018.10.023","article-title":"Dry eye syndrome preferred practice pattern\u00ae","volume":"126","author":"Akpek","year":"2019","journal-title":"Ophthalmology"},{"key":"ref_94","first-page":"1","article-title":"Kaempferol Inhibits Dry Eye-Related Corneal Inflammation In Vitro Via the p38 Pathway","volume":"17","author":"Li","year":"2022","journal-title":"Nat. Prod. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.brainresbull.2009.05.019","article-title":"Corneal transparency: Genesis, maintenance and dysfunction","volume":"81","author":"Qazi","year":"2010","journal-title":"Brain Res. Bull."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Yan, C., Zhang, Z., Jin, L., Liu, M., Wang, T., Yang, J., and Zhang, L. (2025). Analysis of the relevant factors for corneal graft rejection in the southern Liaoning region from 2019 to 2023. Front. Med., 11.","DOI":"10.3389\/fmed.2024.1517198"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1084\/jem.115.5.919","article-title":"Immunohistologic studies on antigen-antibody reactions in the avascular cornea: I. Reactions in rabbits actively sensitized to foreign protein","volume":"115","author":"Germuth","year":"1962","journal-title":"J. Exp. Med."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1515\/znc-2009-7-804","article-title":"Antiproliferative activity on human cancer cell lines after treatment with polyphenolic compounds isolated from Iris pseudopumila flowers and rhizomes","volume":"64","author":"Conforti","year":"2009","journal-title":"Z. F\u00fcr Naturforsch. C"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/tox.22686","article-title":"Kaempferol suppresses cell migration through the activation of the ERK signaling pathways in ARPE-19 cells","volume":"34","author":"Chien","year":"2019","journal-title":"Environ. Toxicol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"14983","DOI":"10.1007\/s11356-020-11466-9","article-title":"Onosma bracteata Wall. induces G0\/G1 arrest and apoptosis in MG-63 human osteosarcoma cells via ROS generation and AKT\/GSK3\u03b2\/cyclin E pathway","volume":"28","author":"Kumar","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s11064-025-04544-2","article-title":"Kaempferol plays a neuroprotection role by alleviating oxidative stress via AKT\/Nrf2\/HO-1 pathway and inhibiting apoptosis in intracerebral hemorrhage","volume":"50","author":"Huo","year":"2025","journal-title":"Neurochem. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40478-025-01927-y","article-title":"Kaempferol enhances ER-mitochondria coupling and protects motor neurons from mitochondrial dysfunction and ER stress in C9ORF72-ALS","volume":"13","author":"Pilotto","year":"2025","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"160","DOI":"10.18240\/ijo.2025.01.20","article-title":"Glaucomatous retinal ganglion cells: Death and protection","volume":"18","author":"Cui","year":"2025","journal-title":"Int. J. Ophthalmol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_105","first-page":"54","article-title":"A network pharmacology-based strategy for predicting the protective mechanism of Ginkgo biloba on damaged retinal ganglion cells","volume":"20","author":"Hua","year":"2022","journal-title":"Chin. J. Nat. Med."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Dahan, A., Oz, M., Yarmolinsky, L., Zahavi, A., Goldenberg-Cohen, N., Khalfin, B., Ben-Shabat, S., and Lubin, B.C.R. (2025). Multi-Target Neuroprotective Effects of Flavonoid-Rich Ficus benjamina L. Leaf Extracts: Mitochondrial Modulation, Antioxidant Defense, and Retinal Ganglion Cell Survival In Vivo. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262311746"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"112021","DOI":"10.1016\/j.intimp.2024.112021","article-title":"Immunomodulatory effects of Kaempferol on microglial and Macrophage cells during the progression of diabetic retinopathy","volume":"133","author":"Albalawi","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jconrel.2022.12.041","article-title":"M1\/M2 re-polarization of kaempferol biomimetic NPs in anti-inflammatory therapy of atherosclerosis","volume":"353","author":"Zhao","year":"2023","journal-title":"J. Control. Release"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2015.05.002","article-title":"Kaempferol and inflammation: From chemistry to medicine","volume":"99","author":"Devi","year":"2015","journal-title":"Pharmacol. Res."},{"key":"ref_110","first-page":"765","article-title":"A comparative study of phytoestrogen action in mitigating apoptosis induced by oxidative stress","volume":"26","author":"Ondricek","year":"2012","journal-title":"In Vivo"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1089\/jmf.2016.3913","article-title":"In vitro anti-inflammatory activity of Ilex cornuta extract mediated by inhibition of extracellular signal-regulated kinase phosphorylation","volume":"20","author":"Kim","year":"2017","journal-title":"J. Med. Food"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Lopez-Miranda, D.Y., Reyes-Chilpa, R., Magos, G.A., Avila Acevedo, J.G., Guzman-Gutierrez, S.L., Martinez-Ambriz, E., Campos-Lara, M.G., Osuna-Fernandez, H.R., and Jimenez-Estrada, M. (2023). Five anti-inflammatory plant species of the Libellus de Medicinalibus Indorum Herbis from Mexico, 1552: A botanical, chemical and pharmacological review. Acta Bot\u00e1n. Mex., e2137.","DOI":"10.21829\/abm130.2023.2137"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"\u0110or\u0111evski, N., Uba, A.I., Zengin, G., Bo\u017eunovi\u0107, J., Ga\u0161i\u0107, U., Ristanovi\u0107, E., \u0106iri\u0107, A., Nikoli\u0107, B., and Stojkovi\u0107, D. (2022). Chemical and biological investigations of Allium scorodoprasum L. flower extracts. Pharmaceuticals, 16.","DOI":"10.3390\/ph16010021"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuro.2022.12.008","article-title":"Kaempferol counteracts toxicity induced by 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine in D. melanogaster: An implication of its mitoprotective activity","volume":"95","author":"Adedara","year":"2023","journal-title":"Neurotoxicology"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3987\/COM-10-S(E)6","article-title":"New and known constituents from Iris unguicularis and their antioxidant activity","volume":"82","author":"Abbaskhan","year":"2010","journal-title":"Heterocycles"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1007\/s12272-009-2006-3","article-title":"Kaempferol glycosides with antioxidant activity from Brassica juncea","volume":"32","author":"Jung","year":"2009","journal-title":"Arch. Pharmacal Res."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1080\/10942912.2023.2205040","article-title":"Anticancer, antioxidant, ameliorative and therapeutic properties of kaempferol","volume":"26","author":"Shahbaz","year":"2023","journal-title":"Int. J. Food Prop."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"134633","DOI":"10.1016\/j.neulet.2019.134633","article-title":"Kaempferol protects retinal ganglion ceils from high-glucose-induced injury by regulating vasohibin-1","volume":"716","author":"Zhao","year":"2020","journal-title":"Neurosci. Lett."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.7150\/ijms.116512","article-title":"Association between disorders of lipid metabolism and oculopathy: An overview","volume":"22","author":"Yang","year":"2025","journal-title":"Int. J. Med. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ptr.5000","article-title":"Aldose reductase inhibitors of plant origin","volume":"28","author":"Veeresham","year":"2014","journal-title":"Phytother. Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"142963","DOI":"10.1016\/j.molstruc.2025.142963","article-title":"Aldose reductase inhibitory activity, molecular docking, ADMET, and density functional theory investigation of flavonoids isolated from Euphorbia pulcherrima Willd Ex Koltz","volume":"1344","author":"Ajaj","year":"2025","journal-title":"J. Mol. Struct."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"8312","DOI":"10.1021\/acs.jafc.4c13123","article-title":"Kaempferol induces DNA damage in colorectal cancer cells by regulating the MiR-195\/miR-497-PFKFB4-mediated nonoxidative pentose phosphate pathway","volume":"73","author":"Wu","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1002\/cbin.10152","article-title":"Kaempferol inhibits cancer cell growth by antagonizing estrogen-related receptor \u03b1 and \u03b3 activities","volume":"37","author":"Wang","year":"2013","journal-title":"Cell Biol. Int."},{"key":"ref_124","first-page":"318","article-title":"Flavonoids from Litsea japonica inhibit AGEs formation and rat lense aldose reductase in vitro and vessel dilation in zebrafish","volume":"83","author":"Lee","year":"2017","journal-title":"Planta Medica"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"133816","DOI":"10.1016\/j.ijbiomac.2024.133816","article-title":"Aldose reductase inhibitory and antiglycation properties of phytoconstituents of Cichorium intybus: Potential therapeutic role in diabetic retinopathy","volume":"277","author":"Ahmad","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.ymthe.2020.06.029","article-title":"Gene therapy intervention in neovascular eye disease: A recent update","volume":"28","author":"Lin","year":"2020","journal-title":"Mol. Ther."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1002\/ptr.70029","article-title":"Potential Therapeutic Actions of Flavonoids Present in Propolis That Modulate Vascular Endothelial Growth Factor Signaling to Regulate Angiogenesis","volume":"39","author":"Lin","year":"2025","journal-title":"Phytother. Res."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"114820","DOI":"10.1016\/j.biopha.2023.114820","article-title":"Anti-angiogenic effect of nano-formulated water soluble kaempferol and combretastatin in an in vivo chick chorioallantoic membrane model and HUVEC cells","volume":"163","author":"Subbaraj","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"105646","DOI":"10.1016\/j.jff.2023.105646","article-title":"Kaempferol relieves the DSS-induced chronic colitis in C57BL\/6J mice, alleviates intestinal angiogenesis, and regulates colonic microflora structure","volume":"107","author":"Yu","year":"2023","journal-title":"J. Funct. Foods"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/JCMA.0000000000001113","article-title":"Study on the bioactive ingredients and mechanism of Huangqi against diabetic retinopathy based on network pharmacology and experimental verification","volume":"87","author":"Lin","year":"2024","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.imbio.2011.05.002","article-title":"Kaempferol from Semen cuscutae attenuates the immune function of dendritic cells","volume":"216","author":"Lin","year":"2011","journal-title":"Immunobiology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.7150\/jca.88038","article-title":"Potential mechanisms underlying inhibition of xenograft lung cancer models by kaempferol: Modulation of gut microbiota in activating immune cell function","volume":"15","author":"Guan","year":"2024","journal-title":"J. Cancer"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"114387","DOI":"10.1016\/j.intimp.2025.114387","article-title":"Research progress on pharmacokinetics, anti-inflammatory and immunomodulatory effects of kaempferol","volume":"152","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Poon, L.Y., Hsu, L.M., Lam, L.K., Huang, X., Xu, P., Liang, Q., Xie, P., and Yang, S. (2025). Mechanistic insights into modified Danggui Buxue Decoction for diabetic retinopathy via integrative analysis. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1648831"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Dong, H., Song, G., Wang, Z., Wu, X., Wang, Q., and Wang, Y.-H. (2025). Kaempferol as a multifaceted immunomodulator: Implications for inflammation, autoimmunity, and cancer. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1671519"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e23090","DOI":"10.1002\/jbt.23090","article-title":"Subacute 28 days oral toxicity study of kaempferol and biochanin-A in the mouse model","volume":"36","author":"Yangzom","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Inthachat, W., Chantong, B., Pitchakarn, P., Takoon, C., Karinchai, J., Suttisansanee, U., and Temviriyanukul, P. (2024). Enhancing therapeutic efficacy of donepezil, an Alzheimer\u2019s disease drug, by Diplazium esculentum (Retz.) sw. and its phytochemicals. Pharmaceuticals, 17.","DOI":"10.3390\/ph17030341"}],"container-title":["Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/8\/996\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T11:06:42Z","timestamp":1786532802000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1999-4923\/18\/8\/996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":137,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["pharmaceutics18080996"],"URL":"https:\/\/doi.org\/10.3390\/pharmaceutics18080996","relation":{},"ISSN":["1999-4923"],"issn-type":[{"value":"1999-4923","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}